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I "Quattro libri de dubbi" di Ortensio Lando (1. Ortensio Lando, "Quattro libri de dubbi". L'editio princeps rigenerata; 2. I "Dubbi" tra cultura antica e Rinascimento)
No full textLa tesi di dottorato ha come oggetto di studio i “Quattro libri de dubbi” di Ortensio Lando, operetta enciclopedica pubblicata a Venezia nel 1552, presso la tipografia di Gabriel Giolito. L’elaborato è distinto in due volumi, il primo dei quali è dedicato all’edizione rigenerata dell’editio princeps dei “Dubbi” (1552), corredata da un profilo biografico dell’autore, da una nota al testo e da tre appendici nelle quali si trascrivono le “Miscellaneae quaestiones” (opera di problemi in latino stampata da Lando nel 1550); il commento di monsignor Annibale Novelli all’edizione espurgata dei “Dubbi” pubblicata da Giovanni Bazachi nel 1597; le lettere che Giolito allega alle due edizioni dei “Dubbi” (1552 e 1556) e alle “Miscellaneae quaestiones”. Il secondo volume è invece pensato per affiancare la lettura dell’edizione dei “Quattro libri de dubbi”, accompagnando lettrici e lettori in un viaggio che mira a individuare le connessioni esistenti tra i quesiti landiani e la cultura letteraria, filosofica, etica e scientifica antica e moderna. L’obiettivo dei capitoli di questo volume, infatti, è scandagliare tematiche e suggestioni presenti nei diversi libri, tentando di rintracciare le fonti principali utilizzate da Lando per dare sostanza ai suoi problemi, nell’ottica di una storia delle idee. Quel che si desidera presentare è un commento di ampio respiro, volto a tracciare le coordinate generali per comprendere le culture e i saperi da cui i “Dubbi” derivano e con cui dialogano, indagando le convinzioni e le idee che hanno fornito a Ortensio Lando la linfa vitale per far crescere e proliferare le sue interrogazioniThis doctoral dissertation examines the “Quattro libri de dubbi”, an encyclopedic work by Ortensio Lando, published in Venice in 1552 by Gabriel Giolito’s printing house. The research is presented in two volumes. The first volume offers a critical edition of the editio princeps (1552), accompanied by a biographical profile of the author, a textual note, and three appendices: the transcription of the “Miscellaneae quaestiones” (a collection of philosophical problems in latin published by Lando in 1550); the commentary by monsignor Annibale Novelli on the expurgated version of the “Dubbi” issued by Giovanni Bazachi in 1597; and the paratextual letters included by Giolito in the 1552 and 1556 editions of the “Dubbi”, as well as in the “Miscellaneae quaestiones”. The second volume functions as a companion to the edition of the “Quattro libri de dubbi”, guiding readers through an interpretive journey aimed at uncovering the intertextual and cultural networks underlying Lando’s inquiries. Special attention is given to the connections between Lando’s questions and the broader literary, philosophical, ethical, and scientific traditions of both classical antiquity and early modernity. Each chapter investigates the thematic structures and intellectual stimuli that shape the four books, tracing the principal sources and conceptual frameworks that Lando drew upon in formulating his doubts. In this way, the study seeks to contribute to a history of ideas, offering a comprehensive commentary that maps the epistemological landscape from which the “Dubbi” emerge and with which they engage. Ultimately, the objective is to shed light on the intellectual convictions and cultural matrices that fueled Lando’s speculative projec
FLEXIBLE DESIGN TOOLS AND TRAINING FOR TEACHERS: RESULTS FROM A EUROPEAN PROJECT
No full textThe need to design courses in diverse teaching scenarios, i.e. face-to-face, blended, or online requires flexibility and modularity, becoming nowadays an increasingly urgent and imperative necessity.
Among the teaching flexibility options, the well known Flipped Classroom (FC) model has been recognized and appreciated in the educational field, but the literature highlights the lack of adequate support for teachers in developing teaching skills for effective learning. To this end, the Erasmus+ Learning Design for Flexible Education project (FLeD Project), involving six European universities and a multidisciplinary research team, has developed a digital teaching design platform, called FLeD Tool, that integrates Scaffolding and Learning Design Patterns guidelines, combining design flexibility with inclusiveness and accessibility.
The project also aimed to create multilingual open access resources on the main topics covered, which have been fully integrated into the FLed Tool platform as guidelines and patterns for the instructional design.
The Tool and the related resources of the Toolkit have been subjected to a validation process by a group of experts. The research evidence of the pilot phase and the first results of the project, led to the development of a MOOC (Massive Open Online Course), a self-paced course in which the flexibility approach is concretely applied to FC to support teachers in the design of flexible and inclusive learning scenarios, using the resources of the Fled Toolkit in a technological design environment, allowing users to interactively experiment with this methodological proposal: as a result, participants have the opportunity to learn about and interact first-hand with the learning environment created by the FLeD project through the resources of the Toolkit and the MOOC.
The original and innovative aspect of the present proposal lies in providing a technological design model and environment that responds to current needs, rich in resources and above all concrete and practical, a tool for university teachers, but also feasible for teachers of schools of all levels.
Participants will be engaged in accessing the MOOC prepared within the project as well as the FLeD tool as a dedicated environment to design flexible learning. Learning analytics collected on the MOOC will also be presented as first results of the self paced learning program
L'illusione general-preventiva. Recenti tendenze politico-criminali di contrasto al dissenso e alla marginalità sociale
No full textNelle più recenti riforme in materia penale, il legislatore ha mostrato di voler ricorrere allo strumento dello ius criminale in chiave di gestione e repressione di forme di protesta e di disagio sociale. Attraverso una sintetica rassegna degli interventi più significativi in tal senso, il contributo si propone di analizzare in modo critico la sempre più radicata tendenza a criminalizzare tanto forme di dissenso ideologico e politico, quanto situazioni di povertà e marginalità sociale, facendo emergere le profonde tensioni che tale indirizzo di politica criminale presenta in relazione ai principi costituzionali di offensività e proporzionalita
Advancing extracorporeal carbon dioxide removal technology: Bridging basic science and clinical practice
No full textRecently, advancements in extracorporeal carbon dioxide removal (ECCO2R) technology have markedly enhanced its clinical applicability and efficacy for managing severe respiratory conditions. This review highlights critical innovations in ECCO2R, such as advanced catheter technologies, active mixing methods, and biochemical enhancements, which have substantially improved gas exchange efficiency and broadened the scope of ECCO2R applications. Integrating ECCO2R into acute and chronic respiratory care has led to a shift toward more mobile and less invasive modalities, promising for extending ECCO2R usage from intensive care units to home settings. By examining these technological advancements and their clinical impacts, this paper outlines the potential future directions of ECCO2R technology, emphasizing its role in transforming respiratory care practices and enhancing patient outcomes
Size of the Cerebral Ventricular System in Patients Affected by Type 2 Diabetes Mellitus: A Retrospective Observational Study
No full textAim: This study is aimed at determining the prevalence of patients with Type 2 diabetes mellitus (T2DM) affected by abnormal ventricular enlargement (normal pressure hydrocephalus). Materials and Methods: Data were collected on diabetic patients from an outpatient diabetology clinic and nondiabetic patients who underwent brain CT or MRI, including sex, age, diabetes onset date, fasting blood glucose, HbA1c, Evans Index, and the time between diabetes diagnosis and neuroimaging. The metabolic profile was assessed by BMI, blood pressure, waist circumference, glomerular filtration rate, total cholesterol, LDL, HDL, and triglycerides. The use of ongoing therapies was recorded and categorized by drug class. Common comorbidities, such as ischemic heart disease, diabetic retinopathy, renal failure, and carotid atherosclerosis, were also documented. Results: Neuroradiological data were available for 272 diabetic patients (mean age: 71.6 ± 11.2 years) and 275 nondiabetic patients (mean age: 70.4 ± 12.5 years). Pathological ventricular enlargement was identified in 116 of 547 individuals (21%), with a higher prevalence among males (68%; p = 0.002). Ventricular enlargement was noted in 25% of diabetic patients and 17.1% of nondiabetic patients (p = 0.02). Diabetic patients with ventricular enlargement were significantly older (mean age: 76.9 years vs. 69.4 years) than those without enlargement (p = 0.01). The duration of diabetes was also significantly longer in patients with enlargement (mean: 16.5 years) compared to those without (p = 0.009). Age, male sex, longer diabetes duration, history of ischemic heart disease, beta-blocker use, and antiplatelet therapy were significantly associated with a pathological Evans Index. In multivariate analysis, antiplatelet therapy was the strongest predictor of abnormal ventricular enlargement in T2DM patients after adjusting for confounding factors (p = 0.01). Conclusion: There is a high prevalence of pathological ventricular enlargement in patients with T2DM. Advanced age, male sex, longer disease duration, and the use of antiplatelet therapy are significantly associated with abnormal ventricular enlargement
Policy Making and the Digitalization of the Public Sector. Actors and Strategies in Italy.
No full textThis book examines the evolving phenomenon of digital transformation in the public sector. First, it provides a theoretical understanding of public sector digitalization, considers policy dilemmas that may hinder it, and assesses strategies for successful digital transformation. It then provides an empirical analysis of public sector digitalization, considered in the context of the EU digital strategy. Drawing on national, regional and local case studies, the book then assesses digital transformation in Italy, in order to examine policy strategies in real contexts. It demonstrates that digitalization is not simply a process of replacing humans with machines, but a complex and controversial process involving policy design and implementation. The policy framework also provides a basis for evaluating the successes and failures of digital government projects, which will be applicable in many other countries. It will appeal to all those interested in public policy, public administration and public management, as well as digitalization and technology studies
Case Report: Parsonage-Turner syndrome due to SEPTIN9 mutation: report of an Italian family with childhood onset and review of the literature
No full textAim: Parsonage-Turner syndrome, also known as neuralgic amyotrophy affects the brachial plexus and includes idiopathic (INA) and rare hereditary forms (HNA). Mutations in the SEPTIN9 gene, which encodes a cytoskeletal GTPase, have been implicated in HNA. While Parsonage-Turner syndrome is typically adult-onset, with stress often acting as a trigger, the presentation in children is less acknowledged. Methods: We report a case of 9-year-old girl with brachial plexus neuritis who carries a SEPTIN9 missense mutation inherited from her father. We conducted a literature review to explore early-onset cases and gain insight into the disease's progression over time. Results: Patient presented with episodic intense pain and severe weakness in her right upper limb since age 5 years. Central nervous system involvement and inflammatory polyneuropathy were excluded. Neurological assessment showed weakness and muscle atrophy in the right shoulder girdle. Dysmorphic features, such as long nasal bridge, hypertelorism, and epicanthal folds, were also noted. Her father reported a similar episode in the past without investigations. SEPTIN9 gene sequencing revealed the missense mutation (c.262C>T; p.Arg88Trp) in both individuals. The review of 109 patients with hereditary neuropathy linked to SEPTIN9 mutations revealed a mean age of onset at 13 years, though the average time from symptom onset to diagnosis was 22 years. The syndrome typically follows a relapsing-remitting course, but monophasic and progressive forms are also described. Conclusion: Clinicians should consider HNA in children with asymmetric upper limb weakness and dysmorphic features, especially with a family history of upper limb neuralgia. Early diagnosis can improve long-term outcomes and avoid unnecessary tests
