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Pompey in the East: the Epigraphical Sources
No full textEsame approfondito delle iscrizioni in onore di Pompeo provenienti dall'Oriente greco negli anni della guerra piratica e della campagna contro Mitridate
Clinical and Genotypic Spectrum of Twinkle-Related Disorders
No full textBackground and objectives: Twinkle, encoded by the TWNK gene, is a mitochondrial DNA helicase that unwinds the double helix of DNA during replication, playing a pivotal role in mitochondrial function. Twinkle-related disorders encompass a variety of genetic disorders characterized by mitochondrial dysfunction. Although several phenotypes have been described, the full clinical and molecular spectrum remains poorly defined. The aim of this study was to characterize the phenotypic and genotypic variability among multinational patients diagnosed with Twinkle-related disorders. Methods: A retrospective cohort study was conducted in patients with Twinkle-related disorders at several specialized centers in Italy, France, Germany, Spain, Denmark, Hungary, and the United States, establishing the Twinkle-Related Disorders International Consortium for Trial Readiness (TReDIC). Data were collected from medical records, including clinical features, age at onset, disease progression, and results from genetic testing. Phenotypic categories included infantile-onset cerebellar ataxia, parkinsonism, primary mitochondrial myopathy (PMM), multisystem involvement, asymptomatic carriers, undetermined phenotypes, and other phenotypes. All patients' diagnoses were confirmed by genetic analysis, and their genetic variants were noted. Outcomes included prevalence of phenotypes, symptom chronology, and mutational patterns. Results: The study included a total of 189 patients (116 female), with a mean age at symptom onset of 40.3 years. At the time of analysis, 70.4% were alive. PMM was the predominant syndrome (85.2%), and most common features were progressive external ophthalmoplegia (84.7%) and skeletal myopathy (55.6%), followed by hearing loss (17.5%) and psychiatric symptoms (15.3%). Most patients (76.8%) presented with neuromuscular symptoms, with fewer showing CNS (19.6%) or multiorgan (3.6%) features at onset; by more than 8 years from onset, these proportions shifted to 54.4%, 23.3%, and 23.3%, respectively. A total of 73 TWNK variants (16 novel) were found, mostly missense, clustered in functionally critical regions. Discussion: This large multinational cohort analysis advances our understanding of Twinkle-related disorders by identifying mutational hotspots with clinical relevance and illustrating the broad phenotypic spectrum and progression patterns. In the context of such rare diseases, the formation of international collaborations, such as TReDIC, can enhance our understanding and support the design of upcoming clinical trials
A Methodology for Imaging Early Bronze Age Structures Buried in Mounds at Al-Tikha, Oman
No full textSince 2022, integrated surveys by researchers from the Sultan Qaboos University in Oman, the Technical University of Crete, Greece, and the University of Pisa in Italy combine geophysical and archaeological studies for the revealing and conservation of Early Bronze Age (EBA) human settlements. These settlements have become archaeogeophysical laboratories for the researchers
involved, due to the different kinds of architectural features based on the period of their origin. 3D ground penetrating radar (GPR) data and AI techniques have served the scientific community in the latter years due to the increased computational power, which allows extracting 3D information on buried remains. Here, we present the results of the ongoing research at the Al-Tikha
site and describe a specific type of archaeological site–dedicated data processing methodology for the assessment of EBA mounds. We applied multipath summation on the GPR sections combined with topography corrections and enhanced the geophysical interpretation by diffraction velocity models based on the kinematic characteristics of diffractions mapped by a
globally trained ML model. A diffraction velocity model can never be accurate as it is based on the number and position of the diffractions over the x-t
plane, making it not suitable for most cases for direct migration. Our methodology suggests the combination of multipath summation and topography corrections as an alternative. The latter proved more efficient than topographical
migration in our examples. This methodology is implemented and tested here with the scope to efficiently image the subsurface of the mounds at EBA settlements. Two mounds were prospected, and buried walls and structural layers were mapped to serve as targets for future excavation, while both mounds were found to have different architectural phases of construction
Development of a pattern recognition algorithm for reconstructing multi-particle events in the Mu2e detector
No full textMu2e is an upcoming experiment at Fermilab and its main goal is to search for the Charged Lepton Flavor Violation (CLFV) in the coherent transition of a muon into an electron on an Al target. In Mu2e, multi-particle events can occur simultaneously within the same time region and it is crucial to accurately identify each particle track, including signals, to improve the robustness of track-finding methods and enhance reconstruction efficiency. p̄ annihilation is one of the background events and produces multiple particles that can mimic signal events. Additionally, photons from radiative pion captures can produce a γ → e+e− pair, which can be used to calibrate the Mu2e momentum scale and the resolution. The Mu2e track reconstruction sequence begins by grouping hits produced in the tracker based on time and z coordinate information, called TimeCluster, and selected hits are processed to reconstruct helices and determine their momentum. The current pattern recognition algorithms identify a single helix per TimeCluster for single-track events. A new pattern recognition algorithm is being developed to reconstruct multi-particle events and its features for finding multiple tracks and the current evaluation results are reported
High-intensity versus very-high-intensity statin, both on top of ezetimibe, in acute myocardial infarction: A pragmatic randomized study
No full textBackground: Early lipid-lowering therapy with "high-intensity" statins is recommended post-acute myocardial infarction (AMI), yet the optimal dose within such regimens remains uncertain. We compared efficacy and safety of very high-intensity versus high-intensity statin regimens, both combined with ezetimibe, initiated during AMI hospitalization. Methods: In a stepped-wedge cluster randomized controlled single-center trial, patients with ST- or non-ST-elevation AMI were assigned in sequential 6-month blocks to either very high-intensity statin (Group A: atorvastatin 80 mg or rosuvastatin 40 mg) or high-intensity statin (Group B: atorvastatin 40 mg or rosuvastatin 20 mg), both combined with ezetimibe 10 mg, daily. The primary endpoint was achieving both LDL-C < 55 mg/dL and ≥ 50% LDL-C reduction at 30 days post-discharge. Secondary endpoints included each primary endpoint component, mean LDL-C levels, safety, and need for dose reduction. Results: Two-hundred-and-twenty patients (mean age 67 years, 63% men) were enrolled. Groups were balanced at baseline for demographic, clinical, and laboratory characteristics. At 30 days, the primary (efficacy) endpoint occurred in 63% of patients in Group A and 52% of patients in Group B (p = 0.13). LDL-C < 55 mg/dL was achieved in 86% of Group A and 73% of Group B (p = 0.02). No significant difference was seen in ≥50% LDL-C reduction. Group A had lower mean LDL-C (43 ± 16 mg/dL vs 48 ± 14 mg/dL; p = 0.046). Statin dose reduction due to intolerance occurred, however, more often in Group A (8% vs 2%, p = 0.03). No differences in liver enzymes were observed. Conclusions: Very high-intensity and high-intensity statin regimens differed minimally in achieving LDL-C targets, but very high-intensity regimens had higher rates of intolerance-related dose reduction
Clinical Benefits of Aloe vera Gel in 0.3% Hyaluronate Eyedrops in Glaucoma Therapy-Related Ocular Surface Disease
No full textFrom Digital Twins to AI Agents: A Synthetic Data Paradigm for Next-Generation Cybersecurity
No full textConvergence of the Euler-Voigt equations to the Euler equations in two dimensions
No full textIn this paper, we consider the two-dimensional torus and we study the convergence of solutions of the Euler-Voigt equations to solutions of the Euler equations, under several regularity settings. More precisely, we first prove that for weak solutions of the Euler equations with vorticity in C([0,T];L2(T2)) the approximating velocity converges strongly in
C([0,T];H1(T2)). Moreover, for the unique Yudovich solution of the 2D Euler equations we provide a rate of convergence for the velocity in C([0,T];L2(T2)). Finally, for classical solutions in higher-order Sobolev spaces we prove the convergence with explicit rates of both the approximating velocity and the approximating vorticity in C([0,T];L2(T2)
English and German suffixoids and their Italian equivalents
No full textThis contribution investigates English and German affixoids and their Italian equivalents from a morphotactic, morphosemantic, and morphopragmatic perspective, particularly in the context of verbal aggression. The suffixoid in the pattern bomb+proof, and the German prefixoid in intensifying expressive adjective compounds of the type blut+arm (with two main accents) ‘intensely poor, lit. blood+poor’ or sau+dumm ‘intensely dumb, lit. sow+dumb’, are examined. Affixoids (both suffixoids, such as +proof, and prefixoids, such as G. blut+) are transitional between compound constituents and derivational affixes (prefixes or suffixes), and thus part of transitional morphology, i.e. they are intermediate between different sub-components of word-formation. The issues investigated include the productivity and profitability of the units studied (cf. Bauer, 2001), their relative degree of morphosemantic transparency/opacity, their positive or negative connotations, the degrees of morphological richness of the different patterns, and whether the affixoid constructions refer to humans, animates, or inanimates. A combination of quantitative and qualitative analyses of data drawn from the literature and from large electronic corpora will demonstrate the pragmatic effects of these morphological processes and their preferred co-texts. A contrastive analysis with Italian morphosemantic equivalents will reveal how the three languages differ due to typological factors
Influence of Live Music and Tasting Assessment on Hedonic and Emotional Responses of Wine in Public Tasting Events
No full textWine represents one of the most complex food matrices from a sensory perspective, as its appreciation emerges from the interaction between chemical composition, perceptual mechanisms, and contextual influences. Contemporary research in oenology and sensory science increasingly recognizes wine evaluation as an integrated perceptual event shaped by cognition, memory, and affect, rather than a simple response to aroma or flavor cues. Live music is widely used in hospitality settings to enhance consumer experience; however, its specific influence on wine appreciation and emotional responses remains insufficiently explored, particularly in real-world contexts. This study investigates how two contrasting musical atmospheres—melancholic/relaxing and upbeat/motivational—modulate hedonic evaluations and emotional profiles during public wine tastings, compared with a no-music condition. Data were collected across five live tasting events (5 Wednesdays of Emotions) using structured questionnaires that included hedonic ratings and multidimensional emotional measures. Statistical analyses were conducted using non-parametric tests, meta-analytic p-value combination, and cumulative link mixed models for ordinal data. The presence of music significantly enhanced overall wine appreciation compared to the silent condition, although the magnitude and direction of the effect varied across individuals and musical styles. Upbeat/motivational music generally produced stronger and more consistent increases in liking than melancholic/relaxing music. Emotional responses—particularly positive surprise—emerged as key mediators of hedonic improvement and showed strong associations with overall liking. Preference profiling revealed distinct response patterns, indicating that auditory modulation of wine perception is not uniform across consumers. These findings support a crossmodal interpretation in which music shapes wine appreciation primarily through emotion-based and expectancy-related mechanisms rather than through direct sensory enhancement. By demonstrating these effects in ecologically valid tasting environments, the study highlights the role of auditory context as a meaningful component of multisensory wine experiences