110023 research outputs found
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[[alternative]]A Study on the Key Factors of Success in the Development of Trade Union Organizations: A Case Study of Taichung Chinese cuisine Industry Union
No full text[[abstract]]本文介紹了臺灣工會制度中存在的問題，包括工會貪污舞弊、工會派系鬥爭、工會成員資格及勞健保問題等。本研究以臺中市小吃業職業工會為研究對象，說明其成員人數多、以勞保為主要業務等情況，臺灣至 110 年止，工會約4,280 家，平均一家人數在 635 人。因此，研究提出若要永續經營，職業工會必須改善傳統印象，開創符合會員需求之業務，以拓展生存空間。本研究發現臺中市小吃職業工會的成員約有招募方式採用理、監事之間的自動互相介紹，顯示出職業工會內部資訊共享和溝通的有效性，並提供完善的制度、福利和各種支持服務，吸引會員加入並提高其滿意度和忠誠度，並積極參與和支持小吃產業的發展，提高小吃業者的專業水平和市場競爭力。研究結論指出該工會的理、監事之間的信任和良好的合作關係，以及沒有招攬會員的壓力，表明其有足夠的會員數量和穩定的財務狀況，能夠更加關注和支持現有會員的需求和利益，進一步提高會員滿意度和忠誠度，這些是小吃職業工會主要成功原因。最後，建議工會能夠為會員提供更多的勞健保諮詢服務、職業培訓等教育訓練的功能等服務，以持續提高職業工會的功能及品質，進而提供更多及有效益的服務。[[abstract]]This article discusses issues in Taiwan's labor union system, such as corruption, factional struggles, membership qualifications, and labor disputes. It focuses on the Taichung City Snack Industry Occupational Union, highlighting its large membership and emphasis on labor and health insurance. With around 4,280 unions in Taiwan and an average of 635 members per union, the study suggests that occupational unions need to improve their image and develop member-oriented businesses for sustainable growth.The research finds that the Taichung City Snack Industry Occupational Union recruits members through mutual introductions among directors and supervisors, demonstrating effective information sharing and communication. The union offers comprehensive systems and benefits, attracting members and increasing satisfaction and loyalty. Actively supporting the snack industry's development, the union enhances professionalism and market competitiveness. Trust, cooperation between directors and supervisors, and absence of recruitment pressure indicate sufficient membership and stable finances, allowing focus on member needs and interests. Recommendations include expanding labor and health insurance consultation services, providing education and training programs, and continuously improving union functions and quali
[[alternative]]A Study on the Intention to Revisit Live Concerts in the Post COVID-19
No full text[[abstract]]音樂節是指以某個主題為中心，由許多音樂演奏或歌唱團體聚集數天或數週 來進行表演的節日。其中現場演唱會指的是以單獨或集體演唱者為中心，在觀眾 面前進行歌聲的現場舞台表演。對於觀眾而言，每個成功的現場演唱會都是一場 讓歌手與觀眾狂歡的藝文休憩音樂活動盛宴。由於目前還未有研究，針對後疫情 階段現場演唱會觀眾再訪意願進行調查。因此，本文以認知評價理論為基礎建立 研究架構，包括影響再訪意願的二個直接因素(沈浸體驗、深刻記憶)及五個間接 因素(觀眾熱情、觀眾互動、表演技能、自我一致、環境氛圍)，以此豐富相關學 術文獻。本研究以台灣消費者為主要研究對象，並以Google表單將研究量表製作問卷，以檢測題項內容是否與構念定義相符，且構念間概念在表面上無重疊之情事，然後完成量表與專家效度驗證與確認。接者，本調查亦進一步探索消費者對於現場演唱會的沈浸體驗與深刻記憶，在後疫情階段對其再訪意願所扮演的角色，以瞭解沈浸體驗在整個模型中所扮演的潛在中介角色與作用，以利未來其他學者可 充分利用本研究的發現和見解。[[abstract]]Music festival is a festival centered on a theme, where many musical or singing groups gather for days or weeks to perform. Live concerts refer to live stage performances centered on individual or collective singers who sing in front of the audience. For the audience, every successful live concert is a feast of artistic, cultural, leisure and music activities for the singers and the audience to revel. Since there is no research yet, a survey is conducted on the willingness of live concert audiences to revisit in the post-epidemic stage. Therefore, this paper establishes a research framework based on cognitive evaluation theory, including two direct factors (immersion experience, deep memory) and five indirect factors (audience enthusiasm, audience interaction, performance skills, self-consistency, and environmental atmosphere) that affect revisit intention, to enrich the relevant academic literature.This study focuses on Taiwanese consumers and utilizes Google Forms to create a questionnaire for measuring the conceptual definitions and potential overlap between concepts. The constructed scale is then validated and confirmed by experts. The study also investigates the role of immersive experiences and lasting memories of live concerts in post-pandemic times, particularly their influence on consumers' willingness to revisit such events. The aim is to understand the potential mediating role and impact of immersive experiences in the overall model, enabling future scholars to utilize the findings and insights of this study
[[alternative]]Exploring the E-Commerce Business Strategy of Beauty Products: Take Company A as an Example
No full text[[abstract]]近年來網路的普及及快速的變遷造就消費市場的改變，新時代零售來臨，依過去產業經營資料顯示，全世界化妝品產業持續蓬勃發展，而台灣地區化妝品保養品市場相當維成長率驚人。在台灣地區，化妝品與保養品除了已經變成生活必需品外，化妝品保養品的品牌形象也屬於消費者重視的議題。國人對美妝品的需求越增加，美妝保養品的消費值也跟著持續成長，美妝保養品已經被認為是民生必需品。美妝品產業也是應用生化科技和高附加價值產業。在臺灣，女性近年來的經濟能力也大幅提昇中，九零年代興起的婦女運動，讓女性意識更加抬頭，各式美妝保養品不論在產品、品牌、成分或行銷手法上也不斷推陳出新，然而不變的是女性對於美的追求。新一代的女性消費者，普遍都願意花更多的時間、金錢在美容上，以滿足女性「寵愛自己」的心態。透過品牌個案研究了解到台灣美妝保養品品牌因應電商產業的經營迅速跨境打出另一番天地。經由研究發現其品牌經營過程中的發展歷程、在東南亞市場所遭遇的困境、競爭及挑戰。對應跨境電商品牌經營的主要重點應注意下列重點，「符合時代脈動，順應市場趨勢」、「有效管理客戶，創造高轉換率」、「即時雙向溝通，拉近顧客距離」、「多元化的經營，深化品牌形象」、「定位品牌態度，鎖定目標客群」、「分析數據成效，需求變成依賴」、「加速虛實整合，全方位的經營」、「消費習慣改變，優化整合平台」。[[abstract]]In recent years, the popularity of the Internet and rapid changes have created changes in the consumer market, and a new era of retailing has arrived. In Taiwan, cosmetics and care products have not only become a necessity, but the brand image of cosmetics and care products is also an important issue for consumers. As the demand for cosmetics increases, the consumption value of cosmetics and care products also continues to grow, and cosmetics and care products are now considered a necessity. The beauty industry is also an industry that applies biochemical technology and high added value. In Taiwan, women's economic power has increased dramatically in recent years. The women's movement that emerged in the 1990s has raised women's consciousness, and all kinds of beauty care products are constantly evolving in terms of products, brands, ingredients and marketing methods. The new generation of female consumers are generally willing to spend more time and money on beauty to satisfy the "pampering" mentality of women. Through brand case studies, we learned that Taiwan's beauty and care brands are rapidly making a name for themselves across the border in response to the e-commerce industry. The study reveals the development process of the brand, the difficulties, competition and challenges in the Southeast Asian market. The main points of cross-border e-commerce brand management should be noted as follows: "conforming to the pulse of the times and market trends", "effectively managing customers to create high conversion rates", "real-time two-way communication to bring customers closer", "diversified operation to deepen brand image", "positioning brand attitude and targeting customer segments", "analyzing the effectiveness of data and turning demand into dependence", "accelerating the integration of virtual and real, all-round The company's business is "to accelerate the integration of the virtual and the real, and to optimize the integration platform as consumer habits change"
[[alternative]]Research on Organizational Development and Expand Strategy of Financial and Insurance-Yung Hsiu Insurance Brokers as an Example
No full text[[abstract]]本研究採用訪談形式以獲得研究相關第一手資料，共訪談了永旭保險經紀人兩位高階主管，針對保險業在增員上所遇到的困難與挑戰，從主管思維分享自身經驗，綜合探討保險經紀人與單一公司在增員制度上與利潤層面上的差異性。透過訪談，分析「增員」對於被增員者與增員者的效益與利益各為何。結論：以兩位保險從業主管增員經驗討論全臺灣之保險相關從業人員可能會遇到增員問題，以其經驗分享延伸討論輔導機制之重要性，包含個人未來職涯發展與規劃、保險業永續經營及社會責任，以此可見得公司增員制度上的公平性與透明化的晉升管道相對重要，不論是白紙增員或者是同業增員都息息相關，故好的輔導機制與主管帶領模式，更攸關從業人員能否在該行業生存的主要因素。[[abstract]]Purpose: This study is conducted in the form of interviews. A total of two senior executives of Yongxu Insurance Brokers were interviewed. The difficulties and challenges they encountered in increasing employees in the insurance industry were combined and analyzed by combining their own experience and executive thinking. The differences between insurance brokers and single companies in terms of recruitment system and profit level are based on interviews and analysis to discuss the benefits and benefits of reinforcements for the recruited and the recruiters. The conclusion: comprehensive insurance related insurance in Taiwan Practitioners will encounter the problem of increasing staff. The counseling mechanism is relatively important, including future life development and planning, sustainable operation and development. The company's fairness and transparent promotion channels are relatively important. They are closely related. A good mentoring mechanism and supervisor leadership model are the main factors that determine whether practitioners can survive in the industry
Glycyrrhiza uralensis root extract ameliorates high glucose-induced renal proximal tubular fibrosis by attenuating tubular epithelial-myofibroblast transdifferentiation by targeting TGF-β1/Smad/Stat3 pathway
No full text[[abstract]]Growing evidences indicate that high glucose toxicity-associated fibrotic effects play a pivotal role in diabetic nephropathy (DN). Tubular epithelial-myofibroblast transdifferentiation is a major hallmark of renal fibrosis event under diabetic stress. Roots of Glycyrrhiza uralensis (Radix glycyrrhizae) used as a sweetener and traditional Chinese medicine possess high potential for renal protection. In this study, a cell model for high glucose (HG) injury with HK-2 renal proximal tubular epithelial cell line and a type-II-diabetes model with Apoeem1/Narl/Narl mice was established and the beneficial effects of aqueous R. glycyrrhizae extract (RGE) was investigated. RGE-induced regulation on the high glucose-induced excessive production of TGF-β1 and the Smad/Stat3 mechanisms of renal fibrosis were determined. HK-2 cells were challenged with 45 mM of high glucose for 48 hr. Following high glucose challenge, the cells were treated with 0.5, 1, and 1.5 mg/ml concentrations of RGE. The effect of RGE on DN was determined using high fructose diet-induced type-II-diabetes in Apoeem1/Narl/Narl mice models. Our results showed that RGE suppressed the expression of HG-induced TGFβ signaling and associated fibrosis mechanism better than the pharmacological drug acarbose. These data suggest that RGE as a potential herbal supplement in attenuating fibrosis-associated diabetic nephropathy and a potential agent in diabetes treatments
Isoliquiritigenin ameliorates advanced glycation end-products toxicity on renal proximal tubular epithelial cells
No full text[[abstract]]Diabetic nephropathy is a serious chronic complication affecting at least 25% of diabetic patients. Hyperglycemia associated advanced glycation end-products (AGEs) increase tubular epithelial-myofibroblast transdifferentiation (TEMT) and extracellular matrix synthesis and thereby causes renal fibrosis. The chalcone isoliquiritigenin, found in many herbs of Glycyrrhiza family, is known for potential health-promoting effects. However, their effects on AGE-associated renal proximal tubular fibrosis are not known yet. In this study, the effect of isoliquiritigenin on AGE-induced renal proximal tubular fibrosis was determined in cultured HK-2 cell line. The results show that 200 μg/mL of AGE-induced TEMT and the formed myofibroblasts synthesized collagen to increase extracellular matrix formation thereby lead to renal tubular fibrosis. However, treatment with 200 nM of isoliquiritigenin considerably inhibited the TEMT and suppressed the TGFβ/STAT3 mechanism to inhibit collagen secretion. Therefore, isoliquiritigenin effectively suppressed AGE-induced renal tubular fibrosis
Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration
No full text[[abstract]]Neural mitochondrial dysfunction, neural oxidative stress, chronic neuroinflammation, toxic protein accumulation, and neural apoptosis are common causes of neurodegeneration. Elamipretide, a small mitochondrially-targeted tetrapeptide, exhibits therapeutic effects and safety in several mitochondria-related diseases. In neurodegeneration, extensive studies have shown that elamipretide enhanced mitochondrial respiration, activated neural mitochondrial biogenesis via mitochondrial biogenesis regulators (PCG-1α and TFAM) and the translocate factors (TOM-20), enhanced mitochondrial fusion (MNF-1, MNF-2, and OPA1), inhibited mitochondrial fission (Fis-1 and Drp-1), as well as increased mitophagy (autophagy of mitochondria). In addition, elamipretide has been shown to attenuate neural oxidative stress (hydrogen peroxide, lipid peroxidation, and ROS), neuroinflammation (TNF, IL-6, COX-2, iNOS, NLRP3, cleaved caspase-1, IL-1β, and IL-18), and toxic protein accumulation (Aβ). Consequently, elamipretide could prevent neural apoptosis (cytochrome c, Bax, caspase 9, and caspase 3) and enhance neural pro-survival (Bcl2, BDNF, and TrkB) in neurodegeneration. These findings suggest that elamipretide may prevent the progressive development of neurodegenerative diseases via enhancing mitochondrial respiration, mitochondrial biogenesis, mitochondrial fusion, and neural pro-survival pathway, as well as inhibiting mitochondrial fission, oxidative stress, neuroinflammation, toxic protein accumulation, and neural apoptosis. Elamipretide or mitochondrially-targeted peptide might be a targeted agent to attenuate neurodegenerative progression
Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay
No full text[[abstract]]Background and aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells through the binding of the viral spike protein with human angiotensin-converting enzyme 2 (ACE2), resulting in the development of coronavirus disease 2019 (COVID-19). To date, few antiviral drugs are available that can effectively block viral infection. This study aimed to identify potential natural products from Taiwan Database of Extracts and Compounds (TDEC) that may prevent the binding of viral spike proteins with human ACE2 proteins.
Methods: The structure-based virtual screening was performed using the AutoDock Vina program within PyRX software, the binding affinities of compounds were verified using isothermal titration calorimetry (ITC), the inhibitions of SARS-CoV-2 viral infection efficacy were examined by lentivirus particles pseudotyped (Vpp) infection assay, and the cell viability was tested by 293T cell in MTT assay.
Results and conclusion: We identified 39 natural products targeting the viral receptor-binding domain (RBD) of the SARS-CoV-2 spike protein in silico. In ITC binding assay, dioscin, celastrol, saikosaponin C, epimedin C, torvoside K, and amentoflavone showed dissociation constant (K d) = 0.468 μM, 1.712 μM, 6.650 μM, 2.86 μM, 3.761 μM and 4.27 μM, respectively. In Vpp infection assay, the compounds have significantly and consistently inhibition with the 50-90% inhibition of viral infection efficacy. In cell viability, torvoside K, epimedin, amentoflavone, and saikosaponin C showed IC50 > 100 μM; dioscin and celastrol showed IC50 = 1.5625 μM and 0.9866 μM, respectively. These natural products may bind to the viral spike protein, preventing SARS-CoV-2 from entering cells.
Section 1: Natural Products.
Taxonomy classification by evise: SARS-CoV-2, Structure-Based Virtual Screening, Isothermal Titration Calorimetry and Lentivirus Particles Pseudotyped (Vpp) Infection Assay, in silico and in vitro study
Rotational diffusometric sensor with isothermal amplification for ultra-sensitive and rapid detection of SARS-CoV-2 nsp2 cDNA
No full text[[abstract]]In the wake of a pandemic, the development of rapid, simple, and accurate molecular diagnostic tests can significantly aid in reducing the spread of infections. By combining particle imaging with molecular assays, a quick and highly sensitive biosensor can readily identify a pathogen at low concentrations. Here, we implement functionalized particle-enabled rotational diffusometry in combination with loop-mediated isothermal amplification for the rapid detection of the SARS-CoV-2 nsp2 gene in the recombinant plasmid as a proof of concept for COVID-19 diagnostics. By analyzing the images of blinking signals generated by these modified particles, the change in micro-level viscosity due to nucleic acid amplification was measured. The high sensitivity of rotational diffusometry enabled facile detection within 10 min, with a limit of detection of 70 ag/μL and a sample volume of 2 μL. Tenfold higher detection sensitivity was observed for rotational diffusometry in comparison with real-time PCR. In addition, the system stability and the effect of temperature on rotational diffusometric measurements were studied and reported. These results demonstrated the utility of a rotational diffusometric platform for the rapid and sensitive detection of SARS-CoV-2 cDNA fragments
State of play in technology and legal framework of alternative marine fuels and renewable energy systems: a bibliometric analysis
No full text[[abstract]]Various endeavors are undertaken by the maritime industry, academia, and policy-makers to reduce greenhouse gas emissions. These include the search for feasible technologies that could be used onboard merchant vessels and are propelled by international legal and social initiatives. To this end, this study aimed to critically analyze the research trends pertaining to the active methods of reducing the negative environmental impact of shipping. The research is focused on alternative fuels and renewable energy systems with respect to the related policy-making and existing legal framework. Therefore, a bibliometric approach was applied to a sample of 234 scientific papers indexed in the SCI-EXPANDED in Clarivate Analytics Web of Science Core Collection. The results indicate that the scientific efforts were made more on alternative fuels, while renewable energy sources only recently became a popular research subject. Moreover, the environmental benefits of prospective technologies are more investigated than their financial aspects. The research effort on alternative maritime fuels was made in parallel with the legal one, both aiming to combat global climate change and magnifying each other