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Passive Upper Airway Thermoregulation and High-Speed Assessment for Conventional versus Menthol Cigarette: Implications for Laryngeal Physiology
No full textPurpose: This investigation combined measures of upper airway temperature (UAT) with high-speed laryngeal imaging in an individual who smoked a filtered conventional and menthol cigarette to identify laryngeal vibratory differences with upper airway temperature change. It was hypothesized that (1) average UAT differences between trials would be similar with UAT change ≤2°C and (2) high-speed parameters would not differ between trials. Method: In a repeated measures design, UAT was measured continuously during smoking. High-speed laryngeal imaging was conducted immediately after each smoking trial and 10 minutes post. Results: Average UAT and end-inspiratory temperature during the menthol trial was unexpectedly low. Immediately following both trials, there was an increase in phase asymmetry, vibratory amplitude (greater magnitude of change for the nonmenthol trial), and the opening phase of the glottal cycle and a decrease in fundamental frequency compared to the baseline. During recovery, parameters returned to the baseline for the nonmenthol trial, however, fundamental frequency continued to be lower and vibratory amplitude continued to be larger at recovery for the menthol trial. The measure of oscillatory onset time did not change across the trials immediately post cigarette trial and during recovery suggesting that smoking resulted in changes in sustained vibratory function rather than the onset behavior. Conclusions: Preliminary findings suggest that continuous thermal mapping and high-speed laryngeal function assessment may provide new information about the manner in which laryngeal tissue responds to passive thermal perturbations with direct implications for laryngeal epithelial and skeletal muscle function. Future large-scale studies are needed to investigate this in detail
Public, health professional and legislator perspectives on the concept of psychiatric disease: a population-based survey
No full textObjective: To assess which mental health-related states of being are perceived as diseases by psychiatrists, non-psychiatric physicians, nurses, parliament members and laypeople. Design and setting: A population-based, mailed survey in Finland. Participants: Respondents from a random sample of 3000 laypeople, 1500 physicians, 1500 nurses and all 200 members of the parliament (MPs) of Finland. Primary outcome measures: Respondents’ perspectives on 20 mental health-related states of being as diseases, measuring the extent of agreement with the claim: ‘[This state of being] is a disease’. Results: Of the 6200 people approached, we received 3259 eligible responses (53%). Two conditions (schizophrenia and autism) were considered to be diseases by at least 75% and two states (grief and homosexuality) were considered not to be diseases by at least 75% in each group. A majority (at least 50% in each group) considered seven states as diseases (anorexia, attention deficit hyperactivity disorder, bulimia, depression, generalised anxiety disorder, panic disorder and personality disorder) and three not to be diseases (absence of sexual desire, premature ejaculation and transsexualism). In six states, there was a wide divergence of opinion (alcoholism, drug addiction, gambling addiction, insomnia, social anxiety disorder and work exhaustion). Psychiatrists were significantly more inclined to considering states of being as diseases relative to other groups, followed by non-psychiatric physicians, nurses, MPs and laypeople. Conclusions: Respondents agreed that some conditions, such as schizophrenia and autism, are diseases and other states, such as grief and homosexuality, are not; for others, there was considerable disagreement. Psychiatrists are more inclined to consider mental health-related states of being as diseases compared with other physicians, who, in turn, are more inclined than other constituencies. Understanding notions of disease may underlie important debates in public policy and practice in areas of mental health and behaviour, and have implications for resource allocation and stigma
Relationship Between Substance Use and the Onset of Spinal Cord Injuries: A Medical Chart Review
No full textBackground: Opioid misuse is a leading health care concern within the United States. In many cases, opioid misuse and opioid use disorder are associated with pain, a secondary health condition affecting individuals with spinal cord injury (SCI). Further, substance use is a known risk factor for SCI, resulting in the potential for a substance-related risk trajectory running from pre- to post-SCI. However, little research has examined substance use prior to SCI since the opioid epidemic began, and so the relative risk of opioids to patients with SCI is unclear. Objective: To determine whether individuals with SCI tested positive for substance use at the time of injury and identify the primary substances used at the time of injury. Methods: This study retrospectively reviewed all medical charts of individuals ages 18 and older who had sustained an SCI during an identified 18-month period and received medical care at a selected level 1 trauma center in the Midwest. Results: Data revealed an 80% combined positive toxicology and/or self-report of substance use immediately prior to the onset of the SCI. Twenty-five percent of males were positive for more than one substance at time of injury. Substances used prior to injury, listed most to least prevalent, were opioids (37.5%), alcohol (25%), marijuana (25%), methamphetamines (12.5%), benzodiazepines (12.5%), followed by cocaine (6.25%) and synthetic cathinone (6.25%). Conclusion: Although opioids were the most common substance used prior to SCI, none of the individuals positive for opioids at the time of injury were identified by the reviewing medical professional as having pain as a secondary health condition either prior to or after injury. However, pain is commonly listed as the primary health concern among individuals living with SCI, and the possibility of opioid use prior to injury likely warrants pain management planning that includes careful pharmacological and nonpharmacological interventions
Phosphorus Abundances in the Hyades and Galactic Disk
No full textWe have measured phosphorus abundances in nine disk stars between -1 = -0.01 ± 0.06 and = 0.03 ± 0.03 dex for the three giants. The consistency suggests abundances derived using the 1.06 μm P I lines are not subjected to temperature or luminosity dependent systematic effects at high metallicities. Our [P/Fe] ratios measured in disk stars are consistent with chemical evolution models with P yields increased by a factor of 2.75. We find [P/O], [P/Mg], [P/Si] and [P/Ti] ratios are consistent with the solar ratio over a range of -1.0 < [Fe/H] < 0.2 with the [P/Si] ratio increasing by ∼ 0.1 - 0.2 dex at the lowest [Fe/H] ratios. Finally, the evolution of [P/Fe] with age is similar to other α elements, providing evidence that P is produced at the same sites
Americans' Perceptions of Transgender People's Sex: Evidence from a National Survey Experiment
No full textDrawing on the first national survey experiment of its kind (n = 3,922), the authors examine Americans’ perceptions of transgender people’s sex and the factors that underlie these perceptions. The authors randomly assigned respondents to a vignette condition describing a transgender person whose self-identified gender (i.e., identifies as a man or a woman), age (i.e., adult or teenager), and gender conformity in physical appearance (i.e., conforming, nonconforming, ambiguous, or unspecified) had been experimentally manipulated. Then, respondents were asked how they would personally classify that person’s sex. The findings suggest that Americans are more likely to perceive a transgender person’s sex as consistent with their sex assigned at birth than with their gender identity. Furthermore, of the experimental manipulations included in the experiment, only the transgender person’s level of gender conformity—not their self-identified gender or age—affects public perceptions of sex. The authors also find distinct cleavages along sociodemographic lines, including politics, sexual orientation, and interpersonal contact with transgender people. Implications for research on sex and gender are discussed
Associations of mental health and family background with opioid analgesic therapy
No full textThere is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated associations of diverse preexisting mental health diagnoses, parental mental health history, and SES in childhood with opioid analgesic prescription patterns nationwide in Sweden. Using register-based data, we identified 5,071,193 (48.4% female) adolescents and adults who were naive to prescription opioid analgesics and followed them from 2007 to 2014. The cumulative incidence of any dispensed opioid analgesic within 3 years was 11.4% (95% CI, 11.3%-11.4%). Individuals with preexisting self-injurious behavior, as well as opioid and other substance use, attention-deficit/hyperactivity, depressive, anxiety, and bipolar disorders had greater opioid therapy initiation rates than did individuals without the respective conditions (hazard ratios from 1.24 [1.20-1.27] for bipolar disorder to 2.12 [2.04-2.21] for opioid use disorder). Among 1,298,083 opioid recipients, the cumulative incidence of long-term opioid therapy (LTOT) was 7.6% (7.6%-7.7%) within 3 years of initiation. All mental health conditions were associated with greater LTOT rates (hazard ratios from 1.66 [1.56-1.77] for bipolar disorder to 3.82 [3.51-4.15] for opioid use disorder) and were similarly associated with concurrent benzodiazepine-opioid therapy. Among 1,482,462 adolescents and young adults, initiation and LTOT rates were greater for those with parental mental health history or lower childhood SES. Efforts to understand and ameliorate potential adverse effects of opioid analgesics must account for these patterns
Maternal prescribed opioid analgesic use during pregnancy and associations with adverse birth outcomes: A population-based study
No full textBackground Published research on prescribed opioid analgesic (POA) use during pregnancy and birth outcomes is limited in scope and has not adequately adjusted for potential confounding factors. To help address these gaps, we estimated associations between maternal POAs during pregnancy and two adverse birth outcomes using a large population-based dataset, multiple definitions of POA exposure, and several methods to evaluate the influence of both measured and unmeasured confounding factors. Methods and findings We obtained data by linking information from several Swedish registers and conducted a retrospective cohort study on a population-based sample of 620,458 Swedish births occurring between 2007 and 2013 (48.6% female; 44.4% firstborn). We evaluated associations between prenatal POA exposure and risk for preterm birth (PTB; <37 gestational weeks) and small for gestational age (SGA; birth weight 2 standard deviations below the expected weight for gestational age or lower). We evaluated the influence of confounding by adjusting for a wide range of measured covariates while comparing exposed and unexposed infants. Additionally, we adjusted for unmeasured confounding factors by using several advanced epidemiological designs. Infants exposed to POAs anytime during pregnancy were at increased risk for PTB compared with unexposed infants (6.4% exposed versus 4.4% unexposed; adjusted odds ratio [OR] = 1.38, 95% confidence interval [CI] 1.31–1.45, p < 0.001). This association was attenuated when we compared POA-exposed infants with acetaminophen-exposed infants (OR = 1.18, 95% CI 1.07–1.30, p < 0.001), infants born to women who used POAs before pregnancy only (OR = 1.05, 95% CI 0.96–1.14, p = 0.27), and unexposed siblings (OR = 0.99, 95% CI 0.85–1.14, p = 0.92). We also evaluated associations with short-term versus persistent POA use during pregnancy and observed a similar pattern of results, although the magnitudes of associations with persistent exposure were larger than associations with any use or short-term use. Although short-term use was not associated with SGA (adjusted ORsingle-trimester = 0.95, 95% CI 0.87–1.04, p = 0.29), persistent use was associated with increased risk for SGA (adjusted ORmultiple-trimester = 1.40, 95% CI 1.17–1.67, p < 0.001) compared with unexposed infants. The association with persistent exposure was attenuated when we used alternative comparison groups (e.g., sibling comparison OR = 1.22, 95% CI 0.60–2.48, p = 0.58). Of note, our study had limitations, including potential bias from exposure misclassification, an inability to adjust for all sources of confounding, and uncertainty regarding generalizability to countries outside of Sweden. Conclusions Our results suggested that observed associations between POA use during pregnancy and risk of PTB and SGA were largely due to unmeasured confounding factors, although we could not rule out small independent associations, particularly for persistent POA use during pregnancy
A multi-labeled tree dissimilarity measure for comparing "clonal trees" of tumor progression
No full textWe introduce a new dissimilarity measure between a pair of “clonal trees”, each representing the progression and mutational heterogeneity of a tumor sample, constructed by the use of single cell or bulk high throughput sequencing data. In a clonal tree, each vertex represents a specific tumor clone, and is labeled with one or more mutations in a way that each mutation is assigned to the oldest clone that harbors it. Given two clonal trees, our multi-labeled tree dissimilarity (MLTD) measure is defined as the minimum number of mutation/label deletions, (empty) leaf deletions, and vertex (clonal) expansions, applied in any order, to convert each of the two trees to the maximum common tree. We show that the MLTD measure can be computed efficiently in polynomial time and it captures the similarity between trees of different clonal granularity well
Crossing the Line: Active Galactic Nuclei in the Star-forming Region of the BPT Diagram
No full textIn this work, we investigate the reliability of the BPT diagram for excluding galaxies that host an AGN. We determine the prevalence of X-ray AGN in the star-forming region of the BPT diagram and discuss the reasons behind this apparent misclassification, focusing primarily on relatively massive () galaxies. X-ray AGN are selected from deep XMM observations using a new method that results in greater samples with a wider range of X-ray luminosities, complete to for . Taking X-ray detectability into account, we find the average fraction of X-ray AGN in the BPT star-forming branch is 2%, suggesting the BPT diagram can provide a reasonably clean sample of star-forming galaxies. However, the X-ray selection is itself rather incomplete. At the tip of the AGN branch of the BPT diagram, the X-ray AGN fraction is only 14%, which may have implications for studies that exclude AGN based only on X-ray observations. Interestingly, the X-ray AGN fractions are similar for Seyfert and LINER populations, consistent with LINERs being true AGN. We find that neither the star-formation dilution nor the hidden broad-line components can satisfactorily explain the apparent misclassification of X-ray AGN. On the other hand, ∼40% of all X-ray AGN have weak emission lines such that they cannot be placed on the BPT diagram at all and often have low specific SFRs. Therefore, the most likely explanation for "misclassified" X-ray AGN is that they have intrinsically weak AGN lines, and are only placeable on the BPT diagram when they tend to have high specific SFRs
An interval of high salinity in ancient Gale crater lake on Mars
No full textPrecipitated minerals, including salts, are primary tracers of atmospheric conditions and water chemistry in lake basins. Ongoing in situ exploration by the Curiosity rover of Hesperian (around 3.3–3.7 Gyr old) sedimentary rocks within Gale crater on Mars has revealed clay-bearing fluvio-lacustrine deposits with sporadic occurrences of sulfate minerals, primarily as late-stage diagenetic veins and concretions. Here we report bulk enrichments, disseminated in the bedrock, of 30–50 wt% calcium sulfate intermittently over about 150 m of stratigraphy, and of 26–36 wt% hydrated magnesium sulfate within a thinner section of strata. We use geochemical analysis, primarily from the ChemCam laser-induced breakdown spectrometer, combined with results from other rover instruments, to characterize the enrichments and their lithology. The deposits are consistent with early diagenetic, pre-compaction salt precipitation from brines concentrated by evaporation, including magnesium sulfate-rich brines from extreme evaporative concentration. This saline interval represents a substantial hydrological perturbation of the lake basin, which may reflect variations in Mars’ obliquity and orbital parameters. Our findings support stepwise changes in Martian climate during the Hesperian, leading to more arid and sulfate-dominated environments as previously inferred from orbital observations