335598 research outputs found
Sort by
The Genesis of Throughput Models for Automated Warehouse Systems - A Drama in three Acts
No full textThe development of automated warehouse systems has been driven by advancements in computing, communication, and control technologies. However, throughput models and guidelines often lag behind industrial implementation. This paper analyzes the historical progression of automated warehouse systems, highlighting the decades-long gap between system realization and model development. By classifying storage technologies and tracing their evolution, we emphasize the need for systematic methodologies to accelerate throughput modeling, ensuring that performance evaluation keeps pace with innovation in warehouse automation
The quantum technology job market: data driven analysis of 3641 job posts
No full textThe rapid advancement of Quantum Technology (QT) has created a growing demand for a specialized workforce, spanning across academia and industry. This study presents a quantitative analysis of the QT job market by systematically extracting and classifying 3641 job postings worldwide. The classification pipeline leverages large language models (LLMs) whilst incorporating a “human-in-the-loop” validation process to ensure reliability. The research identifies key trends in regional job distribution, degree and skill requirements, and the evolving demand for QT-related roles. Findings reveal a strong presence of the QT job market in the United States and Europe, with increasing corporate demand for engineers, software developers, and PhD-level researchers. Despite growing industry applications, the sector remains in its early stages, dominated by large technology firms. However, there is some sign that there may be change to come, indicated by a strong presence of Bachelor and Master’s graduates in the workforce
Leuchtstoff-konvertierte Lichtquellen für die fluoreszenzbasierte, patientennahe Labordiagnostik
No full textChiplabore fur Fluoreszenzanalysen, wie sie in der patientennahen Labordiagnostik eingesetzt werden, kombinieren Anforderungen aus der Medizintechnik und dem Verbrauchermarkt. Eine Lichtquelle, welche die Anforderungen aus beiden Bereichen vereint, ist zum aktuellen Zeitpunkt nicht bekannt. Entweder können im Laborkontext eingesetzte Gasentladungslampen mit einer hohen Strahldichte und einem kontinuierlichen Spektrum oder LEDs mit für den Verbrauchermarkt vorteilhaften Sicherheitsstandards, Leistungsaufnahmen sowie Kosten genutzt werden. Zweck der vorliegenden Arbeit ist die Identifikation einer Lichtquelle, die auf die Bedürfnisse der patientennahen Labordiagnostik zugeschnitten ist. Zentrale Hypothese ist, dass Leuchtstoff-konvertierte Lichtquellen, insbesondere wenn ein Laser den Leuchtstoff pumpt, Vorteile von Gasentladungslampen und LEDs kombinieren und einen geeigneten Kompromiss fur die patientennahe Labordiagnostik darstellen. Um das Potential Leuchtstoffkonvertierter Lichtquellen zu zeigen, erfolgt die Ableitung von Anforderungen an die Lichtquelle auf Basis von allgemeinen Überlegungen sowie konkreten Konzepten. Anschließend werden Anforderungen an verfügbare Leuchtstoffe auf Literaturbasis sowie in einem Charakterisierungssetup abgeglichen. Vielversprechende Konzepte finden eine praktische Umsetzung, die Vorteile in der Anwendung aufzeigt. Als Keramik gesinterter YAG:Ce3+- und LuGaAG:Ce3+-Leuchtstoff wurden als geeignetes Set identifiziert. Angeregt durch einen blauen Laser resultiert ein kontinuierliches Spektrum, das die für die Fluoreszenzanalyse relevanten Wellenlangen abdeckt, und eine im Vergleich zu LED-Lichtquellen mit kontinuierlichem Spektrum höhere Strahldichte aufweist. Durch die höhere Strahldichte der laserangeregten Remote-Leuchtstoffe ist die Umsetzung optimierter Beleuchtungssysteme sowie die Realisierung zusätzlicher Funktionen möglich. Die vorliegende Arbeit zeigt das Potential in einem miniaturisierten spektralen Filter und einer Beleuchtungseinheit mit anpassbarem Ausleuchtbereich. Da laserangeregte Remote-Leuchtstoffe eine Halbleiterlichtquelle zur Lichterzeugung nutzen, bieten diese ähnliche Vorteile wie die LED-Technologie. Mit einer hohen Strahldichte, einem kontinuierlichen Spektrum, der Verfügbarkeit bei relevanten Wellenlangen und vielen Vorteilen einer Halbleiterlichtquelle stellen laserangeregte Remote-Leuchtstoffe daher einen Kompromiss aus Gasentladungslampen und LED-Lichtquellen dar. Durch die vorteilhaften Eigenschaften bieten laserangeregte Remote-Leuchtstoffe das Potential, Chiplabore in der patientennahen Labordiagnostik substanziell weiterzuentwickeln
Temporal dynamics of shame and guilt in adolescent NSSI: an ambulatory assessment study
No full textIntroduction: Nonsuicidal self-injury (NSSI) is a common clinical concern among adolescents, yet the roles of shame and guilt as proximal drivers of NSSI in daily life remain unclear. Using an ambulatory assessment design, we examined how these self-conscious emotions relate to momentary NSSI urges and how they fluctuate before and after NSSI acts.
Methods: We recruited 25 adolescents (M = 15.9 years, 72% female, 8% male, 20% gender-diverse) who reported shame, guilt, and NSSI urges four times per day for seven consecutive days on their smartphones. NSSI acts were logged using event-contingent prompts, followed by repeated ratings 10, 20, and 30 minutes after each act. Linear mixed-effects models were used to test concurrent and lagged associations between shame, guilt, and NSSI urges and to estimate event-related changes in these emotions.
Results: Both shame and guilt were positively associated with concurrent NSSI urges at the within- and between-person levels. Shame showed more pronounced temporal variability, with higher levels on Sundays and during the evening hours, and it increased in the minutes following NSSI. Guilt, however, showed no consistent diurnal or weekly pattern and did not change post-NSSI. Neither emotion predicted higher urges at the next prompt one to approximately three hours later.
Discussion: In adolescents who engage in NSSI, shame and guilt co-occur with episodes of elevated urges rather than predict them over short periods. Shame appears more involved in the aftermath of NSSI, consistent with a maintenance process, whereas guilt tracked urges to a similar extent but did not change post-NSSI. Clinically, spikes in both shame and guilt may serve as actionable real-time markers, and post-episode support targeting self-criticism and anticipated judgment may be especially beneficial. Schools and health care settings can reduce barriers to help-seeking by using non-stigmatizing language around NSSI, given that shame frequently drives concealment
AI-based image analysis for process automation; [KI-basierte Bildanalyse zur Prozessautomatisierung]
No full textIn pathologischen Laboren werden Gewebeproben in einem Produktionsprozess in mehreren Schritten für die anschließende Diagnose aufbereitet. Während ein Großteil der Prozesse automatisiert
stattfindet und Robotik in der Handhabung Einzug hält, ist der erste Arbeitsschritt des Zuschnitts noch durch manuelle Schritte geprägt. Dieser Beitrag stellt eine KI-basierte Automatisierung der Proben beschreibung und -transkription dar. Damit beschreibt der Beitrag einen wichtigen Schritt zur Verbesserung heterogener Prozesse in der Pathologie
Thermomechanical Fatigue and Creep–Fatigue Interaction of Inconel 718 Additively Manufactured by Laser Beam Powder Bed Fusion
No full textThis study investigates the Ni-based superalloy Inconel 718 produced by laser beam powder bed fusion (PBF-LB) under thermomechanical fatigue (TMF) loading. Strain-controlled TMF tests under in-phase and out-of-phase conditions were conducted in the temperature range from 300°C to 650°C. To increase creep–fatigue interaction, tensile dwell times of 10 min at 650°C were introduced in some in-phase TMF tests. After hot isostatic pressing, solution annealing and age-hardening, the PBF-LB material recrystallized and exhibited finely dispersed γ″ precipitates, typical of Inconel 718. In this state, the material showed a cyclic
deformation behavior comparable to that of conventionally-rolled Inconel 718. In tests without dwell times, the TMF lifetimes of PBF-LB Inconel 718 reached almost those of conventionally-rolled Inconel 718. Introducing dwell times significantly reduced the TMF life of PBF-LB Inconel 718. The results suggest that this effect can be attributed to a lack of grain boundary precipitates, which may facilitate grain boundary sliding and promote intergranular crack propagation
Prompt Searches for Very-high-energy γ -Ray Counterparts to IceCube Astrophysical Neutrino Alerts
No full textThe search for sources of high-energy astrophysical neutrinos can be significantly advanced through a multimessenger approach, which seeks to detect the γ-rays that accompany neutrinos as they are produced at their sources. Multimessenger observations have so far provided the first evidence for a neutrino source, illustrated by the joint detection of the flaring blazar TXS 0506+056 in high-energy (E > 1 GeV) and very-high-energy (VHE; E > 100 GeV) γ-rays in coincidence with the high-energy neutrino IceCube-170922A, identified by IceCube. Imaging atmospheric Cherenkov telescopes (IACTs), namely FACT, H.E.S.S., MAGIC, and VERITAS, continue to conduct extensive neutrino target-of-opportunity follow-up programs. These programs have two components: follow-up observations of single astrophysical neutrino candidate events (such as IceCube-170922A), and observation of known γ-ray sources after the identification of a cluster of neutrino events by IceCube. Here we present a comprehensive analysis of follow-up observations of high-energy neutrino events observed by the four IACTs between 2017 September (after the IceCube-170922A event) and 2021 January. Our study found no associations between γ-ray sources and the observed neutrino events. We provide a detailed overview of each neutrino event and its potential counterparts. Furthermore, a joint analysis of all IACT data is included, yielding combined upper limits on the VHE γ-ray flux