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Dynamic Analysis of an Offshore Knuckle-Boom Crane Under Different Load Applications Laws
Get PDFThis study investigates the dynamic behavior of an articulated boom offshore crane under various load application laws. The following steps were taken to perform numerical simulations using the finite-element method (FEM): Definition of the model's geometry, materials, and boundary conditions. The modal analyses reveal significant resonance frequencies in the direction of load application (payload). The crane's displacement, velocity, and acceleration responses are closely related to load application laws, specifically the time required to reach the structure's full payload (epsilon). It is highly correlated with the dynamic factor (maximum acceleration multiplied by payload), which has a wide range of effects on the structure, including the effects of overstress, overturning, buckling, and so on. The main findings reveal a very strong exponential correlation, allowing the dynamic effect to be estimated as a function of epsilon time. This is a useful tool for increasing the safety and reliability of offshore lifting operations
Differences and analogies in thyroid cancer discovered incidentally or by thyroid related screening: A multicenter study
No full textObjective: The prevalence of thyroid cancer (TC) has increased worldwide, and an association with metabolic and cardiovascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid-related imaging for other clinical conditions. Our aim was to assess the prevalence of thyroid-related disease (TD) versus incidental diagnosis (ID) pre-surgery reasons leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities. Design: We performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy. Patients: Consecutive patients with TC were included. Measurements: Data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardiometabolic comorbidities and non-thyroid cancer were collected. Results: Among the 327 enrolled subjects, the diagnosis of TC was prompted by thyroid-related reasons in 262 (80.1%, TD group) and incidental in 65 (19.9%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones; they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extrathyroidal extension, lymph node metastases, AJCC staging or American Thyroid Association (ATA) risk stratification. Conclusions: Biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features
Persistence of CXCR4-tropic virus in people living with four-class drug-resistant HIV and its clinical impact in the modern antiretroviral era
No full textBackground CXCR4-tropic HIV seems to be associated with more clinical events than CCR5-tropic virus. Objectives This study aims to describe the effect of the persistence of CXCR4-tropic virus on the occurrence of clinical events in people with four-class drug-resistant HIV. Methods This is a retrospective study on people with four-class drug-resistant HIV from the PRESTIGIO Registry, with at least two HIV-tropism determinations during follow-up. Follow-up accrued from the date of the first four-class drug resistance evidence (baseline) until death, loss to follow-up or freezing date (31 December 2023). Univariable Poisson regression was used to estimate and compare incidence rates of clinical events. Predictors of clinical events were assessed by multivariable Poisson regression. Results A total of 144 people with four-class drug-resistant HIV [47 (33%) with persistent CXCR4-tropism, 39 (27%) with persistent CCR5-tropism and 58 (40%) with a tropism switch during follow-up] were included with a median follow-up of 7.80 years (IQR = 5.80-10.6). Overall, 117 (81.3%) 4DR-PLWH experienced at least one clinical event during follow-up [incidence rate = 32.5 (95% CI = 29.3-35.9)]. The persistence of CXCR4-tropic virus was associated with an increased risk of HIV-related events among people living with four-class drug-resistant HIV, even in modern ART era. After adjusting for age, sex at birth and CD4+/CD8+ at baseline, standardized viremia copy-years [adjusted-incidence rate ratio = 1.66 (95% CI = 1.24-2.26), P < 0.001] and persistent CXCR4-tropism [adjusted-incidence rate ratio: 2.01 (95% CI = 1.04-3.91), P = 0.037] were associated with the occurrence of HIV-related events. Conclusions Our findings confirm CXCR4-tropism as a marker of HIV progression also in the four-class drug-resistant population, suggesting the need of further prioritization of viro-immunological control and studies of pathogenic mechanisms in presence of CXCR4-tropic multidrug-resistant viral strains
Le fonti
No full textRicostruzione fonti da internazionali a nazionali, costituzione italiana, c.p.p., normativa regionale, rating di legalità, rating di impres
Performance of a full-scale anaerobic UASB digester treating blackwater from an urban city district in Helsingborg, Sweden
No full textMachine learning-based printability assessment and process control of aerosol jet 2D and 3D Printed PEDOT:PSS-based microstructures
No full textHydrophobic Eutectic Solvents for Sustainable Bisphenol A Extraction from Water: Screening and Selection Based on Key Performance Criteria
No full textHydrophobic Eutectic Solvents (HES) are emerging as a promising class of sustainable solvents for water treatment applications, yet their rational selection and performance evaluation remain limited. In this work, we adopted a systematic approach to rank a diverse set of HES, combining terpenes, fatty acids, and trioctylphosphine oxide (TOPO). The screening was based on seven key criteria-viscosity, density, water leaching, pH shift, water uptake, EcoScale score, and chemical stability-aimed at identifying systems with low cross-contamination, high processability, and favorable environmental profiles. Selected HES were then evaluated in liquid-liquid extraction (LLE) using bisphenol A (BPA) as a model compound, with performance assessed via UV-Vis and NMR spectroscopy. The optimized HES, TOPO:menthol, demonstrated an excellent extraction efficiency and very low leaching. Reusability was explored as well as regeneration through back-extraction. Sustainability assessments using the Analytical EcoScale and AGREEprep tools reinforced the viability of the proposed systems. Beyond pollutant removal, this work offers a framework for the molecular-level design and evaluation of HES, advancing their integration into green separation technologies
Recommendations for Studying In Situ Extracellular Vesicles From Solid Tissue
No full textSolid tissue-derived extracellular vesicles (ST-EVs) are extracellular vesicles (EVs) separated directly from solid tissues of both vertebrates and invertebrates. ST-EVs provide a physiologically relevant snapshot of tissue-specific molecular dynamics and can be enriched directly in situ, from tissues in their natural state, preserving the native characteristics of ST-EVs. However, their enrichment presents unique technical challenges compared to EVs derived from biofluids or cell culture media. The need for transparent reporting in ST-EV research is crucial to enhance the reproducibility, comparability, and reliability of research findings. The Solid Tissue Task Force, part of the Scientific Reproducibility Subcommittee of International Society for Extracellular Vesicles, aims to recommend reporting parameters and identify outstanding questions related to the pre-analytical and analytical handling of solid tissues, as well as ST-EV separation and characterization. These steps are essential for advancing the understanding of the biological roles of ST-EVs and their potential clinical applications
Mezzi di ricerca della prova
No full textEsame dei mezzi di ricerca della prova di cui al libro III del c.p.p