2671 research outputs found
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Promoting Inclusion in Decent Work for Ugandan Young People, 2020
No full textThere is little empirical evidence either globally or in Uganda on how experiences of violence in childhood and adolescence affect a) participation in skills programmes, entry into work, and decent employment; and b) about the extent and nature of physical, sexual and emotional violence experienced by young people in their workplaces. The qualitative component of this study examines people's experiences of being recruited into skills and employment programmes in Uganda, how programme recruitment mechanisms might in the exclusion of vulnerable young people, particularly those experiencing violence and/or child labour, and young people's views on the provision of violence prevention strategies within skills training programmes. The qualitative data collected as part of this study comprises of transcripts from four focus group discussions (FGDs) and 24 in-depth interviews (IDIs) with adolescents who either have or have not participated in skills training, and 18 key informant interviews (KIIs)
Diverse and weakly immunogenic var gene expression facilitates malaria infection
No full textPlasmodium falciparum is believed to escape immunity via antigenic variation, mediated in part by 60 var genes. These genes undergo mutually exclusive expression and encode the PfEMP1 surface antigen. The frequency of var switching and the immunogenicity of each expressed PfEMP1 remain unclear. To this end, we carried out a Controlled Human Malaria Infection (CHMI) study with 19 adult African volunteers in The Gambia to gain insight into the effect of naturally acquired immunity on the expressed var gene repertoire during early phase of an infection. Our findings demonstrated a strong correlation between the diversity of var expression, quantified through entropy, and infection outcome. Low-immunity individuals were characterised by high var entropy profiles, higher parasitaemia, and lower sero-recognised PfEMP1 domains compared to high-immunity individuals. For the first time we recorded the probability of var gene switching in vitro and of turnover in vivo, enabling us to estimate both intrinsic switching and negative-selection effects. These processes are rapid, resulting in estimated turnover/switching probabilities of 69% - 97% and 7% - 57% per generation, in vivo and in vitro, respectively. Var (PfEMP1) expression triggered time-dependent humoral immune responses in low immunity individuals, with many PfEMP1 domains remaining weakly immunogenic. We conclude that the role of intrinsic var switching is to reset and maintain a diverse var repertoire. The high var switching rates and weak PfEMP1 immunogenicity benefit parasite survival during the CHMI
Population size, HIV prevalence, and antiretroviral therapy coverage among key populations in sub-Saharan Africa: collation and synthesis of survey data 2010-2023
No full textThis dataset contains surveillance study estimates for population size, HIV prevalence, and ART coverage among female sex workers (FSW), men who have sex with men (MSM), people who inject drugs (PWID), and transgender men and women (TGM/W) from 2010-2023. It was created to support the UNAIDS Estimates Key Population Workbook for use by HIV estimates teams in sub-Saharan Africa. Key population surveillance reports, including Ministry of Health-led biobehavioural surveys, mapping studies, and academic studies were used to populate the database
Proteins identified from pull down experiments of WT, PKG_GFP, PKG_T695A and PKG_T695E
No full textDataset showing the proteins identified from pull down experiments of WT, PKG_GFP, PKG_T695A and PKG_T695E
Dataset: NECTAR3 Randomized Controlled Trial
No full textNECTAR3 is a four-arm trial comparing artemether-lumefantrine with or without single-dose primaquine and sulphadoxine-pyrimethamine/amodiaquine with or without single-dose tafenoquine to reduce P. falciparum transmission in Mali
Rapid Assessment of Avoidable Blindness Report: Peru (2011)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimate
Rapid Assessment of Avoidable Blindness Report: Saudi Arabia, Makkah, Al Taif (2011)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimate
Rapid Assessment of Avoidable Blindness Report: Vietnam, Quang Nam (2012)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimate
Rapid Assessment of Avoidable Blindness Report: Mongolia (2013)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimate
Rapid Assessment of Avoidable Blindness Report: Indonesia, West Java (2014)
No full textA report including output of standardised analysis of vision and eye health survey data including tables of vision impairment prevalence and service coverage estimate