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Projection Augmented Relief Models (PARM): A Guide for Local Planning Authorities
No full textNoA playbook designed to help local authorities explore how PARM can be adopted into practice. It sets out the principles behind the approach, practical steps for design and delivery and examples of how PARM can be used to support engagement
Shaping Entrepreneurial Marketing: A South Asian perspective (Vol 1)
No full textNoShaping Entrepreneurial Marketing, Volume 1: A South Asian Perspective provides an in-depth analysis of how marketing and entrepreneurship have shaped the business landscape in South Asia.
As the region undergoes rapid economic development, this book offers valuable insights into the role of entrepreneurial marketing in the growth of advertising, e-commerce, technology, and small and medium enterprises (SMEs). This timely publication addresses a gap in the literature, offering theoretical and practical contributions to the emerging field of entrepreneurial marketing in developing economies.
This volume is essential for scholars, policymakers, and business leaders seeking to understand the dynamic interplay of entrepreneurship, marketing, and economic development in the South Asian context
Supporting Older People Living With Frailty to Self-Manage Multiple Medicines: An Experience-Based Co-Design of a Complex Intervention Developed in UK Primary Care
No full textYesBackground
Older people face numerous challenges when managing multiple medicines. They are required to cope with complicated and changing medicines regimens and coordinate input from multiple health and social care professionals. When not well managed, medicines can cause harm, and older people are more susceptible to the impact of errors. Nevertheless, there is a lack of interventions addressing the multiple tasks required for them to manage polypharmacy at home.
Objective
To develop a complex behaviour-change intervention to support medicines self-management for older people living with frailty and polypharmacy using Experience-based Co-design (EBCD).
Design
EBCD was used to create a prototype of a resilient healthcare-informed complex intervention with the potential to improve the safety of, and confidence in, medicines self-management for older people who live at home. Extracts from recordings of interviews about people's experiences of polypharmacy were edited into a short film and shown at meetings to determine priorities. Older people taking 5 or more medicines living with mild-to-moderate frailty, their family members and healthcare professionals then participated in co-design workshops to develop these identified priorities into components of a complex intervention. Two focus groups with healthcare staff, older people, and carers explored potential barriers to implementation.
Results
Shared priorities identified were to support change in the following areas: day-to-day practical medicines management; understanding medicines management systems; and communicating with healthcare teams. A logic model was designed to make explicit the intervention's underpinning theory of change. A five-part complex intervention was developed which addresses behaviours with potential to increase safety in medicines management. Intervention content was mapped to relevant behaviour change techniques to aid clarity, precision and specificity in reporting its characteristics.
Conclusions
Using EBCD we were able to co-develop a novel support intervention to improve safety in medicines management at home for older people living with frailty which incorporated: (1) knowledge of medicines and checking medicines received; (2) organising medicines supply; (3) adherence and self-monitoring when taking multiple medicines; (4) dealing with changes in medicines; and (5) knowledge of help available and how, where and when to seek it.
Patient or Public Contribution
A member of the public with lived experience of managing medicines in older age was co-applicant and co-author in this study, supported by an advisory group of older people taking multiple medicines or with experience of supporting family members. Their contribution played a key role in shaping a relevant and respectful complex intervention for this population.NIH
DDGWizard: Integration of feature calculation resources for analysis and prediction of changes in protein thermostability upon point mutations
No full textYesThermostability is an important property of proteins and a critical factor for their wide application. Accurate prediction of ΔΔG enables the estimation of the impact of mutations on thermostability in advance. A range of ΔΔG prediction methods based on machine learning has now emerged. However, their prediction performance remains limited due to insufficiently informative training features and little effort has been made to integrate feature calculation resources. Based on this, we integrated 12 computational resources to develop a pipeline capable of automatically calculating 1,547 features. In addition, a feature-enriched DDGWizard dataset was created, including 15,752 ΔΔG data. Furthermore, we performed feature selection and developed an accurate ΔΔG prediction model that achieved an R2 of 0.61 in cross-validation. It also outperformed several other representative prediction methods in comparisons with independent datasets. Together, the feature calculation pipeline, DDGWizard dataset, and prediction model constitute the DDGWizard system, freely available for ΔΔG analysis and prediction
Evaluation of two raw Indian and Turkish propolis samples as pre-formualtion study for cosmetic preparations [Abstract]
No full textYesGhaida Mustafa is receiving a scholarship for her PhD study by the Schlumberger Foundation Faculty for the future program
Environmental impacts and challenges of CO2 usage for synthesizing products and energy
No full textNoThe use of CO2 is critical to depress the greenhouse effect and manage environmental pollutants in an energy-efficient and economically sensible manner. This chapter analyzes different technologies categorized into direct and indirect uses with emphasis on energy and synthesized products available to date.
Furthermore, in this chapter, the potential, main drawbacks, environmental issues and applicability of each of these approaches for CO2 utilization have been discussed. A research trends analysis shows that there has been a significant increase in research on CO2 utilization, in electro-reduction and hydrogenation technologies since 2016. It seems that the catalyst and process improvement are urgently needed for the successful scale-up of CO2 conversion technology
Introduction
No full textYesThis book is very timely and aligns well with the agenda of the upcoming Fourth International Conference on the financing for development in 2025 of closing the gap between ‘aspiration and financing’. The book appears at a time when global turmoil and conflicts, recent pandemic and food, cost of living crisis and energy crisis have substantially reduced resources available especially for developing countries, to finance SDGs. This book contains perspectives both from academic and industry practitioners and blends the theoretical and empirical research with the contributors’ insights. The chapters herein cover a range of issues relating to the financing of SDGs from China’s Belt and Road initiative, and green financing to a call for the reform of the global financial architecture
"I've not been knocked out, so I'll probably be fine": Amateur Rugby players do not know the risks they are taking
No full textYesConcussion is prevalent in British amateur Rugby and there is currently contradicting evidence of the attitudes and knowledge of concussion in Rugby players. As such this study aimed to investigate the reasons for the variance in attitudes and knowledge of concussion in British amateur Rugby. As concussion is a lived experience within sport, we utilised qualitative interviews using reflexive thematic analysis to assess data obtained from nine amateur Rugby players that had sustained over three concussions to understand if they are aware of the known risks associated with such injuries. Our findings show that poor duty of care from those around the player with suspected concussion was prevalent, and that this poor duty of care enables poor attitudes toward and limited knowledge of concussion. It was also discovered that a lack of education could explain this poor duty of care that is offered to Rugby players by non-players. Poor duty of care and lack of education encourage continued participation from the player with suspected concussion. When there are examples of World Rugby failing in their duty of care of the best players in the world, it is unsurprising that players and non-players in the amateur game follow suit. Therefore, the education of both players and non-players in amateur Rugby matches is paramount, as well as World Rugby improving their concussion practices, in tackling the poor attitudes and knowledge base that we see in the amateur Rugby game
K562 chronic myeloid leukemia cells as a dual β3-expressing functional cell line model to investigate the effects of combined αIIbβ3 and αvβ3 antagonism
No full textYesSeveral of the integrin family of cell adhesion receptors have been popular targets for the development of anticancer agents, but with little clinical success to date. Cancer cells usually express multiple redundant integrins; one hypothesis for the lack of efficacy of current antagonists is their high selectivity for a single integrin. To address this, we developed a functional dual-β3-expressing cell model to investigate the effects of combined αIIbβ3/αvβ3 antagonism. We established that treating K562 chronic myeloid leukemia cells with 0.04 μM phorbol 12-myristate 13-acetate (PMA) for 40 h significantly upregulates functional αIIbβ3 and αvβ3 integrins. This optimized method provides a reliable platform for adhesion and detachment assays, enabling the characterization of dual integrin targeting strategies. Using this model, we demonstrate that combining αIIbβ3 and αvβ3 antagonists (GR144053 and cRGDfV) synergistically enhances inhibition of cell adhesion and promotes cell detachment compared to single-agent treatments. Our findings establish a reproducible approach for studying dual β3 integrin targeting, which can be used to investigate potential strategies for overcoming integrin redundancy in cancer therapeutics.Libyan Ministry of Higher Education
A city “collabatory”: Researchers, commissioners and community members planning interventions together
No full textYesImproving children's health and development in their early years is important, urgent and, cost-effective. But it's difficult to do. Using an example from Bradford in the UK we argue that integration, innovation and community engagement are key. Long-term funding also helps. Problems with multiple causes need “whole system” responses. This includes integration of research, commissioning and service delivery. We test innovations, learn about how they are received, modify them and test again. A dynamic research programme starts with innovations that are “science-based”—things the literature suggests might work—and then evaluates them. Science-based approaches may translate into being “evidence-based”. If a community is not ready for an intervention what needs to be put in place to enhance that readiness? We use two examples of using the Community Readiness Model. For obesity interventions in Roma children the model underlines the need to build trust. For interventions targeting social and emotional health, service planners need to explain what they are seeking to do and why it might be valuable. If the community is on-board, the professionals work together and there is security in broad-based long-term funding our “collabatory” approach just might change bringing up children in this city.National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Yorkshire and Humber (NIHR200166) and National Lottery Community Fund (10094849)