2671 research outputs found
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klebgenomics/KlebNNSsero
No full textThis repository includes data and code from the paper: "Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage" (Stanton et al, 2025)
Extended Data: Exploring mother’s and grandmother’s perceptions of animal-source complementary foods in the diets of young children in The Gambia: A qualitative study
No full textSupporting document for: "Exploring mothers' and grandmothers' perceptions of animal-source complementary foods in the diets of young children in The Gambia: A qualitative study". This includes the
focus group discussion guide, demographic questionnaire, participant information sheet, and participant informed consent form
Exploring interrelationships between structural, social, and biological determinants of vaccine impact in Kenya and Uganda: VAnguard community mixed methods study protocol
No full textThis study explores why vaccines may not work well in some communities in Uganda and Kenya. The study will involve interviews, surveys, and laboratory tests on blood and stool samples from 1,032 participants across selected communities in both countries. Resources include: a study main questionnaire (child and adult), interview guides, and participant information and consent forms
mixmeta: An Extended Mixed-Effects Framework for Meta-Analysis
No full textA collection of functions to perform various meta-analytical models through a unified mixed-effects framework, including standard univariate fixed and random-effects meta-analysis and meta-regression, and non-standard extensions such as multivariate, multilevel, longitudinal, and dose-response models
Databases and R code used for the analysis (trial registration project)
No full textA set of files produced to support a trial registration project. This includes a database of variables associated with improper trial registration, database of registration deficiencies and publication status, database of authors' claims of proper registration at submission, and R code for statistical analysis
Replication Data for: Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults
No full textThis is a replication dataset for the manuscript titled: "Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults.
Maternal Bonding
No full textData collected as part of the 'Supportive and Dignified Maternity Care (SDMC) - development and feasibility assessment of an intervention package for public health systems' study. Women were recruited at health facilities after childbirth. Information regarding maternal bonding was collected at 42 days postpartum
Reconnect social contact data
No full textSocial contact data for the UK from the Reconnect social contact survey, a comprehensive study designed to understand patterns of social interactions across different age groups and settings in the United Kingdom
Investigating microbial population structure and function in the chicken caeca and large intestine over time using metagenomics
No full textAlthough taxonomic variations in chicken gut microbiota have been previously documented, their functional capacity remain poorly understood. To gain a better understanding, we incorporated whole genome shotgun metagenomics to analyse microbial communities of two different organs: the caeca and the large intestine. Results Using 24 samples obtained from the caeca and the large intestine of commercial chickens, we assembled Metagenome-Assembled Genomes (MAGs) and characterise their functional profiles. Afterwards, using 8 samples, we integrated this sequencing data with chicken performance metadata body weight (BW), weight gain, feed intake (FI), feed conversion ratio (FCR) and age. MAGs belonging to specific families were found to be positively associated with changes in performance parameters. Functional analyses suggest changes in nutrient geochemical cycles including hydrogen generation within the carbon-cycle. Furthermore, 108 CAZymes were identified for MAGs belonging to two major families – glycoside hydrolase (GH) and polysaccharide lyase (PL), which are important for breakdown of dietary carbohydrates and fibres. A total of 13 polysaccharide lyases were identified functioning on day 20 with enzymes were specific to organs. Overall, our results provide a deeper understanding of microbial-mediated metabolism concerning key performance parameters in chicken production
Raw Study Data for "Association between social determinants of health and hearing loss in South African children: A secondary data analysis"
No full textGlobally, 34 million children below 15 years have hearing loss (HL) and while research shows associations between social determinants of health and disability in general, research on the associations between these determinants and HL in children is limited. Therefore, this study sought to examine the association between social determinants of health and HL in children using the parental socioeconomic status, such as educational attainment level, employment status and income level, non-medical determinants of health (rurality, housing, type of toilet, availability of piped drinking water, and exposure to cigarette smoke) as proxy factors for social determinants of health in children. This was a secondary data analysis of a cross-sectional survey conducted with 517 children in South Africa. We conducted multivariable logistic regression to test for the association between HL and exposure variables such as non-medical determinants of health and parental socioeconomic status using Stata v18 for Macintosh. Odds ratios (OR) with 95% confidence intervals (CIs) were used to ascertain the odds of HL with exposure variables. One hundred and two participants (n = 102, 19.7%) had HL, including 57 (55.9%) females. Crude analysis showed increased odds of HL in females (OR:1.6; 95%CI: 1.0 – 2.5, P = 0.03 ) and children younger than9 years (OR: 2.0; 95%CI: 1.3 – 3.1, P = 0.003 ). After adjusting for age and sex, exposure to cigarette smoke (aOR: 4.0; 95%CI:2.4 – 6.4, P < 0.001 ), living in a mud house (aOR: 1.6; 95%CI:1.2 – 2.7, P = 0.04 ), lack of piped drinking water (aOR: 1.9; 95%CI:1.1 – 3.1, P < 0.02 ), using pit latrines (aOR: 4.1; 95%CI:1.3 – 13.0, P = 0.01 ), having parents who (i) did not complete high school (aOR: 2.8; 95%CI:1.4 – 2.4, P = 0.01 ), or those earning a combined annual household income (iii) less than 2,883 and $8,006 (aOR:5.0; 95%CI:2.5 – 43.5, P = 0.05 ) increased the odds of HL. Based on these findings, we recommend public health interventions targeting these social determinants to reduce the global burden of HL, and further research to understand the pathophysiology of HL in those exposed to smoking or using pit latrines