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Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
Get PDFSrc基因是哺乳动物中发现的第一个原癌基因，其编码的蛋白是一个酪氨酸激酶，在促进乳腺癌、肺癌等诸多肿瘤的发生、进展和恶化中起着重要的作用。在研究中，研究团队发现Src能够承接生长因子和肥胖微环境相关的因子如胰岛素和瘦素的信号，通过直接磷酸化lipin-1，增强其催化合成甘油脂的活性，提高细胞摄入的脂肪酸向甘油脂尤其是磷脂转化。进一步实验表明，Src磷酸化lipin-1能够加速乳腺癌细胞生长，促进小鼠模型中肿瘤的进展和转移。这项研究不但做出了对脂肪合成途径的调控机制的又一重要发现，还揭示了原癌基因Src可以承接癌细胞内外的活化信号，通过lipin-1为媒介重塑癌细胞脂代谢，使得肿瘤细胞具有增殖和转移的优势。该论文揭示了臭名昭著的原癌基因Src通过直接结合并磷酸化lipin-1（一种磷脂酸磷酸化酶，在脂质代谢中具有重要作用），以增强其酶活性，从而加速甘油酯的合成速率，进而促进乳腺癌的发生发展。
该研究由厦门大学生命科学学院、广州医科大学第五附属医院、第四军医大学西京医院和中山大学孙逸仙纪念医院等单位合作完成，厦门大学生命科学学院博士后宋林涛和广州医科大学第五附属医院刘志华教授为该论文的共同第一作者。【Abstract】Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct substrate of the Src proto-oncogenic tyrosine kinase. Obesity-associated microenvironmental factors and other Src-activating growth factors, including the epidermal growth factor, activate Src and promote Src-mediated lipin-1 phosphorylation on Tyr398, Tyr413 and Tyr795 residues. The tyrosine phosphorylation of lipin-1 markedly increases its PAP activity, accelerating the synthesis of glycerophospholipids and triglyceride. Alteration of the three tyrosine residues to phenylalanine (3YF-lipin-1) disables lipin-1 from mediating Src-enhanced glycerolipid synthesis, cell proliferation and xenograft growth. Re-expression of 3YF-lipin-1 in PyVT;Lpin1−/− mice fails to promote progression and metastasis of mammary tumours. Human breast tumours exhibit increased p-Tyr-lipin-1 levels compared to the adjacent tissues. Importantly, statistical analyses show that levels of p-Tyr-lipin-1 correlate with tumour sizes, lymph node metastasis, time to recurrence and survival of the patients. These results illustrate a direct lipogenesis-promoting role of the pro-oncogenic Src, providing a mechanistic link between obesity-associated mitogenic signaling and breast cancer malignancy.This work was supported by grants from the National Natural Science Foundation of China (#31822027, #31690101, #91854208, #31871168, #82002965), the Fundamental Research Funds for the Central Universities (#20720190084), Project “111” sponsored by the State Bureau of Foreign Experts and Ministry of Education of China (#BP2018017), XMU Training Programme of Innovation and Entrepreneurship for Undergraduates (#2017Y0578, #2018Y1281) and China Postdoctoral Science Foundation (#2019M652254).
该研究也得到了国家自然科学基金，中央高校基础研究项目和中国博士后科学基金等的资助
冰桶挑战邻接矩阵数据集
No full text2014年始于美国的“冰桶挑战（Ice-Bucket Challenge）”曾经风靡世界，并在中国一度引起流行。本案例以360综合搜索（www.haosou.com）的数据为基础，结合各种中文媒体有关“冰桶挑战”的报道，采集整理实证数据并构建了“冰桶挑战”在中国社会网络传播扩散的网络数据集。该案例适用于新闻与传播专业硕士的《数据分析方法》和《社会网络的传播问题研究》等课程，对社会网络分析方法尤其具有针对性。该案例的目的是让学生通过运行网络分析软件，对“冰桶挑战”作为网络宣传的扩散路径进行分析和可视化呈现
2019年机构知识库发展报告
Get PDF本报告为DRAA开放获取工作组“2019开放获取调研报告”的一部分。经过多年的发展和实践，IR建设研究无论从系统论述到理论探讨，再到实践研究，都取得了长足的进步。本报告通过文献调研、网络调查及同行工作交流，对国内IR在2019年中的发展概况作一个梳理总结。内容包括：国内外IR发展态势；IR资源利用及拓展增值服务；IR可持续发展；IR宣传推广与国际化；IR构建平台发展趋势；新技术应用
A Preliminary Study of the Persuasion Approach of Advertisements with Chinese Elements under the “Belt and Road Initiative”
No full text林升栋，中国人民大学新闻学院教授;杨祎纯，厦门大学新闻传播学院硕士研究生;JULIA TAN YIN YIN,厦门大学新闻传播学院博士研究生，马来西亚吉兰丹大学语言暨人文科学中心教师。【中文摘要】丝绸之路是以商品为载体的文化交流。“一带一路”共建坚持市场运作的原则，广告是市场运作的必要元素。中国企业走出国门，在国际市场讲述品牌故事,文化基因决定其会使用 “中国元素”。浙江吉利控股集团收购马来西亚国产车宝腾后,其广告中的中国元素和马来西亚元素都很有文化代表性,为探析“中国元素”广告的说服路径提供了一个很好的实证范本。中国元素激活美学反应，引导消费者深入了解产品，进而提升品牌态度，最终引发购买。当地元素激活民族主义情绪,唤起产品印象,直接导致购买，而后强化品牌态度。
【Abstract】The Silk Road is a kind of cultural exchange mediated by commodities. “The Belt and Road” Initiative adopted the principle of market forces’ in which advertising played an important role. Chinese enterprises enter the world market and tell the brand story to international audiences. The cultural genes determine that they use the traditional “ Chinese elements” in their ads. After Zhejiang Geely Holding Group acquires Malaysian domestic car,Proton’ authors use the advertising materials of Proton and compare the advisements of Chinese elements with those of Malaysian cultural elements’ to make a preliminary empirical exploration of the persuasion route of “Chinese elements”. Chinese elements activate the aesthetic experiences and lead consumers to learn the product information’ then improve the brand attitude’ and finally promote to purchase. Whereas’ local elements activate the nationalist feeling and arouse the product impression，then promote to purchase’ finally enhance the brand attitude.国家自然科学基金项目“东西方不同文化思维方式对广告说服的影响：一个自下而上的脉络建构与验证 ”（71372076
Memory Narration of Patrick Modiano's In the cafe of Lost Youth
No full text翁冰莹，厦门大学外文学院法语系副教授，文学博士。【中文摘要】法国作家莫迪亚诺的小说《青春咖啡馆》以庄严、伤感的情绪书写了神奇的巴黎与迷失的主题,甫一问世就备受关注。借助哈桑“后现代主义”批评视角来审视之，莫迪亚诺通过不确定的时空、不确定的身份以及不确定的叙事者的叙事策略,树立起“记忆叙事”的不确定性;亦通过找寻家、找寻生活与找寻幸福的主题设定，构筑起女主人公露姬不断探究人生价值的深刻内涵。 不仅如此，莫迪亚诺还借助“记忆叙事”策略,在面对“虚无主义”的危机之际不断超越内外、生死、 自我与他者的绝对界限，试图建构起自我乃至自我世界的宏大愿景。
【Abstract】In the cafe of Lost Youth ( Dans le cafe de la jeunesse perdue，2007)，written by the French writer Patrick Modiano，portrays a magical Paris and lost youth in a solemn and sorrowful tone and has won critical acclaims since its release.From the perspective of Hassan's “postmodernism” criticism，Modiano establishes the uncertainty of “memory narration” with uncertain time and space，uncertain identity and uncertain narrative strategy.He also constantly explores the profound value of life with the themes of searching for home，looking for life and finding happiness. With the “memory narration” approach，Modiano strives to construct a grand vision of self and even the world of self in the face of a nothingness” .In doing so，he constantly surpasses the absolute boundaries of internality and externality，life and death，self and others.
others.国家社会科学基金项目“记忆诗学视野下的莫迪亚诺小说研究”（18BWW066
Resource Misallocation,Export Intensity and Product Quality
No full text陈爱贞，厦门大学经济学院教授、博士生导师，经济学博士；闫中晓，厦门大学经济学院博士研究生。【中文摘要】产品质量水平是一国经济发展水平的重要标志。立足中国存在资源错配的现实基础,可从企业内部产品层面分析出口强度增大过程中产品结构和出口目的地结构调整对产品质量的影响机理。基于2000—2007年中国工业企业数据库和中国海关数据库匹配数据的实证检验表明，出口强度增大会抑制其产品质量提升，特别是对一般贸易、出口到中等收入国家的产品质量的抑制作用更大；基于2000—2011年数据的结果依然稳健。进一步的计量检验验证了资源错配会强化出口强度对产品质量的抑制效应；同时，出口强度增大会进一步加重企业资源错配，进而抑制产品质量提升。可见，提升资源配置效率是促进产品质量升级的关键，为此，需要促进资源在区域间、行业间、行业内企业间、企业内产品间的有效流动。
【Abstract】 Based on the reality of resource misallocation in China，this paper analyzes the influence mechanism of export intensity on product quality from the firm's level of internal products. Empirical tests based on the matching data from the China Industrial Enterprise Database and the China Customs Database from 2000 to 2007 indicate that the increase of Chinese enterprises’ export intensity inhibited the improvement of their product quality，and that for enterprises engaged in general trade and exporting to middle - income countries，the negative effect of export intensity was greater. The results using the data from 2000 to 2011 are also robust.Further metrological tests verified that resource misallocation would enhance the inhibiting effect of export intensity on product quality.At the same time，the increase of export intensity would further aggravate the resources misallocation of enterprise and thereby inhibit the improvement of product quality. It can be concluded that improving the efficiency of resource allocation is the key to promoting the upgrading of product quality.Therefore，it is necessary to promote the effective flow of resources between regions，industries，enterprises within the same industry，and products within the same enterprise.国家自然科学基金项目“并购与创新:基于中国装备制造业理论与实证研究” (71573219)；国家社会科学基金重大项目“中国产业创新发展战略研究”（15ZDC013);国家留学基金委项目资助（201806315049
Water Neighboring Relationship in China's Inherent Law and Its Modern Evolution
No full text蔡晓荣，福州大学法学院教授、博士生导师，历史学博士；马传科，福州大学法学院博士研究生，龙岩市中级人民法院二级法官。【中文摘要】在传统中国,围绕着农业灌溉中的用水、排水，以及井水取用、屋檐滴水等问题，形成了系列水相邻关系规范。其规范性内容和核心理念内蕴于国家立法、民事习惯以及相关司法裁判之中。清末以迄民国，伴随着中国近代民法法典化的初步完成，一个以继受大陆法系民法典为基 础的水相邻关系法律规范体系得以最终底定。认真分析相关文本表达，可以发现其立法旨趣与固 有法关于水相邻关系调整的核心理念，实则互为暗合。此外，近代以来的司法实践和社会实证经验，亦在相当程度上表明，固有法中的水相邻关系作为一种“内生秩序”实际上受到这种新式立法的影响甚微。以上客观事实揭示了中国近代民事法律变迁的一种可能面相，同时也促发了我们对中国近代民事立法的另类反思。
【Abstract】In traditional China，a series of water neighboring relationship norms were formed to resolve problems related to water use and drainage in agricultural irrigation，as well as the use of well water and eaves dripping water. Its normative contents and core concepts are embodied in national legislation，civil customs and relevant judicial decisions. From the end of the Qing Dynasty to the Republic of China era，with the initial completion of the codification of civil law in modern China，a textual norm of water neighboring relationship based on the civil code of the civil law system was eventually finalized. However，through careful analysis of the relevant textual expressions，we can find that the legislative will and the core idea of the inherent law regarding the adjustment of the water adjacent relationship are mutually implicit. In addition，the judicial practice and social empirical experience since modern times also indicate，to a considerable extent，that the water neighboring relationship in the inherent law as an “endogenous order” is actually little afected by this new legislation. The above objective facts reveal a possible aspect of the change of modern Chinese civil law while promoting our alternative refections on modern Chinese civil legislation.国家社会科学基金项目“中国近代民法继受视野中的固有法衍化研究”（15BFX028
The “New Language”of Lu Jia and the Slpiritual Starting Point of the Han Dynasty:On the Significance of Lu Jia as the Ancestor of Han Fu
No full text程世和，陕西师范大学文学院教授、博士生导师，文学博士；王艳丽，陕西师范大学文学院博士研究生。【中文摘要】汉初中国的国家形象卑弱无文，但陆贾心中有一个未然而将然的庄严中国。作为汉代第一儒士，陆贾以说南越王辞、说高祖辞以及《新语》与辞赋创作，表现出自铸政治与文学“新语”的能力，表现出实行大一统文化中国梦想的文化胸怀与文学才情。陆贾的时代“新语”,成为汉构筑大一统文化中国的精神起点。陆贾的文学“新语”，不仅为汉大一统文化中国找到了最有意味的文学形式,而且以“奇采”“辩之富”的闳丽之美奠定了汉大赋主体风格。一个真正意义上的中国应该既有“礼义之大”又有“文章光华”这是陆贾“新语”对后世乃至当代中国的历史启示。
【Abstract】The image of China in the early Han dynasty was humble and uncultured，but Lu Jia believed that there should be a solemn image of China，though it had not yet been realized. As the first Confucianist of the Han dynasty，Lu Jia used his persuasions to Liu Bang，the king of the Nanyue Kingdom，and New Words and Fu creation to demonstrate his ability to create political and literary “new words” ；this also showcased his cultural mind and literary talent for realizing his dream of a unified and cultural China. The “new language” of Lu Jia's era became the spiritual starting point for the Han to build a unified and cultural China. Lu Jia's literary “new language” not only found the most meaningful literary expressions for the unified and cultural China of the Han dynasty，but also established the main style of the Han Dafu with the magnificent beauty of language and “richness of debates”. A true sense of China should have both the “greatness of courtesy and righteousness” and the “richness of literature”. This is the historical implications of Lu Jia's “new language’，for later generations and even contemporary China