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Disposizioni comuni ai procedimenti in camera di consiglio
No full textIl contributo descrive ed analizza la disciplina contenuta negli artt. 737-742-bis c.p.c., alla luce dell'elaborazione dottrinale e giurisprudenziale
"La natura dell'invenzione", Conferenza di Franco Lodato, 28 marzo 2025, online.
No full textLa natura ha sempre rappresentato una fonte inesauribile di ispirazione per l'innovazione umana. Attraverso l'osservazione e l'imitazione dei processi biologici, gli inventori hanno sviluppato soluzioni che rispondono a sfide complesse in modo efficiente e sostenibile. Questo approccio, noto come biomimetica, implica l'applicazione di principi e strategie naturali alla progettazione tecnologica. Uno dei pionieri in questo campo è Franco Lodato, un designer industriale italo-americano con oltre 70 brevetti in vari settori, tra cui la sanità, l'elettronica di consumo e i beni di lusso. Lodato ha dedicato la sua carriera a integrare i principi della biomimetica e della sostenibilità nei processi di design, collaborando con aziende di rilievo come Herman Miller, DuPont, Gillette e Pininfarina.
La biomimetica si basa sull'idea che la natura, attraverso miliardi di anni di evoluzione, abbia già risolto molti dei problemi che gli esseri umani affrontano oggi. Ad esempio, l'osservazione del becco del martin pescatore ha ispirato il design dei treni ad alta velocità Shinkansen in Giappone, riducendo il rumore e migliorando l'efficienza energetica. Allo stesso modo, l'analisi della struttura delle ali delle farfalle ha portato allo sviluppo di sensori nanoscalari per rilevare esplosivi, sfruttando le proprietà di riflessione della luce presenti in natura.
Franco Lodato ha applicato con successo i principi della biomimetica in numerosi progetti. Ad esempio, ispirandosi al picchio, ha progettato un'innovativa piccozza per l'azienda italiana CAMP, migliorando l'efficienza e la sicurezza dell'attrezzo. Inoltre, ha contribuito alla creazione di dispositivi di comunicazione avanzati durante la sua collaborazione con Motorola, integrando tecnologie all'avanguardia con design ispirati a forme naturali
Real-World Life Analysis of a Continuous Glucose Monitoring and Smart Insulin Pen System in Type 1 Diabetes: A Cohort Study
No full textBackground: Diabetes affects over 460 million people worldwide and represents a growing public health challenge driven largely by dietary and lifestyle factors. While Type 2 diabetes (T2D) is more prevalent, Type 1 diabetes (T1D) presents unique therapeutic challenges, particularly in younger individuals. Advances in diabetes management, such as continuous glucose monitoring (CGM), insulin pumps (IP), and, more recently, smart multiple dose injection (MDI) pens, have significantly enhanced glycemic control and improved patients’ quality of life. Aim: This study aims to evaluate the baseline characteristics of patients switching from MDI therapy to the Medtronic Smart MDI system [composed of a smart insulin pen (InPenTM) and a connected CGM Medtronic SimpleraTM sensor] and to assess its impact on glycemic outcomes over different time periods (14, 30, and 90 days). Methods: A retrospective observational study was conducted among adults with T1D who initiated Medtronic Smart MDI therapy. Participants were enrolled voluntarily at the Diabetes and Nutrition Clinic in Ast Fermo, Marche Region, Italy. Glycemic parameters were monitored using CGM data and analyzed with descriptive statistics, including mean, standard deviation (SD), and interquartile range (IQR). Comparisons across time periods were performed using the Wilcoxon signed-rank test, with statistical significance set at p < 0.05. Results: This study included 21 participants with a mean age of 51.5 years, a mean BMI of 24.7, and a mean duration of T1D of 21.9 years. The transition from a traditional MDI system to the Smart MDI system resulted in significant improvements in key glycemic parameters: mean Sensor Glucose (SG) decreased from 171.0 mg/dL to 153.5 mg/dL (p = 0.035), Time In Range (TIR) increased from 58.0% to 64.4% (p = 0.005), and time above range (TAR; >180 mg/dL) decreased from 39.0% to 34.2% (p = 0.015). No significant differences were observed in the time below range (TBR). Conclusions: The transition to the Medtronic Smart MDI system significantly enhanced glycemic control by lowering mean glucose levels and increasing TIR. These findings highlight its efficacy in improving hyperglycemia management while maintaining a stable risk of hypoglycemia
Two-membrane etalon
No full textOptomechanics with semi-transparent membrane multioscillators in a high-finesse cavity is an established solution for designing the dispersive interaction, and reaching many achievements, such as the study of nonlinear dynamics, heat transfer, and so on. The multioscillators are dielectric slabs, usually with low reflectivity, constituting an etalon. Here we propose the theoretical and experimental investigation of a low-finesse optical cavity formed by two (nominally identical) parallel semi-transparent membranes. The experiment consists in laser-driving the cavity, detecting interferometrically the field reflected by the etalon, and measuring the intensity of the transmitted field, for different distances within the two membranes. A complete characterization of the membrane sandwich is provided. Moreover, we develop an analytical model to describe the fields, which reproduces all the experimental results, under specific approximations. As expected, the model reproduces the known results when high-reflectivity, and/or fixed mirrors conditions are restored. This work paves the way for a complete and analytical model to describe multi-oscillators "membrane-in-the-middle"optomechanics
Adenosine A3 receptor antagonists as anti-tumor treatment in human prostate cancer: an in vitro study
No full textProstate cancer (PCa) is one of the most common cancers in men, and for patients with PCa that cannot be surgically resected or treated, androgen suppression therapy often results in significant adverse effects. Recent studies have shown that A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer (PCa), and several A3AR agonists and antagonists have been investigated as potential anticancer drugs. In this study, we investigated the potential therapeutic effects of the A3AR antagonists AR 292 and AR 357 in human PCa cell lines. LNCaP, DU-145, and PC3 cell lines were treated with AR 292 and AR 357 compounds, and their cytotoxic effects were determined using viability assays, flow cytometry, and western blotting. Moreover, the drug transporter gene profile was evaluated using RT-PCR in untreated and A3AR antagonist-treated PCa cells. Both AR 292 and AR 357 showed antiproliferative effects with significant cell cycle arrest and induced DNA damage leading to cell death. AR 292 and especially AR 357 modulated the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response. Ferroptosis was induced in DU-145 cells treated with both compounds as well as in PC3 cells treated with AR 357. However, the treatment of PC3 cells with AR 292 and the treatment of LNCaP cells with both AR 292 and AR 357 resulted in necrotic cell death. In conclusion, our study showed that A3AR ligands exert anticancer effects via different mechanisms on PCa cell lines through the activation of multiple molecular pathways
Ciclo di conferenze "Design POV" Design per la moda - incontro con il designer Giacomo Morelli
No full textEffect of dietary commercially processed former foodstuffs on broiler meat microbiological quality, physico-chemical traits and shelf-life extension
No full textThis study evaluated the effects of replacing corn, soybean meal, and soybean oil with commercially processed former foodstuffs (cFF) in broiler diets on the microbiological and physico-chemical properties of chicken meat during refrigerated storage. Two hundred one-day-old male chicks (ROSS 308) were divided into four dietary groups: control (cFF0), 6.25 % cFF (cFF6.25), 12.5 % cFF (cFF12.5), and 25 % cFF (cFF25). At 33 days, 80 birds were slaughtered, and the left breast fillets analysed at 24 h post-mortem (T1) and after 3 (T2), 5 (T3), 7 (T4), and 9 (T5) days of refrigerated storage (4 ± 1 °C). From T3 to T5, TVC and B. thermosphacta counts resulted lower in cFF12.5 and cFF25 than in cFF0. Specifically, at T5, TVC counts were: cFF0=6.35, cFF12.5 = 5.86, and cFF25=4.99 Log CFU/g (P < 0.01). Similarly, for B. thermosphacta, the counts at T5 were: cFF0=5.12, cFF12.5 = 4.69 (P < 0.05), and cFF25=4.58 Log CFU/g (P < 0.01). At T5, Enterobacteriaceae counts were significantly lower in cFF12.5 than in cFF0 (P < 0.05). No significant differences were observed for Pseudomonas spp. For TVBN, cFF25 had a significantly lower value than all other groups at T3 (P = 0.009). At T5, the difference remained significant only compared to cFF0 (cFF0=19.02±0.41, cFF25=16.08±0.44 μg/g; P = 0.008). No differences were found in chemical composition or color, and no notable differences in aw or pH. These results suggest that incorporating up to 25 % cFF in broiler diets can improve microbiological quality of meat without affecting physico-chemical properties
Discriminating Analysis of Metal Ions via Multivariate Curve Resolution–Alternating Least Squares Applied to Silver Nanoparticle Sensor
Get PDFHeavy metals are life-threatening pollutions because of their great toxicity, long-term persistence in nature and their bioaccumulation in living organisms. In this work, we performed multivariate curve resolution–alternating least squares analysis of UV-Vis raw spectra received by a colorimetric sensor constructed on mercaptoundecanoic acid functionalized silver nanoparticles (AgNPs@11MUA) to detect Cd2+, Cu2+, Mn2+, Ni2+, and Zn2+ in water. This combined approach allowed the rapid identification and quantification of multiple heavy metals and showed adequate sensitivity and selectivity, thus representing a promising analytical and computational method for both laboratory and field applications such as environmental safety and public health monitoring
An Insight into Neuronal Processing of Ghrelin: Effects of a Bioactive Ghrelin Derivative on Proteolytic Pathways and Mitophagy
No full textProtein homeostasis (proteostasis) is preserved by an orchestrated network of molecular mechanisms that regulate protein synthesis, folding, and degradation, ensuring cellular integrity and function. Proteostasis declines with age and is related to pathologies such as neurodegenerative diseases and cardiac disorders, which are accompanied by the accumulation of toxic protein aggregates. In this context, therapeutic strategies enhancing the two primary degradative systems involved in the cellular clearance of those abnormal proteins, namely ubiquitin-proteasome system and autophagy-lysosomal pathway, represent a promising approach to counteract the collapse of proteostasis in such pathological conditions. In this work, we explored the processing of ghrelin, a pleiotropic peptide hormone linked to energy metabolism and higher brain functions, which is reported to modulate the protein degradative mechanisms. According to our data, ghrelin is processed by serine hydrolases secreted into the conditioned medium of SH-SY5Y neuroblastoma cell line, commonly used in neurotoxicology and neuroscience research. Ghrelin processing leads to the formation of a shorter peptide (ghrelin(1-11)) that stimulates both the cell proteasome system and autophagy-lysosomal pathway, encompassing the selective autophagy of mitochondria. Our findings suggest that ghrelin processing may contribute to the maintenance of neuronal proteostasis