University of Bari Aldo Moro
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Evaluating the success rates and effectiveness of surgical and orthodontic interventions for impacted canines: a systematic review of surgical and orthodontic interventions and a case series
Full text linkObjectives: The goal is to gather more information on orthodontic traction of impacted canines in the arch or their extraction. Methods: We focused our search on English-language papers published between January 1, 2004, and July 24, 2024 in PubMed, Scopus, and Web of Science that were relevant to our topic. The search strategy employed the Boolean terms "impacted" AND "canine". In addition to the overview, this article discusses a number of clinical instances involving canine disinclusion. Results: The study analyzed 2748 papers from databases like Web of Science, PubMed, and Scopus, resulting in 1455 articles after eliminating duplicates. After examining titles and abstracts, 897 entries were removed. The remaining 558 papers were confirmed, with 543 items removed due to being off-topic. The study includes a qualitative analysis of the 15 final articles. Conclusions: This article concludes that both extraction and orthodontic traction are effective treatments for impacted canines, with the choice depending on patient-specific factors. Advances in surgical techniques and imaging technologies have improved outcomes, while a multidisciplinary, patient-centered approach remains essential. Future research should focus on refining treatment selection criteria and integrating genetic and technological advancements
Diagnostic Challenges of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the Hard Palate
Full text linkTraumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion that may arise from the oral mucosa consisting in an ulcerative lesion usually localized in the tongue or cheek. Palate localization is very rare. Background/Objectives: The aim of this study is to describe a case of TUGSE occurring in the hard palate of an 83 y.o. female patient, manifesting as a non-painful growing palatal lesion approximately of 3.5 × 2 cm with firm consistency and a central area of erosion and erythema, the difficulties in clinical diagnosis, and the criteria for the differential diagnosis. Also, considering the rare occurrence of TUGSE in the palate, we performed a review of the literature too. Methods: A comprehensive review of the literature was conducted following the 2020 PRISMA guidelines and a total of seven records were identified as matching the inclusion criteria of this study. Results Conclusions: Although TUGSE is a benign lesion, the clinical presentation as a proliferative and ulcerative lesion may be challenging for clinicians mainly when arising in rare sites of occurrence (e.g., the hard palate)
Il Mediterraneo nella prima metà del Duecento
No full textXXI capitolo della storia del Mediterraneo medieval
Questioni chiuse e questioni aperte in tema di responsabilità dei funzionari e degli enti in un recente orientamento della Suprema Corte
No full textLa Terza Sezione della Corte di cassazione si è pronunciata su una questione di diritto, che in tempi recenti è stata ripetutamente trattata con esiti uniformi: nel caso di illecito extracontrattuale con pluralità di responsabili solidalmente coobligati e di adempimento da parte di uno di essi, ci si chiede se la possibi-lità di agire in via di regresso ex art. 2055 c.c., comma 2, sia possibile o sia preclusa verso un responsabi-le oggettivo o indiretto.
Nella fattispecie concreta qui dedotta, più precisamente, si è inteso verificare se, a seguito di una serie di attività e di omissioni di un Sindaco - che con il suo comportamento ha concorso a provocare la morte di numerosi cittadini a seguito di eccezionali eventi atmosferici e di dissesti conseguenti - l’adempiente, Autorità statale centrale, possa esercitare la pretesa in via di regresso non solo verso il Sindaco stesso, ma anche verso il Comune. In linea con la giurisprudenza più recente della Suprema Corte, che si innesta peraltro sulla stessa ca-sistica di fondo, la risposta positiva è formulata attraverso la corretta qualificazione dell’attività mal di-spiegata od omessa dal Sindaco, nei termini di un’attività comunque istituzionale, consentendo di impu-tare così direttamente detta attività al Comune stesso, in piena aderenza al sussistente rapporto organico con il proprio funzionario. Per questa ragione, le eventuali strettoie all’applicazione del regresso ex art. 2055 c.c. vengono evitate, attribuendo all’Ente una responsabilità non già indiretta, ma diretta. Le premesse concettuali, peraltro, si ricavano dal lungo itinerario ermeneutico intorno all’art. 28 Cost. e, recentemente, da una nota decisione delle Sezioni Unite della Corte (n. 13246/2019), che ha elaborato puntualmente il contesto delle relazioni tra ente e funzionario, ai fini della corretta qualificazione della re-sponsabilità dell’ente come diretta o indiretta. Anche se l’Ordinanza in commento non ha trattato ex professo - in ragione dell’ordine materiale delle questioni affrontate e del rilievo assorbente della prima - la questione imperniata esclusivamente sull’azionabilità del regresso ex art. 2055 c.c., si è infine inteso trarre dalla decisione qualche indicazione utile pure a questi fini, per il possibile rilievo esteso dell’approccio metodologico adottato dalla Suprema Corte
The Effect of Exercise-Based Interventions on Health-Related Quality of Life of Patients with Hematological Malignancies: A Systematic Review and Meta-Analysis
No full textBackground/Objectives: Hematological cancers encompass a collection of heterogeneous conditions. The need for repeated treatments and prolonged hospitalization leads to a decrease in health-related quality of life. This systematic review and meta-analysis evaluate the effect of exercise interventions on functioning scales, global health status, and symptoms in patients with hematological cancers. Methods: PubMed, Web of Science, and Scopus databases were systematically screened, and randomized controlled trials were
included. The primary outcome was health-related quality of life assessed through the
European Organization for Research and Treatment of Cancer Quality of Life questionnaire. Meta-analysis was performed using a random-effects model and 95% confidence intervals. Results: A total of 14 trials involving 837 patients with mixed cancer types were included. Most studies evaluated exercise interventions during hospitalization, with aerobic and resistance training at moderate intensity being the most common modalities and adherence rates ranging from 28% to 100%. Exercise programs significantly improved physical (SMD 0.23; 95% CI: 0.06 to 0.40; p = 0.008), emotional (SMD 0.19; 95% CI: 0.03 to 0.36; p = 0.020) and cognitive functioning (SMD 0.20; 95% CI: 0.02 to 0.37; p = 0.026), and global health status (SMD 0.24; 95% CI: 0.03 to 0.46; p = 0.027). Significant reductions were observed in fatigue (SMD −0.33; 95% CI: −0.52 to −0.14; p = 0.001), pain (SMD −0.34; 95% CI: −0.53 to −0.15; p = 0.000), and insomnia (SMD −0.22; 95% CI: −0.41 to −0.03; p = 0.024). Heterogeneity was minimal across most domains, suggesting consistent findings. Conclusions: Exercise interventions are effective in enhancing functioning scales and global health status and reducing symptom burden in patients receiving intensive treatments. Future research is required to explore the long-term effects of exercise and develop tailored programs for
specific hematologic malignancies and treatment settings
Rapid palate expansion's impact on nasal breathing: a systematic review
No full textProper nasal breathing is essential for the craniofacial development of children. Maxillary constriction, often
associated with impaired nasal breathing, results in a narrow upper jaw, posterior crossbite, and a high palatal
vault, which elevates the nasal floor and increases nasal resistance. Rapid maxillary expansion (RME) is a
common orthodontic procedure that expands the maxillary dental arch, thereby widening the nasal cavity (NC).
The aim of this systematic review is to evaluate the effectiveness of RME on nasal breathing in pediatric patients.
We searched databases including PubMed, Web of Science, and Scopus using the keywords: ’maxillary,’
’expansion,’ ’palatal,’ ’RME,’ ’disjunction,’ and ’nasal.’ The screening phase concluded with the selection of 13
publications for this review, encompassing randomized controlled trials, cohort studies, and case-control studies.
The quality of the studies was assessed using established criteria, and data were extracted and analyzed. RME
significantly increases the transverse dimensions of the maxilla and NC, contributing to an increase in NC volume. While structural improvements are consistent across studies, functional benefits, such as reduced nasal
resistance, exhibit variability. Factors including age, pre-treatment skeletal conditions, and adenotonsillar hypertrophy influence the efficacy of RME. Certain devices, such as the Hybrid-Hyrax expander (HHE), have shown
promising results in enhancing nasal ventilation.
Overall, RME is an effective intervention for improving nasal breathing in children with maxillary constriction.
However, further research is necessary to fully elucidate the variability in functional outcomes. Future studies
should refine measurement techniques and compare different devices and protocols to optimize RME application
Pratiche di welfare tra formale e non formale: la cura come fabbrica dell’essere
No full textIl clima che caratterizza oggi il mondo della scuola, inteso come il più rappresentativo tra i contesti formali, richiama l’attenzione della pedagogia sociale verso l’analisi di una idea di benessere che si lega sempre più al valore degli attori in campo piuttosto che allo spazio che li ospita. La cura, qui intesa come fabbrica dell’essere, restituisce alla persona una dimensione nuova di costruzione identitaria, che guarda con particolare attenzione al concetto di “occuparsi” e di “preoccuparsi” in quanto cura dell’essere per la propria durata e conservazione. Il contesto esterno, il piano non formale, caratterizza diversamente il concetto di cura declinandolo secondo un principio che sta diventando sempre più individualista e costantemente meno votato al rispetto e all’attenzione verso l’altro da sé. L’occuparsi e il preoccuparsi della nostra vita consistono, invece, nel prendersi cura del nostro tempo, delle relazioni che ci connettono agli altri e, quindi, del mondo sociale.
La pluralità di volti della scuola odierna rappresenta l’esito - sul piano sincronico - di un processo di accelerazione diacronica; infatti, l’aumento della velocità della storia che caratterizza la nostra epoca ha portato a un accavallarsi dei cambiamenti della scuola. La complessità dei volti della scuola viene così a delinearsi in un quadro che vede la crisi del modello tradizionale, aggravato anche dalla difficoltà di un modello di scuola democratica moderna, e che apre via via a un sempre più crescente costrutto pratico di scuola neoliberista. Il richiamo, in questa sede, può sicuramente essere quello che vede nella scuola un modello vicino al concetto tradizionale di tempio della cultura, di tipo ideale, coniugandolo evidentemente con la sfrenata parcellizzazione del presente, del tempo liquido e puntillistico che caratterizza la scuola dell’oggi. In più, vi è attualmente una società che fa della frammentazione valoriale il proprio punto di riferimento più solido, incardinando il pensiero in una moltitudine e multidimensionalità della persona inserita in una logica consumistica, in una dinamica di mercato, di cittadino consumatore piuttosto che responsabile.
Il presente contributo, sulla scorta di queste brevi riflessioni, mira a rimarcare la necessità di instaurare un clima votato al benessere interno della classe, e più in generale allo star bene all’interno del mondo scuola, dando alla stessa il costrutto proprio di comunità educante, restituendo gli elementi indispensabili alla persona in formazione per costruirsi una solida base di valori educativi indispensabili alla convivenza all’interno della comunità. Una pratica di welfare che recupera gli aspetti relazionali più prossimi e li coniuga con una pratica di senso di comunità, e di benessere, che diventano propedeutici alla costruzione di un percorso personale che passa attraverso la pratica di responsabilità, che genera relazioni educative solide, volte alla giusta cura della persona
Xylazine, a Drug Adulterant Whose Use Is Spreading in the Human Population from the U.S. to the U.K. and All Europe: An Updated Review
No full textXylazine, commonly called “tranq” or “sleep cut”, is a strong α2-adrenergic agonist used in veterinary practice as a sedative, analgesic, and muscle-relaxing agent. It has never been approved by the Food and Drug Administration for human use, but its use by people is on the rise. In the last decades, due to its low cost and ease of availability, it has often been illicitly used due to its abuse potential as a drug for attempted sexual assault and intended poisoning. In addition, xylazine’s presence in the human body has also been related to domestic accidental events. Generally, it is combined with multiple other drugs, typically by intravenous injection, potentiating the doping effects. Xylazine’s mechanism of action is different from that of other illicit opioids, such as heroin and fentanyl, and it has no known antidote approved for use in humans. The combination with fentanyl prolongs the euphoric sensation and may heighten the risk of fatal overdose. Furthermore, it may cause adverse effects, including central nervous system (CNS) and respiratory depression, bradycardia, hypotension, and even death. Recent reports of xylazine misuse have risen alarmingly and describe people who become “zombies” because of the drug’s harmful effects on the human body, including serious wound formation that could even lead to limb amputation. This paper is an extensive review of the existing literature about xylazine and specifically deals with the chemistry, pharmacokinetics, pharmacodynamic, and toxicological aspects of this compound, highlighting the most recent studies
Compositional and Defect Engineering of Metal Halide Perovskite-Based Heterojunctions for Efficient Nitrogen Photofixation
No full textDesigning innovative photocatalysts for nitrogen photofixation is becoming crucial for the development of carbon-neutral ammonia production. Metal halide perovskites (MHPs) provide a rich library of materials with an easy tuning of the semiconductor bandgap in order to integrate them in devices with different functionalities. An under-explored path is their exploitation to run a wide range of photoredox reactions mediated by solar light. Herein, heterojunction is developed based on the vacancy-ordered double-perovskite Cs2SnBr6 and carbon nitride nanosheets and demonstrate its ability in running the nitrogen photofixation reaction to produce ammonia under solar light. An investigation is done on full Cs2SnBr6/g-C3N4 system and an optimal range providing an outstanding ammonia evolution rate up to 270 μmol g−1 h−1is identified, which is quantified by means of ion selective electrode. Mechanistic insight into the photofixation reaction is obtained through a combination of advanced spectroscopy and computational modeling. Efficient ammonia production stems from an effective charge transfer from the perovskite to the nitrogen vacancies on the carbon nitride enabled by the proposed absence of self-trapped excitons in Cs2SnBr6, which also provides additional reactive sites through bromide vacancies. This work paves the way to MHP-based catalyst design strategy for sustainable ammonia production
Could the quality characteristics of virgin olive oil influence its geographical classification using untargeted infrared spectroscopy and chemometrics?
Full text linkEnsuring the geographical authenticity of virgin olive oil (VOO) is essential for quality control, fraud prevention, and regional product protection. This study evaluates Near-Infrared (NIR), and Infrared (IR) spectroscopies combined with chemometrics to classify 97 VOO samples from Italy (Apulia, Tuscany) and foreign countries (Morocco, Jordan, Greece, Tunisia, Spain). Partial Least Squares Discriminant Analysis (PLS-DA) effectively classified VOOs according to geographical origin, with sensitivity and specificity values higher than 0.90 in prediction. However, we also examined whether chemical quality traits, such as peroxide values and fatty acid composition, could introduce biases in the classification models. The findings suggest that inconsistent quality grade of samples could affect classification. To mitigate this, a preliminary quality assessment is recommended before applying untargeted spectroscopic methods for authentication. This study highlights the importance of integrating quality control with untargeted approaches, giving suggestions for developing more reliable authentication techniques for VOO and other foods