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Dual Growth Factor Release From Collagen Based Multilayer Films on Ti-Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In-Vivo Study
No full textObjectives:The aim of the present study was to assess the effect of dual growth factor release from collagen-based polyelectrolyte multilayer films (PEMs) on titanium implants on periimplant bone formation and angiogenetic activity in minipig mandibles.Material and Methods:Disc shaped Ti implants (5 × 7 × 1 mm) were coated with polyelectrolyte multilayer films and loaded with rhBMP-2, rhVEGF165, and a combination of both. Uncoated and unloaded Ti implants served as controls. The implants were inserted press-fit into 5 mm trephine cavities in minipig mandibles and evaluated after 4 and 13 weeks for bone formation, bone implant contact, and periimplant expression of CD31.Results:After 4 weeks, there was no significant difference in periimplant bone formation nor bone-implant contact between the different surface conditions. CD31 expression was significantly increased around PEM coated implants loaded with VEGF and BMP each. After 13 weeks, bone implant contact and bone formation were significantly increased only around PEM coated implants with simultaneous release of BMP-2 and VEGF165. Expression of CD31 was significantly enhanced around all PEM coated implants loaded with growth factors regardless of the type or combination.Conclusion:It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.<br
Soziale Rechte einklagen: Gerichte im (west-)deutschen Wohlfahrtsstaat des 20. Jahrhunderts
No full textOn a proof of Xu's conjecture and depths of Galois descents
No full textWe give an explicit formula proving Xu’s conjecture on alternating double zeta values. We also discuss the limitations of Glanois’ motivic Galois descent criterion in this case, as it cannot specify the depth of the descent
Broadband single-shot THz sampling using reflection gratings
Get PDFSingle-shot electro-optic sampling (EOS) is a powerful method enabling the measurement of weak terahertz signals that would otherwise require prohibitively long acquisition times. This is generally achieved by encoding the EOS time delay into a spatial, angular, or frequency coordinate. In general, angular-encoding techniques operate well up to 3 THz but become more challenging for larger bandwidths, due to dispersion and imaging imperfections. Here, we demonstrate a reliable angular-encoding single-shot EOS implementation that reaches frequencies beyond 6 THz. Diffraction simulations are used to design the experimental setup and adapt this technique to commercial reflection gratings, removing the need for custom-built echelon mirrors. Furthermore, we show that, contrary to earlier reports, group delay dispersion from angular dispersion does not reduce the bandwidth of single-shot EOS
Interferometric Evidence of Nonvolatile Anomalous Phase Shifts in Exchange-Spin-Split Josephson Supercurrent Diodes
Get PDFThe recent realization of zero-field, polarity-reversible supercurrent rectification in proximity-magnetized Rashba-type Pt Josephson junctions (JJs) enables the development of superconducting logic circuits and cryogenic memory applications. Here, we demonstrate a nonvolatile anomalous phase shift φ0 directly probed via superconducting quantum interferometry, providing phase-sensitive evidence of spontaneous time-reversal symmetry breaking in these Rashba-type systems. By replacing the Pt barrier with 5d or 4d element layers exhibiting different (para)magnetic susceptibilities, spin–orbit coupling properties, and electronic band structures, we elucidate the role of proximity effects in governing zero-field diode behavior. Ta (W) JJs exhibit zero-field diode efficiencies of ∼17% (∼5%) at 2 K, which are slightly (significantly) lower than those of Pt JJs. Notably, the diode polarity in Ta and W JJs is reversed relative to that in Pt JJs. Combined with the large zero-field diode efficiency (∼15% at 2 K) observed in highly magnetic-susceptible Pd JJs, these results show that nonvolatile φ0 and, consequently, zero-field diode performance can be tuned through proximity engineering of interfacial magnetic ordering and Rashba spin–orbit interaction
Globally synchronized changes in the biosphere, atmosphere, and society identified using public data
Get PDFThe EU Compromise Machine and the Politicisation of Social Policy: Lessons from the Regulation of Platform Work
No full textOver the past few years, the legal status and the working conditions of platform workers have been among the most debated manifestations of the digital transformation of work. Tense negotiations on the EU platform work directive (from 2021 to 2024) epitomize long-standing conflicts in EU social policymaking, namely the opposition between capital and labour, on the one hand, and resistance to EU involvement or impact on Member States’ social arrangements, on the other. This paper provides an in-depth inquiry of the policy process by focussing specifically on the presumption of employment in platform work, which was first proposed as an EU-wide provision and eventually nationalized with its definition left to national arrangements. Drawing on this case and mobilizing the literature on positive integration entrepreneurship, and politicization, we shed light on the ‘drivers’ and ‘inhibitors’ of EU social regulation. On the one hand, we provide evidence that joint entrepreneurship of the European Parliament (EP) and the European Commission is a primary driver and argue for acknowledging the role of the EP as a key entrepreneur of ‘Social Europe’. On the other hand, divisions in the Council, underpinned by domestic politics, hinder ambitious social policy regulation at EU level in several respects. Furthermore, we tease out the role of politicization and theorize its ambivalent role as both a driver and inhibitor, depending on contingent party political orientations, contextual factors, but also the role played by Council presidencies, so far overlooked in the literature. We conclude that the drivers and inhibitors we identify, and the resulting dynamics of compromise, are relevant beyond the case of platform work. While stressing the crucial, yet ambivalent, role of politicization, our findings cast a shadow on what has recently been described as a great come back of ‘Social Europe’ with the European Pillar of Social Rights.Introduction Politicisation: Driving or inhibiting Social Europe? Advancing ambitions: Establishing an employment status for platform workers’ in EU law Politicisation and how the presumption of employment was nationalised Discussion and clonclusion Acknowledgments Footnotes References Supplementary Materia
Thermodynamic topology of Einstein-Maxwell-Dilaton Theories
Get PDFWe present a systematic investigation of the thermodynamic topology for a broad class of asymptotically charged Anti-de Sitter (AdS) black holes in Einstein-Maxwell-Dilaton (EMD) theories, examining how scalar coupling parameters and spacetime dimensions influence black hole thermodynamics. Employing a topological approach that utilizes the torsion number of vector fields constructed from the generalized free energy, we characterize black hole states as topological defects within the thermodynamic parameter space. Through analytical solutions spanning dimensions , , and , including the Gubser-Rocha model, we demonstrate that variations in the dilaton coupling constant , particularly near its critical value , induce transitions between distinct thermodynamic topological phases. Our analysis reveals that certain black hole solutions constitute a novel class designated as , characterized by a torsion number that corresponds to a unique stability structure. We establish that Gubser-Rocha models belong to this topological classification. These results significantly expand the existing classification framework while reinforcing thermodynamic topology as a robust analytical tool for probing the universal properties of black holes in both gravitational and holographic contexts. The findings provide new insights into the relationship between microscopic couplings and macroscopic thermodynamic behavior in extended gravity theories