1194 research outputs found
Sort by
Pulmonary Kaposi sarcoma and disseminated Mycobacterium genavense infection in an HIV-infected patient
Get PDFWe report a case of Kaposi sarcoma (KS) and disseminated infection by Mycobacterium genavense in a 40-year-old HIV-positive man with CD4+ T-cell count 5/µL. He presented with anorexia, diarrhoea, cachexia and multiple firm violaceous nodules distributed over the face, neck and upper and lower extremities. Biopsy of a skin nodule was performed, confirming KS. Immunoperoxidase staining for human herpesvirus 8 was strongly positive. Endoscopic examination revealed erosive duodenopathy. Multiple biopsy samples showed numerous acid-fast bacilli at direct microscopic examination. Real-time PCR (RT-PCR) identified M. genavense. A CT scan showed diffuse pulmonary infiltrates with a 'tree-in-bud' appearance, striking splenomegaly and abdominal lymphadenopathy. A bronchoscopy was performed, revealing typical Kaposi's lesions in the upper respiratory tract. RT-PCR of bronchial aspirate identified M. genavense and Pneumocystis jirovecii. Despite treatment with highly active antiretroviral therapy, antimycobacterial therapy and trimethoprim/sulfamethoxazole, the outcome was fatal
Dermatite de contacto alérgica a sombra de olhos
Get PDFIntrodução: A dermatite de pálpebras secundária à exposição a cosméticos é descrita na literatura entre
2.5% e 26%. A maquilhagem pigmentada pode conter alergénios metálicos, incluindo níquel, crómio e cobalto.
Caso clínico: Doente do sexo feminino, 52 anos, cabeleireira, com antecedentes de atopia. Recorreu à consulta
de Dermatologia com história de prurido, eritema e descamação das pálpebras com 7 meses de evolução. Na sua história médica passada foi referida dermatite do lóbulo da orelha aos brincos. Foi encaminhada à consulta de Alergologia Cutânea para realização de testes epicutâneos com a série básica do Grupo Português de Dermatite de Contactos, série cosméticos, série cabeleireiro e os produtos pessoais da doente (em teste semiaberto). Foram observadas reacções positivas ao sulfato de níquel 5% em vaselina (++ em D3) e valentina D kejal® (sombra de olhos
cinzenta). Conclusões: Os cosméticos são uma potencial fonte sensibilizante da pele da face, especialmente em mulheres com atopia e alteração da barreira cutânea, o que favorece a penetração de alergénios. Isto permite que o níquel em baixas concentrações, mesmo que, como contaminante, desencadeie reacção palpebral.info:eu-repo/semantics/publishedVersio
Hypertrophic olivary degeneration and cerebrovascular disease: movement in a triangle.
Get PDFHypertrophic olivary degeneration is a rare kind of trans-synaptic degeneration that occurs after lesions of the dentatorubro-olivary pathway. The lesions, commonly unilateral, may result from hemorrhage due to vascular malformation, trauma, surgical intervention or hypertension, tumor, or ischemia. Bilateral cases are extremely rare. This condition is classically associated with development of palatal tremor, but clinical manifestations can include other involuntary movements. We describe 2 cases: unilateral hypertrophic olivary degeneration in a 60-year-old man with contralateral athetosis and neurologic worsening developing several years after a pontine hemorrhage and bilateral hypertrophic olivary degeneration in a 77-year-old woman with development of palatal tremor, probably secondary to pontine ischemic lesions (small vessel disease)