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Metal-organic frameworks as potential agents for extraction and delivery of pesticides and agrochemicals
Get PDFYesPesticide contamination is a global issue, affecting nearly 44% of the global farming population, and disproportionately affecting farmers and agricultural workers in developing countries. Despite this, global pesticide usage is on the rise, with the growing demand of global food production with increasing population. Different types of porous materials, such as carbon and zeolites, have been explored for the remediation of pesticides from the environment. However, there are some limitations with these materials, especially due to lack of functional groups and relatively modest surface areas. In this regard, metal-organic frameworks (MOFs) provide us with a better alternative to conventionally used porous materials due to their versatile and highly porous structure. Recently, a number of MOFs have been studied for the extraction of pesticides from the environment as well as for targeted and controlled release of agrochemicals. Different types of pesticides and conditions have been investigated, and MOFs have proved their potential in agricultural applications. In this review, the latest studies on delivery and extraction of pesticides using MOFs are systematically reviewed, along with some recent studies on greener ways of pest control through the slow release of chemical compounds from MOF composites. Finally, we present our insights into the key issues concerning the development and translational applications of using MOFs for targeted delivery and pesticide control
Data-driven minimum entropy control for stochastic nonlinear systems using the cumulant-generating function
Get PDFYesThis paper presents a novel minimum entropy control algorithm for a class of stochastic nonlinear systems subjected to non-Gaussian noises. The entropy control can be considered as an optimization problem for the system randomness attenuation, but the mean value has to be considered separately. To overcome this disadvantage, a new representation of the system stochastic properties was given using the cumulant-generating function based on the moment-generating function, in which the mean value and the entropy was reflected by the shape of the cumulant-generating function. Based on the samples of the system output and control input, a time-variant linear model was identified, and the minimum entropy optimization was transformed to system stabilization. Then, an optimal control strategy was developed to achieve the randomness attenuation, and the boundedness of the controlled system output was analyzed. The effectiveness of the presented control algorithm was demonstrated by a numerical example. In this paper, a data-driven minimum entropy design is presented without pre-knowledge of the system model; entropy optimization is achieved by the system stabilization approach in which the stochastic distribution control and minimum entropy are unified using the same identified structure; and a potential framework is obtained since all the existing system stabilization methods can be adopted to achieve the minimum entropy objective
Optimisation of design and operating parameters of reverse osmosis process for the removal of phenol from wastewater
Get PDFYesReverse Osmosis (RO) is widely used for separating organic and inorganic pollutants in wastewater. In this research, the one-dimensional steady state model of a spiral wound RO for the removal of phenol from wastewater, was simulated using gPROMS software to identify optimal design and operating parameters. The design parameters included the membrane length, width and feed spacer channel and operating conditions included temperature and pressure of the RO process. The optimal design parameters were able to maximise the removal of phenol from wastewater. The simulation results showed that the removal of phenol from wastewater was significantly influenced by the combination of membrane width, operating pressure, and feed temperature. The four main parameters (permeate concentration, solute flow, solute rejection, and water flux) that govern the performance of a reverse osmosis membrane were found to be influenced by the design and operating conditions.Reverse Osmosis (RO) is widely used for separating organic and inorganic pollutants in wastewater. In this research, the one-dimensional steady state model of a spiral wound RO for the removal of phenol from wastewater, was simulated using gPROMS software to identify optimal design and operating parameters. The design parameters included the membrane length, width and feed spacer channel and operating conditions included temperature and pressure of the RO process. The optimal design parameters were able to maximise the removal of phenol from wastewater. The simulation results showed that the removal of phenol from wastewater was significantly influenced by the combination of membrane width, operating pressure, and feed temperature. The four main parameters (permeate concentration, solute flow, solute rejection, and water flux) that govern the performance of a reverse osmosis membrane were found to be influenced by the design and operating conditions
Can Personality Traits Predict Students’ Satisfaction with Blended Learning during the COVID-19 Pandemic?
Get PDFYesThe present study aimed to assess the impact of personality traits on student satisfaction with blended learning which many higher education institutions have adopted since the COVID-19 pandemic in the UK. Personality traits were assessed using the International Personality Item Pool and student satisfaction was recorded on a 7-point Likert scale. Data analysis of 72 undergraduate students revealed that low extraversion and high neuroticism predicted higher levels of student satisfaction. Implications are discussed considering the current pandemic with a view of increasing student satisfaction and in-turn improving National Student Survey results that impact on Teaching Excellence Framework scores and league tables
Exploring families' acceptance of wearable activity trackers: A mixed-methods study
Get PDFYesThe family environment plays a crucial role in child physical activity (PA). Wearable activity trackers (wearables) show potential for increasing children's PA; however, few studies have explored families' acceptance of wearables. This study investigated the acceptability of using wearables in a family setting, aligning experiences with components of the Technology Acceptance Model and Theoretical Domains Framework.
Twenty-four families, with children aged 5-9 years, took part in a 5-week study, where all members were provided with a Fitbit Alta HR for 4 weeks. Acceptability was measured using weekly surveys and pre-post-questionnaires. Nineteen families participated in a focus group. Quantitative and qualitative data were integrated using the Pillar Integration Process technique.
Pillars reflected (1) external variables impacting wearable use and PA and (2) wearable use, (3) ease of use, (4) usefulness for increasing PA and other health outcomes, (5) attitudes, and (6) intention to use a wearable, including future intervention suggestions.
Families found the Fitbit easy to use and acceptable, but use varied, and perceived impact on PA were mixed, with external variables contributing towards this. This study provides insights into how wearables may be integrated into family-based PA interventions and highlights barriers and facilitators of family wearable use.This study is funded as part of a Ph.D. studentship by the Born in Bradford study. The Born in Bradford study receives core infrastructure funding from the Wellcome Trust (WT101597MA) and the National Institute for Health Research (NIHR), under its NIHR ARC Yorkshire and Humber (NIHR200166) and Clinical Research Network (CRN) research delivery support. For this piece of work, funding from the Sport England’s Local Delivery Pilot awarded Born in Bradford funding for this Ph.D. studentship. S.A.C. is supported by the NIHR Leicester Biomedical Research Centre—Lifestyle them
Fathers providing kangaroo care in neonatal intensive care units
Get PDFYes. Kangaroo care (KC) has been used widely in neonatal care to promote bonding/attachment and neurodevelopment for preterm and term infants. However, current literature suggests that research mainly focuses on infants' and mothers' experiences. The role of fathers in caring for their infant/child is changing and evolving in many countries around the globe. Yet little is known about fathers' experiences of KC in neonatal units. This review, therefore, aims to scope the current evidence of Father-infant KC (Father KC) in Neonatal Intensive Care Units (NICUs).
Research question. What impact does KC have upon fathers when their baby is cared for in NIUCs?
Search method. A scoping review was conducted and guided by the framework of Arksey and O'Malley (2005). The data sources consisted of Medline, Embase, America Psychological Association (APA) PsycInfo, Emcare, Cochrane Central, Web of Science, Google Scholar and ProQuest. The study inclusion criteria were: (1) studies involving fathers who had experience of KC with their baby whilst in Neonatal Intensive Care Units (NICUs), and other neonatal care settings, such as Special
Care Baby Nursery (SCBU), delivery/labour room and postnatal ward; (2) literature published from 2000 to 2020; (3) primary studies including qualitative, quantitative, and mixed methods studies; (4) studies published in English.
Results. The total number of studies identified were 13. Seven studies were qualitative and six were quantitative. None were mixed methods. Studies reported several positive KC benefits on fathers, such as reduced stress, promotion of paternal role and enhanced father-infant bond. It was highlighted that KC could be time-consuming for fathers and challenging to practise when balancing work and family life commitments.
Conclusion. This review provides evidence that KC practice has health and wellbeing benefits for fathers and infants in NICUs and other relevant neonatal care settings, The findings of this review support the justification to promote Father KC in NICU environments, and guide policies to include father involvement. Implementing Father KC in NICU settings will assist fathers to care and connect with their baby. Further research is needed to explore how to facilitate and evaluate KC education for fathers from diverse s and cultures
Development and Evaluation of Organometallic Anticancer Drug Candidates
Get PDFThere is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the serious side effects observed with cisplatin, have led research in Medicinal Inorganic Chemistry to using other precious metals for the design of novel anticancer therapeutics. This work reports on the synthesis and characterisation of a series of organometallic drug candidates based on ruthenium, osmium, rhodium, and iridium, followed by investigation of their cancer-inhibiting properties via in vitro and in vivo studies. The cytotoxicity of these complexes against various human cancer cell lines is presented, as well as preliminary studies on their possible modes of action, determined via gene expression studies, cell cycle and apoptosis analysis, reactive oxygen species detection and mitochondrial-membrane potential assays. In addition, to confirm the surprising absence of in vitro toxicity against normal cells exhibited by some compounds, studies on ex vivo/in vitro isolated human lymphocytes from healthy individuals, have been conducted. One lead molecule has been progressed to in vivo studies in mice and toxicity and efficacy were assessed with a series of assays including determination of the maximum tolerated dose and pharmacodynamic studies. Structural modifications of the lead molecule with water-soluble phosphines were subsequently undertaken, with the aim to improve the stability and solubility of the parent 16-electron specie, and evaluations of the biological activity of these novel complexes are presented
Doing the ‘right’ thing: A sociological exploration of pro-social behaviour by independent witnesses
Get PDFIndividual pro-social behaviour has been explored by academics and others in a variety of situations and contexts. Why people act selflessly on behalf of strangers is an intriguing topic and has not been studied in the specific context of the Crown courts before.
This study has three phases. The first allows independent witnesses to describe their emotions, decision-making and motivations for taking part in the criminal justice process where there is no overt benefit for themselves to do so. The study identifies three key points in the witnesses’ journey through the process and tests the reactions of the witnesses at these points. This approach allows any changes in their thinking to be recorded and analysed.
The second phase of the research asks other participants who have not been witnesses to imagine themselves becoming aware of three different scenarios where a violent crime is occurring. These participants are asked to think about their reactions to each scenario, and if they expect themselves to act as witnesses, asks what their motivations would be. The imagining witnesses’ reflections are compared to those of the real witnesses from Phase 1.
Finally, phase three disseminates the results from phases one and two to senior professionals working in the criminal justice sector. Their thoughts and suggestions are also applied to the results to identify and encourage best practise
Intersections between culture, sociodemographic change and caring: a qualitative study of current and prospective family caregivers in mainland China.
No full textAim: As the ageing population in China increases, support required from family caregivers for older relatives living with long-term health conditions also increases. This being so, this thesis explored the experiences and perceptions of current and prospective family caregivers, under the culture of Xiao (孝; filial piety).
Design and Methods: Phase 1 was conducted with 19 Chinese students using 3 focus groups to gain greater familiarity with the culture and inform the main study (Phase 2). Adopting a social constructivist philosophical position, data for Phase 2 were obtained from three generational sub-samples: only-children affected by the One-Child Policy (OCP), parents affected by OCP, and family caregivers in the workforce, totaling 23 participants through virtual in-depth interviews with participants in mainland China. Interviews were translated, transcribed, and analysed using reflective thematic analysis.
Findings and Conclusion: Phase 1 confirmed the centrality of the concept of Xiao to attitudes and beliefs around future caregiving for parents. Phase 2 findings’ overarching theme was ‘Competing pressures’, which comprised of three inextricably linked themes: (i) Caregiving beliefs, (ii) Contextual factors, and (iii) Caregiving conditions. Participants expressed meaningful desires to fulfil obligations, reflecting value-based convictions, stemming from their socio-cultural environment. Stressors experienced reveals structural and personal barriers to seeking support. Ultimately, extensive demands and limited coping strategies could diminish meaning in caregiving. This thesis makes a novel contribution on perceptions and experiences of family caregivers of older relatives within China as a collectivist society. Findings have implications for research, policy, and practice, highlighting the need for culturally attuned services to build resilience
Interfacial cocrystallization using oily phase via liquid−liquid phase separation
No full textYesCocrystals consist of two molecules bonded together in a single crystal lattice giving rise to wide applications including improving solubility of poorly soluble pharmaceuticals. Cocrystallization reaction occurs in the oily phase of liquid–liquid phase separation (LLPS) after it is mixed with coformers. Indomethacin–saccharin cocrystal formation was monitored in situ, and the kinetics of crystallization were determined. The crystallization rates show that the process can be proposed to prevent unwanted oily phase formation during LLPS.Research Development Fund Publication Prize Award winner, Sep 2022