Rajesh Varma
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Biochemical applications and application of indicators in blood and lymph after a new feed additive based on bentonite
No full textThe aim of the study was to assess the physiological and biochemical action the new feed additive.The studies were carried out on white laboratory rats of the Spraque Dawley line. The additive consisted of four ingredients - bentonite, barley, wheat, calcium phosphate, in the ratio (2: 8: 8: 2). The use of fortified, enriched with vegetable fat-protein components, feed additive with natural montmorillonite (bentonite) affects the protein, carbohydrate and fat metabolism in the body, contributes to an increase in the weight of the animal. After prolonged intake of the feed additive, enzymatic activity and an increase in the content of protein, glucose, and lipids in the blood were observed. The feed additive has a good adsorptive and antioxidant effect, reducing toxic products, participating in the inactivation of free radicals, and exerting a protective effect on cell membranes. When feeding with a fodder additive, the protein content in the diet increased, as compared with the control, it should be noted that the phosphorus content in the blood and lymph increased, the increase in energy costs increased with an increase in muscle mass. The supplement is high in calories, has an antioxidant and adaptogenic effect, maintains a balance of biochemical and oxidative processes and can be recommended as a safe and effective supplement to the daily diet of farm animals.</p
Prevalence of gastric cancer precursor lesions in patients of a secondary care center in a state in south of Brazil
No full textBackground: Atrophy of the gastric mucosa and intestinal metaplasia is considered malignant precursor lesions of gastric cancer, which is considered the fifth most common neoplasm in the world and the third cause of death from cancer. The main risk factor is the infection by Helicobacter pylori (H. pylori), which increases up to six times the risk of gastric cancer, through gastritis, atrophy, and hypochlorhydria, consequences of the infection. Other risk factors are also worth noting, like smoking and a family history of gastric cancer.Objective: To investigate the prevalence of malignant precursor lesions and their associated factors in patients who underwent upper gastrointestinal endoscopy.Methods: A descriptive, observational study was performed based on an analysis of endoscopic gastric biopsies performed in two affiliated private laboratories to the Unified Health System (Sistema Único de Saúde [SUS]) in a city in Paraná state. Patients were assessed for age, sex, active or recent smoking, family history of gastric cancer, and previous treatment for H. pylori. The samples were evaluated for the presence of glandular atrophy, intestinal metaplasia, dysplasia, and H. pylori infection.Results: A total of 1,549 medical records and patient reports were evaluated and 945 were eligible, the average age was 52.2 (±14.3) years old and most patients (73.3%) were female. The prevalence of H. pylori infection was 47.5% (n= 449) and the highest percentage was between 30-39 years (58.7%). Among H. pylori-positive (+) patients who had developed intestinal metaplasia, there is more risk of having incomplete than complete metaplasia (OR: 4.34; 1.1–17.1; 95%CI). Patients who smoke are more increase the risk to developed glandular atrophy (OR: 1.91; 1.09-3.33; 95%CI) and intestinal metaplasia (OR: 1.93; 0.72-5.11; 95%CI). Conclusion: The study reinforces risk factors such as smoking and H. pylori infection as precursors for developing pre-neoplastic lesions in a population in southern Brazil, highlighting the importance of smoking cessation and prevention of H. pylori infection and the treatment of infected patients.</p
The dark proteome of rodent hepatitis E virus: Analysis of intrinsically disordered regions
No full textHepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or Intrinsically Disordered Protein (IDPs) are regions or proteins that are characterized by a lack of definite structure. These regions or proteins play significant roles in a wide range of biological processes, such as cell cycle regulation, control of signaling pathways, etc. IDPRs or IDPs in proteins are associated with the virus’s pathogenicity and infectivity. The occurrence of intrinsic disorder in the proteome of rat HEV remains to be elucidated, which prompted us to explore its dark proteome. In this study, the unstructured/disordered regions of ORF proteins of rat HEV have been examined. We have analyzed the prevalence of intrinsic disorder by using a set of computational predictors. The intrinsic disorder propensity analysis showed that the ORF proteins consisted of a varying fraction of intrinsic disorder. The ORF3 protein was identified with a maximum propensity for intrinsic disorder while the protein ORF6 showed the least propensity for the intrinsic disorder. Further, the analysis revealed ORF6 as highly structured protein (ORDP); ORF1 and ORF4 as moderately disordered proteins (IDPRs); and ORF3 and ORF5 as highly disordered proteins, categorizing them as ordered protein (ORDP), a protein having Intrinsically Disordered Region (IDPR) and Intrinsically Disordered Proteins (IDP) respectively. Such disordered regions may play several important roles in the pathogenesis and replication of viruses. Collectively, this comprehensive study data from our investigation suggested ORF protein’s role in the regulation and pathogenesis of rat herpesvirus.</p
Hysteria and its deceptive masks
No full textHysteria still exists, even if this stigmatizing term has been abandoned in favor of more descriptive terms (dissociative disorders, conversion disorders, functional disorders), and represents a frequent and disabling pathology. Even if in some situations, the establishment of a definitive diagnosis remains difficult, more and more clinical and paraclinical signs are developing to help in the diagnosis and the error rate is low. Thus, the clinician must currently make a positive diagnosis of conversion and no longer, as unfortunately often in the past, confine himself to evoking by default such a possibility in the face of an atypical picture accompanied by an extensive negative paraclinical assessment. The most probable etiology concerns triggering factors of a psychiatric nature (traumatic episode or psychic stress, vulnerability with a field of abuse in childhood, comorbidity of anxio-depressive disorders), which can, in turn, lead to changes in brain function, the exact neurobiological correlate of which remains to be determined, even if many leads have recently been suggested by brain imaging. The care of these patients requires an in-depth and specialized examination, if possible, with the help of a neurologist, then psychiatric care, combined with somatic follow-up. In the future, a better understanding of the etiological mechanisms will make it possible to develop more specific treatments.</p
Clinical mentorship for specialized care. Training paradigms and emerging challenges of assessment
No full textIntroduction: The following research is developed within the framework of the Project 135 of the National School of Nursery and Obstetrics (ENEO), with the contribution of the GIIIDEE Group (Interdisciplinary Group of Innovation and Research of Educational Assessment in Nursery). The global context had many significant changes starting 2019, since the emergence of COVID-19, a phenomenon that had significant repercussions on the training and assessment of the clinical skills in real scenarios with important implications for internships in students of higher education, both undergraduate and postgraduate.Theoretical framework: The theoretical referent is the Model of Reflexive Mentorship for Nursery. The clinical tutor is a professional specialist in nursery in charge of the clinical training of his/her students in real scenarios, in order to develop their critical thought, clinical judgment and decision making in the clinical field or community insert, both in metropolitan and foreign headquarters. Objective: The main goal of this document is to identify the training challenges and the assessment of the clinical mentorship for the tutors specialized in mentorships, orientations and guides in the clinical practices that take place in real contexts at different locations of the Unique Program of Nursery Specialties (PUEE).The methodology consisted on a bibliographical research in order to realize the state of art. The results show four important challenges for clinical mentorship at PUEE in the post-pandemic stage. The theoretical and methodological challenges are diverse in order to provide the mentorship as a unified policy with the commented perspectives that appear in the document. The teaching in situ and the formative assessment can potentiate the didactics in mentorship and the development of professional skills.</p
Environmental awareness on solid waste management practices: A case study in Angolan secondary schools
No full textThis paper presents a case study on the environmental awareness of the students of secondary schools in Angola and analyses the environmental education programs in the two cycles. The study was carried out in the four largest provinces of Angola and the results were obtained from questionnaires to the students and interviews with the school coordinators and the waste management officers in the region. The results show that the students have moderate consumption habits of electricity and water, demonstrated by 40% of students following the appropriate attitude, and have reasonable knowledge about the scenarios that produce large environmental impact, marking 3 out of 9 options: river pollution, toxic waste in the soil and sewage discharge on the beach as the most relevant, together reaching almost 50% of the responses. However, they have a gap in knowledge about the health impact of solid waste disposal in dumps site close to urban areas, as evidenced by the high number of children and adolescents living near these areas and with some of them helping their families as waste pickers. The poor environmental education program and the nonexistence of school activities on these issues contribute for disassociate the linkage of waste disposal in dumps with diseases. As waste disposal in dumps is current in almost all provinces in Angola, except Luanda, environmental education in schools plays an important role in preparing children and adolescents to adopt practices in the future that protect the environment and contribute to the reduction of public health problems. In addition, children and adolescents can indirectly influence their parents on these issues.</p
Potential health risk estimation of naturally occurring radionuclides intake due to the consumption of seafood around Coastal zone
No full textAs part of a regional baseline study, the distribution of naturally occurring radioactive materials in the marine fish diversity consumed by different age group representatives living in the Kalpakkam coastal zone was studied. The average activity of natural radionuclide in 238U, 232Th, and 40K (n = 40) was 28.51, 239.58, and 118.95 Bq kg-1, respectively. The annual dose of ingestion, lifetime carcinogenic risk assessment and cancer risk assessment due to 238U, 232Th, and 40K were estimated by marine fish diversity in children aged 1-4,5-9,10-14,15-17 years, adults, pregnant women, and the fishing community. The Hospital-Based Cancer Registry (HBCR) compares to the coastal zone. Statistical studies such as Pearson correlation analysis, Principle component analysis, and Cluster analysis report check that the current levels of natural radionuclide do not pose a significant radioactivity threat to the residents based on the activity of the radionuclide.</p
The spin of dioxygen as the main factor in pulmonology and respiratory care
No full textNot many doctors are aware of the most important obstacle in pulmonology and respiration care which is determined by the electronic structure of molecular oxygen. In great contrast to a huge majority of chemically stable substances, the O2 molecule possesses two non-paired electrons with parallel spins.</p
Minimizing human race creating an unknown climate leading to pandemics-Need of the time
No full textWe are on a planet that orbits the Sun which emits a huge amount of energy. The climate we experience is a result of an energy gradient across Earth and an imbalance in energy across the world due to axial tilt of Earth rotation.</p
Pandemic panic and the culture of complacency
No full textThe many legacies bequeathed to us by the COVID-19 pandemic have embraced novel approaches to vaccine development, a greater awareness of the principles of hygiene among the general public, the need for governments to take a proactive stance when faced with unfamiliar pathologies, and the role of specialist medical and scientific advisers. However, many of the claimed protocols are medieval in nature and have little scientific evidence to support their introduction. Similarly, we have failed to grasp the importance of the anti-vaccination campaigns, which are always founded on ignorance or willfulness, but on previous examples of duplicitous behavior by those in authority, coupled with our poor understanding of the way virus variants function, have engendered a sense that many of the precautions taken may have been unnecessary (Ford, 2020a). In consequence, I fear that future threats from hemolytic viruses of high transmissibility may be met with complacency. Improved public education, and greater academic transparency concerning the nature of risk, will be necessary if a future pandemic is to be effectively controlled.</p