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Measuring the Occupants' Well-Being in the Built Environment: Towards the Integration of Physiological and Environmental Parameters in a Multidomain BIM-Based Platform
There is increasing interest in developing multidomain monitoring systems for the built environment, covering not only structural health-related aspects but also focusing on environmental and physiological parameters directly determining the occupants' comfort and well-being. Integrating this information in the Building Information Modelling (BIM) of a building makes the whole ecosystem interconnected, thus providing a feedforward loop capable of improving people's well-being as well as building energy consumption. This paper presents the preliminary results of the solution proposed within the framework of the European project MULTICLIMACT, seeking tools enhancing resilience at multiple scale levels. Results prove the feasibility and the efficiency of the proposed approach to integrate data from a plethora of multidomain sensors in a flexible, modular, and interoperable manner
- «Per fare mortadella»: mortadella e mortarolo nel Vocabolario storico della lingua italiana della gastronomia
Carriere in rosa: il diversity management nelle aziende sanitarie
Lo scopo della ricerca è stato quello di analizzare uno dei temi del cambiamento organizzativo, ossia
le differenze che sussistono quando un ruolo apicale è ricoperto da una figura femminile piuttosto che
maschile. È stata data particolare attenzione al settore sanitario, in cui la presenza femminile è crescente
e quella nei ruoli dirigenziali è ormai paritetica. Attraverso un’intervista face-to-face con alcune figure
manageriali di strutture sanitarie, si sono analizzate le conoscenze che possiedono le donne manager sul
tema, quanto e come si affronti il problema all’interno delle organizzazioni sanitarie e se sia presente
l’attenzione per adottare strumenti volti a gestirlo
Exchangeable Copper Excess and Zinc Deficiency in the Serum of Patients with Colorectal Cancer
Copper (Cu) and Zinc (Zn) are altered in colorectal cancer (CRC) but their association with the clinical classification of the tumor has not been fully explored. To examine the association of Cu and Zn homeostasis in the onset and severity of CRC, we performed an exploratory case-control study comparing the serum levels for Cu, the exchangeable component of Cu in serum (CuExc), Zn, the ratio between them (CuExc:Zn), ceruloplasmin [Cp, concentration (iCp) and its activity (eCp), Cp specific activity (eCp:iCp)], and the Cu:Cp, assessed in 31 consecutive CRC patients before surgical resection to those obtained from 37 healthy controls (CTRL). Additionally, we correlated the analyte levels with the indices of the pathological tumor, node, and metastasis (TNM) staging, namely tumor (T), node (N), and metastasis (M), evaluated at the histopathological examination. We found that Cu, CuExc, CuExc:Zn, iCp, eCp, eCp:iCp, and Cu:Cp ratios increased while Zn decreased in CRC patients. In addition, correlation analyses showed that CuExc and Zn levels confirmed the CRC diagnosis. Specifically, CuExc:Zn further increased the discrimination between the individuals of the two groups, providing an area under the curve (ROC AUC) = 0.94. Elevated CuExc was the strongest factor associated with CRC resulting in 15-fold increased odds. These data were confirmed through a multivariable regression model revealing an effect of Zn and CuExc on the CRC risk, with the CuExc resulting in 11-fold increased odds of having the disease. We also found that most of the Cu biological variables analyzed were associated with T, while the CuExc was associated with M. The current pilot study demonstrates that excess labile Cu pool, Zn deficiency, and even further their combination in the CuExc:Zn provide information about CRC in terms of diagnosis, risk of having CRC, and CRC disease stage
Retrospective Dosimetric Comparison of HDR Interventional Radiotherapy (Brachytherapy) Versus Planning with VMAT and Electron Beam Therapy for Non-Melanoma Skin Cancer Treatment
Rinnovate scansioni procedurali per l’applicazione delle pene sostitutive
Il contributo analizza in chiave critica le modifiche integrativo-correttive apportate dal d.lgs. 31/2024 alla disciplina applicativa delle pene sostitutive delineata dalla riforma Cartabia (l. 134/2021 – d.lgs. 150/2022).
The paper analyses the integrative-corrective amendments made by Decree 31/2024 to the discipline (for the application) of substitute punishments outlined by the Cartabia reform – Law 134/2021, Decree 150/2022