University of Bari Aldo Moro
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IL mondo c'è ancora: territorio città ambiente
No full textSeguendo una lucida indicazione di Hannah Arendt, il libro descrive la modernità come un lungo processo di "alienazione dal mondo", di cui oggi si hanno prove - fra l'altro - nell'urbanizzazione infinita del pianeta, nella dematerializzazione mediatica delle relazioni, nell'aggravarsi della crisi ecologica, nel trasformarsi del Mediterraneo in mare ribollente e così via.
Insistendo sul carattere ecositemico e comune del mondo, il libro individua nel territorio la dimensione da cui si può partire per ricostruire la relazione perduta con esso riscoprendosi come abitanti e come soggetti civici che si prendono cura della varietà eco-antropica dei luoghi.
In tal senso, il libro approfondisce e sviluppa la prospettiva dell'eco-territorialismo come via di accesso a questa possibilità
DistillRecDial: A Knowledge-Distilled Dataset Capturing User Diversity in Conversational Recommendation
No full textConversational Recommender Systems (CRSs) facilitate item discovery through multi-turn dialogues that elicit user preferences via natural language interaction. This field has gained significant attention following advancements in Natural Language Processing (NLP) enabled by Large Language Models (LLMs). However, current CRS research remains constrained by datasets with fundamental limitations. Human-generated datasets suffer from inconsistent dialogue quality, limited domain expertise, and insufficient scale for real-world application, while synthetic datasets created with proprietary LLMs ignore the diversity of real-world user behavior and present significant barriers to accessibility and reproducibility. The development of effective CRSs depends critically on addressing these deficiencies.To this end, we present DistillRecDial, a novel conversational recommendation dataset generated through a knowledge distillation pipeline that leverages smaller, more accessible open LLMs. Crucially, DistillRecDial simulates a range of user types with varying intentions, preference expression styles, and initiative levels, capturing behavioral diversity that is largely absent from prior work. Human evaluation demonstrates that our dataset significantly outperforms widely adopted CRS datasets in dialogue coherence and domain-specific expertise, indicating its potential to advance the development of more realistic and effective conversational recommender systems
54. Il diritto e la religione tra globalizzazione e multiculturalismo: una traccia identitaria nell’Unione Europea
No full textL’evoluzione contemporanea dei nostri sistemi giuridici si inserisce in un quadro globale segnato e caratterizzato da una crescente complessità sociale, culturale e istituzionale, in cui le trasformazioni geopolitiche si collegano, intrecciandosi, con i processi di globalizzazione, mobilità umana e pluralismo normativo. Il diritto, in tale contesto, non può più essere inteso come un sistema chiuso e autosufficiente, ma va considerato come una struttura dinamica chiamata a confrontarsi con la molteplicità degli ordinamenti, dei valori e delle varie appartenenze.
La evidente crisi dello Stato-Nazione come un unico titolare della sovranità giuridica e, contestualmente, l’emergere di nuove forme di governance sovranazionale, con particolare riferimento alla situazione esistente nell’Unione Europea, impongono una riconsiderazione sul modo in cui anche sotto il profilo giuridico le società considerano le alterità e le differenze . Si può affermare che il diritto contemporaneo è chiamato ad affrontare la sfida di riuscire a ripensare i propri paradigmi in un contesto globale caratterizzato da una crescente complessità e interconnessione, all’interno del quale la pluralità /molteplicità dei vari ordinamenti giuridici, delle diverse identità, sia culturali sia religiose, impone un metodo interpretativo flessibile, multilivello e inclusivo, capace di riuscire a coniugare tutela dei diritti e riconoscimento delle differenze
Diritto, economia e società a Taranto nei secoli XV-XVI
No full textLo studio si concentra sul passaggio di Taranto da università feudale a demaniale sotto il diretto dominio regio. Dopo la morte dell'ultimo Principe Giovanni Antonio Del Balzo Orsini nel 1463, l'Università deliberò la sottomissione spontanea a Re Ferdinando I di Napoli. La città mirava a ottenere privilegi reali, riduzioni di gabelle feudali e nuove immunità. Le numerose richieste presentate alla Corona riguardavano ambiti fiscali, economici, giudiziari e amministrativi. Un focus centrale è dedicato agli ordinamenta civitatis del 1465. Tale ordinamento istituì un Consiglio Generale di 108 membri, ripartiti in modo paritetico tra nobili, mercanti e artigiani popolari. Questo sistema di governo, con un Consiglio Esecutivo di Nove e un Consiglio dei Dodici, rifletteva il crescente peso della classe mercantile. I privilegi concessi definirono gli equilibri politici locali e alimentarono il significativo dinamismo commerciale della città. I mercanti tarantini ottennero ampie franchigie ed esenzioni in tutto il Regno, assicurandosi un ruolo commerciale di rilievo
Pediatric, adult, and late onset multiple sclerosis: Cognitive phenotypes and gray matter atrophy
No full textObjectives: We aim to investigate cognitive phenotype distribution and MRI correlates across pediatric-, elderly-, and adult-onset MS patients as a function of disease duration. Methods: In this cross-sectional study, we enrolled 1262 MS patients and 238 healthy controls, with neurological and cognitive assessments. A subset of 222 MS patients and 92 controls underwent 3T-MRI scan for brain atrophy and lesion analysis. Multinomial probabilistic models identified likelihood of belonging to cognitive phenotypes (“preserved-cognition,” “mild verbal memory/semantic fluency,” “mild multi-domain,” “severe attention/executive,” and “severe multi-domain”) and experiencing MRI abnormalities based on disease duration and age at onset. Results: In all groups, the likelihood of “preserved-cognition” phenotype decreased, whereas “mild multi-domain” increased with longer disease duration. In pediatric- and adult-onset patients, the likelihood of “mild verbal memory/semantic fluency” phenotypes decreased with longer disease duration, and that of “severe multi-domain” increased with longer disease duration. Only in adult-onset patients, the likelihood of “severe executive/attention” phenotype increased with longer disease duration. All groups displayed escalating probabilities of cortical, thalamic, hippocampal, and deep gray matter atrophy over disease course. Compared to adult, pediatric-onset patients showed lower probability of experiencing thalamic atrophy with longer disease duration, while elderly-onset showed higher probability of experiencing cortical and hippocampal atrophy. Interpretation: Age at MS onset significantly influences the distribution of cognitive phenotypes and the patterns of regional gray matter atrophy throughout the disease course
STATINS CHANGE miRNA EXPRESSION IN CIRCULATING ENDOTHELIAL PROGENITOR CELLS FROM HYPERTENSIVE PATIENTS
No full textIntroduction: Statins are still one of the most common and effective
treatments to prevent atherosclerosis progression. In addition to
reducing high plasma concentration of LDL, statins may contribute
to counteract vascular inflammation and endothelial disfunction in
patients at cardiovascular (CV) risk. Endothelial dysfunction correlates
to an impaired availability of circulating endothelial progenitor
cells (EPCs), physiologically recruited from bone marrow in response
to vascular damage. EPCs contribute to re-endothelialization and vascular
integrity.
Aim: We investigated whether statins might help to ameliorate EPCs
number and function, therefore helping to elucidate potential additional
mechanisms for statins protective effects on CV disease-prone
patients.
Methods: Hypertensive patients receiving (STAT, n = 51, 24F, aged
67.7 ± 9.6) or not (NO-STAT, n = 24, 13F, aged 63.1 ± 11.3) statin treatment
underwent routine laboratory and instrumental examinations to
assess arterial stiffness and organ damage (ABI, PWV). Quantitative
and functional analysis was performed on EPCs isolated from patients
of both groups. Small RNAseq was carried out to identify potential changes in microRNAs expression related to statin treatment. Statistical
difference (p < 0.05) was considered significant.
Results: PWV estimated vascular age was significantly higher in
STAT (vs NO-STAT) patients. As expected, total cholesterol and LDL
levels were lower in STAT (vs NO-STAT) patients. Interestingly, the
total number of EPCs (by flow cytometry) and their ability to migrate
(by wound healing assay) was significantly improved in STAT (vs NOSTAT)
patients. Expression (by microRNAseq analysis) of miR-3960,
mir-328-3p, mir-10400-5p, all involved in invasion and inflammation,
was found downregulated in STAT (vs NO-STAT) patients.
Conclusions: Preliminary findings suggest that the improved EPCs
availability may represent an additional mechanism by which statins
ameliorate vascular protection, likely dependent, at least in part, by
modulation of specific microRNAs expression. Moreover, our findings
emphasize the importance of EPCs as a potentia
Measurement of ψ(2S) to J/ψ cross-section ratio as function of multiplicity in pPb collisions at sNN=8.16 TeV
No full textThe production ratio of ψ(2S) to J/ψ charmonium states is presented as a function of multiplicity in proton-lead collisions at a centre-of-mass energy of sNN=8.16 TeV, for both prompt and nonprompt sources. The total luminosity recorded by the LHCb experiment corresponds to 13.6 nb−1 for pPb collisions and 20.8 nb−1 for Pbp collisions, where the first particle corresponds to the particle traveling towards the detector. Measurements are performed in the dimuon final state at forward (backward) centre-of-mass rapidity, with respect to the proton direction, 1.5 < y*< 4.0 (−5.0 < y*< −2.5) for pPb (Pbp) collisions. A multiplicity dependence of the prompt production ratio is observed in pPb collisions, whereas no dependence is found in nonprompt production, nor in either prompt or nonprompt production in Pbp collisions. These results suggest that in the Pb-going direction additional suppression mechanisms beyond comover effects may be present, possibly related to the formation of quark-gluon plasma. This highlights a transition from small to large collision systems and provides important insight into the suppression of charmonia in proton-nucleus collisions
L'origine plebiscitaria dello Stato italiano. profili storico-giuridici di un "istituto" ottocentesco
No full textIl saggio esamina le posizioni della dottrina giuridica con riferimento al valore e al significato dei plebisciti del 1860
Social and relationship capital and idiosyncratic volatility: is there a nexus? Evidence from the European financial market
No full textThis study investigates the impact of social and relationship capital (SRC) on the volatility of stock returns for financial companies in the European Union. While prior research has examined the link between SRC and market returns, this study uniquely explores its influence on both systematic and idiosyncratic components of volatility. Using a sample of 140 EU banking, insurance, and asset management firms from 2002 to 2021, we apply Marshall’s (2015) model to decompose total volatility. The findings reveal that firms with high SRC typically exhibit greater total volatility, largely driven by systematic risk, whereas low-SRC firms are more influenced by idiosyncratic factors. These results are robust across various specifications, including lagged data and sector-specific analyses. This study underscores the importance of SRC for financial intermediaries. Its implications are multifaceted. For investors, high-SRC firms align more closely with market movements, facilitating market-oriented strategies but offering fewer diversification benefits, whereas low-SRC firms expose portfolios to greater firm-specific risks. For regulators, the evidence underscores the role of SRC in shaping risk profiles, informing supervisory practices that increasingly incorporate ESG considerations. Finally, for financial institutions, SRC emerges as a driver of stakeholder trust and reputation and a determinant of exposure to systematic shocks