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The founding of the Capodimonte Museum in 1957 and the creation of its conservation laboratory: scientific conservation/restoration in Naples in the context of post-war Italy
No full textThe paper deals with the birth of the Capodimonte Museum, which was inaugurated in its present location on May 5, 1957. Since the early 19th century, the 'modern' art collections had been housed in the Palazzo degli Studi, today's MANN (Museo Archeologico Nazionale di Napoli), along with the archaeological collections. After the end of the World War II, the Soprintendente Bruno Molajoli had the opportunity to shape his project of transferring them in the Royal Palace of Capodimonte, which became available after the end of the Savoia monarchy. The new conservation and scientific laboratories that were set up on this occasion according to advanced standards, and the restorations carried out in this period are illustrative of the state of the art at the time in Italy. Molajoli consciously positioned himself within the international context; he invited the most qualified and well-known restorers of the time to work in Naples in the new laboratory. The standards used in carrying out the interventions and the level of control and assistance offered by the scientific laboratory are the subject of the article. On the basis of a discussion of selected illustrative works of art among those whose restoration we have again carried out in recent years, it throws light on one museum laboratory at such an important time in the development of conservation science, highlighting the progress and contradictions of those decisive years
Maritime religiosity in Roman Adriatic Italy: anchorages, coastal shrines, promontories, sanctuaries, and temples in Aquileia, Ravenna, and Ancona (150 BCE – 250 CE)
No full textLinking Comorbidity and Inflammation: The Role of Comorbidity Polypharmacy Score in Chronic Limb-Threatening Ischemia
No full textIntroduction: Chronic limb-threatening ischemia (CLTI) is a severe manifestation of peripheral artery disease, frequently associated with multimorbidity and polypharmacy. Chronic low-grade inflammation plays a pivotal role in atherosclerosis progression, and hematologic markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are gaining value as prognostic tools. Aim: To investigate the relationship between the Comorbidity-Polypharmacy Score (CPPS) and inflammatory biomarkers in patients undergoing elective revascularization for CLTI. Methods: This retrospective study included 442 CLTI patients treated at the Vascular Surgery Unit, University of Siena. CPPS was calculated by summing the number of chronic diseases and long-term medications, stratifying patients into 4 groups: mild, moderate, severe, and morbid. Pre-operative bloodwork was analyzed to calculate NLR, PLR, and SII. Statistical analysis included ANOVA and linear regression. Results: CPPS distribution was mild (22.6%), moderate (54.3%), severe (21.9%), and morbid (1.2%). Inflammatory markers increased significantly with CPPS severity. Mean NLR rose from 3.1 ± 2.1 in mild to 5.8 ± 3.7 in morbid (P < 0.001), PLR from 145.0 ± 89.5 to 227.2 ± 112.9 (P < 0.001), and SII from 835.7 ± 707.6 to 1710.6 ± 944.0 (P < 0.001). Hemoglobin decreased from 13.6 ± 2.1 g/dL to 11.5 ± 1.7 g/dL (P = 0.03). Linear regression showed significant positive correlations between CPPS and NLR (R2 = 0.28), PLR (R2 = 0.35), and SII (R2 = 0.33). Conclusions: Higher CPPS is associated with elevated inflammatory markers and declining hemoglobin, suggesting that multimorbidity and polypharmacy contribute directly to systemic inflammation. CPPS, alongside NLR, PLR, and SII, may support risk stratification and personalized management in CLTI patients
Smartphone-Driven Augmented Reality Headset for Low-Light Mobility Assistance in Retinitis Pigmentosa
No full textPurpose: To evaluate the effectiveness of a smartphone-driven augmented reality (AR) headset in expanding the functional visual field and improving mobility performance under low-light conditions in patients with retinitis pigmentosa (RP). Design: Prospective, single-center before-and after study. Subjects: Thirty-two patients (18 females, 14 males; median age: 55.5 years) with genetically confirmed typical RP, a binocular uncorrected distance visual acuity (BUVA) of ≥ 20/200, and VF restricted to < 10 degrees in both eyes. Methods: Participants were assessed at baseline and under AR-assisted conditions. The AR system consisted of XREAL One glasses paired with an iPhone 15. Visual function was evaluated through ETDRS visual acuity, Pelli-Robson contrast sensitivity, and tangent screen perimetry. Functional mobility was assessed using the Multi-Luminance Mobility Test (MLMT). Data were analyzed using paired t-tests and Wilcoxon signed-rank tests. Main outcome measures: The primary outcome was the change in MLMT score, secondary outcomes included changes in binocular visual field area, contrast sensitivity, and uncorrected binocular visual acuity (BUVA) with and without the AR device. Results: Use of the AR headset resulted in a ∼3.4-fold enlargement in binocular VF (P < .001) and a median improvement of 3 points in MLMT score (from median 3 to 6; P < .001). The proportion of patients able to complete the MLMT at 1 lux increased from 0% to 88%. While standard minification mode reduced BUVA by 0.58 logMAR (P < .001), the 4 × mode maintained baseline acuity (P = .166) and improved contrast sensitivity (P < .001). Conclusions: This study demonstrates that a consumer-grade AR headset combined with a smartphone can deliver substantial improvements in low-light mobility and visual field function for RP patients, offering a scalable and affordable alternative to conventional low-vision aids. These findings highlight the potential of leveraging consumer technologies for accessible, patient-centered visual rehabilitation
Calculation of life cycle-based emission factors for administrative services: A replicable framework for climate action in the public sector
Get PDFMunicipal services are rarely evaluated systematically for their environmental impacts. This study introduces an innovative life-cycle-based methodology for calculating emission factors for 21 municipal services, thereby filling a critical gap in public-sector impact assessment. Services are classified into administrative office services (e.g., identity card issuance, residence changes, marriage licenses) and macro-services (e.g., school canteen management, green maintenance, bulky waste collection). While administrative office services are often considered intangible and underestimated in environmental terms, both types require significant resources and generate measurable impacts. The methodology quantifies Carbon Footprints (CFs) of municipal services, producing emission factors per functional unit. Unlike previous fragmented assessments focused on specific sectors or public activities, this study applies a unified, systems-based framework. The results are consolidated into a structured database made of standardized emission factors (EFs), which serve as proxies when site-specific data are unavailable and facilitate replication across different institutions and geographic contexts. Applied in the Municipality of Grosseto (Italy), results show that macro-services account for 78.55 % of total emissions (particularly from school canteens and green maintenance), while site inspections and document processing are the most impactful administrative functions. The approach helps local authorities identify emission hotspots and align services with strategic planning tools such as Sustainable Energy and Climate Action Plans (SECAPs). By providing a flexible and transferable evaluation framework, this study advances environmental accounting practices in the public sector and supports evidence-based climate strategies with broader policy relevance. © 2025 The Author
Deep Learning in Multiomics Sciences: Where We are, Emerging Topics, and Future Challenges
No full textReproductive Life Stages and Female Sex-Specific Patterns in Uveitis Activity: Data From the AIDA Network Uveitis Registry
Get PDFOBJECTIVE OR PURPOSE: To investigate whether noninfectious uveitis (NIU) activity varies across reproductive life stages (RLS) according to sex. DESIGN: Observational, retrospective, cross-sectional registry-based study. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: The study recruited female patients with NIU (regardless of anatomical location or underlying etiology) as the main study group and male patients as controls to allow sex-based comparisons. They were enrolled in the AIDA Network Uveitis Registry between 2020 and 2025. METHODS, INTERVENTION, OR TESTING: RLS (prepuberal, early puberty, late puberty, reproductive, perimenopause, and podtmenopausal) were approximated using age intervals derived from epidemiological data. Study outcomes were flare frequency, anterior chamber cells (ACC), anterior chamber flare, vitreous haze, new posterior segment inflammatory signs, and immunosuppressive treatment (IST) exposure. RESULTS: Four hundred twenty-five female and 275 male patients were included. Median (IQR) relapse number in 12 months was 0.8 (1.3) [min 0.0-max 2.0] in prepuberty, 1.0 (2.0) [0.0-5.0] in early puberty, 0.0 (1.0) [0.0-5.0] in late puberty, 0.5 (1.0) [0.0-8.0] in reproductive age, 1.0 (1.0) [0.0-10.0] in perimenopause, and 0.5 (1.0) [0.0-7.5] in post-menopause (P =. 014). There was a statistically significant interaction between RLS and sex (P =. 044), with a perimenopausal peak retained only in women. In subjects with active anterior involvement, differences in the distribution of ACC grades among RLS were observed, with a peak in prepuberty and early puberty (P =. 004). Proportions of subjects receiving IST were higher in prepuberty and puberty than in the remaining RLS (P =. 012). CONCLUSIONS: RLS are clinically relevant modifiers of uveitis activity and should guide patient education, risk stratification, and therapy. Early puberty and perimenopause increase relapse risk; pediatric cases show more severe anterior inflammation and require more systemic IST