2671 research outputs found
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Generating opposition to universal health care policies in the United States: an analysis of private health industry advertising on Meta platforms
No full textCampaign advertising media dataset for "Generating opposition to universal health care policies in the United States: an analysis of private health industry advertising on Meta platforms" (Chow, et al.)
Wastewater surveillance overcomes socio-economic limitations of laboratory-based surveillance when monitoring disease transmission: the South African experience during the COVID-19 pandemic
No full textThis data was used to complete data analysis for the manuscript "Wastewater surveillance overcomes socio-economic limitations of laboratory-based surveillance when monitoring disease transmission: the South African experience during the COVID-19 pandemic". The data includes aggregated laboratory case data and wastewater data for two serwersheds in South Africa. Representative socio-economic data from a Quality of life survey was used, and details on sampling can be found at www.gcro.ac.za
Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1
No full textNew antimalarials are needed due to the threat of emerging resistance against existing antimalarial therapies. A phenotypic screen uncovered the N-aryl acetamide class that inhibits the development of P. falciparum asexual ring-stage parasites. The structure–activity relationship of this class was investigated, and key modifications were introduced that produced WEHI-326 with potent antimalarial activity. Enhancing the metabolic stability of this class will be a future challenge to achieve efficacy in a malaria mouse model. WEHI-326 was found to have a moderate barrier to resistance and a moderate rate of asexual kill, potently inhibited gametocyte and gamete development, and in turn, blocked the transmission of parasites to the mosquito. Forward genetics and cross-resistance profiling determined that parasites resistant to N-aryl acetamides had mutations in rhomboid protease 8 (ROM8) and the putative cation channel, CSC1. WEHI-326 will be an important tool in unraveling the role of ROM8 and CSC1 in P. falciparum development
Replication Data for: The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi
No full textThis is a replication dataset for the manuscript titled: "The impact of introducing the RTS,S/AS01E malaria vaccine delivered through routine immunization programmes on mortality in young children: 46-month evaluation of cluster-randomized deployment of the vaccine in Ghana, Kenya and Malawi.
Validation of algorithms identifying diagnosed Obstructive Sleep Apnoea and narcolepsy in coded primary care and linked hospital activity data in England
No full textData management scripts for study validating algorithms identifying diagnosed Obstructive Sleep Apnoea and narcolepsy in coded primary care and linked hospital activity data in Englan
Occupation, violence, and displacement in the West Bank
No full textIsraeli settlement expansion in the West Bank has intensified violence in the occupied Palestinian territories (oPt). This violence escalated after attacks by Hamas on Israel on 7 October 2023 and the subsequent military campaign in Gaza. This study examines the possible impacts of military and land occupation on displacement, injuries, and deaths in the West Bank. This cross-sectional observational study analyses casualties and displacement data in the West Bank and Israel from May 1, 2014, to June 30, 2024. Sources include the United Nations Office of Coordination of Humanitarian Affairs, Statista, and the Palestinian Central Bureau of Statistics. Death and injury rates per 100,000 person-years were calculated and compared across populations. Interrupted time-series analysis compared observed Palestinian deaths, injuries, and displacement to expected levels since October 2023. Chi-square analysis examined demolition patterns by West Bank area. GIS mapping methods visualized spatial variations in casualties and demolitions. Death and injury rates were substantially higher for Palestinians than Israelis: RR=5.72 (95% CI 2.38, 13.75; p <0.001) for deaths and RR=16.47 (6.86, 39.56; p<0.001) for injuries. Refugee camps had increased death rates: IRR = 7.91 (5.26, 11.89; p < 0.0001) compared to non-refugee camp populations. Since October 2023, West Bank deaths were 25% higher than expected: RR = 1.25 (1.15, 1.36; p < 0.0001) and displacement 17% higher: RR = 1.17 (1.12, 1.21; p < 0.0001). Nablus and Jenin recorded the highest fatalities. Jabal al-Mukkabir in East Jerusalem experienced the highest number of demolitions. Our study confirms a significant disparity in rates of conflict-related traumatic injuries and deaths between Palestinians and Israelis. The findings emphasize the need to limit military force against civilians, to hold the Israeli government accountable for demolitions and displacement, and to instigate protective measures in refugee communities. Policy efforts should prioritize conflict de-escalation, including reaching a sustainable political solution
Machine learning-based equations for improved body composition estimation in Indian adults
No full textSupporting files for “Machine learning-based equations for improved body composition estimation in Indian adults”. This includes: (S1) a list of data quality rules applied for inclusion in the study; (S2) performance metrics (compared with DXA-based measurement) for different prediction algorithms using all predictors in training data; (S3) Performance metrics (compared with DXA-based measurement) for different prediction algorithms using all predictors in test data, overall and stratified by age (<40 years test n = 122 female and 185 male, 40 + years test n = 167 female and 133 male); (S4) Performance metrics (compared with DXA-based measurement) for different prediction algorithms using all predictors in test data, based on 25 datasets where the DXA-based outcomes were randomly permuted (to provide a null or baseline scenario to compare against performance on the real data); (S5) Performance (Mean Absolute Error) of the LASSO with alternate sets of predictors; (S6) Coefficients for each outcome in full model; (S7) Information about model performance for other outcomes (trunk fat mass (kg), trunk lean mass (kg), L1-L4 fat mass (kg), L1-L4 lean mass (kg), appendicular fat mass (kg), and appendicular fat mass percentage (%)); and (S8) Minimum, 1st percentile, 99th percentile, and maximum of each predictor in the training data
Baselines_Application_Data
No full textThis repository contains code and data processing scripts for the paper "Mind the Baseline: The Hidden Impact of Reference Model Selection on Forecast Assessment"
A cluster-randomized trial of interventions for adolescent mental disorders in Zimbabwe
No full textYoung people have low uptake of mental health. We compared two task-shifted mental health care models, i.e., adult Friendship Bench (FB) delivered by community health workers and Youth Friendship Bench (YouFB) delivered by trained university students in Harare, Zimbabwe. We hypothesised that the peer-delivered YouFB would have greater uptake and effectiveness in managing common mental disorders (CMDs) in 16–19-year-olds compared to the standard FB model. We also aimed to evaluate the reach, fidelity, acceptability and cost of the YouFB compared to standard FB
Projections of heat related mortality under combined climate and socioeconomic adaptation scenarios for England and Wales
No full textThis study projects heat-related mortality in England and Wales at Government region level under combined climate and socioeconomic scenarios, focusing on the implications of different pathways on adaptive capacity and resilience. Using UK specific climate projections and socioeconomic narratives, and employing a timeseries regression analysis we estimated the impacts of consistent pairs of Representative Concentration Pathways (RCPs) and Shared Socioeconomic Pathways (SSPs) on future heat-related health burdens. Our findings indicate significant increases in heat-related mortality under high emissions scenarios, with the highest burden observed in the RCP8.5-SSP5 scenario (2050s: 10,317, 2060s: 19,478, 2070s: 34,027), due to combined high temperatures and population growth and ageing in this scenario. Conversely, the lowest burden is seen under RCP2.6-SSP1 (2050s: 3,007, 2060s: 4,004, 2070s: 4,592), reflecting effective adaptation and lower warming levels. These values represent an increases from a baseline of 634 annual heat related deaths (1981–2021). The contribution of individual drivers, regional variations and the impact of potential power outages during heatwaves were also examined. These projections highlight the combined role of mitigation and adaptation, with a focus on resilience, in response to climate change and demonstrate that adaptation beyond the observed bounds will be required to limit heat related mortality to the baseline level even under low emission scenarios