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    The total testing process harmonization: the case study of SARS-CoV-2 serological tests

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    The total testing process harmonization is central to laboratory medicine, leading to the laboratory test's effectiveness. In this opinion paper the five phases of the TTP are analyzed, describing, and summarizing the critical issues that emerged in each phase of the TTP with the SARS-CoV-2 serological tests that have affected their effectiveness. Testing and screening the population was essential for defining seropositivity and, thus, driving public health policies in the management of the COVID-19 pandemic. However, the many differences in terminology, the unit of measurement, reference ranges and parameters for interpreting results make analytical results difficult to compare, leading to the general confusion that affects or completely precludes the comparability of data. Starting from these considerations related to SARS-CoV-2 serological tests, through interdisciplinary work, the authors have highlighted the most critical points and formulated proposals to make total testing process harmonization effective, positively impacting the diagnostic effectiveness of laboratory tests

    Development of KITWPA amplifiers for the DARTWARS project

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    Noise at the quantum limit over a broad bandwidth is a fundamental requirement for the future cryogenic experiments for neutrino mass measurement, dark matter searches and, CMB measurement as well as for the fast high-fidelity readout of superconducting qubits. In the last years, Josephson Parametric Amplifiers (JPA) have demonstrated noise level close to the quantum limit but, due to their narrow bandwith, only few detectors/qubits per line can be read in parallel. An alternative and innovative solution is based on superconducting parametric amplification exploiting the traveling wave concept. DARTWARS (Detector Array Readout with Traveling Wave AmplifieRS) is a three years project that aims at developing high-performing innovative Traveling Wave Parametric Amplifiers (TWPAs) with high gain, high saturation power and large bandwidth, characterized by nearly quantum limited noise for low temperature detectors and qubit readout. The Kinetic Inductance Traveling Wave Parametric Amplifiers (KI-TWPAs) constructed using NbTiN and operated in a three-wave mixing (3WM) mode have exhibited outstanding dynamic range and low-noise characteristics, nearing the quantum limit. The ultimate goal of the project is to optimize the design, explore new materials, and investigate alternative fabrication processes in order to enhance the overall performance of the amplifier. In this contribution we present the advancements made by the DARTWARS collaboration to produce a first working prototype of a KITWPA, from the production to the characterization

    Investigation of the impact of additive manufacturing techniques on the acoustic performance of a coiled-up resonator

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    Acoustic metamaterials (AMMs) offer innovative solutions for physics and engineering problems, allowing lighter, multiphysics, and sustainable systems. They are usually studied analytically or numerically and then tested on prototypes. For this reason, additive manufacturing (AM) techniques are a popular way of quickly realising AMMs' innovative geometrical designs. However, AM parameters are often standardised without considering the specific issues of each AMM geometrical shape, leading to a possible mismatch between the analytical (or numerical) and experimental results. In this study, a simple AMM-a coiled-up resonator-has been produced with different AM technologies [fused deposition modeling (FDM), stereolithography (SLA), and selective laser melting and materials (polylactic acid, polyethylene terephthalate glycol, resin, flexible resin, and stainless steel). The sound absorption performance of these samples has been measured in two research labs in Italy and compared with the analytical and numerical calculations. This permitted the identification of the best combinations of AM technologies, their setup, and materials matching the expected results. The SLA/resin combination performed better overall; however, cheaper and more easily manageable samples made with FDM and polyethylene terephthalate glycol can achieve the same acoustic performance through the optimal AM printing setup. It is expected that this methodology could also be replicated for other AMMs

    METROLOGICAL TRACEABILITY OF MOISTURE CONTENT MEASUREMENTS IN PLANT-ORIGIN BULK MATERIALS

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    This document explains advantages and disadvantages of the measurement methods for the moisture content determination of plant-based materials in order to identify the best one which can provide metrological traceability to SI units. The term “moisture” is generic and, to have proper Calibration and Measurement Capabilities (CMCs) and Certified Reference Materials (CRMs), a better specification of the measurand should be given. Currently, no CMCs for moisture content measurement in the plant-origin bulk materials, as well as respective CRMs, are available in the KCDB. Undoubtedly, those CMCs and CRMs are crucially needed to provide metrological traceability in this area

    High-Q Fano resonances in diamond nanopillars

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    We report on the optical behaviour of a nanostructured diamond surface on a glass substrate. The numerical model reveals that a simple geometrical pattern sustains Fano-like resonances with a Q-factor as high as 3.5 · 105 that can be excited by plane waves impinging normally on the surface. We show that the geometrical parameters of the nanopillars affect both the resonant frequency and the line shape. The nanostructured surface can be straightforwardly used as a refractive index sensor with high sensitivity and linearity. Our findings show that diamond-based meta-surfaces are a valuable nanophotonic platform to control light propagation at the nanoscale, enabling large field enhancement within the nanoresonators that can foster both linear and nonlinear effects

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