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Effects of Resistance vs High Intensity Interval Training on Myokines and Cancer Cell Suppression in Breast Cancer Survivors: A Randomized Trial
No full textPurpose: Reducing recurrence and mortality is crucial for breast cancer survivors. We investigated the effects of a 12-week resistance training (RT) vs high-intensity interval training (HIIT) program on myokines, cytokines secreted by skeletal muscle cells at rest in response to muscle contraction, and cancer cell inhibition. Methods: Twenty-eight survivors of breast cancer (age 55.5 ± 8.8 yr, body mass index 27.9 ± 5.1 kg/m2, time since diagnosis 31 ± 12.3 months) were randomly allocated to a 12-week supervised moderate to high intensity RT (n = 14) or HIIT (n = 14) program 3 days per week. Resting blood was collected before and post exercise program (at least 48 hours before the first and after the last exercise session) to measure serum levels of myokines (decorin, interleukin 6 [IL-6], secreted protein acidic and rich in cysteine [SPARC], and oncostatin M [OSM]) and triple negative MDA-MB-231 cell growth in vitro, using real time cellular analysis to determine growth rate. Results: Exercise attendance was 85% for RT and 81% for HIIT. Serum levels of SPARC for RT and OSM for HIIT significantly (p < 0.05) increased (11 to 15%) after 12 weeks, with no significant differences between groups. MDA-MB-231 cell growth was significantly (p < 0.05) reduced for both RT and HIIT by 22% and 25%, respectively, with no significant difference between groups. Reductions in MDA-MB-231 cell growth in HIIT were associated with improvements in lean and fat mass. Conclusions: A program of RT or HIIT can increase levels of myokines (an effect considered beneficial given their potential cancer-suppressive effects) and inhibit growth of MDA-MB-231 cells in survivors of breast cancer. In addition, development of the anti-tumor environment may be mediated by exercise-related changes in muscle strength and body composition
Le “propagandiste comuniste”. Antifasciste, esuli, clandestine
No full textNella responsabilità della classe dirigente comunista di aver dato minore spazio alla valorizzazione del ruolo femminile nel processo di opposizione al fascismo e successiva democratizzazione del paese, va annoverato anche il caso delle attiviste clandestine, in patria o in esilio. Il Casellario Politico Centrale (CPC) ha schedato un numero cospicuo di “propagandiste comuniste” che a vario titolo hanno svolto compiti e azioni dirette a contrastare il regime. L’antifascismo femminile è diventato oggetto della storiografia in tempi più recenti andando a colmare un vuoto “colpevole” da parte di chi voleva scrivere quella storia solo al maschile
Politizar la traducción clásica chilena: ‘La Salvación de las Repúblicas de América’ en la esfera hispanohablante (1887-1939)
No full text¿Qué se discutía en términos políticos cuando aparecieron las primeras traducciones del griego antiguo y el latín en Chile de principios del siglo XX? Este artículo expone las lecturas públicas y privadas de estas traducciones por los críticos literarios. Este enfoque en la interpretación del público conllevó la aplicación de historia conceptual de lo político al análisis de los ejemplos famosos del corpus de textos. La investigación propone que la audiencia se interesó en dos ámbitos de los textos, que fueron el valor traductológico de una obra de arte traducida con fidelidad al autor original, y el rol cultural en un ambiente de declive de la latinidad. El estudio concluye que los críticos publicitaron el prestigio político que significaba trasladar a los clásicos griegos y latinos al español durante un contexto de guerra
Dynamics of phytoplankton communities in the Baltic Sea: insights from a multidimensional analysis of pigment and spectral data: part II, spectral dataset
No full textThe use of hyperspectral satellite missions opens new opportunities for
integrated approaches to the study of phytoplankton communities. The Baltic
Sea, with its distinct mixture of marine and freshwater characteristics, is a natural
laboratory for understanding marine ecosystems. In this study, we analyzed a
dataset from the Baltic Sea containing simultaneous phytoplankton pigment
concentrations and absorption spectra. We applied spectral derivative analysis
and unsupervised machine learning techniques to identify the unique statistical
relationships among phytoplankton pigments and inherent optical properties.
The statistical analysis of the absorption spectra provides the basis for a predictive
model to assess pigment concentrations from optical measurements.
Additionally, we compare our results to know assessment methods, such as
Gaussian spectral decomposition, that link the spectral analysis with
phytoplankton pigment content. This study investigates the potential of
statistical, data-driven analytical approaches in the development and validation
of models for retrieving phytoplankton community composition. The integration
of these findings with existing research contributes to the advancement of
remote sensing capabilities for monitoring marine ecosystems in the Baltic Sea
Digital Transformation and Last-Mile Logistics in Food Delivery: A Comparative Analysis of Urban and Peripheral Models
No full textThis study investigates the impact of digital technologies on the logistics sector, focusing on last-mile delivery in the food delivery industry in Italy. The research specifically compares two cities, Urbino and Milan, highlighting the differ
ences in how Just Eat and Glovo operate in urban and peripheral contexts. In Urbino, small restaurant businesses face significant logistical challenges due to the absence of a robust food delivery network, requiring them to handle delivery services inde
pendently. This contrasts with Milan, where both platforms offer more comprehen
sive delivery solutions. By analyzing variables such as delivery price, minimum order price, delivery times, and customer reviews, the study identifies Glovo’s flex
ible business model as better suited to smaller cities like Urbino, where fluctuating demand and limited resources make managing logistics difficult. The case of Alfonsino, a food delivery platform that has successfully operated in small towns, further supports this conclusion. The findings suggest that adopting a model like Glovo’s “Order & Delivery,” which offers greater flexibility and lower costs, could enhance delivery services in smaller cities. The research also highlights future opportunities for exploring the environmental impacts of crowdshipping and the role of technological advancements, such as autonomous delivery, in shaping the future of last-mile logistics
LA PUBBLICA SICUREZZA CIBERNETICA NELLA VIGILANZA BANCARIA: PROFILI RICOSTRUTTIVI DI UN MODELLO NEO-PUBBLICISTICO
No full textL'esponenziale diffusione della tecnologia che ha trasformato in modo radicale la struttura delle comunicazioni, dell'economia e delle interazioni sociali ha reso la cybersecurity una delle priorità emergenti per i governi di tutto il mondo, per garantire continuità e protezione nel funzionamento dei servizi essenziali e delle attività economiche. Ciò assume particolare rilevanza l'inquadramento delle Information and comunication technology o ICT nelle forme di tecnologia impiegate per creare, scambiare, utilizzare e immagazzinare informazioni e dati nell’ambito bancario: si tratta di un asset che assume un ruolo catalizzatore di così tanti interessi da indurre ad una riflessione in ordine alla coerenza sul suo mantenimento all'interno delle garanzie proprie della supervisione a favore, invece, di un modello neo-pubblicistico, a livello europeo, per la protezione di questo complesso supporto digital
Le reazioni delle reti interorganizzative sociosanitarie agli eventi catastrofici. Il caso del terremoto del 2016 nelle Marche
No full textThis study aims to analyze the evolution of the structure of the interorganizational network that links the centers that provide social and mental health services in the province of Ascoli Piceno, following the 2016 earthquake. The analysis was carried out using Social Network Analysis, based on data from both databases and structured interviews. In addition, in-depth interviews were conducted to delve deeper into the meaning and context of social relationships within the network. The results show that organizations, to address the situation, develop formalized initiatives, but the evolution of the network also depends on both the geographical location and the available resources
Il residuo della libertà
No full textSi affrontano sinteticamente alcuni temi fondamentali legati alla situazione carceraria in queste pagine che riprendono l'introduzione al convegno "In carcere. Criticità riflessioni proposte", pronunciata il 27 novembre 2024 nell’Aula Magna del Rettorato dell’Università degli Studi di Urbino Carlo Bo
Registrare, integrare, restituire. Etnografia e tecniche multimodali oltre la rappresentazione dell'esperienza
No full textThe widespread use of ethnography has sparked interdisciplinary debates on various issues, including the relationship between data collection, categorization, representativeness, experience, and sensoriality, as well as the role of writing and creative methods. This article contributes to these discussions by examining the integration of diverse media and techniques—such as video, audio, photography, and other digital tools—into ethnographic texts. While reaffirming the centrality of writing as a tool for reflexivity and methodological objectivity, it explores the possibilities and implications of employing multimodal heuristics in the production of situated knowledge