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EFFICACY OF A DESIALYZING PROBIOTIC-BLEND IN REDUCING SIGNS OF COLITIS AND SERUM/FECAL SIALIC ACID CONCENTRATIONS IN CHRONIC ENTEROPATHIC DOGS
No full textAutomatic Ontology-based Validation of Enterprise Architecture Principles
No full textEnterprise Architecture (EA) principles serve as foundational guidelines governing the
design, implementation, and evolution of enterprise systems. However, their valida-
tion poses significant challenges due to their articulation in natural language, which
often lacks the precision needed for automated processes. EA models, predominantly
represented graphically, require human interpretation to ensure alignment with these
principles. This research addresses these challenges by introducing an ontology-based
validation approach, leveraging semantic technologies to formalize and partially auto-
mate the validation of EA principles.
The study follows the Design Science Research (DSR) methodology, which provides a
rigorous framework for developing and evaluating practical solutions. Through iterative
cycles of design, implementation, and validation, the research refines the approach to
ensure both methodological rigor and practical relevance.
At the core of this approach lies the ArchiMEO ontology, a formal semantic representa-
tion tailored to capturing EA concepts and their relationships. By transforming natural
language principles into machine-interpretable rules and mapping them to EA mod-
els using ArchiMEO, the approach enables automated reasoning and validation. The
structured representation of principles and models facilitates accurate assessments of
compliance and reduces reliance on manual intervention.
The methodology was evaluated through three comprehensive case studies in real-world
enterprise settings. These case studies demonstrated the translation of existing EA mod-
els and principles into the ArchiMEO ontology, followed by the application of automated
validation techniques. The results confirm the scalability and applicability of the ap-
proach, highlighting its effectiveness in ensuring adherence to EA principles, enhancing
decision-making, and improving enterprise governance.
This research contributes to the field of EA management by offering a systematic and
scalable solution to automating the validation of EA principles. By bridging the gap between natural language principles and graphical EA models, the ontology-based valida-
tion approach empowers organizations to align their strategic objectives with operational
realities, fostering more effective and resilient enterprise systems
Foreword
No full textThe attempt to conceptualize the role of nature in the organization of the city and the territory dates back a long time and, in particular, stems from the recognition of the inadequacy of GDP as a measure of a nation’s true wealth. Senator Bob Kennedy's speech in his 1968 presidential bid ended something like this: “GDP measures everything except what makes life truly worth living.” That speech, which challenged powerful financial interests, became a landmark critique of GDP. From that moment on, a line had been drawn. The debate has since continued, marked by both advances and setbacks
From earthquake reconstruction towards Sustainable cities and regions in the Post Covid 19 Era.
No full textLatest activities and joint research developed in collaboration between UNICAM-SAAD
(School of Architecture and Design), the Toyo University, and the REDI Consortiu
Enhanced Macrophage and Granulocytic Recruitment with Increased Neo-Angiogenesis in Chicken Embryo Yolk Sac Following In Ovo Probiotic Blend Administration
No full textThe yolk sac (YS) plays a pivotal role in avian embryonic development, contributing to
both haematopoiesis and immune maturation. This study aimed to evaluate the effects of
in ovo administration of a commercial probiotic blend (Slab51®) on YS cellular dynamics
in chicken embryos. At embryonic day (ED) 18, Ross308 broiler eggs were injected with
either the probiotic suspension (P) or sterile saline solution (C). YS tissues were sampled
at 8, 12, 24 and 36 h post-inoculation for histological and immunohistochemical analysis.
Probiotic-treated embryos exhibited a significant reduction in granulocytic foci within the YS,
potentially reflecting enhanced peripheral migration of mature granulocytes. Concurrently, a
progressive increase in Iba-1+ macrophages was observed in the probiotic group, suggesting
accelerated macrophage differentiation. Immunophenotyping revealed a predominance of
M1-iNOS+ macrophages across all timepoints, although a significant increase inM2-CD204+
macrophages was detected at 36 h in probiotic-treated embryos, indicating a possible antiinflammatory
shift. Furthermore, amarked increase in CD31+ endothelial cells in the probiotic
group supports an associated rise in neo-angiogenesis. These findings suggest that in ovo
probiotic administrationmodulates the YSmicroenvironment by promoting earlymacrophage
recruitment, macrophage polarization and vascular remodeling. To our knowledge, this is the
first report to demonstrate probiotic-induced structural and immunological alterations in the
chicken embryo YS. These results provide novel insights into the early immunomodulatory
effects of probiotics and highlight the potential of the YS as a key mediator of host–probiotic
interaction during embryogenesis
Osservatorio sulla giurisprudenza costituzionale
No full textSi tratta di rubrica fissa della Rivista, nella quale sono passate in rassegna le decisioni della Corte costituzionale in materia di esecuzione forzata emesse nel trimestre di riferimento
New design high energy density Li-ion battery based on self-standing electrodes configuration
No full textThe utilization of lithium-ion batteries (LIBs) is currently pervasive as high-performance energy storage technology.
While graphite anode and LiFePO4 (LFP) cathode can be regarded as a baseline for improvements in the
field of materials, their utilization is now revamping at production level, mainly because of their cost, safety and
acceptable performances. In this context, many different approaches have already been explored to boost cell
performance by optimizing its design. Nevertheless, further improvements can still be achieved to make commercial
batteries more performing and reduce the costs, such as optimization of current collectors design. In this
regard, an easy coating technique is applied to produce self-standing electrodes of both Graphite and LFP with
high areal loadings, demonstrating their application in a Li-ion full cell with improved energy density. Both
electrodes are first tested in lithium half-cells, displaying suitable interfacial and ion transport properties and
good cycling performance and capacity retention. Furthermore, coin-type full cell delivers good cycling performance
and excellent coulombic efficiency at C/3, with a limited capacity fade over 300 cycles and an initial
energy density of about 240 Wh Kg− 1an+cat. Moreover, the self-standing electrodes are used in single-layer pouch
(SLP) cell format, showing promising results for possible upscaling, despite further optimization are needed. The
obtained results ultimately lead to the possibility of using this electrode design to further decrease cost and
weight of commercial batteries, especially for application in electronic devices, increasing at the same time the
achievable energy density
Nutritional Support for Prevention and Treatment of Pressure Injuries in Adults: An Integrative Narrative Literature Review
No full textIntroduction and Objectives: Pressure injuries (PIs) are a significant issue for international healthcare systems. Particularly common among older adults with reduced mobility, PIs represent a considerable socio-healthcare burden, which deeply impacts the psychological well-being of patients. Malnutrition is one of the main risk factors for the development of PIs, as malnutrition hinders healing and increases the risk of complications. For these reasons, implementing appropriate nutritional interventions, often underestimated in clinical practice, is crucial to manage PIs effectively. This study primarily aimed to identify and synthesize the best scientific evidence on nutritional interventions to prevent, facilitate, or improve the healing of PIs in an adult population. Additionally, both qualitative and quantitative outcomes were analyzed. Methods: A narrative literature review was conducted using the PubMed–Medline, Scopus, and Google Scholar databases to potentially include potential studies. The scientific validity of the study was ensured using the Scale for the Assessment of Narrative Review Articles (SANRA) and the pre-registration of the OSF database was performed using the PICOS method, which is employed in numerous studies of this type. Randomized controlled trials (RCTs) published within the last 10 years and in English were included. Results: Out of the 1507 records identified, 8 RCTs were included, published between May 2014 and May 2023. One study focused on patient education and self-care in nutrition related to PIs, while the remaining seven focused on intensive nutritional interventions or the administration of dietary supplements to treat PIs directly. Positive therapeutic effects were observed using collagen peptides, vitamin C, and arginine. Furthermore, the topical application of fish oil showed a protective effect. Conclusions: This study found that targeted nutritional interventions have a direct positive impact on PIs and an indirect effect on care, reducing complications and the duration of intensive care and healing times for PIs. Future systematic studies are recommended to broaden the understanding of the studied care framework
Looseness for Choreography-based Software Architectures on Blockchain
No full textBlockchain-based software architectures have been used to support inter-organisational interactions modelled through BPMN choreographies. However, some interactions emerge at runtime, advocating for looseness, which support is still limited in blockchain settings. For this reason, this work proposes an approach to support loose interactions in choreography-based software architectures on blockchain. We identify various perspectives of loosely specified choreographies and demonstrate how to accommodate their design and runtime phases within a blockchain environment
Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease
No full textBackground: Protein truncating variants (PTVs) in SORL1 are observed almost exclusively in Alzheimer’s Disease (AD) cases, but the effect of rare SORL1 missense variants is unclear. Methods: To identify high-priority missense variants (HPVs), we applied ‘domain mapping of disease mutations’ for the 637 unique coding SORL1 variants detected in 18,959 AD-cases and 21,893 non-demented controls. Results: In this sample, PTVs and HPVs associated with respectively a 35- and 10-fold increased risk of early onset AD and 17- and 6-fold increased risk of overall AD. The median age at onset (AAO) of PTV- and HPV-carriers was 62 and 64 years, and APOE-genotype contributed to AAO-variability. The median AAO of PTV- and HPV-carriers is ~8–10 years earlier than wild-type SORL1 carriers, matched for APOE-genotype. Specific HPVs are highly penetrant and lead to earlier AAOs than PTVs, suggesting possible dominant negative effects. Conclusion: Our results justify a debate on whether HPV carriers should be considered for clinical counseling. Supplementary information: The online version contains supplementary material available at 10.1186/s13024-025-00907-z