University of Naples Federico II
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Toward the definition of moderate psoriasis: an expert opinion
No full textBackground: The clinical definition of moderate psoriasis is debated, affecting treatment eligibility and patient outcomes. Objective: A panel of Italian dermatologists aimed to propose practical criteria to define moderate psoriasis, based on a comprehensive literature review and clinical experience. Methods: The panel reviewed publications between 2016 and 2024 focusing on key severity scores, including the Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), Dermatology Life Quality Index (DLQI), and Physician's Global Assessment (PGA), along with special area involvement and patient-reported outcomes. Results: Despite variability among studies, and the lack of universally accepted thresholds, the panel defined moderate psoriasis as a BSA of 5%-10%, DLQI of 5-10, a PGA score of 3, and involvement of at least two special areas (e.g. scalp, face, genitals, nails, hands, or feet). Distressing itch and psychosocial impact were also recognized as critical elements influencing perceived disease burden. A composite PGA-based approach, integrating objective measures with patient-centered criteria, is proposed for identifying patients with moderate psoriasis who may benefit from systemic therapy. Conclusion: This pragmatic approach may help bridge the gap between guidelines and real-world clinical practice, ensuring more accurate treatment allocation and reducing undertreatment of psoriasis
Lo spazio e il tempo della decisione politica: rischi e opportunità nel ricorso alle nuove tecnologie
No full textL'intervento si sofferma sulla regolazione da applicare nel circuito decisionale parlamentare che si forma con il sussidio degli strumenti di intelligenza artificiale nelle attività di produzione normativa, organizzazione dei lavori e interazione con i cittadini
Compost Tea as a Natural Bioactive Solution: Unlocking the Antimicrobial and Antiviral Potential of Bell Pepper and Citrus Wastes
No full textStrumenti di Supporto alle Decisioni per la rigenerazione urbana: lo strumento ArcGIS Survey123 per la costruzione collaborativa di mappe tematiche
No full textLa qualità della città influenza direttamente il benessere dei suoi abitanti: spazi ben progettati possono favorire il benessere fisico, mentale e sociale, ridurre le disuguaglianze e promuovere l’inclusione [1, 2]. Per decenni, il PIL è stato considerato l’indicatore principale del progresso di una nazione. Tuttavia, sebbene questa misura economica sia utile per analizzare la crescita produttiva, non descrive il reale benessere delle persone e delle comunità. Il concetto di Benessere Equo e Sostenibile (BES), sviluppato dall’ISTAT nel 2010, nasce dalla necessità di misurare la qualità della vita delle persone utilizzando un insieme di indicatori che comprendono diverse dimensioni, non solo economiche, andando “oltre il PIL”. Il BES riflette un cambiamento culturale che interpreta i territori non solo come produttori di ricchezza economica, ma anche come ecosistemi socio-culturali dove il benessere può essere promosso collettivamente. Nell’ambito della rigenerazione urbana, l’uso delle Tecnologie dell’Informazione e della Comunicazione (TIC) ha trasformato il ruolo dei cittadini, rendendoli protagonisti attivi nei processi decisionali. Negli ultimi anni, grazie a tali tecnologie, i cittadini (sapere comune) sono sempre più coinvolti attivamente dal sapere esperto nei processi decisionali finalizzati ad elaborare strategie di sviluppo capaci di rispondere alle sfide che caratterizzano le nostre città. In questa prospettiva, nella valutazione della rigenerazione delle città, gli approcci delle scienze dure (“dati hard”) sono sempre più integrati con quelli basati sulle scienze “soft” (“dati soft”). Il presente contributo intende proporre un approccio valutativo per analizzare la qualità della vita nelle città dal punto di vista della comunità. Nello specifico si propone una mappatura collaborativa di informazioni e indicatori soggettivo/percettivi, capaci di esprimere l’interazione tra comunità e spazio urbano. Nel presente studio, testato nel centro storico di Napoli (Italia), ArcGIS Survey123 è utilizzato come strumento di coinvolgimento e di partecipazione attiva della comunità per la valutazione della qualità della vita nelle città da un punto di vista soggettivo/percettivo, ad integrazione dei quadri valutativi esistenti, basati su dati oggettivo/quantitativi, e a supporto di processi di trasformazione urbana più inclusivi
The cost of being early or late: Biological and economic outcomes of age at first calving in dairy buffaloes
No full textAge at first calving (AFC) is a key determinant of lifetime productivity and profitability in dairy herds, yet its long-term effects in dairy buffaloes remain poorly documented. This study evaluated the influence of AFC on milk yield and composition, reproductive performance, and economic outcomes in Italian Mediterranean buffaloes reared under commercial conditions. Data included 576,028 test-day records from 27,744 buffaloes across 110 herds, collected over a 10-yr period (2013–2023). Animals were grouped into 8 AFC classes and stratified by parity order, namely: primiparous, mid-parity (second–third parities), and greater parity (≥4). Productive traits comprised daily milk yield, fat and protein content, SCS, and cumulative yields of milk, fat, and protein per lactation, whereas reproductive traits included calving interval (CIN) and days open (DO). Mixed-model analysis indicated that mid- and greater-parity buffaloes calving between 35 and 38 mo achieved higher daily milk yield, whereas daily milk yield increased progressively with AFC in primiparous buffaloes. Milk fat content was unaffected by AFC, whereas the highest protein percentages were observed in mid-parity buffaloes calving at AFC between 32 and 34 mo. Somatic cell score significantly decreased as AFC increased across all parity groups, except in primiparous buffaloes, where an increase in SCS was observed in buffaloes with AFC between 37 and 38 mo. Moreover, CIN and DO were shortest in buffaloes calving the first time between 32 and 37 mo. The economic analysis integrated model-based estimates of milk yield with farm-level cost data from the Farm Accountancy Data Network covering the same 10-yr period. Production costs were organized into 3 categories: direct costs, overheads, and imputed costs. Based on this structure, the average production cost was estimated at €1.38/L of milk. Total production costs per lactation were calculated as the unit cost multiplied by the estimated cumulative milk yield for each AFC class and parity group. Revenues were obtained in the same way, by applying the actual farm-gate milk price (€1.50/L) to the estimated cumulative milk yields, providing a standardized framework for comparison across AFC classes. Net profit was calculated as the difference between total revenues and production costs, yielding an overall average of €314 per lactation across all AFC and parity groups. The highest net profit was recorded in mid-parity buffaloes whose first calving occurred between 37 and 38 mo of age, with an average net return of €339 per lactation. Overall, buffaloes calving the first time between 34 and 42 mo achieved significantly higher net profit compared with other AFC classes. Conversely, both early (42 mo) AFC values were associated with reduced net profits, driven by lower milk yields. Overall, these results indicate that targeting an AFC of 35 to 38 mo provides the most favorable balance between biological performance, udder health, reproductive efficiency, and farm profitability
Developing a persona-driven, mHealth-enabled care model for young men with hypogonadism: a methods-based approach to early risk stratification and prevention
No full textBackground: Early-onset hypogonadism is an emerging cardiometabolic risk marker in young men, yet current care pathways remain fragmented and insufficiently tailored to patients' multidimensional needs. Digital health technologies offer an opportunity to support early risk stratification, promote self-management, and facilitate long-term prevention. This study presents a methodological framework combining Blueprint Persona modeling and multidisciplinary co-design to support the development of tailored digital health interventions. Objective: To apply a persona-based, co-design methodology to develop a patient-centered, mHealth-enabled care model for young men with hypogonadism. Methods: We screened 800 males aged 15–35 years; 55 were diagnosed with hypogonadism. Using the European Commission “Blueprint Persona” methodology, we constructed a representative persona (“Luigi”) and validated it through a multidisciplinary Focus Group (11 experts). Unmet needs were identified and translated into key functional requirements for an mHealth-supported chronic care pathway. Results: The hypogonadal cohort demonstrated a higher metabolic burden compared to eugonadal peers and reported priorities centred on sexual health, mood and musculoskeletal well-being, and prevention of premature cardiovascular risk. Despite significant psychosocial vulnerabilities, digital readiness was high. The co-design process generated a structured, mHealth-enabled intervention concept integrating teleconsultations, guided diagnostic/therapeutic steps, behavioral monitoring, and adherence-support features. Conclusions: The Blueprint Persona methodology enabled the systematic translation of clinical, psychosocial, and behavioral insights into a digitally supported care model tailored to young men with hypogonadism. This Methods Article describes the development framework underlying the proposed intervention. A prospective evaluation will assess feasibility, adherence, and impact on cardiometabolic risk and quality of life
Investigating the uniaxial compressive mechanics of graded polymer foams via in-situ synchrotron X-ray microtomography
No full textGraded polymer foams are emerging as transformative materials for structural applications, outperforming uniform foams due to their spatially tailored density and microstructural features. However, harnessing their full potential requires a deep understanding of how their macroscopic mechanical behavior relates to their complex microstructure evolution. In this study, we elucidate the uniaxial compressive response of graded foams using in-situ synchrotron X-ray microtomography, complemented by comparative experiments on uniform foams of varying densities. Our findings reveal that graded foams exhibit both qualitatively and quantitatively distinct mechanical behavior, driven by unique microscale deformation mechanisms. We evaluate and discuss their superior energy absorption performance and demonstrate how the density, cell size and circularity profile evolves under increasing macroscopic strain. Notably, the graded architecture enables precise control over the localization and progression of densification bands, offering unprecedented design flexibility for advanced structural applications
Non-Surgical Submarginal Instrumentation of Peri-Implant Mucositis With Delivery of Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid: A Randomized Clinical Trial
No full textObjectives: To evaluate the effects of submarginal instrumentation (SI) with or without adjunctive delivery of sodium hypochlorite (NaOCl)/amino acids and cross-linked hyaluronic acid (xHyA) gel in the treatment of peri-implant mucositis (PM). Material and methods: Forty implants supporting single-unit crowns diagnosed with PM in 40 patients were randomly assigned to test (SI + NaOCl/amino acids and xHyA) or control group (SI alone). The primary outcome was mean BoP change. Full-Mouth Plaque Score (FMPS), Full-Mouth Bleeding Score (FMBS), modified plaque index (mPlI), and probing depth (PD) were assessed as secondary outcomes. Clinical parameters were assessed at baseline, 3 and 6 months. Disease resolution was also recorded. Results: Two patients were lost during follow-up while 38 patients completed the study without adverse effects. After 6 months, all clinical parameters improved statistically significantly in both groups (p 0.05); conversely, an initial PD = 5 mm yielded a statistically significant difference (p < 0.05). Disease resolution correlation with test group was statistically significant with a 3.77 odds ratio. Conclusion: Within the limitations of the present study, adjunctive delivery of NaOCl/amino acids and xHyA to SI yielded superior clinical outcomes compared with SI alone in the treatment of PM. Trial registration: ClinicalTrials.gov: NCT05926297