40171 research outputs found
Sort by
Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage (archive)
Get PDFParkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically
progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances. Lewy's
body and Lewy's neurite are the main findings in brain biopsies of patients with PD. The main component is alphasynuclein, a misfolding protein that plays an essential role in the pathogenesis of PD. This study aims to determine
the association between serum alpha-synuclein levels during the PD stage and compare the levels between PD
patients and healthy populations of the same age. A case-control study was conducted on 62 people with PD and
20 normal subjects as controls in the outpatient Department of Neurology of Dr. M. Djamil General Hospital and
Ibnu Sina Islamic Hospital, Padang, from March to September 2020. The ELISA method examined serum alphasynuclein examination, and the PD stage was assessed according to Hoehn and Yahr stages. The differences in alphasynuclein levels between cases and controls and between stages of PD were analyzed by the Mann-Whitney test.
Alpha-synuclein levels in PD patients were higher than in controls, and this difference was statistically significant
(p<0.05). On the other hand, alpha-synuclein levels were higher in the severe stage than in the mild stage but not
statistically significant (p>0.05). In conclusion, there was no association between alpha-synuclein levels and the
stage of Parkinson's disease. Still, serum alpha-synuclein levels in PD patients were significantly higher than in the
healthy populatio
RPS DDA (Rencana Pembelajaran Semester) Dasar-dasar Agronomi
No full textRPS DDA berisikan silabus pembelajaran perkuliahan dasar-dasar agronomi pada semester
Exploration And Characterization Of Hanjeli Nutfah Plasma (Coix Lacrima-Jobi L.) In West Sumatra Province
Get PDFHanjeli is one of the alternative food crops that are high in nutrients, healthful, easy to grow, and adaptable to a wide range of environmental circumstances. Due to the limited understanding of people who believe Hanjeli is a wild plant or weed, usage of this commodity is still quite low in Indonesia. To save and prevent the loss of genetic resources, it is vital to study, inventory, and characterize Hanjeli so that plant breeders can use it to create greater varieties in the future. The goals of this study are to: (1) learn about the existence and types of Hanjeli plants in West Sumatra Province; (2) collect Hanjeli germplasm; and (3) learn about the morphological diversity and level of similarity of Hanjeli plants as a starting point for germplasm conservation of Hanjeli plants in West Sumatra. This study took place in four districts/cities in West Sumatra Province from June to November 2021. This study is carried out using a survey method with purposive sampling. The NTSYSpc2.02i application is used to present morphological data descriptively and for similarity analysis. 69 Hanjeli accessions were discovered throughout the exploration process. Hanjeli grows between 6 to 1575 meters above sea level and can thrive in a variety of environments, including arid ground and regions near water sources (starting on the outskirts of streams to the edges of rice fields). For all characters, the phenotypic similarity study of Hanjeli plants yielded similarity coefficients ranging from 0.67 to 1. At 0.67, the accessions were divided into two groups: 66 accessions in the first group, and 3 accessions in the second group