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Evaluating the role of the diagnostic radiographer in identifying child safeguarding concerns: A knowledge, attitude and practice survey approach
Get PDFYesChild safeguarding and the appropriate identification of suspected victims represents a global phenomenon. Diagnostic imaging is acknowledged as a contributory diagnostic service but the role of the radiographer in the identification and escalation process is less well understood. Method: A Knowledge, Attitude and Practice (KAP) survey was constructed to evaluate knowledge base in the context of the patient–radiographer interaction, the shaping of attitude towards child safeguarding and attitudes held towards their role plus the actual practical experiences of managing child safeguarding concerns. Results: Respondents demonstrated a inconsistent knowledge base with respect to physical, social and radiographic signs and symptoms of child safeguarding concern. A positive attitude towards the role of the radiographer in child safeguarding was demonstrated but one that was shaped more by experience than pre-registration education. Assessment of concerns was chiefly influenced by clinical history and appreciation of aetiology. Practically, radiographers have infrequent involvement with the identification and escalation of concerns. Whilst some statistically significant relationships between responses and demographics did exist, these were either sporadic or argued to be a result of natural variation. Conclusion: Assessment of physical and social signs of child safeguarding concern are argued to be becoming more challenging. Radiological signs continue to be visible to radiographers but with increasing use of other imaging modalities these signs are becoming more varied in nature and are providing new challenges. Radiographers are capable of escalation when required to do so. Implications for practice: To maximise the contribution of the profession, education needs to account for imaging modality worked with, in combination with an understanding of related aetiology. Previously existing concerns with respect to escalating processes are no longer in evidence and radiographers are both willing and able to contribute to that process
Dissolving and Swelling Hydrogel-Based Microneedles: An Overview of Their Materials, Fabrication, Characterization Methods, and Challenges
Get PDFYesPolymeric hydrogels are a complex class of materials with one common feature—the ability to form three-dimensional networks capable of imbibing large amounts of water or biological fluids without being dissolved, acting as self-sustained containers for various purposes, including pharmaceutical and biomedical applications. Transdermal pharmaceutical microneedles are a pain-free drug delivery system that continues on the path to widespread adoption—regulatory guidelines are on the horizon, and investments in the field continue to grow annually. Recently, hydrogels have generated interest in the field of transdermal microneedles due to their tunable properties, allowing them to be exploited as delivery systems and extraction tools. As hydrogel microneedles are a new emerging technology, their fabrication faces various challenges that must be resolved for them to redeem themselves as a viable pharmaceutical option. This article discusses hydrogel microneedles from a material perspective, regardless of their mechanism of action. It cites the recent advances in their formulation, presents relevant fabrication and characterization methods, and discusses manufacturing and regulatory challenges facing these emerging technologies before their approval
Cyber governance in Africa: at the crossroads of politics, sovereignty and cooperation
Get PDFYesAfrica has recently focused on an ambition to achieve digital transformation through the pursuit of various flagship initiatives which are aimed at achieving its ‘Agenda 2063’ objectives. Digital transformation will be better achieved through appropriate cyber governance policies and mechanisms, and the success of Africa’s Digital Transformation Strategy 2020-2030 hinges on diverse factors. According to the Strategy, African governments have a fundamental responsibility to create an enabling environment, with policies and regulations that promote digital transformation across foundation pillars, which include cybersecurity. The Strategy also stipulates the need to reinforce the region’s human and institutional capacity to secure the cyberspace by building trust and confidence in the use of cyber technologies. The aim of the paper is to examine Africa’s cyber governance agenda in relation to peace and security. While there are political dimensions to determining the thresholds of such discourses in Africa, the uncertainties of governance mechanisms, political underpinnings and limitations in digital capacity may mean that international standards of cyber governance have merely been theoretical in the African context. The paper examines Africa’s extant policies and political strategies for cyber governance, and the region’s interaction with international cyber governance processes. The paper further discusses the prospects and challenges to cyber governance in the region, and the approaches to leveraging international cooperation in promoting cyber stability in the region
Apigenin cocrystals: from computational pre-screening to physicochemical property characterisation
Get PDFYesApigenin (4′,5,7-trihydroxyflavone, APG) has many potential therapeutic benefits; however, its poor aqueous solubility has limited its clinical applications. In this work, a large scale cocrystal screening has been conducted, aiming to discover potential APG cocrystals for enhancement of its solubility and dissolution rate. In order to reduce the number of the experimental screening tests, three computational prescreening tools, i.e., molecular complementarity (MC), hydrogen bond propensity (HBP), and hydrogen bond energy (HBE), were used to provide an initial selection of 47 coformer candidates, leading to the discovery of seven APG cocrystals. Among them, six APG cocrystal structures have been determined by successful growth of single crystals, i.e., apigenin-carbamazepine hydrate 1:1:1 cocrystal, apigenin-1,2-di(pyridin-4-yl)ethane hydrate 1:1:1 cocrystal, apigenin-valerolactam 1:2 cocrystal, apigenin-(dl) proline 1:2 cocrystal, apigenin-(d) proline/(l) proline 1:1 cocrystal. All of the APG cocrystals showed improved dissolution performances with the potential to be formulated into drug products
Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance
No full textYesPoloxamers or Pluronics®-based nanogels are one of the most used matrices for developing delivery systems. Due to their thermoresponsive and flexible mechanical properties, they allowed the incorporation of several molecules including drugs, biomacromolecules, lipid-derivatives, polymers, and metallic, polymeric, or lipid nanocarriers. The thermogelling mechanism is driven by micelles formation and their self-assembly as phase organizations (lamellar, hexagonal, cubic) in response to microenvironmental conditions such as temperature, osmolarity, and additives incorporated. Then, different biophysical techniques have been used for investigating those structural transitions from the mechanisms to the preferential component’s orientation and organization. Since the design of PL-based pharmaceutical formulations is driven by the choice of the polymer type, considering its physico-chemical properties, it is also relevant to highlight that factors inherent to the polymeric matrix can be strongly influenced by the presence of additives and how they are able to determine the nanogels biopharmaceuticals properties such as bioadhesion, drug loading, surface interaction behavior, dissolution, and release rate control. In this review, we discuss the general applicability of three of the main biophysical techniques used to characterize those systems, scattering techniques (small-angle X-ray and neutron scattering), rheology and Fourier transform infrared absorption spectroscopy (FTIR), connecting their supramolecular structure and insights for formulating effective therapeutic delivery systems.The Sao Paulo Research Foundation - FAPESP (Grant 2019/20303-4; 2019/14773-8), National Council for Scientifc and Technological Development - CNPq (308819/2022-0), ERASMUS Program Fellowship, and The Coordination for the Improvement of Higher Education Personnel - Brazil (CAPES) - Finance Code 001
What does Landnám look like? Excavations at Swandro and Old Scatness
No full textNoResearch at two multi-period settlement mounds, Old Scatness (Shetland; Dockrill et al. 2010) and Swandro (Rousay, Orkney; ongoing, Bond and Dockrill 2016), suggests that many first-generation Scandinavian settlements occur at pre-existing Pictish settlements and associated landscapes. Both sites have settlement biographies that provide evidence for long sequences spanning the Early Iron Age to the Norse period, including evidence for landnám, or first settlement. Settlement on existing Pictish ‘estates’ (high-status settlements with associated agricultural land, often originating in the Iron Age or earlier) would provide access to both maritime and agricultural resources, and it is suggested that ‘estate taking’ may have been a means of procuring key locations. The term landnám is used in several ways in archaeology; Cleasby in his Icelandic–English dictionary defined it as ‘taking possession of land as settler, settlement’ (Cleasby and Vigfússon 1874), while Danish palynologist Iversen used it in the 1940s to describe features in pol-len diagrams which he thought indicated clearance of the landscape by incoming Neolithic farmers, and it is still used in this sense (Iversen 1941). In North Atlantic archaeology it is often used in the context of settlement of a presumed empty landscape by the Norse in Iceland or the Faroe Islands. Here we use it in preference to the more loaded term ‘colonisation’ to indicate initial Norse settlement
Intergenerational differences in healthy eating beliefs among British Pakistanis with type 2 diabetes
No full textYesThere are growing concerns on how to prevent, slow down and induce remission of type 2 diabetes mellitus (T2DM). Recent evidence has found diet and lifestyle interventions can cause remission of T2DM, however, there are challenges for diverse groups such as British Pakistanis who are four times more at risk of T2DM. There is a need to understand the food behaviours of different generational groups to develop culturally appropriate strategies to support diabetes prevention programmes.
This study explores beliefs about healthy eating and food practices related to T2DM among British Pakistanis to understand the challenges they face in implementing healthy diets.
We carried out 26 semi-structured qualitative interviews via telephone and face-to-face. The sample included T2DM British Pakistanis living in Bradford (UK), aged between 18 and 71 with a mean age of 50 (SD = 17.04). Among the participants, 14 were women (54%) and 12 were men (46%), with interviews conducted in both English (76%) and Urdu (24%). Participants were grouped under three generation groups based on age (first generation 65+; second generation 40-64; younger generation 18-39 years). There was no biological link between the generational groups, and they were not part of the same family. Data were analysed using qualitative reflexive thematic analysis.
Findings were categorised into three themes: knowledge and awareness of diabetes symptoms; social and family context of food practices and making sense of healthy eating. The family was the fundamental unit of understanding food-related health behaviours. Eating traditional food was perceived as healthy and deemed practical for first generations who were the initial members of their family to settle in the UK as well as the second generations who had parents born in Pakistan. Younger British Pakistanis were born in the UK and reported that they struggled to eat alternative foods within the home and manage their T2DM.
These findings improve our understanding of how three generations of British Pakistanis with T2DM negotiate healthy diets. There is a need for culturally tailored diet modifications and interventions, where different generational needs can be specifically targeted to adopt healthier diets which should be shared and encouraged
Review of substitutive assistive tools and technologies for people with visual impairments: recent advancements and prospects
No full textYesThe development of many tools and technologies for people with visual impairment has become a major priority in the field of assistive technology research. However, many of these technology advancements have limitations in terms of the human aspects of the user experience (e.g., usability, learnability, and time to user adaptation) as well as difficulties in translating research prototypes into production. Also, there was no clear distinction between the assistive aids of adults
and children, as well as between “partial impairment” and “total blindness”. As a result of these limitations, the produced aids have not gained much popularity and the intended users are still hesitant to utilise them. This paper presents a comprehensive review of substitutive interventions that aid in adapting to vision loss, centred on laboratory research studies to assess user-system interaction and system validation. Depending on the primary cueing feedback signal offered to the user, these technology aids are categorized as visual, haptics, or auditory-based aids. The context of use, cueing feedback signals, and participation of visually impaired people in the evaluation are all considered while discussing these aids. Based on the findings, a set of recommendations is suggested to assist the scientific community in addressing persisting challenges and restrictions faced by both the totally blind and partially sighted people
Optimal planning and operation of distribution systems using network reconfiguration and flexibility services
No full textYesThis paper proposes a novel approach for the reliability cost-based optimization of Distribution Systems (DS), considering tie line-based network reconfiguration method with integration of Distributed Energy Resources (DER). An optimal Energy not Supplied (ENS) index is proposed, where the capacity is handled by curtailment devices in the network such as sectionalizers and the energy supplied by DERs which considers Flexibility Services (FS) within a market environment. The decision variables include the investment and operation of tie-lines and buying regulation services from DER such as Distributed Generation (DG) and Battery Energy Storage Systems (BESS). The results validate the cost-effectiveness of the proposed method through implementation of these technologies to improve the reliability of the DS, within a comprehensive set of case-study scenarios for a 16-bus UK generic distribution system (UKGDS). The case study results indicate that significant savings can be achieved through the proposed method, ranging between 36%-71% depending on the level of automation in tie-line operations in combination with the settlement price for the power-balance of FS. This illustrates that the proposed DS reliability cost-based optimization method could have a significant impact for real world DG and BESS applications.Innovate UK GCRF Energy Catalyst Pi-CREST project under Grant number 41358 and University of Bradford under the SURE Grant scheme (Grant Number 023000/66005)
The Integration Of Synthetic Biology With Metabolically And Phenotypically Emergent Multicellular Simulations For Medical And Other Applications
No full text“The Integration Of Synthetic Biology With Metabolically And Phenotypically Emergent Multicellular Simulations For Medical And Other Applications” aimed to extend Synthetic Biology computer assisted design spatiotemporal capabilities via multicellular simulation, with translational contextualization, targeting the biophysical 3D spatial extension of a Synthetic Biology associated solver of stochastic Gillespie algorithms, NGSS, achieved best through ChemicalMatrixFusion. Following extensive reviews, the methodological strategies explored agent-based, vertex-based and domain-based modelling. Unreal Engine 4 development (UnrealMulticell3D) would be contrasted with multithreaded mesh generation (SynthMeshBuilder) and a novel biophysical high performance diffusion solver (ChemicalMatrixRM_CUDA). Concluding insights included bias-reducing Monte Carlo strategies, accelerated development yet performance hurdles of specialized gaming engines, careful memory management and resolution of biophysics using CUDA GPU acceleration, and a practical demonstration of the benefits of integrating performant modular solutions for biophysical, bioregulatory and mechanistic capabilities for visualized, high-dimensional time-course multicellular simulations, implicated primarily for hypothesis modelling. Such simulations had tomographic and topological characteristics, implicating “recursive” multimodal, hybrid strategies at multiple scales. Multiplanar visualization, as illustrated, and digital reconstruction could be deemed underutilized. The novel cytohistological genetics encyclopaedia and biological network explorer, BioNexusSentinel, developed here evidenced artificial intelligence mediated development and R preprocessing as beneficial. Omics data was implicated for future parameterization of translational medical simulations, along with genome scale network models, and the morphological representation of complex substructure. Meanwhile, the translational review would emphasize the importance of assays and micrographs, high-throughput combinatorial strategies and machine learned inferences within automated Design-Build-Test-Learn engineering, as well as documenting resources for Synthetic Biology computational modelling.Engineering and Physical Sciences Research Council grant EP/R043787/