324677 research outputs found
Sort by
Giselle tra Parigi, Bordeaux e Lione: questioni di trasmissione
No full textIl saggio indaga la diffusione e la trasmissione di Giselle, celebre balletto romantico, tra Parigi e le principali città della provincia francese Bordeaux e Lione. Emerge l'importanza della partitura coreica manoscritta di Henri Justamant quale testimone fondamentale per conoscere la coreografia originaria del balletto dato a Parigi nel 1841, finora ritenuta perduta
A Quantile Regression Approach for Remaining Useful Life Estimation with State Space Models
No full textThe Effect of Number of Fins per Transistor on the TID Response of 12LP FinFET Technology
No full textThis article presents an analysis of the total ionizing dose (TID) response of n-channel transistors in the 12LP fin-based field effect transistor (FinFET) technology, with a focus on the impact of fin count per transistor. Previous studies, such as those by Vidana (2023), have shown increased off-state current ( IDS-off ) in n-channel FinFETs caused by charge buildup in shallow trench isolation (STI) oxides. However, these trends vary based on the number of fins used in the device. This work introduces a physics-based data-driven model supported by TCAD simulations to explain the fin count dependence on TID response. The model identifies variability in charge trapping in different STI regions, specifically highlighting the role of silicon nitride layers in mitigating leakage in devices with two or fewer fins. This research not only corroborates prior findings but also provides new insights into the electrostatic sensitivities unique to nanoscale FinFETs, offering a better understanding of TID effects and potential device hardening strategies
Clinical, functional, and laboratory course of children and adolescents with severe asthma after discontinuation of biologics
Get PDFBackground: Although the benefits of biologics in severe asthma are well established, the optimal strategy to discontinue therapy remains controversial. Aim: to evaluate clinical, functional, and laboratory course of children and adolescents with severe asthma after biological therapy withdrawal due to sustained good control. Secondary aim was to identify clinical or inflammatory markers predictive of asthma control after discontinuation. Materials and methods: this retrospective study included patients 6-19 years with severe asthma followed at the University Hospital of Padua in whom a biologic therapy was discontinued after at least 24 months of treatment. Clinical (GINA, CASI, exacerbations), functional (spirometry), inflammatory (FeNO, IgE, eosinophils), pharmacological (ICS dosage), and quality-of-life (PAQLQ) data were collected over a 24-month follow-up. Results: twenty-three asthmatic patients (34.8% female) were included. 19 treated with Omalizumab, 3 Dupilumab, and 1 Mepolizumab. At withdrawal, all had well-controlled asthma (GINA and CASI 3). Clinical control scores, spirometry, PAQLQ remained stable overtime. No exacerbation increase was observed. One patient resumed biologic therapy. An increase in eosinophil counts was found in patients classified as not fully controlled at 24 months. Conclusions: clinical and functional benefit of biologics may persist for up to 24 months after biologic withdrawal. After biologic discontinuation, most children maintained symptom control and good quality of life, suggesting that biologic therapy may be stopped in appropriately selected cases. At the same time a close follow-up, including assessment of clinical control, functional parameter and biomarkers, is needed to promptly identify signs associated with possible loss of control
How Excavation Activity is both a Blessing and a Curse for the Palaeontological Heritage: The Case Study of the Fossils from the “Lastame” in the Verona Province (Northern Italy)
No full textAmong cultural heritage, fossils are one of the most “neglected” goods, especially in Italy, both for unawareness by the public and for economic interests due to excavation activity. The Cretaceous sedimentary rocks of the Lessini Mountains, especially the “lastame” stone quarries of the surroundings of Sant’Anna d’Alfaedo (Verona province, Italy), hold some of the most important marine vertebrate findings of northern Italy and many invertebrates. All these findings were possible thanks to the extensive quarrying activity present in those mountains for the extraction of the “lastame” (or “Prun Stone”),
responsible for a high fraction of the local income of many activities. Unfortunately, partly due to National Cultural Heritage Laws, quarrymen are not incentivised to contact authorities or palaeontologists when they find some valuable findings for fear of a halt to the excavation activity, harmful to their profit. It is not uncommon to see fossils destroyed or lost, thereby harming the palaeontological heritage of the region and hampering scientific research. Herein, we present a risk management proposal for better securing the palaeontological heritage of the “lastame” with analyses of vulnerability, the magnitude of risks, and possible solutions
Study on discharge and short circuit generation in CMS GE1/1 triple-GEM detectors during Run 3
No full textThe installation of the new GE1/1 station of Gas Electron Multiplier (GEM) detectors in the Compact Muon Solenoid (CMS) experiment was completed during the Long Shutdown 2 (LS2) phase of the Large Hadron Collider (LHC). The GE1/1 station has been operational in the CMS detector since the beginning of the Run-3 data-taking phase, and for the first time the GEM technology was deployed on a large scale, comprised of 144 chambers and tested in running conditions as integral part of the CMS data acquisition, reconstruction, and analysis chain. The deployment of the GEM detector required careful planning throughout the years, posing several challenges of practical and conceptual nature in integrating an entirely new subsystem in the existing CMS frame. Operations on the other hand provided a unique opportunity to test the GEM technology in never-before seen conditions, and an occasion to study their behavior during data taking.In describing some of the solutions to the posed challenges and the findings during the data-taking, the article will focus on the aspects related to power system management, including high-voltage and current monitoring, which is intrinsically related to the response of the chamber due to the workings of the GEM foil charge flow. To this end, this article will illustrate the operations of GE1/1 detectors in the first two years of Run-3, with a particular focus on the analysis of discharge occurrences, on the generation of short circuits in GE1/1 GEM foils and on the adopted mitigation strategies. The applied layout of the GEM detectors is thoroughly described, and detailed operating conditions of the detectors are discussed, along with the actions taken to mitigate these events
Bilayer target for efficient production of 47Sc from proton-induced irradiation
No full textThe production of 47Sc for nuclear medicine applications is a complex challenge requiring innovative approaches to enhance yield and purity. In this study, we introduce a bilayer-target strategy using natural vanadium (natV) and enriched 50Ti irradiated by intermediate-energy proton beams. This novel methodology significantly advances the field, offering improved production efficiency without compromising radionuclidic purity, crucial for theranostic applications in precision medicine
Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters
Get PDFOrganelle contact sites are crucial for cellular function, enabling the exchange of lipids, ions, and other molecules between different organelles. The ability to track these contact sites in vivo has been significantly advanced by the development of SPLICS (Split-GFP-based Contact Site Sensors) reporters, which have provided unprecedented insights into the intricate network of organelle communication. This innovative and powerful tool allows the real-time visualization of different organelle interactions in living cells and in vivo thus unraveling the complexity of their dynamic in the context of cellular homeostasis. Recent studies highlighted the dynamic nature of organelle contact sites either in terms of tethering/untethering and of movement of the contact itself in time and space: whether unique temporal behaviors and contact site-specific dynamics of different organelle interactions exist is currently unknown. In this study, we investigated the spatiotemporal distribution of various organelle contact sites using time-lapse in vitro and in vivo imaging and discovered an evolutionarily conserved dynamic pattern among different contact sites, influenced by the specific partner organelles involved. These findings highlight the importance of spatial and temporal regulation at organelle contact sites, which may underlie their diverse physiological functions. The discovery of contact site-specific dynamics opens new avenues for understanding the regulation of organelle interactions in health and disease, with potential implications for developing targeted therapeutic strategies
Trace element levels in the sharks and rays of Amvrakikos Wetlands National Park, Greece
No full text: Amvrakikos Wetlands National Park is a semi-enclosed embayment in northwest Greece and the last known megafauna hotspot in the country, hosting populations of 10 shark and ray species. The area is highly eutrophic, with pollution being the main threat to the marine environment. In this work, we estimated the levels of cadmium (Cd), mercury (Hg), lead (Pb), copper (Cu) and nickel (Ni) in the flesh of six shark and ray species caught in Amvrakikos Gulf to investigate their levels and understand the potential health risks associated to their consumption. In total, 61 samples were collected and analysed. Significantly higher concentrations were detected on average for Cu. Embryos were found to accumulate higher levels of copper, suggesting maternal offloading. The relatively high levels of Cu are related to agriculture and sewage treatments and are by the findings of other studies in the Amvrakikos Gulf
Proceedings of the 1st International Workshop on Terminological Neologism Management (NeoTerm 2025)
No full textThe European Network on Lexical Innovation (ENEOLI, COST Action 22126)1 organized the first edition of the International Workshop on Terminological Neologism Management (NeoTerm 2025)2, held on June 18th, 2025, in Thessaloniki, Greece. The event took place at the Aristotle University Research Dissemination Center and was co-located with the 4th International Conference on Multilingual Digital Terminology Today (MDTT 2025)3, which followed on June 19-20. The workshop brought together researchers and professionals from a wide range of disciplines– terminology, linguistics, artificial intelligence, and information science– fostering an interdisciplinary dialogue around one of the most dynamic aspects of language: the creation and management of new terms. The central aim of NeoTerm 2025 was to explore the challenges and opportunities involved in collecting, describing, processing, and representing newly coined terms in language resources. The workshop welcomed a number of different perspectives, encouraging contributions that addressed both practical applications and theoretical reflections on neology