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"Ius" e tirannicidio: alcune declinazioni storiche (e storiografiche)
No full textThe paper proposes a historiographical reconstruction of the political-juridical arguments that justify tyrannicide in the medieval and modern age.
Specifically, it points out this doctrine’s medieval roots, which present continuous and juridically relevant recalls to “caesaricide”, and discloses the complex historical-political dynamics of modern religious strifes as a fertile ground of the pro-tyrannicide theories strong developmen
Exploring nuclear structure with multiparticle azimuthal correlations at the LHC
Full text linkDetails of the nuclear structure of 129Xe, such as the quadrupole deformation and the nuclear diffuseness, are studied by extensive measurements of anisotropic-flow-related observables in Xe–Xe collisions at a centre-of-mass energy per nucleon pair sjavax.xml.bind.JAXBElement@5d161bd=5.44 TeV with the ALICE detector at the LHC. The results are compared with those from Pb–Pb collisions at sjavax.xml.bind.JAXBElement@ac2e18f=5.02 TeV for a baseline, given that the 208Pb nucleus exhibits a very weak deformation. Furthermore, comprehensive comparisons are performed with a state-of-the-art hybrid model using IP-Glasma+MUSIC+UrQMD. It is found that among various IP-Glasma+MUSIC+UrQMD calculations with different values of nuclear parameters, the one using a nuclear diffuseness parameter of a0=0.492 and a nuclear quadrupole deformation parameter of β2=0.207 provides a better description of the presented flow measurements. These studies represent the first systematic exploration of nuclear structure at TeV energies, utilizing a comprehensive set of anisotropic flow observables. The measurements serve as a critical experimental benchmark for rigorously testing the interplay between nuclear structure inputs and heavy-ion theoretical models
Psychosocial well-being in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their caregivers: A prospective study
No full textEffectiveness of Dupilumab and Omalizumab in Bullous Pemphigoid: A Nationwide Retrospective Cohort Study
No full textBullous pemphigoid (BP) is the most common autoimmune blistering skin disease worldwide. In the difficult-to-treat BP or if standard therapies are contraindicated, the use of biologics may be also considered although there is no strong evidence supporting their use. This study aimed to investigate clinical and diagnostic findings as well as treatment outcomes among patients diagnosed with BP and undergoing omalizumab or dupilumab in a real-world setting. A multicenter retrospective cohort study was performed across 15 Italian tertiary referral hospital. Medical records of 2435 BP patients were screened, identifying 58 (2.3%) Caucasian patients who met the inclusion criteria. Within this study population, 39 (67.2%) were treated with dupilumab and 19 (32.8%) received omalizumab. Disease control was achieved in 90.6% of dupilumab-treated patients and complete remission on minimal therapy was observed in 71.0%. Omalizumab-treated patients achieved disease control in 77.8% of cases and 64.7% obtained complete remission on minimal therapy. Log-rank test comparing relapse rate between treatment groups was not significant (p = 0.58). Finally, parameter estimates associated with the fixed effect of time were consistently negative, indicating a generally significant (p = < 0.05) decrease in scores over time for patients treated with both biologics. This cohort of patients undergoing dupilumab or omalizumab adds to the existing evidence concerning the effectiveness of biologic agents in BP. Both biologics seem to be promising treatment adjuvants in the management of BP, with dupilumab showing a descriptive trend toward better outcomes
The Value of Baseline [18F]FDG-PET in Predicting the Progression-Free Survival in Patients with Thymic Epithelial Tumours: A Systematic Review and Meta-Analysis
No full textDamped Bloch wave propagation in periodic architected viscoelastic materials: A Fourier-based scheme with quasi-Monte Carlo integration
No full textThis paper investigates the behavior of microstructured viscoelastic metamaterials with complex topologies, focusing on their wave propagation characteristics, specifically the behavior of damped Bloch waves. Fourier-based methods are used to solve the governing dynamic equations, taking into account both spatial and temporal damping effects. The study addresses eigenproblems related to Bloch wave dispersion, with a particular emphasis on rational eigenproblems, which are solved using an enhanced derationalization technique previously proposed by the authors. To efficiently approximate the Fourier coefficients, the technique utilizes the quasi-Monte Carlo integration method, which is particularly effective for complex geometries. An illustrative example based on triply periodic minimal surface structures is provided to demonstrate the effectiveness of the proposed approach. The results highlight the potential of these metamaterials for applications in noise reduction, impact resistance, and other advanced engineering fields
From north to south: exploring Italian sun-exposure habits through the “Save your skin” campaign
No full textBackground: Sun exposure is the main external risk factor for skin cancer, affecting melanoma and non-melanoma differently. Although increased awareness of sun-induced skin damage and appropriate photoprotection has helped to reduce melanoma incidence, inadequate sun protection persists, influenced by geographical, social, and cultural factors. Italy’s varying climates —from the colder north to the warmer south— impact sun exposure behaviours. Objectives: This study examined sun protection habits from the 2023 “Save your skin” campaign to identify at-risk groups and support targeted education. Materials & Methods: Participants completed anonymous questionnaires on sun exposure, sunscreen use, and skin cancer history. Results: Among 1,773 participants, 45% spent 2-4 weeks per year in the sun on holiday, 26% experienced occupational sun exposure, and 33% used tanning beds. Despite darker skin types, only 26% tanned easily; severe sunburn rates were consistent across regions. Central and southern participants reported more sun exposure on holiday than northern participants (p < 0.001); work-related sun exposure was more common in the south. Tanning bed use was higher in the north (p < 0.001). Although 62.46% always used sunscreen, only 32.51% applied it correctly. Misconceptions about sunscreen were widespread, and actinic damage was more frequent among those with lower photoprotection awareness. Conclusion: Inadequate sun protection is widespread in Italy, with regional differences in sun exposure and tanning bed use. Misconceptions about sunscreen are common, and the rate of proper application is low. The higher incidence of actinic damage among those with less photoprotection knowledge highlights the need for targeted education to improve sun safety and reduce skin cancer risk
