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Revealing One-to-Many Event Relationships in Event Knowledge Graphs
No full textObject-centric process mining is recognized to overcome the limitations of traditional process mining by offering approaches for the analysis of processes with multiple case notions such as collaborations. Event knowledge graphs are an effective tool for gathering, manipulating, and visualizing event and entity relations. Current approaches focus on inferring correlations between events and objects and directly-follows relationships between events correlated to the same object. However, object-to-object relations may hide one-to-many relations between events essential for understanding the actual flow among processes. We propose an approach to reveal these one-to-many causal relationships in an event knowledge graph. By defining when two events are causally related and extending the standard approach of event knowledge graphs construction to reveal them. We assess the approach using two case studies
Evaluation of cytotoxic effects of capillene and 2,4-pentadiynylbenzene isolated from Artemisia campestris subsp. variabilis (Ten.) Greuter essential oil and identified by NMR studies
No full textArtemisia is a vast genus of the Asteraceae family, comprising around five-hundred species, that has a large distribution in Europe, America, Asia, and Australia. Species of this genus have been reported to have several ethnopharmacological activities, and some of them are also largely used as food and spices. Artemisia campestris subsp. variabilis (Ten.) Greuter is a quite rare species endemic to Sicily, Sardinia, and Southern Italy. Seeking to delve deeper into the phytochemistry and pharmacological aspects of this species, in this work we investigated the essential oil (EO) obtained from the aerial parts of Sicilian accessions, hitherto unexplored, growing wild near Messina, Italy. The chemical composition of the EO, obtained by hydro-distillation method, was evaluated by GC and GC–MS. The most abundant constituent was capillene (36.45 %), principal representative of the alkynes class (50.69 %). However similar amount of hydrocarbon monoterpenes was identified (49.18 %), with β-pinene present at 35.31 %. The two alkyne compounds were confirmed by isolation and 1H NMR and 13C NMR spectroscopic characterization. The EO and its main constituents have been tested for possible cytotoxic activity against three human tumor cell lines (A375, MDA-MB 231, and CaCo2) and a human non-tumor cell line (HEK293) using the MTT assay. The EO showed remarkable cytotoxic activity against all cell lines tested with IC50 values ranging between 7.55 μg/mL and 23.05 μg/mL. 2,4-Pentadiynylbenzene exhibited potent cytotoxic activity with IC50 values ranging between 0.25 and 0.45 μg/mL for HEK293 and CaCo2 cells, respectively, while capillene showed very similar IC50 values ranging between 0.14 and 0.52 μg/mL for A375 and CaCo2 cells, respectively. The results demonstrated a remarkable cytotoxic activity against human tumor cell lines and suggest that A. campestris subsp. variabilis EO and could be regarded as a natural bioactive source and, in the future, further analyses could clarify the mechanism of action of the EO and its main constituents
Numerical derivation of multivariate functions
No full textWe consider the problem of the numerical derivation of a function of several real variables. The proposed numerical method is based on the singular value expansion of the integral formulation of the derivative problem generalised to the multivariate case. The resulting derivation method is able to compute the partial derivatives of a multivariate function sampled at points in general position. The accuracy of the proposed method is analysed and confirmed by numerical tests performed for different distributions of the sampling points
Gestione economico-contabile ed approvvigionamento
No full textA partire dai primi anni ’90 del secolo scorso, nell’ambito di un più ampio processo di riforma dell’organizzazione (d.lgs. 3 febbraio 1993, n. 29; d.lgs. 31 marzo 1998, n. 80) e dell’attività (legge 7 agosto 1990, n. 241) della pubblica amministrazione, finalizzato a rendere la sua azione maggiormente efficace, efficiente ed economica, in coerenza coi principi di imparzialità e buon andamento (art. 97 Cost.), il Legislatore è intervenuto anche in materia sanitaria procedendo ad un graduale riordino della relativa disciplina (d.lgs. 30 dicembre 1992, n. 502; d.lgs. 7 dicembre 1993, n. 517; d.lgs. 19 giugno 1999, n. 229). L’obiettivo in tal modo perseguito era quello di assicurare una progressiva razionalizzazione del Servizio sanitario nazionale, eliminando sprechi e disfunzioni delle strutture e delle attività connesse alla prestazione di servizi sanitari, a garanzia del cittadino e del principio di equità distributiva; in questa prospettiva, per razionalizzare l’uso delle risorse, venivano altresì rafforzate le modalità di controllo e verifica delle prestazioni (legge delega 30 novembre 1998, n. 419). In particolare, nel quadro di un disegno riformatore ispirato, per significativi profili, a principi e regole analoghe a quelle operanti nel settore privato, i suindicati obiettivi sono stati perseguiti nel settore sanitario tramite innovazioni normative che hanno riguardato anzitutto la struttura organizzativa dei soggetti coinvolti; del resto, l’assetto di ente ha inevitabili ripercussioni sui risultati del suo operato. Più precisamente, con il d.lgs. n. 502 cit. si è avviato un processo che ha condotto alla «regionalizzazione» del sistema ed alla «aziendalizzazione» degli enti coinvolti, con non trascurabili conseguenze riguardanti la loro gestione economico-finanziaria e patrimoniale, il sistema della contabilità ed i meccanismi di controllo c.d. gestionale. Si tratta di profili che, peraltro, risultano strettamente connessi con le particolari procedure da osservare ai fini dell’approvvigionamento (specie di beni e servizi): anche queste, infatti, come è facilmente intuibile, sono in grado di impattare su un ottimale utilizzo delle risorse disponibili e, dunque, sull’efficacia ed efficienza dell’azione amministrativa rivolta alla tutela della salute
Valorization of Spent Coffee ground (SCG) and Coffee Silverskin (CS) as a source of Nutrients and Bioactive Compounds
No full textIn a world where a greener approach is increasingly necessary, it is mandatory to reduce waste production and reuse residues from the company’s supply chain. Spent Coffee grounds (SCG) and Coffee Silverskin (CS) are two important by-products of coffee production, being sources of important dietary fibers and bioactive compounds, which is why some authors have proposed their reuse in the nutraceutical, food and cosmetic industries. However, their nutrients chemical content has been insufficiently studied. Therefore, the aim of the present review was to investigate the main components, such as carbohydrates, dietary fibers, lipids, and bioactive compounds of SCG and CS. In addition, the most common extraction methods to obtain these afore mentioned nutrients were evaluated
Coordinating REST Interactions in Service Choreographies using Blockchain
Get PDFIn Service Oriented Computing (SOC), different services interact and ex-
change information to reach specific objectives. To model inter-organizational
SOC systems, Choreography modeling languages emerged to represent the
distributed coordination among the involved organizations. From the real-
ization perspective, blockchain technology is emerging as a promising run-
time supporting peer-to-peer communication without the need for a central
coordinator, thanks to its intrinsic security, trust and decentralization char-
acteristics. However, while blockchain can bring many advantages, techno-
logical barriers still limit its adoption in organizations, due to the costly and
time-consuming learning process. For this reason, we propose RESTChain,
a framework enabling in an automatic way the interactions that take place
among the participants in a service choreography exploiting blockchain tech-
nology. Starting from a choreography specification, the framework provides
a set of Mediators and automatically generates a Smart Contract that co-
ordinates the service interactions. The mediators are software components
that are directly connected with the smart contracts and expose REST APIs
in compliance with the role played by the organizations in the choreography.
In this way, the services deployed by one organization can communicate with
the services made available by another organization through the blockchain,
in a secure and transparent manner. The proposed approach has been im-
plemented on the Layer 2 Polygon blockchain and has been validated on a
Market Retail case study analyzing its efficiency in terms of costs and times
A bibliographic study of biochar and hydrochar: Differences and similarities
No full textBiomass conversion by thermochemical processes has gained increasing interest due to its carbon-neutral and/or
carbon-negative effect. The most common thermochemical approach is pyrolysis, which results in the production
of biochar, a well-known carbon-rich material with properties comparable to those of materials derived from
fossil sources. In the last decade, hydrothermal carbonization of biomass has attracted attention due to its simple
requirements, low cost and lower temperatures, producing a carbon-rich material called hydrochar. This
bibliographical study, based on the Scopus database and focused on the last 5 years, without forgetting earlier
articles, aims to define the main differences between the two processes and the physico-chemical properties of
each char, to summarise the main techniques for their characterisation and to highlight the areas of application
according to their properties. This review suggests that it would be strategic to distinguish between the terms
hydrochar and biochar to ensure efficient characterisation and appropriate application