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L’alleanza educativa tra scuola e famiglia per un progetto di vita inclusivo: le opinioni delle figure di sistema a scuola The educational alliance between school and family for an inclusive life project: The opinions of system figures at school
No full textIl contributo intende esplorare il ruolo delle figure di sistema nella scuola, da
intendersi come organizzazione, per la promozione di un’alleanza autentica tra
scuola e famiglia, quale conditio sine qua non per la costruzione di un progetto
di vita realmente inclusivo. Dopo un excursus sull’evoluzione teorica e normativa
che ha portato all’affermazione di un approccio bio-psico-sociale nella concettualizzazione
della disabilità e della centralità del progetto di vita, si presentano
i risultati di un’indagine esplorativa condotta con 52 docenti italiani aventi
incarichi di sistema. I risultati, ottenuti tramite l’Analisi Tematica Riflessiva,
evidenziano che queste figure riconoscono la propria funzione di mediatori nella
relazione scuola-famiglia, agendo attraverso dialogo, disponibilità e fiducia reciproca.
Pur emergendo barriere organizzative e culturali alla partecipazione familiare,
lo studio conferma la necessità di un impegno congiunto e istituzionale
volto a rafforzare processi collaborativi e strategie di co-progettazione educativa.
Le figure di sistema appaiono, pertanto, configurarsi come promotori di
una cultura inclusiva, capace di sostenere l’autonomia e il benessere degli studenti
«Nominis ut mixti, sic corporis Hermaphroditus, concretus sexu»: la rappresentazione dell’androgino dall’antichità all’età moderna
No full textStudent Academic Success Prediction Using Learning Management Multimedia Data With Convoluted Features and Ensemble Model
No full textCritical analysis of the impact of artificial intelligence integration with cutting-edge technologies for production systems
No full textIdentification of the first-in-class dual inhibitor targeting BAG3 and HSP70 proteins to disrupt multiple chaperone pathways
No full textIn the complex network of cellular physiology, the maintenance of cellular proteostasis emerges as a critical factor for cell survival, particularly under stress conditions. This homeostasis is largely governed by a sophisticated network of molecular chaperones and co-chaperones, among which Bcl-2-associated athanogene 3 (BAG3), able to interact with the ATPase domain of Heat Shock Protein 70 (HSP70), plays a pivotal role. The BAG3-HSP70 functional module is not only essential for cellular homeostasis but is also involved in the pathogenesis of various diseases, including cancer, neurodegenerative disorders, and cardiac dysfunction, making it an attractive target for therapeutic intervention. Inspired by our continuous interest in the development of new chemical platforms able to interfere with BAG3 protein, herein we report the discovery of compound 16, the first-in-class BAG3/HSP70 dual modulator, obtained by combining the multicomponent Ugi reaction with the alkyne-azide Huisgen procedure in a sequential tandem reaction approach. Through a combination of biophysical analysis, biochemical assays, and cell-based studies, we elucidated the mechanism of action of this inhibitor and assessed its potential as a therapeutic agent. Hence, this study can open new avenues for the development of novel anticancer strategies that leverage the simultaneous disruption of multiple chaperone pathways
Age effects in primary education: A double disadvantage for second-generation immigrants
No full textManagement Cost Efficiency and Technology Gap: Cooperative vs. Non‐Cooperative Credit Banks
No full textThis paper analyses the difference between cooperative and non-cooperative banks in Italy in terms of managerial efficiency and technological inefficiency. We disen- tangle the metafrontier and group-specific frontiers using data from 1994 to 2015, decomposing the efficiency scores of the two bank groups into cost-efficiency scores and cost technology gap ratios. Cooperative banks have greater efficiency scores across all regions and for each group-specific technology frontier. The findings indi- cate that the primary cause of inefficiency for the two bank groups is not manage- ment inefficiency but rather the technology gap. Furthermore, cooperative banks exhibit lower cost efficiency inequality than non-cooperative banks in most regions
Cina, sport e società. Una prospettiva sociologica.
No full textQuesto libro offre un'analisi sociologica approfondita del rapporto tra sport e società in Cina, un contesto in rapida evoluzione e di crescente rilevanza globale. Il testo esplora lo sviluppo storico dello sport cinese, le politiche pubbliche, le pratiche sportive e le tensioni tra modernizzazione, tradizione e globalizzazione. Attraverso studi di caso su calcio, tennis e scherma, il volume indaga le dinamiche di potere, le disuguaglianze sociali e le rappresentazioni mediatiche che caratterizzano il panorama sportivo cinese. Destinato a studenti, ricercatori e professionisti, il libro coniuga teoria sociologica e analisi empirica, offrendo strumenti critici per comprendere come lo sport rifletta e plasmi la società cinese contemporanea
Global Boundedness of the Weak Solutions to Componentwise Coercive Parabolic Systems
No full textWe obtain essential boundedness of the weak solutions to the Cauchy-Dirichlet problem for quasilinear parabolic system which is modeled on the p-Laplacian vectorial operator
Towards Efficient Modeling of Non-Radiative Decay in Extended INVEST: Overcoming Computational Challenges in Quantum Dynamics Simulations
No full textIn the last years, an increasing number of fully organic molecules capable of thermally activated delayed fluorescence (TADF)
have been reported, often with very small or even inverted singlet-triplet (INVEST) energy gaps.1 These molecules typically
exhibit complex photophysics, due to the close energy levels of multiple singlet and triplet states, which create various
transition pathways towards emission.2 A predictive model for the rates of these transitions is thus essential for assessing the
suitability of new materials for light-emitting devices.
Quantum Dynamics (QD) calculations are ideal for this purpose, as they include quantum effects, without the limitations of firstorder
perturbative approaches, also allowing taking into account more than two electronic states at once. However, the huge
computational demands of QD methodologies, especially for large molecules, currently limit their use as a standard tool,
necessitating the development of novel methodologies.3
To address this problem, we here employ a strategy that allows including almost the whole set of the vibrational coordinates by
selecting the key elements of the Hilbert space that significantly impact dynamics, thereby hugely reducing the computational
burden.4.5 Application of this protocol to two relatively large INVEST molecules reveals that internal conversion in these systems
is very fast, making indirect emissive pathways a possible channel for the population of the S1 state.5
More importantly, this study demonstrates that the dynamics can be accurately described even with a significantly reduced
vibrational space, thus allowing to perform quantum dynamics calculations that yield accurate transition rates in a few minutes
of computational time.