239700 research outputs found
Sort by
I partenariati dell’amministrazione condivisa: il caso delle comunità energetiche rinnovabili
No full textIl contributo analizza il modello delle comunità energetiche rinnovabili nel prisma dell'amministrazione condivisa e si sofferma sul quadro legislativo europeo e nazionale e sui benefici economici, ambientali e sociali derivanti dalla costituzione delle CER. Il contributo analizza altresì il ruolo della pubblica amministrazione al fine di promuovere e realizzare le CER e le prospettive di evoluzione del rapporto tra amministrazione pubblica e cittadini conseguenti alla diffusione del modello di produzione e consumo di energia in forma condivisa
Microbiological Analysis Conducted on Raw Milk Collected During Official Sampling in Liguria (North-West Italy) over a Ten-Year Period (2014–2023)
No full textMilk has been consumed by humans for thousands of years for its nutritional properties. In recent years, raw milk demand has increased, valued for its authenticity and connection to local traditions. In Italy, the sale of raw milk is allowed exclusively through direct sale from the producing farm to the final consumer, either at the producing farm itself or through vending machines. However, the consumption of raw milk is not without risks. Among these, microbiological ones are relevant. These can lead to severe symptoms, particularly in vulnerable populations. For this reason, although consumers are advised to boil raw milk before consumption, producing farms in Italy are required to meet the microbiological criteria outlined in the Provision of 25 January 2007. In this retrospective study, the results of the analyses performed on 355 raw milk samples collected in Liguria between 2014 and 2023 for the detection of Campylobacter spp., Salmonella spp., Listeria monocytogenes, Staphylococcus aureus, and Escherichia coli O157 were analysed to better characterise the associated risk for consumers. The samples were collected during official controls by the local veterinary health services at vending machines of seven producing farms. Overall, six samples tested positive for C. jejuni, while only one sample tested positive for Salmonella enterica subsp. enterica, Serovar Veneziana. Listeria monocytogenes, S. aureus, and E. coli O157 were never responsible for non-compliances. Interestingly, three of the six samples positive for C. jejuni derived from the same producer. In farms where positive samples were detected, certain structural and/or operational non-compliances were identified. It can be concluded that, although the scenario in question does not present any cause for concern, it is nevertheless essential to implement a series of preventive measures in order to guarantee the safety of raw milk. These measures include the implementation of biosecurity practices, the maintenance of strict hygiene protocols during milking, and the adherence to the cold chain distribution protocol until the final stage of distribution
Body Mass Index and Sporadic Medullary Thyroid Cancer: Insights from a Large Series
Get PDFExcess adipose tissue has been linked to increased prevalence and aggressiveness in many cancers, but its role in medullary thyroid cancer (MTC) remains unclear. This study analyzed anthropometric and clinical data of a large series of patients with sporadic MTC to assess the impact of excess adipose tissue on MTC prevalence, aggressiveness, and outcome. Patients with obesity presented a less aggressive MTC compared to patients with normal weight or overweight, smaller tumors, lower T and N stages, and lower preoperative calcitonin levels. Somatic mutations occurring in RET and RAS genes did not differ across BMI categories. At the end of follow-up, patients with obesity showed less structural disease, resulting in a lower need for further surgical treatments. These findings suggest that patients with obesity experience less aggressive MTC, potentially due to increased medical examinations in this population
STRATEGIE DI SVILUPPO TURISTICO SOSTENIBILE NELLE AREE INTERNE. Il caso studio della Lunigiana e della Media Valle del Serchio nel Progetto PRIN Underlandscape.
No full text
Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus
No full textThe viral hypothesis for human sporadic breast carcinoma is based on the murine model of Mouse Mammary Tumor Virus (MMTV)-induced mammary tumors. Known risk factors like estrogens, obesity, and alcohol do not play a direct causal role. The Human Betaretrovirus (HBRV), also called Human Mammary Tumor Virus (HMTV), is the human homolog of MMTV, implicated in sporadic breast carcinoma (80% of ductal carcinoma in situ and 40% of invasive tumors). In contrast, hereditary breast carcinomas lack viral sequences. Murine mammary tumor histotypes are determined by specific viral strains activating definite molecular pathways via insertional mutagenesis. Similarly, the diverse histotypes observed in human invasive breast carcinoma may be influenced by a viral etiology. A study of 253 invasive breast carcinoma cases, representing 15 histotypes, detected HBRV/MMTV-ENV sequences in 20%, consistent with international literature. All histotypes tested positive except those linked to hereditary syndromes, such as medullary, apocrine, and metaplastic carcinoma. This distinction reinforces the reported lack of association between HBRV/HMTV and hereditary breast cancer, while supporting a viral etiology for sporadic carcinoma. Relevant characteristics of sporadic histotypes align with the “hit and run” hypothesis of viral carcinogenesis. Histotype differences may result from molecular pathways activated by Int genes, though mechanism beyond insertional mutagenesis and the possibility of specific HBRV strains cannot be ruled out. The potential for detected viral sequences to originate in human tumors from endogenous MMTV or contamination with murine material is critically examined
Speleothem elemental composition: A global view on dominant drivers and environmental patterns
No full textEnvironment, Occupation, and Chronic Maxillary Sinusitis in Pre-Roman Italy
No full textObjective: To assess the frequency of chronic maxillary sinusitis (CMS) in a pre-Roman archeological skeletal assemblage from Italy and to evaluate the occurrence of CMS in combination with its environmental and sociocultural context. Materials and methods: A total of 131 adult individuals from the pre-Roman site of Pontecagnano (eighth to third centuries bce) in southern Italy with intact maxillary sinuses of ≥ 50% preservation were macroscopically and microscopically observed for the presence of osseous changes per published diagnostic criteria of CMS. Results: CMS was present in 57.2% of individuals. The prevalence of CMS was higher in females than in males, and this difference was statistically significant (p = 0.043). The frequency of CMS increased with age-at-death. Bilateral CMS occurred more frequently than unilateral CMS. The differences in the prevalence of CMS in the Etruscan (700-450 bce), Samnite (450-375 bce), and final pre-Roman (375-200 bce) phases of occupation were not statistically significant. Discussion: In combination with viral and bacterial infections, occupational activities (metallurgy, ceramic and textile production, and agriculture) and environmental factors (volcanic ash, marshy environments, and sub-Saharan dust plumes) likely stimulated respiratory disease and resultant CMS in the inhabitants of Pontecagnano. This study provides a framework for future research on CMS and respiratory diseases in the Mediterranean region, in relation to environmental, climatic, and anthropogenic influences. The limited number of individuals per period prevented a proper diachronic analysis. Osteoarcheological assemblages from the Mediterranean region should be systematically analyzed for CMS to increase understanding of how climate, environment, industrialization, and urbanicity affected human health through time
Dairy Wastewaters to Promote Mixotrophic Metabolism in Limnospira (Spirulina) platensis: Effect on Biomass Composition, Phycocyanin Content, and Fatty Acid Methyl Ester Profile
No full textThis study explores the mixotrophic cultivation of Limnospira platensis using dairy byproducts, specifically scotta whey (SW), buttermilk wastewater (BMW), and dairy wastewater (DWW), to promote biomass production and enhance the composition of bioactive compounds. By assessing various concentrations (1%, 2%, and 4% v v−1) of these byproducts in a modified growth medium, this study aims to evaluate their effect on L. platensis growth, phycocyanin (C-PC) content, and fatty acid methyl ester (FAME) profiles. The results show that the optimal biomass production was achieved with 2% scotta and dairy wastewater, reaching maximum concentrations of 3.30 g L−1 and 3.19 g L−1, respectively. Mixotrophic cultivation led to increased C-PC yields, especially in buttermilk and dairy wastewater treatments, highlighting the potential for producing valuable pigments. Additionally, the FAME profiles indicated minimal changes compared to the control, with oleic and γ-linolenic acids being dominant in mixotrophic conditions. These findings support the viability of utilizing dairy byproducts for sustainable L. platensis cultivation, contributing to a circular bioeconomy while producing bioactive compounds of nutritional and commercial interest
La lingua delle novelle di Marco Cademosto (1544)
No full textL’articolo tratteggia la figura di Marco Cademosto (Lodi, 1477-?, post 1544), detto Marco da Lodi dai contemporanei, collocandola nell’ambiente culturale della Roma curiale della prima metà del Cinquecento entro cui operò come musico, rimatore e novellista. Analizza quindi la lingua delle sei novelle di cui è autore (edite in coda, in pagine non numerate, del suo "Sonetti et altre rime, con proposte , et resposte de alcuni huomini degni, et con alcune novelle, capitoli, et stanze", Roma, Antonio Blado, 1544), rilevandone l’arretratezza fonomorfologica rispetto alla codificazione bembiana, comune a tanta novellistica del tempo, e l’insistita ma mal padroneggiata imitazione della sintassi di Boccaccio.This paper outlines the Marco Cademosto’life (Lodi, 1477-?, post 1544), known as Marco da Lodi by his contemporaries, placing him in the cultural environment of papal Rome in the first half of the 16th century, in which he acted as a musician, poet and short story writer. It then analyses the language of the six short stories he wrote (published at the end, on unnumbered pages, of his "Sonetti et altre rime, con proposte , et resposte de alcuni huomini degni, et con alcune novelle, capitoli, et stanze", Rome, Antonio Blado, 1544), highlighting their phonomorphological backwardness ‒ common to a lot of contemporary short story writing ‒ compared to Bembo's codification and the insistent but poorly mastered imitation of Boccaccio’s syntax