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Consensus on the definition, components, timeframe and grading of composite outcome of postoperative pulmonary complication—protocol for an international mixed-method consensus study (PrECiSIOn)
No full textIntroduction Postoperative pulmonary complications (PPCs) represent a significant cause of postoperative morbidity and even mortality. However, there is a lack of consensus regarding this composite endpoint, the definition of the individual components, classification and optimal outcome measures. This study aims to refine the PPCs composite framework by evaluating its construct validity, assessing the necessity and risks of a composite measure and exploring the feasibility of differentiating severity categories. Methods A Delphi consensus process will be conducted, engaging an international multidisciplinary group of 30–40 panellists, including clinicians, researchers, patients, public representatives and health economists. Through iterative rounds, the study will seek agreement on the individual components of the PPCs composite. Additionally, consensus will establish a framework for a composite outcome measure based on a standardised severity classification, appropriate timeframes and weighted grading of PPCs. Analysis Consensus, defined by ≥75% concurrence in multiple choice questions or on Likert–scale statements, will be evaluated from round 2 onwards. Delphi rounds will be continued until all statements have reached stability of responses evaluated by χ2 tests or the Kruskal-Wallis test. Ethics and dissemination The study will be conducted in strict compliance with the principles of the Declaration of Helsinki and will adhere to ACCORD guidance for reporting. Ethics approval has been obtained for this study from the University of Wolverhampton, UK (SOABE/202425/staff/3). Informed consent will be obtained from all panellists before the commencement of the Delphi process. The results of the study will be published in a peer–reviewed journal with the authorship assigned in accordance with ICMJE requirements. Trial registration number NCT06916598 (clinicaltrials. gov)
Configuration, Performance, and Commissioning of the ATLAS b-jet Triggers for the 2022 and 2023 LHC data-taking periods
No full textIn 2022 and 2023, the Large Hadron Collider produced approximately two billion hadronic interactions each second from bunches of protons that collide at a rate of 40 MHz. The ATLAS trigger system is used to reduce this rate to a few kHz for recording. Selections based on hadronic jets, their energy, and event topology reduce the rate to Ô(10) kHz while maintaining high efficiencies for important signatures resulting in b-quarks, but to reach the desired recording rate of hundreds of Hz, additional real-time selections based on the identification of jets containing b-hadrons (b-jets) are employed to achieve low thresholds on the jet transverse momentum at the High-Level Trigger. The configuration, commissioning, and performance of the real-time ATLAS b-jet identification algorithms for the early LHC Run 3 collision data are presented. These recent developments provide substantial gains in signal efficiency for critical signatures; for the Standard Model production of Higgs boson pairs, a 50% improvement in selection efficiency is observed in final states with four b-quarks or two b-quarks and two hadronically decaying τ-leptons
Screening assay for polyester hydrolyzing microorganisms using fluorescence-labeled poly(butylene adipate)
No full textDespite recent advances, there is still a demand for more efficient enzymes hydrolyzing synthetic polymers. Automated high throughput screening strategies of microorganisms from different environments could yield novel enzymes but require specific methods for detection of polymer hydrolysis in complex matrices. Here, 5-carboxy-fluorescein (5-FAM) was covalently coupled to poly(butylene adipate) (PBA) and blended at 1 %, 5 % and 10 % w/w concentrations with non-labeled PBA. Hydrolysis of PBA by the Thc_Cut1 cutinase from Thermobifida cellulosilytica was confirmed via quantification of the released monomers 1,4-butanediol and adipic acid, weight loss and FTIR analysis. Upon incubation with Thc_Cut1, hydrolysis of all three fluorescent labeled PBA blends lead to a clear fluorescence increase of up to 4000 RFU while no signal change was detected for the blank and for heat-inactivated enzyme (signal below 500 RFU). In a next step, as a model organism Pichia pastoris expressing the identical cutinase was cultivated in the presences of labeled PBA. Despite the complex matrix, a fluorescence increase of up to 500 RFU was observed for P. pastoris expressing the enzyme while no significant signal change was seen for the control strain (lacking Thc_Cut1 expression). Likewise, extracellular enzymes from the fungi Fusarium solani and Alternaria alternata hydrolyzed labeled PBA leading to fluorescence increases of 1328 and 1187 RFU. This indicates that 5-FAM covalently coupled to polymers could be used for development of simple and high throughput screening platforms to identify polymer decomposing microorganisms and enzymes
ABS0404 DIFFERENCES IN NAILFOLD VIDEOCAPILLAROSCOPY ANALYSIS COMPARING LIMITED CUTANEOUS AND DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS: A DETAILED, RETROSPECTIVE STUDY
No full textVictòria A. Burguera i Puigserver, Entre el negoci privat i la caritat popular. La redempció de captius a la Corona d’Aragó baixmedieval (1410-1458), Madrid, CSIC, 2024, pp. 197.
No full textCorrection to: Long-term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real-world experience in Italy(Neurological Sciences, (2024), 10.1007/s10072-024-07494-9)
No full textThe article “Long‐term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real‐world experience in Italy”, written by Luca Gentile, Anna Mazzeo, Chiara Briani, Silvia Casagrande, Marcella De Luca1, Gian Maria Fabrizi, Christian Gagliardi, Chiara Gemelli, Francesca Forcina, Marina Grandis, Valeria Guglielmino, Giacomo Iabichella, Luca Leonardi, Alessandro Lozza, Fiore Manganelli, Roberta Mussinelli, Filomena My, Giuseppe Occhipinti, Silvia Fenu, Massimo Russo, Angela Romano, Alessandro Salvalaggio, Matteo Tagliapietra, Stefano Tozza, Giovanni Palladini, Laura Obici and Marco Luigetti, was originally published electronically on the publisher’s internet portal on 16 April 2024 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 27 July 2024 to © The Author(s) 2024 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0. The original article has been corrected
Sprachvariation im Deutschen zwischen Theorie und Praxis. Fachsprachlichkeit, Inklusion, Didaktik, Übersetzung, Kontrastivität
No full textVariation ist in der Sprache omnipräsent. Systemimmanenter Sprachwandel, Kontaktsprachphänomene im Zuge der Internationalisierung in Wirtschaft und Gesellschaft, Neuerungen in inklusiven Sprachvarietäten und in genderfairer Sprache – das Spektrum der Varietäten erweitert sich immer schneller. Hinzu kommen das postmigrantische Deutsch und die Fachsprachen mit ihren immer stärker differenzierten Wortschätzen und Strukturen. Dies bleibt nicht ohne Auswirkungen auf die Alltags- und Standardsprache.
Dieser Band beleuchtet die sprachlichen Wandlungs- und Diversifizierungsprozesse im Zusammenhang mit Fachsprachlichkeit, Inklusion, Sprachdidaktik, Übersetzung und Kontrastivität. Theoretische Reflexionen stehen neben praktischen Aspekten der Varietätenlinguistik, beispielsweise zur konkreten Umsetzung grundsätzlicher Erkenntnisse im Bereich der Leichten Sprache. Der Band bietet somit einen breiten Überblick über aktuelle Forschungsergebnisse und zeigt neue Forschungstrends der germanistischen Varietätenlinguistik auf