Archivio della ricerca della Scuola Superiore Sant'Anna
Not a member yet
26957 research outputs found
Sort by
Characteristics of patients with suspected cardiac amyloidosis in Tuscany and Umbria: Insights from the cardiac amyloidosis RegistRY (CARRY)
Get PDFEstimated total amyloid burden from 18F-florbetaben positron emission tomography predicts all-cause mortality in light-chain cardiac amyloidosis
Get PDFAims: The positron emission tomography (PET) tracer 18F-florbetaben is a promising diagnostic tool for light-chain cardiac amyloidosis (AL-CA). A greater cardiac uptake might signal more amyloid burden and a worse outcome. We aimed to assess the prognostic significance of 18F-florbetaben uptake in AL-CA. Methods and results: Consecutive patients with AL-CA underwent 18F-florbetaben PET scans. Total amyloid burden (TAB; calculated as mean standardized uptake value multiplied by molecular volume) was assessed in the left and right ventricles (LV/RV) in early (5-15′) and late (50-60′) acquisitions. The endpoint was all-cause mortality. Forty patients (median age 69 years, 73% males, Mayo 2004 Stage III in 80%) underwent 18F-florbetaben PET with a median time from tissue biopsy of 21 days (interquartile range, IQR 7-83). Late LV TAB, but not early LV TAB, correlated with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity (hs)-troponin T. Over 13 months after the PET scan (IQR 5-21), 65% of patients died. A late LV TAB ≥273 cm3 (cut-off derived from spline curve analysis) predicted 18 and 24 month all-cause mortality independently from baseline variables, including NT-proBNP, hs-troponin T, and Mayo 2004 stage. Late RV TAB ≥135 cm3 independently predicted 18 and 24 month all-cause mortality. Patients with both late LV and RV TAB ≥ cut-offs had a shorter survival than those with only LV TAB ≥ cut-off and those with TAB in both ventricles < cut-offs (Log-rank 16.52, P < 0.001). Conclusion: 18F-florbetaben PET imaging offers valuable prognostic information in AL-CA. Values of late TAB measured in the LV and RV are strong predictors of all-cause mortality
Advancing Cardiovascular Risk Stratification and Functional Assessment: A Narrative Review of CPET and ESE Applications
Get PDF
Wealth, Inheritance, and Concentration: Italy and Its Regions From the Unification to the Great War
Get PDFAA.VV, Speciale Osservatorio sul danno alla persona: anticipazione dell’evento morte e risarcimento, a cura di D. Amram, in Danno e responsabilità 2025, n. 3, p. 269 ss.
No full textLo studio illustra i risultati della ricerca condotta dall’Osservatorio sul danno alla persona in materia di
conseguenze risarcitorie in caso di perdita di chance di sopravvivenza e anticipazione dell’evento
morte della vittima primaria alla luce dei principi resi noti dalla recente giurisprudenza di legittimità.
The essay focuses on the results of the analyses developed within the permanent Observatory on
lower case-law related to the implications on non-pecuniary losses compensation for the loss of
chance of surviving in case of anticipation of the victim’s death, considering the recent principles
stated by the Italian High Court
