Archivio della ricerca della Scuola Superiore Sant'Anna
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G. Comandé - D. Amram - M. Lamanuzzi, La violazione della privacy in sanità, tra diritto civile e diritto penale, in A. Oliva - M. Caputo (a cura di), Itinerari di medicina legale e delle responsabilità in campo sanitario, Giappichelli, Torino 2025, p. 606 - 616
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Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration
No full textInflammation plays a pivotal role in tissue repair, and its modulation is crucial to avoid excessive immune activation or suppression. Three-dimensional scaffolds that can control the release of anti-inflammatory agents over time and space offer a promising approach to regulate the immune response while providing structural support during healing. In this study, we developed an electrospun biomimetic scaffold incorporating ibuprofen-loaded mesoporous silica nanoparticles with an ultrasound-responsive alginate coating. Optimal parameters for safe and non-invasive ultrasound stimulation (i.e., frequency, intensity, and duration) were identified to induce weakening of the interaction among the alginate chains, enabling on-demand drug release from the nanoparticles. In vitro studies with human macrophages confirmed the biocompatibility and anti-inflammatory efficacy of the nanoparticles at concentrations up to 1 mg mL−1. The results demonstrated that ultrasound stimulation further amplified the therapeutic effect even at very low concentrations (≥0.05 mg mL−1) of the tested nanoparticle suspensions. The electrospinning process was optimised to produce nanoparticle-containing polyvinylidene fluoride nanofibers that are aligned and piezoelectric, mimicking the architecture and electroactivity of native tissues. The resulting scaffold exhibited excellent biocompatibility and effectively reduced inflammatory markers in vitro. Furthermore, controlled ibuprofen release from the scaffold was successfully triggered on-demand through repeated ultrasound stimulations, applied up to seven days after immersion. By combining structural support, biocompatibility, and the capacity for drug release in response to safe, non-invasive ultrasound stimulations, this scaffold represents a compelling platform for localised modulation of inflammation and the promotion of functional tissue regeneration
Glass Transition and Crystallization of Chitosan Investigated by Broadband Dielectric Spectroscopy
No full textChitosan films obtained by solution casting were investigated by broadband dielectric spectroscopy (BDS) to explore both their glass transition and the effects of thermal annealing on molecular dynamics, deriving from residual water content as well as from cold crystallization. Glass transition at low temperatures could be evidenced in as-produced as well as thermally annealed films, where non-Arrhenian dielectric relaxation processes, consistent with a structural (α) relaxation, could be detected. The process detected at low temperatures could reflect the dynamics of residual water slaved by the polymer matrix. Secondary (β) relaxations, along with a slow process ascribed to interfacial polarization at the amorphous/crystalline interfaces, were concurrently detected. In most cases, a further Arrhenian process at intermediate temperatures (αc) was present, also indicative of crystallization. Notably, the α processes, due to the primary relaxation of the polymer matrix plasticized by water, could be discriminated from other processes, present in the same frequency range, thanks to improvements in the dielectric fitting strategy. All relaxation processes showed the expected dependence on Ta. The more accurate exploration of the glass transition for chitosan helps to better rationalize its crystallization behavior, in view of an optimized application of this biopolymer
I “perimetri penali” di cybersicurezza dopo la legge n. 90/2024: dissimmetrie intra-sistematiche ed extra-sistematiche nella tutela penale dei sistemi informatici e telematici di rilevanza pubblica
No full textIl contributo analizza in chiave critica la non uniforme definizione di diversi "perimetri” per l’applicazione di regimi sostanziali e processuali differenziati in materia di contrasto alla criminalità informatica e cybersicurezza, che impedisce di ricostruire in termini unitari lo “statuto penale” dei cybercrime realizzati ai danni di sistemi “critici”, perché pubblici o altrimenti significativi per la cybersicurezza nazionale ovvero per l’interesse della collettività
Bridging the gap: how GHG accounting tools can support beer companies in the implementation of circular economy strategies
No full textThis study presents a greenhouse gases (GHG) accounting tool developed for Italian breweries aimed at the quantification of the carbon footprint (CF) of the organizations, thus enabling a self-assessment of their contribution to climate change. The tool builds on a Microsoft Excel interface that allows breweries to input site-specific data related to materials, energy, emissions, and waste across their life cycle in accordance with both the GHG Protocol and the ISO 14064-1 standard. A methodological framework is developed based on 7 steps, which include : i) organizational and operative boundaries definition, iii) identification of the databases for the calculations of emission sources and emission factors iv) calculation of CF which allows v) to perform a screening study and the hotspot identification, followed by vi) a check with literature in order to vii) perform a CE strategies assessment. This procedure made possible to build a valuable and reliable tool, in line with international standard and easy to replicate in other contests. The tool indeed enables companies to identify environmental relevant processes (hotspot analysis) and to implement relevant circular ecosystem innovation. This is possible thanks to its ability to create collaboration within ecosystem actors and allowing a trial-and-error process
