Rajesh Varma
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An unusual presentation of a secondary extramedullary plasmacytoma
No full textPlasma cell dyscrasias are a group of entities characterized by neoplastic proliferation of a single clone of plasma cells, typically producing a monoclonal Immunoglobulin [1].</p
Proof of Einstein’s postulates
No full textBased on the assumption that the experiment confirms the STR, it is shown that the value of the speed of light is a very slowly decreasing function of its frequency, so that at a frequency of 2.2989.10-18 S-1, the speed of light becomes zero. Such light represents resting particles – photonics that could serve as the Absolute Reference System, but due to their negligible mass, do not have a noticeable effect on the processes taking place. This explains Einstein’s principle of relativity. The formulas for the change in the speed and frequency of light during the transition from one IRS to another, within the measurement error, remain unchanged, which proves the postulate of the constancy of the speed of light in any IRS. It is shown that all STR formulas include not the speed of light, but the fundamental constant C, equal to the speed of light with a frequency ν = ∞. The proposed explanation of the correctness of Einstein’s postulates is logically, apparently, the only possible one.</p
The potential use of O6-Benzylguanine, and O6-Methylguanine for the treatment of Alzheimer’s Disease, and T. brucei group trypanosomes infections
No full textVery recently we had published a paper entitled ‘The Potential Development Sulfonylhydrazines for the Treatment of Alzheimer’s Disease’ [1]. Our paper was a development from an observation by others from 1997, where a remarkable remission in Dementia was observed in cancer patients following treatment with the chemotherapeutic agent BCNU (Carmustine, 1,3-Bis(2-chloroethyl)-1-nitrosourea) [2]. </p
A new form of discrete real Fourier transform and its potential applications
No full textThe paper will present a new version of a real discrete Fourier transform, based on a symmetric frequencies combination of sine and cosine functions. Basic aspects of the construction as well as the potential applications will be discussed. This will include elements of the standard Fourier analysis as well as applications to the class of differential equations in string theory.</p
Common sense and quantum mechanics
No full textIt is shown how changing only one word in the usual interpretation of quantum mechanics makes it possible to turn its puzzles and miracles into obvious trivialities</p
Evaluation of the concentration of suspended particles in underground subway stations in Tehran and its comparison with ambient concentrations
No full textSubway lines are responsible for 20% of the total passenger traffic in Tehran. Particulate matter is one of the most important major pollutants in subway stations and increasing their concentration leads to numerous health consequences for passengers and subway employees. This study aims to investigate the concentration of PM10 and PM2.5 in four underground metro stations and compare them with the concentration of these particles in the open air. Seasonal sampling (April 2018 - April 2019) of particulate matters was conducted in the middle months of all four seasons for one week in the middle months of each season at peak traffic times from 8am to 12am, at three locations (entrance, middle, and exit in each station) and also at outside ambient of each station. The results are then compared with the relevant standards. The main sources of suspended particulate matter in the underground subway stations were due to passenger traffic, train piston pressure, floor cleaning, maintenance operations, wheel-rail wear and braking, and the performance of the ventilation system in the subway station. The results of the monitoring measurements in this study showed that the annual average concentrations of PM10 and PM2.5 in the four underground subway stations were 68 μg/m3 and 47 μg/m3 and in the outdoor ambient around these stations were 42 and 29 μg/m3, respectively. Also, this study showed that in the four underground subway stations, the annual average concentrations of PM10 and PM2.5 were 1.5-1.7 times higher than those in the outdoor ambient, respectively.</p
Antimicrobial and synergistic potential of Ocimum gratissimum leaves and Petiveria alliacea bark against some selected microorganisms
No full textBackground: This study was carried out to investigate the antimicrobial and synergistic potential of the leaves of Ocimum gratissimum and bark of Petiveria alliacea against some tested bacterial and fungal isolates. Fresh and matured leaves of Ocimum gratissimum and bark of Petiveria alliacea were collected from the Institute of Agriculture, Research and Training, Ibadan, Nigeria. The specimens were identified at the Herbarium unit of the Department of Botany, Obafemi Awolowo University, Ile-Ife, Nigeria. The pathogenic organisms used include bacteria namely, Providencia stuartii, Bacillus cereus, Staphylococcus aureus, Corynebacterium Pyogenes, Streptococcus faecalis, Klebsiella oxytoca, Klebsiella pneumonia, Escherichia coli, Pseudomonas fluorescence, Serratia rubidae, Proteus mirabilis, Salmonella pullorum; and fungi namely, Trychophyton tonsurans, Candidia albicans, Trychophyton rubrum, Penicillium expansium, Alternaria sp, Fusarium sp, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, and Penicillium camenberti. Methods: Pure isolates of the tested microorganisms were obtained from the department of microbiology, University of Ibadan, Ibadan, Nigeria. The bacterial isolates were maintained on nutrient agar slant and the fungal isolates were on Sabouraud Dextrose Agar (SDA). Antimicrobial sensitivity test (AST) followed by Clinical and Laboratory Standard Institute. Minimal bactericidal and fungicidal concentrations were determined following established protocols. Results: Fungal isolates of Aspergillus flavus, Penicillium expansiumm, Trychophyton rubrum, and bacterial isolates Klebsiella oxytoca, Klebsiella pneumonia, Escherichia coli, Proteus mirabilis, and Salmonella pullorum were all resistant to the plant extract. Findings from this study opined that ethanolic extract of Ocimum gratissimum leaves is more potent than the methanolic and aqueous extracts of Petiveria alliacea. Conclusion: The plant extracts showed greater antimicrobial activity against bacterial- with respect to fungal isolates suggesting a broader spectrum of activity with ethanolic extract on the gram-positive and the gram-negative bacteria. </p
Targeted delivery of therapeutic oligonucleotides in pancreatic cancer
No full textCurrently, the most common treatment options for pancreatic cancer include chemotherapy, radiation, and surgery. These treatment options are not specific to the cause of the disease and therefore result in a large number of side effects including nausea, fatigue, hair loss, etc. The use of oligonucleotides may be a more efficient and safe method of cancer therapy. This mini-review will cover how oligonucleotides have been used to treat diseases in the past as well as different methods for delivery into the body and finally the applications of oligonucleotides in pancreatic cancer therapy.</p
Review of the monograph# Mateusz Kuczabski’s Health Security Implications for National Security
No full textThe reviewed monography by Mateusz entitled J. Kuczabski „Health Security Implications for National Security” fills a significant gap, because, despite the availability of extensive foreign and domestic literature on health safety, it is difficult to find a commonly agreed definition. The potentially useful distinction between “health and safety”, “health system”, “healthcare system” and “health security” has not been developed in the literature. Interestingly, the author notes significant discrepancies in the understanding and application of the concept of health security existing even in UN agencies, for example between the United Nations Development Program (UNDP) and the World Health Organization (WHO). The results of the research by M. J. Kuczabski presented and prepared by the author may serve as an indication of the direction of future transformations in the field of health security and health policy in relation to the Polish security system.</p
Psychological and attitudinal assessment of patients with Fibromyalgia undergoing antalgic management: a short report
No full textObjectives: Fibromyalgia (FM) is a widespread condition that is difficult to manage medically. Often algologists are faced with patients who are poorly compliant with pharmacological treatment or with concomitant mood problems. There are treatments tailored to temperament and character patterns. In this study using the division into pain persistence and pain avoidance patterns, a stratification was hypothesized to facilitate its medical management using self-administered questionnaires. Methods: We screened the population consisting of FM patients to four different questionnaires, namely the Temperament and Character Inventory (TCI), Hospital Anxiety and Depression Scale, Short form 36 and the INTERMED- Self Assessment.Results: A total of thirty-two patients were enrolled. The analyzed population showed preponderant pain avoidance characteristics (90.7%). The persistence pattern proved to be present in only 9.3% of the population. The FM patients examined also reported an incidence of anxiety disorder of 71.9% and depressive disorder of 75%.Conclusion: Dividing the population with FM into patterns yielded uniform results. This justifies a multidisciplinary approach in these FM patients. The high incidence of anxiety and depression from the test results is an outcome that suggests the adoption of the HADS tool in the antalgic evaluation of FM patients.</p