110023 research outputs found
Sort by
台灣老舊街區轉型案例研究-以臺北市赤峰街為例
No full text[[abstract]]舊市區有著完備的都市基礎，具備既有的人口和都市機能，有著方便的生活網
絡和基本建設，反之無意義的擴張、增加新建設會提高額外的都市經營成本，降低公
共服務效率，造成市中心空洞化，間接形成閒置的建築和空間的增加。
因此在面對城市發展與老舊街區的議題，需要面對的不只是城市的擴充與建設，
如何定義古蹟及歷史建築和鄰近街道之關係、利用閒置空間與固有的建設加以修繕，
保存文化價值，達到最高的利用效率，亦為現今發展最重要的議題。
故本研究透過文獻分析、田野調查及親身參與，分析台灣老舊街區轉型之成功
案例，並以赤峰街做為比較對象，梳理其歷史背景、興衰原因、轉型契機及發展近況
，紀錄其發展歷程。探究如何從⾯臨產業的凋零的⽼舊街區，至今成為⽂創店家、公
共藝術裝置隨處可⾒的臺北新興景點，以及如何⾯對⽼舊街區沒落、⽼屋重新利⽤的
議題
活化地方吉祥物成為地方特色之個案探討 -以台中霧峰區地方吉祥物「貓頭鷹-霧霧」為例
No full text[[abstract]]台中霧峰山區是貓頭鷹的重要棲地，霧峰桐林社區以人巢箱復育數量驟減的貓頭鷹，目前
已獲得很好的成效。這些在社區環保生態努力保育下的貓頭鷹，是天人共好的代言者，也
成了霧峰的吉祥物與守護神。在霧峰與貓頭鷹相關文學、藝術創作蔚為風氣，並以社會設
計的角度導入多元的文化創意資源，期盼讓貓頭鷹以各種創意之姿在霧峰各角落出現，這
也正是霧峰貓頭鷹吉祥物角色最重要的溫度與內涵，此研究將追蹤探索聚焦於以社會設計
角度出發的吉祥物《貓頭鷹-霧霧》相關創作內容為例，包含文創商品設計、社區整體營造
與大學社會責任(USR)深化地方經營，如何一步步多元活化社區整體與產業，並讓霧峰特
色文化城鎮再添一筆驚喜
資訊電機學院資訊傳播學系
No full text[[abstract]]夢的世界是虛幻且神祕的，只要短時間一過就無法十分清楚的將夢記住，但 透過夢境記錄應用程式就能在意識剛清醒時刻，把前晚的夢用文字的方式先行記 錄於暫存中以免忘記，可是夢中的含義通常只有自己能夠領略，感受很深刻，但 卻只能以單方面的向聽眾訴說了既長又乏味的夢境冒險，且結局可能還會令人感 到無聊，因此在夢境記錄應用程式加上了有如以字轉圖的 AI 生成圖片功能，將 夢境轉換成色彩繽紛的圖片，提高與他人互動的樂趣。[[note]]郭思妤(Shi-Yu Kuo
數位科技應用於語言學習平台開發設計之研究
No full text[[abstract]]隨著數位科技的演變，已於人們的日常生活中帶來許多的便利性與趣味性， 讓生活增添了不少色彩；各產業面對知識經濟，其運作形態也因趨勢而改變。從 教育領域的角度探索，推動數位科技融入教學中，而本研究想藉由數位科技的便 利，突破傳統學習上受時間與空間侷限的因素，讓學習更多元、更寬廣；將目標 設定於國小生的語言學習系統之開發，其語言學習，不外乎需要了解詞彙、記住 單字、發音、語法等，需要讓學生能與日常生活的環境結合，故由此方式開發一 款遊戲學習 APP，讓學童於學習上不受學習地點與時間的限制，以及透過遊戲機 制（如積分、闖關、生命值、求救等）的方式進行學習，藉此提升國小生對語言 學習的興趣；此外，對於學校教材不排斥才能對課外語言讀物產生學習興趣
超現實風格插畫海報創作研究-以善待動物議題為題
No full text[[abstract]]近年來，動保意識逐漸抬頭，國際對於動物議題的關注度提高。透過新聞的報
導使撲殺、虐待、棄養等傷害動物的事件逐漸被政府正視，雖然動物保護法的法律
規範日益增進，但瞭解動物問題根本的民眾比例是相對較少的。因此本研究以善待
動物議題為題，並透過超現實風格插畫表現技法進行海報創作，希望以此特殊風格
吸引大眾目光，甚至引發興趣，使民眾願意主動關心動物議題，才能有效提升大眾
對動物保護的觀念與知識
IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis
No full text[[abstract]]Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocytes into the inflamed joint synovium. Interleukin (IL)-17 is a critical inflammatory mediator that participates in the progression of OA, although the mechanisms linking IL-17 and monocyte infiltration are not well understood. Our analysis of synovial tissue samples retrieved from the Gene Expression Omnibus (GEO) dataset exhibited higher monocyte marker (CD11b) and vascular cell adhesion molecule 1 (VCAM-1) levels in OA samples than in normal, healthy samples. The stimulation of human OA synovial fibroblasts (OASFs) with IL-17 increased VCAM-1 production and subsequently enhanced monocyte adhesion. IL-17 affected VCAM-1-dependent monocyte adhesion by reducing miR-5701 expression through the protein kinase C (PKC)-α and c-Jun N-terminal kinase (JNK) signaling cascades. Our findings improve our understanding about the effect of IL-17 on OA progression and, in particular, VCAM-1 production and monocyte adhesion, which may help with the design of more effective OA treatments
Involvement of the hemP-hemA-smlt0796-smlt0797 Operon in Hemin Acquisition by Stenotrophomonas maltophilia.
No full text[[abstract]]The hemin acquisition system of Stenotrophomonas maltophilia was elucidated in this study. To identify the TonB-dependent outer membrane receptor for hemin in S. maltophilia, the hemin acquisition systems of Pseudomonas aeruginosa were referenced. PhuR, HasA, and HxuA are three known TonB-dependent outer membrane receptors involved in hemin acquisition by P. aeruginosa. Thus, HemA (Smlt0795) and Smlt2937, the orthologs of PhuR and HasA/HxuA in S. maltophilia, were first considered. KJΔEnt, a stenobactin-null strain, was used as the parental strain for the hemin utilization assay. Deletion of hemA, but not Smlt2937, of KJΔEnt impaired hemin acquisition under iron-depleted conditions, indicating that HemA is the TonB-dependent receptor for hemin uptake. The hemA gene is a member of the hemP-hemA-smlt0796-smlt0797 operon, whose expression was upregulated in a fur mutant and under iron-depleted conditions. The contribution of the hemP-hemA-smlt0796-smlt0797 operon to hemin acquisition was investigated by in-frame deletion mutant construction and hemin utilization assays. Inactivation of hemP, smlt0796, and smlt0797 of KJΔEnt insignificantly affected hemin acquisition under iron-depleted conditions. However, hemP deletion in a fur mutant increased hemin acquisition under iron-depleted conditions. Collectively, we revealed that (i) HemA likely functions as the outer membrane receptor for hemin uptake; (ii) HemP, a predicted transcriptional factor, apparently functions as a repressor of the expression of the hemA transcript; and (iii) in a fur mutant, HemP has a negative impact on hemin acquisition under iron-depleted conditions. IMPORTANCE Stenotrophomonas maltophilia is an emerging multidrug-resistant opportunistic pathogen, increasing the difficulty of treatment of this infection. Iron is a critical element for bacterial viability. Heme is the most abundant iron source in the human host; thus, heme is the major iron source for a pathogen in the infection niche. Blocking iron acquisition from heme can be an alternative strategy to control S. maltophilia infection. Although several hemin acquisition systems have been reported in various pathogens, very little is known about the hemin acquisition systems of S. maltophilia. By in-frame deletion mutant construction and hemin utilization assays, we demonstrated that HemA (Smlt0795) is the TonB-dependent outer membrane receptor for hemin uptake and that HemP (Smlt0794), a predicted transcriptional factor, had a negative impact on hemin acquisition in a fur mutant. The negative regulatory role of HemP in hemin acquisition is first reported
Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
No full text[[abstract]]Five new dimer compounds, namely Taiwaniacryptodimers A–E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae
Recognition of a Novel Gene Signature for Human Glioblastoma
No full text[[abstract]]Glioblastoma (GBM) is one of the most common malignant and incurable brain tumors. The identification of a gene signature for GBM may be helpful for its diagnosis, treatment, prediction of prognosis and even the development of treatments. In this study, we used the GSE108474 database to perform GSEA and machine learning analysis, and identified a 33-gene signature of GBM by examining astrocytoma or non-GBM glioma differential gene expression. The 33 identified signature genes included the overexpressed genes COL6A2, ABCC3, COL8A1, FAM20A, ADM, CTHRC1, PDPN, IBSP, MIR210HG, GPX8, MYL9 and PDLIM4, as well as the underexpressed genes CHST9, CSDC2, ENHO, FERMT1, IGFN1, LINC00836, MGAT4C, SHANK2 and VIPR2. Protein functional analysis by CELLO2GO implied that these signature genes might be involved in regulating various aspects of biological function, including anatomical structure development, cell proliferation and adhesion, signaling transduction and many of the genes were annotated in response to stress. Of these 33 signature genes, 23 have previously been reported to be functionally correlated with GBM; the roles of the remaining 10 genes in glioma development remain unknown. Our results were the first to reveal that GBM exhibited the overexpressed GPX8 gene and underexpressed signature genes including CHST9, CSDC2, ENHO, FERMT1, IGFN1, LINC00836, MGAT4C and SHANK2, which might play crucial roles in the tumorigenesis of different gliomas
The Effectiveness of Fuzi in Combination with Routine Heart Failure Treatment on Chronic Heart Failure Patients
No full text[[abstract]]Ethnopharmacological relevance: Fuzi, Aconiti Lateralis Radix Praeparata, is widely used in Traditional Chinese Medicine (TCM) for the treatment of acute heart failure (HF) for 2000 years. However, the clinical evidence of Fuzi in the treatment of chronic HF is limited, especially when used in combination with Western medications.
Materials and methods: This population-based propensity score (PS)-matched cohort study aimed to evaluate the effectiveness of Fuzi on the chronic HF. From 4753 chronic HF patients who had used TCM herbal medicine, we performed 1:1 PS matching and selected target patients with (n = 921) and without (n = 921) Fuzi use for further analysis. The primary outcomes were all-cause mortality and composite cardiovascular (CV) outcomes. Hazard ratio (HR) was calculated by Cox proportional hazard regression and the competing risk analysis. The dose-response relationship and the association between the initiation of TCM herbal medicine and the primary outcomes were evaluated by restricted cubic spline (RCS) functions.
Results: There was no difference in all-cause mortality (HR, 0.99; 95% confidence interval [CI], 0.76-1.27) and composite CV outcomes (HR, 0.96; 95% CI, 0.84-1.11) between the Fuzi user and non-user groups. For CV safety issue, the result showed that Fuzi use was not associated with a higher risk of cardiac arrhythmias (HR, 1.03; 95% CI, 0.83-1.29). The dose-response relationship showed that Fuzi cumulative dose (?150g) was associated with lower composite CV risk (HR, 0.76; 95% CI, 0.59-0.99). In addition, the RCS model showed that late initiation (?2.5 years) of TCM herbal drugs in chronic HF patients had a higher risk of all-cause mortality (HR, 1.81; 95%CI, 1.07-3.08).
Conclusions: This study is the first real-world evidence to demonstrate the effect of Fuzi combined with routine HF treatment. Importantly, the result indicated that long-term Fuzi use had a significant benefit in preventing cardiovascular events. The late initiation of TCM herbal drugs was associated with a higher risk of all-cause mortality. Further clinical trials are needed to support or undermine the assumption of using Fuzi and current Western medications to treat chronic HF