Rajesh Varma
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Holistic cancer management as a model for the emergence of a personalized bio-psycho-socio-spiritual model of diseases, development and management
No full textPsycho-social support lies at the core of Patient and Family-Centered Care (PFCC) that health care systems aim to transform. The objective is to comprehensively inform patients and families of their health issues, empower them to take charge of their illness, and participate in making choices about managing their health and wellbeing [1].</p
Application of the standard case definition in the case of Congo-Crimean Hemorrhagic Fever (CCHF) in the Zhambyl region of Kazakhstan
No full textIn the presented case, a typical example of CCHF is described, a patient who lives in an endemic territory and had risk factors for infection – cattle keeping and tick bite. The patient sought medical help in a timely mannert, but his diagnosis of CCHF was made late, due to underestimation of the risk factors for CCHF infection and non-use of the standard case definition. The correct diagnosis was made only after the appearance of the hemorrhagic syndrome. The appearance of bleeding in patients with CCHF presents a high risk of infection for others. But timely isolation and intensive treatment allowed for the prevention of infection of contact persons and save the patient’s life.</p
The effects of carisoprodol on endochondral ossification: A review of the literature and implications for bone health
No full textCarisoprodol is a medication commonly prescribed for musculoskeletal pain, but recent studies have raised concerns about its potential negative effects on bone development and health, particularly in relation to endochondral ossification. Endochondral ossification is a critical process that involves the transformation of cartilage into bone, which is essential for the formation of long bones in the body. Carisoprodol has been shown to reduce the activity of osteoblasts while increasing the activity of osteoclasts, leading to an imbalance in bone formation and resorption. Studies also suggest that carisoprodol may inhibit osteoblast differentiation, decrease bone density, strength, and microarchitecture, and affect the expression of genes involved in endochondral ossification. These negative effects may be due, in part, to its inhibition of the Wnt signaling pathway. Healthcare providers should carefully consider the potential risks of carisoprodol on bone development and health when prescribing this medication. Alternative treatments may be considered for patients at high risk of bone-related complications.</p
Development of a management guide wheel for cervical cancer
No full textWe designed and developed a management guide wheel for cervical cancer to facilitate a standard approach and improve the quality of care in managing patients diagnosed with different stages of cervical cancer. Each step of the wheel considers the patient’s current medical condition, FIGO stage, and the possible treatment modalities for cervical cancer in her case. We reviewed existing international guidelines on the management of cervical cancer and compared their respective recommendations. This guide wheel is based on recommendations by the following organizations: the National Comprehensive Cancer Network (NCCN), the Society of Gynecologic Oncology (SGO), the European Society of Gynaecological Oncology (ESGO), the European Society for Medical Oncology (ESMO), the American Society of Clinical Oncology (ASCO), the British Gynaecological Cancer Society (BGCS) and the International Federation of Gynecology and Obstetrics (FIGO). </p
Hereditary elliptocytosis discovered during work-up for infective endocarditis: About a case
No full textHereditary elliptocytosis is a group of red blood cell membrane disorders that are characterized by elliptical-shaped erythrocytes and shortened red blood cell survival [1]. It is due to protein abnormalities involving the horizontal skeletal network of the red cell membrane, including the spectrin dimer-dimer interaction or the spectrin-actin-protein 4.1 junction complex [2].</p
An ethno-botanical study of medicinal plants in Dilla Zuria Woreda of Gedo Zone, Southern Ethiopia
No full textThe present study was carried out to investigate the diversity and use of medicinal plants, and to document the indigenous knowledge of the local community. The typical ethnobotanical methodologies were applied during the study. Eighty-one informants were selected by the preferential sampling of which 61 were males and 20 were females. The selected individuals were considered knowledgeable in their view of medicinal plants. Data were collected using semi-structured interviews, field observation, group discussion, and specimen collection. Informant consensus, preference ranking, direct matrix ranking, and informant consensus factor were computed. A total of 105 plant species were identified belonging to 105 genera and 52 families. Of the total plants, 70 plant species have medicinal values and are recorded from the study area. Based on the study, the family Asteraceae was found to be the most prominent family with 8 species under 8 genera followed by Fabaceae which comprise 6 species under 6 genera. Of medicinal plants collected in the area, 79.66% were used to treat human ailments, 17.79% were used to treat both human and livestock ailments, and 2.54 % were used to treat livestock ailments. Of the total medicinal plants, herbs were the dominant making 45 (47.5%) followed by shrubs 35(29.46%), trees 15(15.75%), and climbers 10(7.35%). Leaf (41%) was the most frequently utilized medicinal plant part followed by root which is (18%). About 44 different kinds of diseases in the local community were identified and have been treated by existing and identified medicinal plants. The most widely used method of preparation was in the form of crushing (44%) followed by boiling (17%) and powdering (10%). The majority of preparations used fresh parts (53.63%) more than the dried forms (36.81%). Oral (50%) and dermal (30.92%) applications were the common routes of administration. Agricultural expansion, overgrazing, over-harvesting of plants for different household utensils, and other human-induced problems were the major threats to natural habitats in general and medicinal plants in particular. Therefore, it is recommended that awareness creation through training and education with the participation of government and non-governmental organizations on sustainable use and conservation of plant resources should be encouraged.</p
Methods of prevention of calcium deficiency in pediatric practice
No full textIt is known that the prevention of deficiency conditions in children is one of the most urgent tasks of preventive pediatrics. The importance of timely recommendations for optimizing the replenishment of microelements and vitamins is undeniable, and understanding the importance of using calcium and vitamin D supplements significantly reduces the risk of adverse health effects in childhood and later life.</p
Program design considerations for bone health in premenopausal women
No full textThe purpose of this literature review is to critique training studies that have examined the effects of jump-landing programmes on bone health parameters in premenopausal women. Activities such as jumping and hopping have been proposed to achieve the desired unusual or atypical strain distributions on the skeleton for women who are habitually inactive and not involved in high-impact sports, however specific protocols to optimise bone health are currently lacking. From this review, it can be concluded that jump-landing protocols that; utilise brief jumping episodes (10 - 100 jumps/day, 3 - 7 days/week), are 4 - 18 months duration, and present loading magnitudes of between 2 - 6 body weights (BW) and rates of >43 BW.sˉ¹, can result in significant gains in femoral neck bone mineral density of 0.6 – 3.4% in premenopausal women. Evidence from this review has the potential to inform future exercise recommendations used to improve bone health during the critical premenopausal period, and to both reduce and delay the incidence of osteoporotic fracture in the years post menopause.</p
Evaluating the Effectiveness of Reasoned-action Theories (TRA, TPB, IBM) for Explaining Low E-commerce Adoption in a Developing Country: A Structural Equation Modelling (SEM) approach AI trends in digital humanities research
No full textThis paper explains the process of e-commerce adoption through reasoned action theories (theory of reasoned action (TRA), theory of planned behavior (TPB), and integrated behavioral model (IBM)) in a developing country. Owing to a lack of precedent in the study settings, the study first validated empirical scales for measuring psychosocial drivers of behavior using exploratory and confirmatory factor analyses. Subsequently, the study validated the aforementioned models using structural equation modeling, and also integrated sociodemographic characteristics as precursor variables in the model with the greatest predictive power. Results depicted that while TRA and TPB explain behavior well, it is IBM that is the most effective in explaining online consumer behavior, and underlined the importance of using volitional, sociodemographic, and individual-level factors (knowledge of e-commerce and environmental constraints to use e-commerce) to explain online consumer behavior. The study has numerous implications for e-commerce vendors operating in developing countries as the validated scales and models can be used to assess individual perceptions regarding e-commerce and to design effective communication strategies, respectively. </p
What should be the goal of our environmental efforts?
No full textThe world’s population has already reached almost 8 billion people and continues to grow rapidly. Environmental and climatic changes caused by human activity are continuously progressing; therefore, their impact on the further development of civilization has become one of the most acute and widely discussed problems.</p