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Carlo Felice Cillario - violin recordings for 'La voce del padrone' 1930s
No full textThese recordings were made for 'La voce del padrone' (His Master's Voice) in Italy, in the late 1930s and released as a 78RPM discs. Carlo Felice Cillario, violin. Riccardo Simonelli, piano
Submission to the Joint Select Committee on Social Media and Australian Society
Full text linkRecommendations
Recommendation 1. Provide online safety education and critical media literacy in schools and communities. Sexual education and critical sexual media literacy earlier in the curriculum and in families would help to mitigate the negative effects of younger children accessing or encountering online pornography via social media.
Recommendation 2. Promote and support ongoing conversations about online safety with parents, carers, peers and trusted experts and expand availability of youth specialist counsellors to provide online safety advice and education.
Recommendation 3. Implement strong laws and enforcement strategies to ensure social media companies comply with agreed industry codes and develop tools, moderation and features that support safer online platforms and experiences using ‘safety by design’ and ‘privacy by design’ principles.
Recommendation 4. Reform of Australia’s Privacy Act and specific online privacy laws and industry codes should be hastened and developed in parallel to align with the Online Safety Act to ensure that these are complementary, mutually reinforcing and fit for purpose.
Recommendation 5. Resource research and technology testing (e.g. for age verification in practice) to provide evidence of emerging online safety issues, safety technologies and literacy needs to inform the design of education, changes in codes, and new platform features and interface designs. The decision of Meta to abandon deals under the News Media Bargaining Code.
Recommendation 6: The case for a funding mechanism that ensures that digital platforms contribute to the sustainability of news production remains valid. However, the News Media Bargaining Code is less likely to be able to perform this role over the medium-term. The Federal Government should investigate the possibility of developing a levy on online advertising whose revenues would be earmarked towards the support of news production, with particular focus on public interest journalism and news provision to underserved communities and rural, regional and remote areas. The important role of Australian journalism, news and public interest media in countering mis- and disinformation on digital platforms.
Recommendation 7: There is a need for legislation that can effectively respond to the challenge of misinformation, particularly with regards to political content. Such legislation needs to have due regard to principles of free speech, legitimate differences of opinion, and respectful disagreement that characterise robust liberal democracies. The algorithms, recommender systems and corporate decision making of digital platforms in influencing what Australians see, and the impact of this on mental health.
Recommendation 8: That the Australian government adopts measures similar to the European Union's Digital Services Act (DSA) to ensure greater digital platform transparency. Other issues in relation to harmful or illegal content disseminated over social media, including scams, age-restricted content, child sexual abuse and violent extremist material.
Recommendation 9: Any regulations placed on social media platforms to prevent harm to users be extended to immersive media platforms to ensure that platforms are accountable for user safety and proactively prevent harm. This could be achieved through implementing combinations of AI-driven monitoring tools and real-time behaviour controls that can mitigate harmful interactions as they happen. Proactive governance should focus on fostering positive community norms and inclusive environments from the start
Submission to the Productivity Commission: Harnessing Data and Digital Technology & Building a Skilled and Adaptable Workforce
No full textThis submission responds to the Productivity Commission’s Interim Report on Harnessing Data and Digital Technology and Building a Skilled and Adaptable Workforce. These domains are not merely technical or economic in nature; they are deeply embedded within broader social, cultural, and institutional transformations that demand nuanced and contextually grounded policy responses
Conclusion: the road ahead: where should we go now to improve healthcare quality in acute settings?
No full textThis final article in our 12-part series articulating a suite of quality improvement studies completes our report on the Deepening our Understanding of Quality in Australia (DUQuA) program of work. Here, we bring the Supplement’s key findings and contributions together, tying up loose ends. Traversing the DUQuA articles, we first argued the case for the research, conducted so that an in-depth analysis of one country’s health system, completed 5 years after the landmark Deepening our Understanding of Quality Improvement in Europe (DUQuE), was available. We now provide a digest of the learning from each article. Essentially, we have contributed an understanding of quality and safety activities in 32 of the largest acute settings in Australia, developed a series of scales and tools for use within Australia, modifiable for other purposes elsewhere, and provided a platform for future studies of this kind. Our main message is, despite the value of publishing an intense study of quality activities in 32 hospitals in one country, there is no gold standard, one-size-fits-all methodology or guarantee of success in quality improvement activities, whether the initiatives are conducted at departmental, organization-wide or whole-of-systems levels. Notwithstanding this, armed with the tools, scales and lessons from DUQuA, we hope we have provided many more options and opportunities for others going about strengthening their quality improvement activities, but we do not claim to have solved all problems or provided a definitive approach. In our view, quality improvement initiatives are perennially challenging, and progress hard-won. Effective measurement, evaluating progress over time, selecting a useful suite of quality methods and having the persistence to climb the improvement gradient over time, using all the expertise and tools available, is at the core of the work of quality improvement and will continue to be so
Prodrug Amphiphile Nanoassemblies for Targeted Treatment of Pancreatic Cancer
No full textCancer is a diverse and complex condition. Tackling cancer effectively requires a multidisciplinary team and close collaboration between clinicians, biologists, chemists and material scientists. The project outlined is a collaboration between CSIRO and the Kolling Institute of Medical Research to develop a series of lipid-based cisplatin and gemcitabine prodrug amphiphiles with the capacity to self-assemble when dispersed in aqueous solution to form functional nanoparticles. Nanoparticles have garnered interest for their ability to deliver high payloads of drug, utilize targeting moieties to enhance localization into tumours and reduce side effects. Lipid prodrug self-assembly systems are advantageous as they are endogenous and different prodrug lipids can be combined to tailor the nanoparticle to a specific need. Nanoparticles can be prepared to mimic biological components such as high-density lipoproteins (HDLs) to avoid detection by the Reticuloendothelial (RES) system. Furthermore, the associated apolipoproteins on the surface of the rHDLs such as ApoA-II have the capacity to direct them towards tumours, enhancing the efficacy of the nanoparticle.
This thesis explored the complex strategy behind the development of a series of cisplatin and gemcitabine prodrug amphiphiles, their resulting nanoparticle dispersions and their efficacy in vitro and in vivo. A variety of disciplines were covered, from organic synthesis, structural characterization including NMR spectroscopies, ESI\MS, and HPLC, physicochemical characterization including DSC, TGA, POM, SSAXS, cryo-TEM and DLS, in vitro cytotoxicity assays, and a preclinical in vivo study using cell line derived tumours xenografted in mice to evaluate antitumour efficacy, biodistribution and histological features of the tumour. The result is the diverse, comprehensive and rigorous investigation and characterization of nanoparticles which may become a translatable therapeutic in the future.Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library
Structural And Magnetic Properties Of Some Vacancy Ordered Osmium Halide Perovskites
Full text linkThe structures and magnetic properties of the Os4+ (5d4) halides K2OsCl6, K2OsBr6, Na2OsBr6 and Na2OsBr6.6H2O are described. K2OsCl6 and K2OsBr6 have a cubic vacancy-ordered double perovskites structure but undergo different symmetry lowering structural phase transitions upon cooling associated with a combination of the relative size of the ions and differences in their chemical bonding. The structure of Na2OsBr6.6H2O has been determined for the first time and the thermal stability of this established using a combination of in-situ diffraction and TGA. Na2OsBr6.6H2O and Na2OsBr6 are isostructural with the analogous iridium chlorides, Na2IrCl6.6H2O and Na2IrCl6, dehydration proceeds via different intermediate phases. The magnetic moments of four compounds display Kotani-like behaviour consistent with a Jeff = 0 ground state, however the magnetic susceptibility measurements reveal unusual low temperature properties indicative of a weakly magnetic ground state