University of Bari Aldo Moro
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Da scarto infestante a risorsa salutistica: ricerca e valorizzazione della Salicornia europaea L. per nuove formulazioni di interesse nutraceutico
No full textQuesta tesi di dottorato ha focalizzato la sua attenzione sulla valorizzazione della Salicornia europaea
L., pianta alofita delle aree costiere mediterranee. Le caratteristiche fitochimiche della Salicornia, in
particolare la presenza di polifenoli, flavonoidi e lignani, le conferiscono potenziali benefici
antiossidanti, antimicrobici e antinfiammatori. Diverse metodologie di estrazione, incluse tecniche
green come l'estrazione con ultrasuoni (UAE) e Natural deep eutectic solvent (NADEs), sono state
ottimizzate per massimizzare la resa di composti bioattivi.
In seguito all’ottimizzazione delle condizioni di estrazione in EtOH 50% emerge come un tempo di
estrazione di 11 minuti e un rapporto matrice solvente pari a 1:9 (g/mL) risulta essere il più efficace
in termini di recupero di composti bioattivi e antiossidanti tra cui principalmente isoramnetine e loro
derivati. La selezione di solventi green come i NADEs, ha mostrato come l’estratto in prolina: acido
malico, sia il migliore su tre fronti: attività antiossidante, antimicrobica e stabilità del contenuto totale
di polifenoli nel tempo.
Questi risultati evidenziano un elevato potenziale della Salicornia per l’industria alimentare e
farmaceutica, promuovendo al contempo la sostenibilità ambientale attraverso l’utilizzo sia di
solventi ecocompatibili che di una pianta endemica del Mediterraneo capace di crescere su terreni ad
alta salinità altrimenti non utilizzabili per coltivazioni convenzionali. Questo studio si inserisce nel
contesto delle strategie europee del Green Deal e della Blue Economy, mirando alla creazione di
nuove filiere produttive intercettando nuovi mercati ed opportunità economiche. Pertanto, la
valorizzazione della S. europaea rappresenta un approccio innovativo per il settore nutraceutico,
combinando ricerca scientifica, economia circolare e sviluppo territoriale.This doctoral thesis focused its attention on the enhancement of Salicornia europaea L., a halophytic
plant of Mediterranean coastal areas. The phytochemical characteristics of Salicornia, particularly the
presence of polyphenols, flavonoids and lignans, give it potential antioxidant, antimicrobial and antiinflammatory
properties. Various extraction methodologies, including green techniques such as
ultrasonic extraction (UAE) and Natural deep eutectic solvent (NADEs), have been optimized in
order to maximize the yield of bioactive compounds.
Following optimization of extraction conditions in EtOH 50%, it emerges that an extraction time of
11 minutes and a matrix-solvent ratio of 1:9 (g/mL) is the most effective in terms of recovery of
bioactive and antioxidant compounds including mainly isorhamnetins and their derivatives. The
selection of green solvents such as NADEs, showed that the proline: malic acid extract is the best on
three fronts: antioxidant activity, antimicrobial activity and stability of total polyphenol content over
time.
These results highlight a high potential of Salicornia for the food and pharmaceutical industries,
while promoting environmental sustainability through the use of both environmentally friendly
solvents and an endemic Mediterranean plant capable of growing on high-salinity soils otherwise
unsuitable for conventional crops. This study is in line with the European Green Deal and Blue
Economy strategies, aiming to create new production chains by tapping into new markets and
economic opportunities. Therefore, the enhancement of S. europaea L. represents an innovative
approach for the nutraceutical industry, combining scientific research, circular economy and
territorial development
Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives
Full text linkArtificial intelligence (AI) is rapidly transforming diagnostic approaches in different
fields of medical sciences, demonstrating an emerging potential to revolutionize
dermatopathology due to its capacity to process large amounts of data in the shortest
possible time, both for diagnosis and research purposes. Different AI models have been
applied to neoplastic skin diseases, especially melanoma. However, to date, very few
studies have investigated the role of AI in dermatoses. Herein, we provide an overview
of the key aspects of AI and its functioning, focusing on medical applications. Then, we
summarize all the existing English-language literature about AI applications in the field of
non-neoplastic skin diseases: superficial perivascular dermatitis, psoriasis, fungal infections,
onychomycosis, immunohistochemical characterization of inflammatory dermatoses,
and differential diagnosis between the latter and mycosis fungoides (MF). Finally, we
discuss the main challenges related to AI implementation in pathology
LEARNING AS EXPERIENCE-EMBODIED. REORIENTING LEARNING PROCESSES IN THE AGE OF HUMAN, SOCIAL AND CULTURAL TRANSITIONS
No full textHow can teachers navigate an era of transition, where technologies,
environmental crises, and social shifts redefine education? What role does
lived experience play in learning today? This reflection stems from a two
year professional development programme for in-service teachers,
exploring the grammars of didactic processes and the implicit dimensions
of teaching professionalism. The educator is a mediator of meaning,
intertwining knowledge and lived experience to foster new forms of
understanding. From a phenomenological perspective, learning is not an
abstract process but an embodied experience, rooted in the dynamic
interplay of body, mind, and environment. Teaching thus becomes an act
of co-construction, where knowledge emerges through dialogue between
subjectivity and shared epistemologies. Reaffirming the centrality of
experience reimagines school not only as a place of instruction but as a
generative space, equipping individuals to engage meaningfully with
change
Eligibility of Outpatients with Chronic Heart Failure for Vericiguat and Omecamtiv Mecarbil: From Clinical Trials to the Real-World Practice
Full text linkBackground: Several drugs are emerging as potential therapeutic resources in the context of chronic heart failure (CHF), although their impact on daily clinical practice remains unknown. The objective of this study was to investigate the theoretical eligibility for vericiguat and omecamtiv mecarbil (OM) in a real-world outpatient setting. Methods: A cross-sectional observational study was conducted, enrolling all patients with CHF who had at least one visit between January 2023 and January 2024 in a dedicated outpatient clinic of a tertiary referral center. Theoretical eligibility for vericiguat and OM in our population was assessed by adopting the criteria of the respective phase III clinical trials (VICTORIA trial for vericiguat and GALACTIC-HF trial for OM). Results: In 350 patients with CHF, the rate of individuals eligible was 2% for vericiguat and 4% for OM. A value for left ventricular ejection fraction (LVEF) over the clinical trials’ cutoffs was observed in 41% of cases for vericiguat and 69% for OM. The absence of a recent heart failure (HF) worsening was found in 78% of cases for vericiguat and 72% for OM. Conclusions: Only a small proportion of CHF patients would be eligible for vericiguat and OM in a real-world outpatient setting. The absence of a recent HF worsening and an LVEF over the established trials’ cutoffs are the main causes of non-eligibility. Further studies are required to assess the efficacy of these drugs in a wider population in order to increase the candidates for these beneficial treatments
Digitalizzazione dell’agricoltura e cooperative agricole
No full textIl contributo analizza il ruolo delle cooperative agricole come veicolo privilegiato per una digitalizzazione inclusiva, funzionale alla transizione verde delineata dalla PAC 2023–2027. Attraverso l’esame della normativa europea, del Piano strategico nazionale e del PNRR, si evidenzia come la digitalizzazione, in un’ottica sistemica, possa rafforzare la competitività delle strutture collettive
Le “voci” dei briganti nei processi davanti alla Corte d’Assise di Bari
No full textIl saggio analizza i fascicoli istruttori per fatti di manutengolismo commessi negli anni 1862 e 1863 e raccolti dalla Corte d’Assise di Bari prima che la competenza in materia di brigantaggio passasse al locale tribunale militare di guerra, secondo le disposizioni del R.D. n. 1414 del 20 Agosto 1863. L’indagine svolta consente di individuare metodi e pratiche dei crimini posti in essere dai briganti, attraverso le narrazioni dei querelanti, dei testimoni e degli stessi imputati nonché di conoscere quali furono le prassi procedurali e sostanziali adottate dai magistrati che ebbero a trattare quei process
Detection of RS Oph with LST-1 and modelling of its HE/VHE gamma-ray emission
No full textContext. The recurrent nova RS Ophiuchi (RS Oph) underwent a thermonuclear eruption in August 2021. In this event, RS Oph was detected by the High Energy Stereoscopic System (H.E.S.S.), the Major Atmospheric Gamma Imaging Cherenkov (MAGIC), and the first Large-Sized Telescope (LST-1) of the future Cherenkov Telescope Array Observatory (CTAO) at very-high gamma-ray energies above 100 GeV. This means that novae are a new class of very-high-energy (VHE) gamma-ray emitters. Aims. We report the analysis of the RS Oph observations with LST-1. We constrain the particle population that causes the observed emission in hadronic and leptonic scenarios. Additionally, we study the prospects of detecting further novae using LST-1 and the upcoming LST array of CTAO-North. Methods. We conducted target-of-opportunity observations with LST-1 from the first day of this nova event. The data were analysed in the framework of cta-lstchain and Gammapy, the official CTAO-LST reconstruction and analysis packages. One-zone hadronic and leptonic models were considered to model the gamma-ray emission of RS Oph using the spectral information from Fermi-LAT and LST-1, together with public data from the MAGIC and H.E.S.S. telescopes. Results. RS Oph was detected at 6.6σ with LST-1 in the first 6.35 hours of observations following the eruption. The hadronic scenario is preferred over the leptonic scenario considering a proton energy spectrum with a power-law model with an exponential cutoff whose position increases from (0.26 ± 0.08) TeV on day 1 up to (1.6 ± 0.6) TeV on day 4 after the eruption. The deep sensitivity and low energy threshold of the LST-1/LST array will allow us to detect faint novae and increase their discovery rate
Evaluation of the Quality of University Research from a Regional Perspective Using a Synthetic Indicator
No full textThis paper deals with a proposal for the evaluation of scientific research in Italian universities from a regional perspective. A synthetic indicator based on the Wroclaw taxonomic method was constructed using the percentile rankings of 61 Italian universities in three notable international rankings and in the ANVUR VQR assessment. Despite the simplicity of the methodological approach used to generate global rankings, we emphasize that a ranking is not able to capture the complexity of a multidimensional phenomenon that depends on both endogenous and exogenous variables of a university. Rankings are often criticized by academics but have a strong influence on stakeholders, potential students, lecturers, policy makers and funding bodies
Gaetano Salvemini and the Adriatic question from the First World War to the Treaty of Rapallo
No full textThis essay intends to investigate the political thought and action of Gaetano Salvemini regarding the "Adriatic question” - the relations between Italy and the South Slavs during the Great War. The end of his militancy in the Italian Socialist Party coincided with his decision to support the positions of democratic irredentism. The participation of Italy in the war would have realized the process of national unification, with the annexation of Trentino and Venezia Giulia, regions inhabited mainly by an Italian population.
In the final phase of the conflict, Salvemini’s polemic was directed against the Italian Foreign Minister, Sidney Sonnino, who was accused of hostility towards the nascent Yugoslav nationalism. According to Salvemini, Italy should have come to terms with the nascent Kingdom of the Serbs, Croats and Slovenes, even at the cost of renouncing the aspirations over Istria and Dalmatia, promised to Italy in the Treaty of London, signed on April 1915.
The defeat of Sonnino's policy at the Paris Peace Conference was welcomed with satisfaction by Salvemini, who then applauded the signing of the Treaty of Rapallo, on November 1920, with which Italy and the Kingdom of the Serbs, Croats and Slovenes solved the dispute over the common border
The Natural History of a Neapolitan Miracle The Secret of San Gennaro’s Blood
No full textThis book examines Naples’s patron saint, Gennaro, the history of his blood relic, and the mystery of its periodical liquefaction.
Three times a year, Neapolitans gather to witness the recurring phenomenon of the liquefaction of San Gennaro’s blood. From the seventeenth century to the present, crowds have prayed to the city’s patron for protection from fires, earthquakes, plagues, droughts, and the fury of Mt. Vesuvius. In the “miraculous” moment of transposition from solid to liquid, the faithful seek respite from the ills of the world in the saintly blood, a visual reminder of the blood of Christ spilled for their salvation. In Naples, the periodical liquefaction of San Gennaro’s blood is not officially recognized as miraculous by the Catholic Church, which now more cautiously refers to it as a prodigy. Nevertheless, for centuries, this phenomenon has been called “a miracle” in liturgical texts approved by the ecclesiastical authority and in the words of bishops, cardinals, popes, and saints. However, not everyone agreed. This volume follows the efforts of theologians, alchemists, charlatans, and scientists who, through the centuries, have tried to answer questions such as: Is the liquefaction of San Gennaro’s blood really a miracle? If not, how is it possible to explain a phenomenon that occurs only on dates liturgically relevant to the saint?
The Natural History of a Neapolitan Miracle will be of great value to those interested in Religious Studies, Italian Studies, Medieval and Early Modern Studies, as well as the History of Science, Anthropology, and Ethnography