2671 research outputs found
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Reproduction Package for "A food system transformation can enhance global health, environmental conditions and social inclusion"
No full textA reproduction package for "A food system transformation can enhance global health, environmental conditions and social inclusion" that contains the MAgPIE model version used in the article, required input data, and the latest raw model results. For details see BodirskyEtAl_2025_FSDP-reproduction-package.tar.xz/README.md (replicated next to the archive file). Extracted archive requires 170 GB of storage
Rapid Assessment of Avoidable Blindness Report: Qatar (2023)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimates
ecthomson/Contamination-Phylogeny
No full textThis script is designed to automate the process of analyzing viral genomic data, focusing on identifying cross-contamination events and constructing phylogenetic trees. It integrates sorting, filtering, and phylogenetic analysis tools
ahyoung-lim/Arbo_riskmaps_public
No full textRepository contains data, scripts, and key outputs from "The overlapping global distribution of dengue, chikungunya, Zika, and yellow fever"
lucy-gf/flu_model_LG
No full textData and code for "The potential global health impact and cost-effectiveness of next-generation influenza vaccines: A modelling analysis"
Maternal and perinatal outcomes of Somali migrant women in comparison to host populations in the Global North: a systematic review and meta-analysis
No full textData and supporting files for "Maternal and perinatal outcomes of Somali migrant women in comparison to host populations in the Global North: a systematic review and meta-analysis"
opensafely/post-covid-kidney-outcomes
No full textThis is the code and configuration for our research: "Long-term kidney outcomes after SARS-CoV-2 infection
Robinah23/Community-Vaccine-Impact-Vulnerability-Index-
No full textData and R code associated with the Community Vaccine Impact Vulnerability Index (CVIVI) analysis outlined in "Mapping Community Vulnerability to reduced Vaccine Impact in Uganda and Kenya: A spatial Data-driven Approach". This integrates data on multiple risk factors associated with reduced vaccine impact to identify communities at risk, and key drivers of vulnerability
Rapid Assessment of Avoidable Blindness Report: Zambia, Copperbelt (2022)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimates
Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations
No full textBackground: Glycated hemoglobin (HbA1c) measures the average blood sugar level over the past three months. As a vital biomarker of blood glucose levels, it is used to diagnose Type-2 diabetes mellitus (T2D) and monitor glycemic control. A heritability estimate of 47% to 59% suggests that about half of the variation in HbA1c levels can be attributed to genetic factors. Despite African populations being the most genetically diverse and unique for fine-mapping, there is a paucity of data on the genetic drivers of HbA1c in African individuals. In this study, we performed functional annotation and a Phenome-Wide Association Study (PheWAS) of HbA1c-associated variants in two African populations.
Method: In this study, we utilized summary statistics of the HbA1c GWAS meta-analysis of 7,526 individuals from South Africa and Uganda to conduct a PheWAS using GWASATLAS. We also performed a functional analysis using the functional mapping and annotation (FUMA) tool. Single nucleotide polymorphisms (SNPs) were prioritized using the SNP2GENE function, while the gene expression patterns and shared molecular functions were explored in the GENE2FUNC.
Result: Three genome-wide significant loci were identified with the lead SNPs: rs6724428, rs148228241, and rs8045544 – mapped to GULP1 , HBA1 , and ITFG3 genes, respectively. The minor allele frequencies of rs148228241 (0.07) and rs8045544 (0.19) are rare or non-existent in non-African populations. Both rs8045544 and rs148228241 are significantly associated with the mean corpuscular hemoglobin concentration (MCHC). A lower MCHC is associated with alpha thalassaemia, resulting from deletions in HBA1 and HBA2 genes. Such deletions are prevalent in malaria-endemic regions of Africa due to their selective survival advantage. The rs6724428 variant is associated with skeletal functions, reflecting the link between glucose metabolism and bone mineral density.
Discussion: Our findings highlight the interplay between glucose metabolism, erythropoiesis, and skeletal health. The significant associations of HbA1c-variants with both skeletal function and MCHC underscore the potential of these variants to impact broader physiological processes. A large-scale study of African individuals will be essential to unravel genetic variants influencing HbA1c