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MAdLandExpression: integrating sexual reproduction into the Physcomitrium patens expression atlas
No full textPhyscomitrium patens is a bryophyte model system particularly valuable for evolutionary developmental and comparative genomics studies. Sexual reproduction in bryophytes offers unique insights into the evolution of land plant reproduction. Unlike seed plants, bryophytes have a dominant gametophyte phase and provide significant advantages for studying sexual reproduction, such as the possibility to maintain embryo-lethal mutants through vegetative propagation or the presence of motile male gametes. More than 25 years after the first publications of transcriptomic data for P. patens, expression data of most developmental stages of P. patens as well as its responses to various biotic and abiotic perturbations have been represented by microarrays or RNA-seq datasets. To facilitate the use of such data, we introduce the MAdLandExpression atlas as a successor of PEATmoss (Physcomitrium Expression Atlas Tool), integrating its 109 P. patens expression experiments and expanding it with 20 recently published RNA-seq samples of sexual reproduction stages, thus completing the coverage of the P. patens life cycle. The MAdLandExpression atlas also introduces new features for data visualization and analysis, such as the comparison of samples from multiple datasets and gene set normalization. Using this tool, the sexual reproduction dataset was analyzed, identifying genes potentially important for egg and sperm cell development, and confirming the behavior of known key genes in sexual development observed in previous studies
M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans
No full textNear field optical visualization of the nanoscale phase percolation dynamics of a VO<sub>2</sub> oscillator
No full textSelf-sustained resistance oscillation in vanadium dioxide (VO2) are of significant interest for phase-based information encoding applications. However, the underlying mechanism behind the current-induced insulator-to-metal phase oscillation and its spatiotemporal dynamics remains elusive. Here, using high-resolution near-field optical imaging, we uncover distinct current-induced phase transition pathways in VO2(001) thin films. We show that the formation of a persistent metallic patch within active region, defined as the area between the electrodes in a two-terminal model device serves as a prerequisite for oscillations. In this region, transient conductive filaments as narrow as 140 nm bridge the patch to the electrodes. Additionally, we observe oscillation modulated optical signals that extend well beyond the active region, providing clear evidence for a mechanism that would couple neighboring oscillators. Our work provides direct insight into the percolation dynamics that controls the oscillatory state of a VO2 oscillator, paving the way to optimally designed oxide electronics
