Archivio della ricerca della Scuola Superiore Sant'Anna
Not a member yet
26957 research outputs found
Sort by
Toward Trusted Optical Communications with Optical Physical Unclonable Functions and Blockchain
No full text
Cardiac Resynchronization Therapy, Remodeling, and Outcome in Patients With Amyloid Transthyretin Cardiomyopathy
No full textUltrasound‐Responsive Polymeric Piezoelectric Nanoparticles for Remote Activation and Neuronal Differentiation of Human Neural Stem Cells
No full textThe regenerative capacity of the central nervous system (CNS) is limited. Understanding and enhancing the mechanisms that induce neural differentiation of neural stem cells (NSCs) is crucial for advancing regenerative medicine; one significant challenge in this effort is the remote delivery of pro-differentiation cues. In this framework, a nanotechnology-based solution able to remotely trigger the differentiation of human NSCs (hNSCs) into neurons is proposed. The approach involves organic piezoelectric nanotransducers, which can be remotely activated by low-intensity ultrasound (US) for local and noninvasive electrical stimulation. Highly biocompatible piezoelectric polymeric nanoparticles, when activated by US, demonstrate the ability to induce calcium influx, exit from the cell cycle, and neuronal differentiation in hNSCs, as evidenced by calcium imaging experiments and the expression analysis of the NeuN post-mitotic neural marker; additionally, an increased outgrowth of the developing axons is observed. Gene expression analysis moreover suggests that the neural differentiation mechanism induced by piezoelectric stimulation acts by upregulating the calcium signaling-sensitive NeuroD1 neural inducer and the Lamb1 marker, independently of the c-Jun/c-Fos pathway. Considering the high biocompatibility and the good piezoelectricity of the polymeric nanotransducers used in this work, it is believed that this “wireless” stimulation approach holds high potential in CNS regenerative medicine
L’Osservatorio della Popolazione delle Aree Interne della Toscana [The Population Experience Observatory in Rural Areas of Tuscany]
No full textRiassunto:
Questo documento racconta l’esperienza dell’Osservatorio della Popolazione delle Aree Interne della Toscana, una piattaforma partecipativa e uno strumento gestionale che pone al centro cittadini e comunità locali come protagonisti della propria salute. Attraverso il coinvolgimento diretto di residenti, amministrazioni comunali, aziende sanitarie ed enti del terzo settore, l’Osservatorio indaga bisogni, percezioni e priorità, ma anche risorse e potenzialità delle comunità delle aree interne, offrendo spunti di riflessione per ripensare i servizi sanitari e pubblici e delineando un nuovo paradigma per concepire la salute della popolazione in questi territori. Le evidenze raccolte dimostrano che le aree interne non sono soltanto contesti “fragili”, ma esprimono un forte senso di comunità, capace di proteggere la salute collettiva e con il potenziale di costituire una risorsa strategica per il futuro. In tal senso, la sperimentazione mostra come le aree interne possano trasformarsi in veri laboratori di innovazione, in grado di generare modelli e ispirazioni replicabili anche in altri territori.
Summary:
This document presents the initiative of the Population Experience Observatory in rural areas of Tuscany, a participatory platform and management tool that positions citizens and local communities as active protagonists of their own health. By directly engaging residents, mayors, local health authorities, and third-sector organizations, the Observatory explores local needs, perceptions, and priorities, as well as community resources and capacities. Its work provides valuable insights to rethink the delivery of public and healthcare services and to outline a renewed vision of population health in these territories. The evidence shows that rural areas are more than “vulnerable” settings; they demonstrate a strong sense of community that can protect collective health and serve as a strategic asset for the future. In this perspective, the initiative highlights how rural areas can act as genuine laboratories of innovation, capable of generating models and practices that can be adapted and applied in other contexts
Delle p.e.c. e dei mestieri: l'impostazione giurisprudenziale in tema di inammissibilità "digitale"
No full text
Scalable Compression of Massive Data Collections on HPC Systems
No full textThe exponential growth of digital data poses a significant storage challenge, straining current storage systems in terms of cost, efficiency, maintainability, and available resources. For large-scale data archiving, highly efficient data compression techniques are vital for minimizing storage overhead, communication efficiency, and optimizing data retrieval performance. This paper presents a scalable parallel workflow designed to compress vast collections of files on high-performance computing systems. Leveraging the Permute-Partition-Compress (PPC) paradigm, the proposed workflow optimizes both compression ratio and processing speed. By integrating a data clustering technique, our solution effectively addresses the challenges posed by large-scale data collections in terms of compression efficiency and scalability. Experiments were conducted on the Leonardo petascale supercomputer of CINECA (leonardo-supercomputer.cineca.eu), and processed a subset of the Software Heritage archive, consisting of about 49 million files of C++ code, totaling 1.1 TB of space. Experimental results show significant performance in both compression speedup and scalability
Recovery of ripening capacity in 'Rocha' pears treated with 1-MCP through the application of 1-NAA: Physiological and molecular analysis insights
No full textStoring 'Rocha' pear treated with 1-methylcyclopropene (1-MCP) in controlled atmosphere is a common commercial strategy to extend pear storage time and prevent postharvest disorders. However, this strategy represents a challenge to the fruit industry because 1-MCP treatment obstructs the normal fruit ripening, potentially affecting the quality to consumers. To explore possible mechanisms to reactivate ripening, 'Rocha' pears treated with 1-MCP were exposed to 2 and 4 mM 1-naphthaleneacetic acid (1-NAA) and stored at 20 ± 2 °C for 15 days. Typical ripening indicators, such as firmness, skin color, ethylene and aroma volatiles production, sugar content, and the genetic expression of ethylene-related enzymes (ACS and ACO) and receptors (PcETR1, PcETR2, and PcETR5) were determined over the 15 days of storage. A PCA analysis incorporating both physiological and biochemical data showed that 1-NAA promoted the recovery of ripening capacity in 1-MCP treated pears. Treating pears with 1-NAA led to increased activity of genes like PcACS1, PcACS4, and PcETR2, which are involved in ethylene signalling and production. This resulted in higher levels of ethylene and compounds associated with ripening, as well as softer texture, more yellow color, and higher sucrose content. The boost in ethylene-related gene activity likely heightened ethylene sensitivity and production in the treated pears. Consequently, these fruits showed accelerated softening, color change, and aroma development. This suggests that 1-NAA treatment can reverse the ripening inhibition caused by 1-MCP, possibly by enhancing ethylene sensitivity and production. This mechanism could enable consistent ripening of 'Rocha' pears after they are taken out of cold storage, and it may have similar effects on other fruits