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Style mixing houses: The role of high- and low-level visual features in human house facade evaluation
No full textAn adaptive, continuous-learning framework for clinical decision-making from proteome-wide biofluid data
No full textMass spectrometry (MS)-based proteomics provides deep molecular insights from patient samples, but clinical use has been limited by missing values, static biomarker panels, and the need for targeted assay development. We present a framework - Adaptive Diagnostic Architecture for Personalized Testing by Mass Spectrometry (ADAPT-MS) - that enables direct diagnostic and prognostic interpretation of discovery-mode proteomics data at the level of individual samples. ADAPT-MS dynamically retrains simple, robust classifiers based on the proteins quantified in each sample, eliminating the need for imputation or fixed panels. Applied to plasma and cerebrospinal fluid datasets across diseases and clinical centers, it achieves high performance and generalizability using robust, transparent and generalizable statistical models. A single proteomic measurement can support multiple diagnostic questions via retrospective cohort matching, with each classification taking only seconds. As population-scale proteomics datasets grow, this approach lays the foundation for scalable, real-time, and personalized diagnostics directly from proteome-wide data. Such a community effort may help to transform discovery proteomics into a routine clinical tool
Expanding the life framework of values (advance online)
No full text1. Conceptualising and organising the range of value orientations and worldviews underpinning human–nature relationships is useful for understanding different, and sometimes conflicting, perspectives on how nature should be managed and working towards just and equitable policies.2. We test the applicability and current scope of the Life Framework of Values (living from-, living in-, living with- and living as-nature) by aligning it with pre-existing literature, drawn heavily from the context of wildlife management and conservation, but with wider relevance.3. Pre-existing value categorisations align with the Life Framework of Values in accounting for instrumental, relational and intrinsic values of nature. However, the framework does not account for the multiple ways in which people may be considered as living against-, living separated from- and living disconnected from-/living indifferently to-nature. By first considering these additional worldviews, we then propose the introduction of a complimentary overarching living apart from nature value frame.4. We identify three pathways by which people may fall within the living apart from nature frame: (1) loving nature so deeply that you choose to separate yourself from it (living separated from nature), (2) disregarding nature to the extent that you are willing to destroy it (living against nature) and (3) becoming indifferent or disconnected, a state that can emerge from modern urban lifestyles (living disconnected from-/living indifferently to-nature).5. Synthesis and applications. Including the living apart from nature frame to the Life Framework of Values allows for a more realistic and complete view of the diversity of human–nature interactions thus helping it contribute to addressing the global biodiversity crisis and transforming societies towards more sustainable pathways. Future research should focus on empirically testing the extent to which people fit discretely and consistently into Life Frames or worldviews as opposed to simultaneously holding diverse positions on different specific issues
Unveiling the Sources of X-Ray Luminosity in DESI Galaxy Groups: Insights from the SRG/eROSITA All-sky Survey
No full textWe use the first eROSITA all-sky survey to investigate the contributions of active galactic nuclei (AGN) and extended gas to the total X-ray luminosity (LX) of galaxy groups with different halo masses (Mh) at different redshifts. The presence of AGN in their central galaxies is identified using multiwavelength catalogs, including the X-ray counterparts, the ASKAP radio catalog, and the DESI spectroscopic measurements. We apply the stacking method to obtain sufficient statistics for the X-ray surface brightness profile and the LX for groups with different central AGN properties. We find that the X-ray groups exhibit the highest LX, followed by groups with QSO, radio, Baldwin-Phillips-Terlevich AGN, and non-AGN centrals. Moreover, the LX of the Mh less than or similar to 1013h-1M circle dot groups is dominated by the central AGN, while the X-ray emission from extended gas tends to be more prominent in the Mh greater than or similar to 1013h-1M circle dot groups. In groups where the AGN play a major role in X-ray emission, the contribution from extended gas is minor, resulting in significant uncertainties concerning the extended X-ray emission. When the subset containing the X-ray-detected counterparts is excluded, the extended gas component becomes easier to obtain. A correlation has been identified between the X-ray luminosity of the central AGN and extended gas. However, once we account for the positional offset, their correlation becomes less prominent. Currently, the results are not conclusive enough to confirm whether there is a connection between the AGN feedback and extended gas. However, they provide a new perspective on the feedback processes in the history of group assembly
Impact of active galactic nuclei and nuclear star formation on the ISM turbulence of galaxies: Insights from JWST/MIRI spectroscopy
No full textActive galactic nuclei (AGNs), star formation (SF), and galaxy interactions can drive turbulence in the gas of the interstellar medium (ISM), which, in turn, plays a role in SF taking place within galaxies. The impact on molecular gas is of particular importance, as it serves as the primary fuel for SF. Our goal is to investigate the origin of turbulence and the emission of molecular gas, as well as low-and-intermediate-ionisation gas, in the inner few kpc of both AGN hosts and star-forming galaxies (SFGs). We used archival JWST MIRI/MRS observations of a sample consisting of 54 galaxies at z < 0.1. We present flux measurements for the H-2 S(5)lambda 6.9091 mu m, [ArII]lambda 6.9853 mu m, [FeII]lambda 5.3403 mu m, and [ArIII]lambda 8.9914 mu m emission lines along with velocity dispersion estimated by the W80 parameter. For galaxies with coronal line emission, we included measurements of the [MgV]lambda 5.6098 mu m line. We compared the line ratios to photoionisation and shock models to explore the origin of the gas emission. AGNs exhibit broader emission lines than SFGs, with the largest velocity dispersions observed in radio-strong (RS) AGNs. The H(2 )gas is less turbulent compared to ionised gas, while coronal gas presents higher velocity dispersions. The W80 values for the ionised gas show a decrease when going from the nucleus out to radii of approximately 0.5-1 kpc, followed by an outward increase up to 2-3 kpc. In contrast, the H-2 line widths generally display increasing profiles with distance from the center. Correlations between the W-80 parameter and line ratios such as H2S(5)/[Ar II] and [Fe II]/[Ar II] indicate that the most turbulent gas is associated with shocks, enhancing H-2 and [Fe II] emissions. Based on the observed line ratios and velocity dispersions, the [FeII] emission is consistent with predictions of fast shock models, while the H-2 emission is likely associated with molecules formed in the post-shock region. We speculate that these shocked gas regions are produced by AGN outflows and jet-cloud interactions in AGN-dominated sources; whereas in SFGs, they might be created through stellar winds and mergers. This shock-induced gas heating may be an important mechanism of AGN (or stellar) feedback, preventing the gas from cooling and forming new stars
Luminescence Thermometry of a Nd<sup>III</sup> and Nd<sup>III</sup>/Yb<sup>III</sup> Imidazole Derived-Based MOFs: Thermally Enhanced Ytterbium Emission
No full textLanthanides' luminescent thermometry operating in biological windows highlights its promising applications, constantly improving performances, and interesting new findings. This work presents two MOFs, a homometallic sample based on neodymium (1) and a heterometallic one including ytterbium cations (2) as thermometers in the physiological temperature range, operating in biological windows (BWs). These materials were developed with the aim of understanding their thermometric performance and to gain deep knowledge into the energy transfer between the mentioned cations. The homometallic sample achieved a maximum relative sensitivity (Sr) of 0.59%K−1 at 20°C by using the luminescence intensity ratio (LIR) of the two components that contribute to the main emission band ca. 1060 nm, which is associated with the 4F3/2 → 4F11/2 transition. In the case of the heterometallic sample, interestingly, there is an increase in the intensity of the ytterbium cation emission as the temperature increases. This behavior was rationalized by means of theoretical calculations and matches other examples from the literature. The YbIII/NdIII intensity ratio achieves a maximum Sr 0.53%K−1 at 20°C