Traektoria Nauki
Not a member yet
1424 research outputs found
Sort by
Genetic and Epigenetic Profiling of Embryos in Assisted Reproduction Technologies
Full text linkPreimplantation genetic testing improves assisted reproductive technology outcomes in high-resource settings, yet implementation in genetically diverse African populations remains virtually absent despite elevated genetic disease burden. This study aimed to characterise the genetic and epigenetic profiles of embryos from Nigerian couples undergoing assisted reproductive technology and assess clinical outcomes following genetic selection. We conducted a prospective, multicentre study across 30 fertility clinics in Nigeria's six geopolitical zones between January 2023 and June 2024, enrolling 246 couples and yielding 1,248 embryos for comprehensive genetic analysis. Embryos underwent next-generation sequencing for chromosomal assessment, targeted testing for monogenic disorders, and epigenetic profiling using bisulfite sequencing and chromatin immunoprecipitation. Statistical analysis employed generalised linear mixed models with random intercepts for clinic clustering using R version 4.3.0. Overall, the aneuploidy rate was 48.6% (95% CI: 45.8-51.4%), increasing from 35.4% in women under 35 years to 78.2% in those over 40 years. Single euploid embryo transfers achieved significantly higher implantation rates than morphology-selected transfers: 42.8% versus 26.3% (OR = 2.09, 95% CI: 1.47-2.97, p < 0.001). Preimplantation genetic testing for sickle cell disease demonstrated a diagnostic accuracy of 98.2%. Nigerian embryos exhibited 1,203 differentially methylated regions compared to European populations and 3-fold greater mitochondrial haplogroup diversity. Genetic embryo selection substantially improves Nigerian assisted reproductive technology outcomes but requires population-specific protocols rather than direct application of international standards
Role of Computational Biology Models in Dermatoglyphics And Forensic Anatomy: A Review
Full text linkAutomated fingerprint systems are very accurate with clear prints, but they do not work well with damaged or unclear evidence. This review assessed how well computational biology models perform in fingerprint analysis compared to manual methods. We searched five databases from 2018 to 2024, following PRISMA guidelines. We included 33 studies using machine learning for fingerprints, with data from 169 forensic examiners and 744 fingerprint pairs from real cases. We measured accuracy, false-negative rates, and group differences using meta-analysis in R. Computational models achieved 99.6% accuracy on clear prints, while manual checks achieved 92%. Both methods had a 7.5% false negative rate. 85% of examiners made at least one mistake, and algorithms worked 15–25% worse for less-represented groups. Deep learning achieved better fingerprint recognition but struggled with poor-quality prints. Computational biology models are best with clear evidence, but real forensic work still needs both algorithms and human experts
A Study of the Incorporation of Artificial Intelligence in Language Learning
Full text linkThis paper explains how artificial intelligence (AI) can transform language learning by examining its uses, advantages, and limitations. Focusing on recent empirical research in the area of investigation, the study examines the effects of intelligent tutoring systems, natural language processing, automated feedback platforms, and chatbots, all enabled by AI, to foster learner engagement, learner autonomy, and skills development. The results indicate that AI supports individualised, responsive teaching, allowing any student to learn at their own pace and correct mistakes in real time. Nevertheless, issues such as algorithmic bias, overreliance, and accessibility remain. The resulting research paper demonstrates that although the concept of AI, in general, shows maximum potential, its use needs to be normalised with humanness and its ethical implications in language teaching to ensure it is inclusive and prosperous
Analysis of Forehand Smash Angles in Badminton Athletes in Banda Aceh City
Full text linkAlong with advances in sports science and motion analysis technology, it is expected that coaches and athletes can improve the quality of their game through a more measurable and research-based approach. In badminton, the forehand smash technique is one of the main ways to attack and gain points. Therefore, it is very important to understand how the angle of the stroke can affect both the accuracy and speed of the smash. This study aims to analyze the effect of forehand smash angle on the accuracy and speed of shots of badminton athletes. The method used in this study is descriptive quantitative. The population studied included athletes from two badminton clubs in Banda Aceh City, namely PB Pasha Jaya and PB Bullodzher, with a total sampling technique. In this study, the sample consisted of 10 athletes from both clubs in Banda Aceh City selected by the total sampling method. Data was collected through video recordings of smash movements from various angles and analyzed using Kinovea software. The findings from the study showed that the most effective angle for forehand smashes, which produces the best balance between speed and accuracy, lies between 70° to 78°. Within this angle range, the shuttlecock generally has a steep downward trajectory and falls in strategic areas, especially in targets 1 and 2 which are the opponent's back right and left regions. An angle of 78.48° was recorded as the most accurate for target 1, while 70.03° for target 2. The average speed measured in this angle range ranged from 103 km/h to 123 km/h, showing effectiveness at high levels of play. The characteristics of these angles allow for shots that dive sharply, are difficult to return, and are precisely aimed. The results of this study emphasize that smash success depends not only on physical strength, but also on the ability to adjust the angle of attack, proper timing, and strategic shuttlecock placement. Thus, the combination of biomechanical techniques, angle mastery, and good decision-making are important factors to create powerful, fast, and accurate forehand smashes
Legal Protection Of Sasak Geguritan As An Expression Of Traditional Culture
Full text linkFor Indonesians, intellectual property, especially traditional songs, is a common heritage within the Indonesian community and always carries the value of togetherness. The Indonesian government protects traditional songs as expressions of traditional culture through Law No. 28 of 2014 on copyright. To this end, the paper will explain how lawmakers provided legal protection for Ekspresi Budaya Tradisional before and after the Copyright Act came into effect. This study employs the normative method of analysing the obtained legal materials. The protection of Ekspresi Budaya Tradisional in Indonesia under Law No. 28 of 2014 aims to prevent monopolistic practices or commercialisation and to avoid the destruction or commercial use of Ekspresi Budaya Tradisional without the State's consent as the Copyright Holder. However, despite this government effort, many aspects of protection periods still need improvement and do not comply with international conventions or regulations ratified in Indonesia
Система роботи з естетичного виховання дітей старшого дошкільного віку в умовах закладу дошкільної освіти
Full text linkThe article highlights the characteristics of the system of aesthetic education of older preschool children in preschool educational institutions. It outlines the leading approaches and trends in contemporary scientific research on aesthetic education for preschool children. The concept of "aesthetic education" is revealed in the scientific and pedagogical literature. Proposed are conditions for implementing the system of aesthetic education for older preschool children in preschool educational institutions. It is concluded that the effectiveness of aesthetic education is ensured by the holistic organisation of the educational process, the creation of an aesthetically rich subject-spatial environment, active interaction between teachers and parents, as well as taking into account the individual characteristics of each child, which contributes to the development of their artistic taste, emotional sensitivity, and ability for creative self-expression.У статті висвітлено характеристику системи роботи з естетичного виховання дітей старшого дошкільного вікув умовах закладу дошкільної освіти. Окреслено провідні підходи та тенденції сучасних наукових досліджень, присвячених проблемі естетичного виховання дітей дошкільного віку. Розкрито поняття «естетичне виховання» в науково-педагогічній літературі. Запропоновано умови для реалізації системи роботи з естетичного виховання дітей старшого дошкільного вікув умовах закладу дошкільної освіти. Зроблено висновок про те, що ефективність естетичного виховання забезпечується цілісною організацією освітнього процесу, створенням естетично насиченого предметно-просторового середовища, активною взаємодією педагогів і батьків, а також урахуванням індивідуальних особливостей кожної дитини, що сприяє розвитку її художнього смаку, емоційної чутливості та здатності до творчого самовираження
Implementation of the Rice Supply and Food Price Stabilisation Policy (SPHP) in Balikpapan City, Indonesia
Full text linkThis research aims to analyse the implementation of the food supply and price stabilisation policy through the distribution of SPHP Rice in Balikpapan City, and the inhibiting and supporting factors for its implementation. This type of research is qualitative, using descriptive methods to observe phenomena and produce descriptive data in narrative form directly. Based on research on the implementation of the food supply and price stabilisation policy through the distribution of SPHP rice, the study concludes that the policy addresses communication challenges, particularly in conveying information to shop employees and the general public, despite authorities' use of various socialisation methods. Competent human resources and adequate equipment support the implementation of this policy, though budget constraints, especially in the transportation sector, pose obstacles. The actors demonstrate a strong commitment to implementing the program and are active in outreach, monitoring, and law enforcement. A straightforward and well-coordinated bureaucratic structure, supported by inter-agency collaboration, ensures the program runs smoothly. To increase policy effectiveness, improvements in reporting mechanisms, more efficient resource allocation, and increased awareness and compliance with policies are needed
Ethnolinguistic Features of Words Denoting Colours in Azerbaijani Proverbs and Sayings
Full text linkВ статье анализируются этнолингвистические особенности употребления цветообозначений в азербайджанских пословицах и поговорках. Автор рассматривает символику цветов, их когнитивные и эмоциональные функции, а также их роль в создании культурного кода азербайджанского народа. В исследовании подчеркивается, что цветообозначения являются не только частью языковой картины мира, но и важным элементом народного творчества, отражающего философию и традиции народа. Особое внимание уделено семантическому анализу основных цветов, таких как белый, черный, красный и желтый, их символическому значению в культурном контексте. Работа вносит вклад в понимание роли цвета в языковой картине мира, а также в сохранение и популяризацию богатого фольклорного наследия Азербайджана.The article analyses the ethnolinguistic features of using colour denotations in Azerbaijani proverbs and sayings. The author considers the symbolism of colours, their cognitive and emotional functions, and their role in creating the cultural code of the Azerbaijani people. The study stresses that colour symbols are not only a part of the linguistic picture of the world but also an important element of folk art, reflecting the philosophy and traditions of the people. Special attention is paid to the semantic analysis of basic colours such as white, black, red and yellow and their symbolic meaning in the cultural context. The work contributes to the understanding of the role of colour in the linguistic picture of the world and the preservation and promotion of Azerbaijan's rich folklore heritage
Addressing the Root Causes of Plagiarism: Strategies For Promoting Originality and Critical Thinking in Student Writing at Tertiary Institutions
Full text linkPlagiarism is a common problem in institutions of higher learning and defeats the very purpose of higher education, which is to develop critical thinking and enhance intellectual integrity. The study aims to explore the various causes of plagiarism and strategies for promoting originality and critical thinking among students in tertiary institutions. The study evaluates different types of plagiarism, including accidental, self-plagiarism, and intentional plagiarism, while identifying the root causes among students, such as family pressure, lack of self-control, poor attitude towards learning, poor time management, and inappropriate usage of digital resources or technology. The research also indicated that addressing and mitigating all these factors requires a dynamic approach, utilising plagiarism detection tools, educating students on the importance of academic integrity, and creating awareness of plagiarism as an unethical academic practice. The paper also emphasises the need for originality and critical thinking through active learning, peer collaboration, and continuous assessment. By encouraging students to use original content and actively develop their thoughts, institutions can reduce the rate of plagiarism. In conclusion, institutions must create an environment that fosters originality and critical thinking in writing
Bioprinting: 3D Printing of Tissues and Organs, Role in Bio Modelling and Medical Research
Full text linkThis research investigates the capabilities and applications of bioprinting technology in tissue engineering and medical research through a comprehensive analysis of various printing methods and outcomes. The study examined data from 30 research facilities implementing different bioprinting technologies, including extrusion-based, inkjet-based, and laser-assisted systems. Statistical analysis revealed strong correlations between printing parameters and tissue outcomes, with significant relationships between printing speed and structural integrity (r = 0.78, p < 0.001) and material viscosity and cell viability (r = 0.82, p < 0.001). Extrusion-based systems achieved printing speeds of 10-15 mm/s while maintaining cell viability rates of 80-90%, whereas laser-assisted systems demonstrated superior precision with resolution down to 10 micrometres. Tissue models showed varying success rates, with skin constructs achieving 85% appropriate structural organisation and cartilage models demonstrating mechanical properties reaching 60-80% of native tissue values. Implementing bioprinting technology reduced drug screening timelines by 40% while achieving 85% accuracy in predicting adverse reactions. These findings demonstrate significant potential for bioprinting applications in medical research, particularly in drug development and tissue engineering, while highlighting critical areas requiring further development, especially in vascularisation strategies for larger tissue constructs