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Einfluss der Nachpolymerisationstemperatur und der anschließenden Wasserlagerung auf die mechanischen Eigenschaften und die Dimensionsgenauigkeit von 3D-gedruckten Prüfkörpern und Brücken
No full textKann eine Checkliste die Patientensicherheit im Rahmen einer endotrachealen Intubation in Notfallsituationen verbessern? : eine prospektive randomisierte kontrollierte Studie
No full textIntake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: a prospective analysis in the EPIC cohort
No full textFibrin clot strength is associated with increased risk of major adverse cardiac events after TAVR
No full textBackgroundPatients after transcatheter aortic valve replacement (TAVR) are at increased risk of both major adverse cardiac events (MACE), including ischemic and thrombotic complications, as well as significant bleeding. Given this delicate balance between prothrombotic and hemorrhagic risk, the assessment of hemostatic markers might help identify patients at increased risk.AimTo identify hemostatic markers associated with MACE and bleeding following TAVR.MethodsIn this prospective single-center cohort study, of patients undergoing TAVR from November 2020 to June 2022, the association of hemostatic profiles and clinical outcomes was assessed. The profiling included thromboelastography (TEG), light transmission aggregometry (LTA), and conventional laboratory markers to assess thrombogenicity. The outcome was MACE (death, myocardial infarction, or stroke) and major/non-major clinically relevant bleeding at 6 months.ResultsOf the 107 patients included, 104 completed follow-up. At 6 months, 9% experienced MACE, and 10% had clinically relevant bleeding. Platelet–fibrin clot strength, reflected by the maximum amplitude (MA-citrated kaolin) in thrombelastography, was elevated in patients with MACE (per 1 mm increase: HR 1.26 [1.02;1.56], p = 0.03). Fibrin’s role in the maximum clot strength was crucial. Elevated fibrinogen levels, increased citrated functional fibrinogen (MA-CFF), and faster fibrin formation (alpha-angle[α]) associated with a higher risk of MACE (per 20 mg/dL fibrinogen increase: HR 1.15 [1.02–1.28], p = 0.02; per 5 mm MA-CFF increase: HR 1.59 [1.12–2.26], p ConclusionSelected hemostatic markers associated with the risk of MACE and bleeding within 6 months in patients post-TAVR, with fibrin clot strength identified as a principal marker
Frequent high-level rifaximin resistance in Escherichia coli associated with long-term treatment of patients with liver cirrhosis : a prospective, controlled study
No full textWe conducted a prospective, controlled study to assess the prevalence of high-level rifaximin resistance in intestinal Escherichia coli (E. coli) among patients with liver cirrhosis (LC). Rectal swabs were collected from consenting adult LC patients at Freiburg University Medical Center. Swabs were cultured on MacConkey agar plates supplemented with rifaximin at two concentrations (32 µg/mL and 256 µg/mL), and pink/red colonies were identified as E. coli using standard methods. Minimum inhibitory concentrations (MICs) of rifaximin and a panel of additional agents were determined using microdilution assays. Of the 100 patients enrolled, 49 received rifaximin (median duration 22 weeks), and 51 served as controls. Patients receiving rifaximin had more advanced LC (Child B/C, 75% vs. 50%) and more frequent concurrent antibiotic use (22% vs. 12%). High-level rifaximin-resistant E. coli strains were recovered from 67% (33/49) of rifaximin-treated patients, compared to 12% (6/51) of controls (P < 0.001). Cross-resistance to rifampicin was complete, with no clear associations with other resistance phenotypes. A subset of five high-level resistance swabs was assessed for homogeneity of colonization by randomly picking E. coli strains from a non-supplemented MacConkey agar plate. Homogeneous colonization with high-level rifaximin-resistant E. coli was found in 80% of cases. The prevalence of high-level rifaximin-resistant intestinal E. coli in LC patients on long-term rifaximin treatment is extremely high (67% vs. 12%). While rifaximin may remain effective in preventing hepatic encephalopathy (HE), its potential use in preventing spontaneous bacterial peritonitis might be severely limited by the emergence of resistance
Das Blühangebot der Salweide: der Einfluss von Position und Dimension der Äste auf die Blütenzahl
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„Ein Mittel des Friedens und des Dialogs“ : zur Aktualität der Katholischen Soziallehre unter Papst Leo XIV.
No full textCooling efficiency of trees and short vegetation in large cities across the globe
No full textHot extremes are increasing with climate change. Urban green spaces can help to mitigate these extremes through evaporative cooling and shading. We assess the non-linear effects of tree and short vegetation on human thermal comfort, as quantified by the Universal Thermal Climate Index (UTCI), in 216 large cities worldwide. On average, the cooling efficiency of trees is 6 times larger than that of short vegetation. However, comparable cooling efficiencies of short vegetation are found in central North America, central and eastern Europe and southern Africa. These results highlight vegetation’s cooling potential in the hottest months and the usefulness of short vegetation where their cooling efficiencies are comparable to trees, while short vegetation is cheaper and easier to establish compared to trees. Notably, cooling efficiencies of both vegetation types can be negative in some cities, indicating that increasing vegetation cover does not always enhance, and may even reduce, human thermal comfort. In contrast, cooling efficiency derived from land surface temperature (LST) shows more consistent and stronger cooling. This divergence underscores that LST-based assessments can overestimate the comfort benefits of urban greening. Our findings emphasize the necessity to incorporate thermal comfort metrics like UTCI into urban heat mitigation assessments, and provide guidance for the planning and managing of urban green spaces to achieve efficient cooling sustainably with limited space and water resources
Photochemical spin‐state switching of an all‐organic molecular system with visible light
No full textControlling the spin state of a molecule using the spatiotemporal properties of visible light is of interest for spintronic devices in information technology or (bio)medical applications. We, herein, report an all-organic visible light-induced photochromic system than can switch from a diamagnetic (singlet) to a paramagnetic (triplet) state. This is realized by precisely tuning orbital symmetry and internal molecular strain in a [5]helicene scaffold substituted with an indanedione π-acceptor. Irradiation with visible light at cryogenic temperatures gives a kinetically meta-stable paramagnetic diradical state with a solvent-dependent ground-state multiplicity (triplet or singlet), which can be thermally switched back to its initial diamagnetic state