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Self Portrait Through Objects
Get PDFThis graphite drawing is a self portrait, just in a different form. Rather than creating an image of my physical self, I have depicted items that are important and representative of me. There are a couple of books, as literature is greatly impactful in my life; my paint pallet, in order to illustrate my passion for art; fabric, in order to depict my loved of sewing; white roses from my graduation cap; my great grandma’s tea cup; and my button collection. Through all of these things I believe that you can get a general understanding of who I am and what I am passionate about. I worked in this piece to push my understanding of graphite to a point where I can use it to its fullest potential
Effects of the Ras-GEF inhibitor, BAY-293, on mitotic rate, cyclin levels and promoter activity in Tetrahymena species
Get PDFCancer is a complex disease characterized by uncontrolled growth resulting from genetic and epigenetic mutations. Receptor tyrosine kinases are a class of growth factor receptors whose signaling pathways are often dysregulated in cancer. The Ras GTPase plays a key transduction step in conveying the growth signal to the downstream kinases in the growth pathway, ultimately resulting in the phosphorylation of enzymes and transcription factors which help move the cell into S phase. In mammals, cyclin D1, a key cyclin responsible for the G1/S transition, is among the genes which are expressed in response to Ras signaling.
Until recently, Ras was considered “undruggable”; however, several new drugs targeting Ras activity are in various stages of clinical testing. BAY-293 is a preclinical cancer drug that disrupts the communication of Ras with its activating guanine exchange factor (GEF), a protein commonly known as Sos. Tetrahymena thermophila are free-living protozoans that express homologs of Ras. Our previous studies have shown that BAY-293 reduces mitotic rate in Tetrahymena thermophila. Since we are currently unable to obtain the strain of T. thermophila on which we have worked in the past, we purchased Tetrahymena (unknown species) from Ward’s Biological and sequenced their mRNA in order to determine their species, which we believe to be T. pyriformis. Our current study aims to determine the effects of BAY-293 on mitosis levels in this Tetrahymena species, as well as to investigate the effects of BAY-293 on cyclin production and promoter activity as determined by H3K27ac levels
2025 Title Page
Get PDFThe title page for the 2025 Inaugural ICC New Scholar\u27s Conference Proceedings
Cedrus Press Author Roadmap Bookmark
Get PDFAuthor\u27s Roadmap CedrusPress\u27 bookmark promoting faculty book and textbook open-access publishing services offered by Digital Services
Digital Services Informational Bookmark
Get PDFDigital Services bookmark promoting the role of Digital Services in Cedrus Press, CedarCommons, and CedarScholar
2024-2025 Men\u27s Golf Team
No full textColor photograph of a men\u27s golf teamhttps://digitalcommons.cedarville.edu/mens_golf_gallery/1056/thumbnail.jp
2024-2025 Men\u27s Tennis Team
No full textColor photograph of a men\u27s tennis teamhttps://digitalcommons.cedarville.edu/tennis_gallery/1084/thumbnail.jp
