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Exploration of Early-Treatment-Associated Changes in Metabolic and Inflammatory Biomarkers in First-Episode Psychosis in Italian Patients
No full textStudies conducted in first-episode psychosis (FEP) patients have shown alterations in inflammation and metabolism. Our objective was to investigate potential treatment-related effects on these systems in Italian FEP patients undergoing either an experimental treatment consisting of a multi-element psychosocial intervention (EXP), including cognitive–behavioural therapy, or treatment as usual (TAU). A total of 191 FEP patients with first contact between April 2010 and March 2011 were clinically assessed at baseline and after 9 months of treatment, and the serum levels of 19 analytes were determined through single or multiplex enzyme-linked immunosorbent assays (ELISAs). A significant increase was observed in leptin levels and a significant decrease in Glucagon-Like Peptide-1 (GLP-1) levels during the treatment (time effect, p < 0.001 for both), with no significant interaction between time and treatment type. Although ghrelin levels changed significantly over time in the whole cohort (p = 0.008), a significant decrease was observed only in the EXP group (post hoc test: p = 0.001). None of the biomarkers measured at baseline showed a predictive effect on treatment efficacy, and no significant associations were identified between changes in clinical scores and changes in biomarker levels. These results suggest that early-phase psychosis treatments are associated with possible effects on metabolic regulation
Housing tenure, wages, and market outcomes
No full textThis paper delves into the relationship between homeownership and wage, a topic that has received less attention when compared to the impact of homeownership on (un)employment (Yang, 2019). As in Coulson and Fisher (2009), this paper can distinguish between micro-level and aggregate-level results, namely, easier access to homeownership reduces reservation wages but improves labour market outcomes. However, when the distinction between outright homeowners and homeowners with a mortgage is considered, the paper supports a recent empirical finding by Brunet et al. (2025) that outright homeownership harms job search and increases reservation wage. This paper also aims to tie this strand of literature with studies on job stability and homeownership (Coulson et al., 2022). Finally, the proposed model can explain some housing markets facts
Osservatorio Corte europea dei diritti dell'uomo (Non contrasta con la libertà di espressione la condanna a pena (multa) sospesa per la rimozione del ritratto ufficiale del Presidente della Repubblica all’interno di alcuni municipi + La Corte europea condanna la Russia per le diffuse, flagranti e reiterate violazioni di diritti umani nell’ambito del conflitto armato in Ucraina, a partire dal 2014 + Indebitamente ristretto il diritto alla corrispondenza di un detenuto per fatti di mafia)
No full textGiurisprudenza Corte ED
Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer
No full textUpdated dosimetric comparison of HDR interventional radiotherapy (modern brachytherapy) with Cobalt-60 versus VMAT and electron beam therapy for NMSC
No full textRadio-chemotherapy and interventional radiotherapy (modern brachitherapy) in vaginal carcinoma: a monocentric experience
No full textMachine Learning-Based Clinical Decision Support System for Hepatic Fibrosis Risk Prediction in General Practice
No full textImpact of Ruthenium-106 plaque displacement in ocular interventional radiotherapy (modern brachytherapy)
No full textValidating the Existential Quest Scale using item response theory
No full textThe Existential Quest Scale (EQS) is a brief instrument designed to assess individuals’ willingness to engage with existential quest in both religious and secular contexts. As the construct of existential quest becomes increasingly relevant for understanding psychological flexibility, identity development, and social attitudes in multicultural societies, ensuring the validity of its measurement is essential. Previous validations of the EQS have relied on Classical Test Theory (CTT), which limits comparability across groups and item-level precision. This study aims to evaluate the EQS using Rasch modeling, a robust item response theory (IRT) approach that overcomes such limitations. Drawing on a large, heterogeneous sample (N = 4,378), we assessed dimensionality, item functioning, and measurement invariance across sex, age, and religious affiliation. Results confirmed the unidimensional structure of the EQS, its ability to discriminate levels of existential quest, and its psychometric invariance across demographic groups. Findings also suggested revisions to item and response category functioning to enhance scale performance. By applying IRT to the EQS, this study advances the psychometric assessment of complex, culturally adaptive constructs and supports the EQS as a rigorous tool for research and applied settings
Asphalt concretes including bitumen modified with compounds based on crumb rubber from waste tires: A laboratory and field study
No full textEnd-of-life tires represent one of the major waste streams in terms of volume generated annually, worldwide. One of the possible destinations for the waste rubber from end-of-life tires is asphalt concrete, but the many recycling techniques that are currently adopted in different countries present disadvantages (economic, logistic or performance) that hinder their diffusion. An innovative technology has been recently developed, dealing with the use of waste rubber in the production of compounds for bitumen modification, in partial or total replacement of the styrene-butadiene-styrene (SBS) polymers. The objective of the present paper is the characterization of hot-mix asphalt (HMA) made with compound-modified bitumen. The investigated mixes were produced in the laboratory and in the asphalt plant; the latter were laid on a trial highway section. The shear-gyratory compacted specimens and the cores taken from the trial section were analysed in terms of volumetric properties, indirect tensile strength, stiffness and fatigue performance. The experimental data were statistically validated through t-test. The results showed that the HMA with compound-modified bitumen, compared to the HMA with SBS-modified bitumen, had similar voids content, stiffness and strength, but a slightly improved fatigue performance (+15 % on both ε6 and σ6 parameters), which can be associated with a lower severity of the ageing experienced by the binder during the mixing. The combined use of SBS and compound modifiers may entail an increase (about 30 %) of the HMA stiffness