University of Bari Aldo Moro
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Introduzione. «Le parole sono importanti»: la vulnerabilità linguistica e la “forza del linguaggio”
No full textQuesta introduzione al primo "Dizionario di genere" pubblicato in Italia, che raccoglie le definizioni utili per la comprensione dei fenomeni sociali legati al genere, insiste su quella variabile specifica della “vulnerabilità sociale” che può ben essere definita come “vulnerabilità linguistica”, che si riferisce al fatto che chi non possiede le parole e i loro significati non padroneggia la realtà che quei termini descrivono
A study on the use of Flashbulb Memories features to discriminate true from fabricated autobiographical memories for negative events
No full textStudies so far have strived to define the characteristics of autobiographical memories accounting for their veracity and accuracy. Our study aimed to test whether it is possible to distinguish between true and fabricated autobiographical memories by adopting the Flashbulb Memory Checklist (FBMC), a validated tool used to assess the phenomenological features of emotional autobiographical memories. We asked participants to first recall a negative event truly experienced in the last 12–18 months and report a negative event that they never experienced. We calculated the FBMC scores (i.e., FBM Specificity, FBM Confidence) and checked whether these would help to distinguish between true and fabricated memories for negative events. Our findings showed that FBMC scores can be informative for memories’ evaluation although they do not allow a proper discrimination between the two types of memories. The legal implications of our findings are discussed
Aquaporin-4 in Astrocytes and Glial Cells: Structural Insights and Functional Implications
No full textThis chapter delves into the structural and functional roles of aquaporin-4 (AQP4) in astrocytes. AQP4, a pivotal water channel protein, is essential for brain water homeostasis, neuronal protection, and injury response. Structurally, AQP4 exists as M1 and M23 isoforms, forming orthogonal arrays of particles (OAPs) crucial for efficient water transport and the formation of the blood–brain barrier (BBB). Functionally, AQP4 maintains the extracellular environment, supports neuronal activity, and facilitates metabolic waste clearance via the glymphatic system. Dysregulation of AQP4 is implicated in neurological diseases such as gliomas and neuromyelitis optica, affecting brain edema and cell migration. In addition, AQP4 plays a critical role in neurodevelopment, influencing processes like neurogenesis and synaptogenesis. Understanding AQP4’s diverse roles underscores its potential as a therapeutic target in treating neurodevelopmental and neurodegenerative disorders
Older Patients with Elevated Pre-sepsis PTFV1 Demonstrate Greater Occurrence of Atrial Fibrillation and Worse In-Hospital Outcomes
No full textBackground: Elevated P-wave terminal force in lead V1 (PTFV1) >5000 μV*ms is a predictor of atrial fibrillation and stroke in a general population. The risk for atrial fibrillation and ischemic stroke is high in sepsis but predictors are lacking.
Objectives: Analysis of a prospective, observational cohort study with subjects categorized by PTFV1 (lower and higher than 5000 μV*ms) cutoffs and by age (older and younger than 60 years old).
Methods: Of the 360 consented sepsis patients, 273 had evaluable pre-sepsis electrocardiograms (ECG). PTFV1 was measured by 3 independent and blinded assessors using the Mitutoyo 500-195-30CAL Absolute Digimatic Caliper on the last available ECG before sepsis onset. Patient characteristics and outcomes were compared between lower (PTFV1 < 5,000 μV*ms) and higher PTFV1 (PTFV1 > 5,000 μV*ms), and older and younger patients with elevated pre-sepsis PTFV1.
Results: The median age was 63 years [IQR 53, 71], 44% women. Median of the last ECG prior to sepsis-onset was 1 day [IQR, 0, 9]. 32% of individuals had pre-sepsis PTFV1 > 5,000 μV*ms, and were mostly females. Older patients with PTFV1 > 5,000 μV*ms had greater pre-sepsis left atrial diameter, more in-hospital new-onset atrial fibrillation, greater Charlson Comorbidity Index score, and worse clinical trajectory, compared to younger patients with PTFV1 > 5,000 μV*ms.
Conclusions: Older individuals with elevated pre-sepsis PTFV1 had greater occurrence of AF and worse outcomes during sepsis. Future studies will test pre-sepsis PTFV1 as a predictor of in-hospital and longitudinal outcomes in older sepsis patients at risk of atrial fibrillation, stroke and frailty
Evaluation of Five Ready-to-Use Bases for the Topical Administration of Propranolol Hydrochloride to Treat Infantile Hemangioma
No full textBackground/Objectives: Since 2008, following clinical studies conducted on children that revealed the ability of the β-adrenergic antagonist propranolol to inhibit capillary growth in infantile hemangiomas (IHs), its oral administration has become the first-line treatment for IHs. Although oral propranolol therapy at a dosage of 3 mg/kg/die is effective, it can cause systemic adverse reactions. This therapy is not necessarily applicable to all patients. Topical skin applications could help maintain a high drug concentration at local sites and also represent a characteristically easy method of administration for pediatric patients. Because no topical propranolol dosage forms are commercially available, such formulations may be prepared at hospitals and pharmacies. Methods: In the present study, we identified a simple method for preparing topical propranolol hydrochloride formulations at 1% w/w with five commercial ready-to-use bases and evaluated the pharmaceutical profiles. The physical stability of the extemporaneous formulations was predicted by performing an accelerated centrifuge test and assessed by visual inspection after one month storage at 25 °C. The chemical stability of the drug in the five formulations was assessed by using a high-performance liquid chromatography (HPLC) method. In vitro drug-release and permeability experiments were conducted through synthetic membranes and the outer pavilion of a pig’s ear by utilizing Franz-type diffusion cells. Results: The results indicated that the release of the drug was significantly influenced by the internal structure and physicochemical properties of each base. Conclusions: Specifically, the formulations prepared with the hydrophilic bases could be easily prepared and yield satisfactory results, representing a potential effective therapy for IHs in pediatric patients
Corpo
No full textIl saggio attraversa le modificazioni concettuali che sono intervenute nel pensiero contemporaneo, a partire da M. Mauss fino a P. Preciado, a proposito del rapporto tra corpo e tecnica, con un approccio di natura antropologico-filosofico. In particolare, elabora lo slittamento tra l'idea di "avere un corpo" a quella, ben supportata dalla riflessione teoretica di J.-L. Nancy, incentrata sull'"essere corpo", che ridisegna radicalmente il rapporto di assoggettamento del corpo alla tecnica
Dietary inclusion of Tenebrio molitor L. frass affects nutrient digestibility, ruminal fermentation activities, blood metabolites, and milk performance in goats
No full textThis research aimed to evaluate the inclusion of mealworm frass (MF, from Tenebrio molitor L.) in the rations of dairy goats. The hypothesis was that adding MF may improve the utilization of protein. Twenty-four Damascus goats (body weight similar to 48.2 +/- 0.9 kg) of the third and fourth parity were divided into three groups (n = 8). Goats in the control group (MF0) were fed Egyptian clover ad libitum plus a concentrate feed mixture to cover 55 % of their nutritional requirements (basal diet). Goats in the second (MF1) and third (MF3) groups received the basal diet supplemented with 1 % and 3 % MF, respectively. The experimental period lasted 120 days, (30 days prepartum and 90 days postpartum). Digestibility, performance, blood metabolites, and milk yield and quality were assessed. The inclusion of MF in rations increased (P < 0.05) digestibility coefficients for DM and CP (dry matter and crude protein). Concentration of ruminal ammonia and volatile fatty acids were higher (P < 0.05) for goats fed on a diet containing 3 % MF. Likewise, the estimated blood metabolites (total proteins, albumin, globulin, urea, creatinine, ALT, and AST) were significantly increased (P < 0.05) for the MF3 goats. Actual milk, fat-corrected milk (4 %), and energy-corrected milk yields were higher (P < 0.05) for MF1 and MF3 goats. The best feed conversion was observed with the MF3 group compared to the control (0.98 vs. 1.17 kg DMI/kg milk). The economic efficiency of milk improved (P < 0.05) for MF1 and MF3 goats by 22, and 50 %, respectively. In conclusion, incorporating mealworm frass up to 3 % in the concentrate feed mixture enhanced goat growth and feed utilization rate as well as milk production
“Online or offline? That is the question”. The wine distribution channels dilemma
No full textThis paper aims, with an exploratory approach, at understanding which variables affect wine consumers when they opt for online or offline purchasing channels decisions. In order to do so, in this study authors carry out a comparative analysis between the wine preferences of Italian and Chinese consumers. The examination of the reasons behind purchasing or not purchasing wine online or via social media among Chinese and Italian consumers reveals some interesting similarities in the factors influencing their decisions
Re: Justine Panian, Caiwei Zhong, Sharon H. Choi, et al. Efficacy of Treatments After Lenvatinib in Patients with Advanced Renal Cell Carcinoma. Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2024.11.011
No full textNot availabl
Measurements of ψ(2S) and χc1(3872) production within fully reconstructed jets
No full textThis paper presents the first measurement of ψ(2S) and χc1(3872) meson production within fully reconstructed jets. Each quarkonium state (tag) is reconstructed via its decay to the J/ψ(→μ+μ-)π+π- final state in the forward region using proton-proton collision data collected by the LHCb experiment at the center-of-mass-energy of 13TeV in 2016, corresponding to an integrated luminosity of 1.64\,fb-1. The fragmentation function, presented as the ratio of the quarkonium-tag transverse momentum to the full jet transverse momentum (pT(tag)/pT(jet)), is measured differentially in pT(jet) and pT(tag) bins. The distributions are separated into promptly produced quarkonia from proton-proton collisions and quarkonia produced from displaced b-hadron decays. While the displaced quarkonia fragmentation functions are in general well described by parton-shower predictions, the prompt quarkonium distributions differ significantly from fixed-order non-relativistic QCD (NRQCD) predictions followed by a QCD parton shower