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My teammate is an AI : evaluating generative AI in game asset creation through a post-gamejam study
Get PDFThis study explores the integration of generative AI into game development, focusing
on its use during a university-led game jam involving undergraduate students. The
research investigates whether generative AI holds significance for the future of game
creation - highlighting its potential or otherwise to transform asset production, team
dynamics, and creative workflows. It examines how AI-driven tools such as ChatGPT
and DALL-E impacted the development process, enabling hybrid roles and
streamlining production tasks that involve repetitive visual patterns or templated
interface elements. However, limitations emerged, including asset reliability, quality,
and creative customisation challenges. Finding what this means for the broader
industry while emphasising the importance of refining AI tools to balance efficiency
with artistic integrity. A significant number of participants (46%) reported notable
learning gains, reflecting improved technical skills and a deeper understanding of AI's
role in creative processes. These results point to broader questions for future policy,
including intellectual property, ethical data use, and inclusive development - although
such issues were not explicitly raised by participants during the study. This research
offers insights for advancing AI-human collaboration models to support sustainable,
innovative, and culturally diverse game production.peer-reviewe
The true flaw in the ontological proof : Anselm, Kant, Husserl
Get PDFGod is a being than which nothing greater can be conceived. The Fool hath
said in his heart that there is no God, and the Fool understands what he
is saying. Thus, he thinks that God is only in the understanding but does not
exist in reality. But since existing is greater than not existing, a God found in
the understanding alone would not be a being than which nothing greater can
be conceived, which contradicts the definition of what we are speaking about.
Therefore, God is not only in the understanding, but exists.peer-reviewe
An introduction to dark field CT (DFCT) : a game changer for the future of CT?
No full textComputed tomography (CT) technology has undergone
rapid evolution in recent years. The introduction of
photon-counting CT has already begun reshaping the
fundamental principles of CT imaging. In this context
of innovation, dark-field CT (DFCT) is emerging as
a promising advancement, offering a new imaging
contrast based on small-angle X-ray scattering rather
than traditional attenuation. This article aims to explore
the potential role of DFCT in medical imaging, reviewing
the current state of the technology, its underlying
physical principles, and the advantages demonstrated
in preclinical studies, particularly in detecting
microstructural changes in tissues such as the lungs and
bones. Although still in the experimental phase, DFCT
represents a novel and potentially transformative tool
that could complement conventional CT and expand
diagnostic capabilities in the future.peer-reviewe
Midwifery education : a pathway to achieving the sustainable development goals
Get PDFMidwifery education stands at the heart of the global
effort to achieve the 2030 Sustainable Development Goals
(SDGs). This keynote highlights how investment in
high-quality, competency-based midwifery education,
aligned with International Confederation of Midwives
(ICM) standards, is a powerful and cost-effective strategy
to improve maternal and newborn outcomes and advance
social and economic development. Evidence indicates
that universal access to midwifery care could prevent
over 4.3 million maternal and newborn deaths by 2035.peer-reviewe
Cosmological scalar perturbations in Horndeski-like gravity
Get PDFScalar-tensor theories are promising dark energy models. A promising scalar-tensor theory, called Horndeski-like gravity, is coming from the application of the Horndeski gravity in string theory and cosmology that takes into account two dilaton fields. In this work we study the stability of the scalar sector of this theory and compare it with that coming from the previously studied tensor sector. With the first-order formalism we investigate the allowed background solutions. Focusing on the background solution with a single scalar field, the entropy coming from particle production Sin and that of the apparent horizon S will be studied, which translates into entropy bounds. These entropy bounds are compared with the stability of the scalar and tensor sector as well. The gravitational slip (minus one) to entropy ratio is also considered as a possible replacement for the usual shear viscosity to entropy ratio for black holes.peer-reviewe
Collecting from the future embedding strategic foresight in museum collections development
No full textThe paper calls for an alternative mode to the present-centric collections
development practices guided by futures-oriented perspectives. This new approach,
tentatively referenced to a curated choice of strategic foresight tools, would
introduce the concept of “future memories” in collections management. Thanks
to these tools, museums would be better equipped to anticipate societal change,
address representational gaps, and curate collections for relevance in a multiple range
of futures.peer-reviewe
Deprescribing tendencies within primary health care : a literature review
No full textThe author would like to acknowledge the
University of Buckingham for the opportunity to
provide this review within its course.BACKGROUND: Polypharmacy increases in older persons and in
multimorbid patients thus becoming prevalent
in primary health care. While deprescribing
offers a patient-centered, systematic approach
to reducing potentially inappropriate medicines,
implementation remains inconsistent based on
clinical, systemic, and patient-level factors.AIM: The purpose of this literature review is to outline
the enablers and barriers of deprescribing
in primary care and, on the basis of current
evidence, identify successful solutions for
implementation.METHOD: A review of the literature was performed utilising
PubMed, Medline, Cochrane Library and Embase,
as institutional databases. English publications
between 2020 and mid-2025 were screened
utilising predefined inclusion and exclusion
criteria. The Critical Appraisal Skills Programme
(CASP) framework was used to critically appraise
the peer-reviewed articles. Data were synthesised
thematically with arising patterns grouped into
their own main themes and sub-themes.RESULTS: Dominant themes that occurred were prescriber
confidence, patient refusal, time constraints, and
lack of overt guidelines as key barriers. Enablers
such as multidisciplinary collaboration, use of
evidence-based deprescribing tools (e.g. STOPP/
START, Beers Criteria), and patient engagement
were reported across all settings. Implementation
strategies varied between settings but the
majority contained important pharmacist
interventions, education programmes, and
formal implementation protocols.CONCLUSION: Deprescribing within primary care can be done
and is necessary but requires multi-faceted
interventions targeting individual prescribers,
systems, and patients. To enhance uptake
and sustainment, deprescribing has to be
incorporated into routine care in combination
with training, decision aids, and policy-level
promotion.peer-reviewe
Offshore renewable energies : exploring floating modular energy islands : materials, construction technologies, and life cycle assessment
No full textFloating modular energy islands (FMEIs) are modular, interconnected floating structures designed to collectively produce,
store, convert, and transport renewable energy. This review aims to establish a foundation for developing innovative approaches
to sustainably harness multi-energy sources in offshore environments. It leverages existing technological expertise while
exploring new solutions to address specific challenges associated with FMEIs. The review initially presents existing technologies for floating energy structures and assesses their applicability to FMEI. The structural materials that could be utilised for
the construction of a floating energy island are subsequently reviewed. Next, the offshore construction technologies suitable
for FMEI are reviewed. Finally, studies on the life cycle assessment of hybrid energy systems are examined, highlighting the
environmental advantages of integrating multiple renewable energy sources, thereby underscoring the potential of FMEIs.peer-reviewe
More is not always better : delta-downscaling climate model outputs from 30 to 5 min resolution has minimal impact on coherence with Late Quaternary proxies
No full textBoth proxies and models provide key resources
to explore how palaeoenvironmental changes may have impacted diverse biotic communities and cultural processes.
While proxies are thought to provide the “gold standard”
in reconstructing the local environment, they only provide
point estimates for a limited number of locations. On the
other hand, models have the potential to afford more extensive and standardized geographic coverage of multiple bioclimatic variables. A key decision when using model output is the appropriate geographic resolution to adopt; models are coarse scale, in the order of several arc degrees, and
so their outputs are usually downscaled to a higher resolution. Most publicly available model time series have been
downscaled to 30 or 60 arcmin, but it is unclear whether such
resolution is sufficient for certain applications like species
distribution models or whether this may homogenize environments and mask the spatial variability that is often the
primary subject of analysis. Here, we explore the impact
of increasing the resolution of model output from 30 to
5 arcmin using the delta-downscaling method, which interpolates and applies the long-term difference between past
and present model datasets to a higher-resolution grid of observed present-day climate. We seek to determine to what
extent further downscaling captures climatic trends at the site
level through direct comparison with proxy reconstructions,
evaluating different versions of the output from the HadCM3
Global Circulation model for annual temperature, mean temperature of July, and annual precipitation against a large empirical dataset of pollen-based reconstructions from across
the Northern Hemisphere. Our results demonstrate that models tend to provide broadly similar accounts of past climate
to that obtained from proxy reconstructions, with coherence
tending to decline with age and at higher altitudes. However,
our results imply that using the delta method to downscale to
a very fine resolution has a minimal net effect on the coherence of model output with pollen records in most cases. Optimal spatial resolution is therefore likely to be highly dependent on specific research contexts and questions, with careful
consideration required regarding the trade-off between highlighting local-scale variations and increasing potential error
via unreliable interpolation.peer-reviewe
Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5
No full textThe aryl hydrocarbon receptor interacting protein (AIP) is a cytoplasmic molecular co-chaperone and tumour suppressor that assists in protein stability and complex formation involving the aryl hydrocarbon receptor. Germline mutations in the AIP gene predispose to pituitary tumourigenesis with patients exhibiting an aggressive clinical phenotype. Full length AIP proteins harbouring N-domain mutations (R9Q, R16H, V49 M and K103R) were purified from E.coli utilizing a methodology that maintained structural integrity and monomeric stability. Mutations did not significantly affect the thermal stability of the protein and caused no overall disruptive effect in the protein structure. The mutations studied lowered the binding affinity of AIP towards two of its binding partners; heat shock protein 90β and phosphodiesterase 4A5 (PDE4A5). The inhibition of phosphodiesterase activity by AIP was also greatly reduced by all mutants. While previously published data has mainly concentrated on the tetratricopeptide repeats of the C-domain of AIP, we present clear evidence that AIP N-domain mutations play a significant role in two protein:protein interactions with partner proteins. The complex interactome of AIP suggests that any observable change in one or more of its binding partners cannot be disregarded as it may have repercussions on other biochemical pathways.peer-reviewe