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Mid-channel braid bar induced turbulent bursts: analysis using octant events approach
Get PDFYesIn a laboratory, a model of a mid-channel bar is built to study the turbulent flow structures in its vicinity. The present study on the turbulent flow structure around a mid-channel bar is based on unravelling the fluvial fluxes triggered by the bar’s 3D turbulent burst phenomenon. To this end, the three-dimensional velocity components are measured with the help of acoustic doppler velocimetry (ADV). The results indicate that the transverse component of turbulent kinetic energy cannot be neglected when analyzing turbulent burst processes, since the dominant flow is three-dimensional around the mid-channel bar. Due to the three-dimensionality of flow, the octant events approach is used for analyzing the flow in the vicinity of the mid-channel bar. The aim is to develop functional relationships between the stable movements that are modelled in the present study. To find the best Markov chain order to present experimental datasets, the zero-, first-, and second-order Markov chains are analyzed using the Akaike information criterion (AIC) and the Bayesian information criterion (BIC). The parameter transition ratio has evolved in this research to reflect the linkage of streambed elevation changes with stable transitional movements. For a better understanding of the temporal behaviors of stable transitional movements, the residence time vs. frequency graphs are also plotted for scouring as well as for depositional regions. The study outcome herein underlines the usefulness of the octant events approach for characterizing turbulent bursts around mid-channel bar formation, which is a precursor to the initiation of braiding configuration.This research and APC was funded by King Saud University, Riyadh, Saudi Arabia through Researchers Supporting Project number (RSP-2021/297)
The effect of PEO homopolymers on the behaviours and structural evolution of Pluronic F127 Smart Hydrogels for Controlled Drug Delivery Systems
Get PDFYesUnderstanding the structure-property relationships of drug delivery system (DDS) components is critical for their development and the prediction of bodily performance. This study investigates the effects of introducing polyethylene oxide (PEO) homopolymers, over a wide range of molecular weights, into Pluronic injectable smart hydrogel formulations. These smart DDSs promise to enhance patient compliance, reduce adverse effects and dosing frequency. Pharmaceutically, Pluronic systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and ease of injectability as solutions before transforming into gel matrices at body temperature. This paper presents a systematic and comprehensive evaluation of gelation and the interplay of microscopic and macroscopic properties under both equilibrium and non-equilibrium conditions in controlled environments, as measured by rheology in conjunction with time-resolved Small Angle Neutron Scattering (SANS). The non-equilibrium conditions investigated in this work offer a better understanding of the two polymeric systems’ complex interactions affecting the matrix thermo-rheological behaviour and structure and therefore the future release of an active pharmaceutical ingredient from the injectable DDS
Impact of COVID-19 on carers of people with dementia in the community: Findings from the British IDEAL cohort
Get PDFYesUnpaid carers for people with dementia play a crucial role in society. Emerging evidence suggests the COVID-19 pandemic has negatively impacted on carers. This study sought to explore the impact of the COVID-19 pandemic on carers for community-dwelling people with dementia and compare responses with pre-pandemic data.
Data were collected between September 2020 and April 2021 in England and Wales. Carers were identified from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) cohort and data were collected either through the telephone, video conferencing, or an online questionnaire. Responses from 242 carers were compared against benchmark data from the IDEAL cohort collected pre-pandemic. Analyses were conducted for the full sample of carers and spousal/partner carers only.
In total 48.8% of carers thought their healthcare needs were negatively affected during the pandemic. Compared with pre-pandemic data carers were more lonely and experienced less life satisfaction. There was little impact on carers' experience of caregiving, although carers felt trapped in their caregiving role. Carers were more optimistic and had higher social contact with relatives. There were changes in the methods carers used for contacting relatives and friends. Most carers coped very or fairly well during the pandemic. There was little difference in the experiences of spousal/partner carers and the full sample.
After a long period of providing care under pandemic conditions carers require additional support. This support needs to be focused on alleviating feelings of loneliness and increasing life satisfaction. Services need to consider how to improve access to health care, particularly resuming face-to-face appointments.Economic and Social Research Council, Alzheimer's Society, National Institute for Health Research
Digital capabilities in the construction industry
No full textNoDigitalization is transforming the way of doing business, and the construction industry is experiencing its fair share. It has necessitated the influx and growth of digital technologies application on construction projects and, to a larger extent, construction firms. In as much as this is a great initiative, early adopters in construction are still exploring, experimenting, and exploiting the potential of these digital transformations in their projects. There appears to be a gap in the digital capabilities needed in the construction life cycle and how these should be developed. A systematic review approach was used to identify digital technologies used in the construction industry. Literature on organization and digital capabilities was used to identify these capabilities and supported with examples from the UK and Australia to explain the capabilities. A case was made for how developing countries can develop digital capabilities in the construction industry from geographical distribution analysis from the systematic review and inference from the identified capabilities and the enabling approaches. Three main digital capabilities (digital mindset, digital infrastructure/investment and digital skillset) with sub-capabilities and two main approaches (firm and external) to developing these capabilities are discussed in this chapter. By implication, these capabilities are also useful in the construction industry in developing countrie
Green light for green credit? Evidence from its impact on bank efficiency
Get PDFYesWe assess, for the first time in the literature, the impact of green credit on bank efficiency. We find that green credit has a negative impact on bank efficiency. However, the effect is heterogeneous among different types of banks. While small and low capitalized banks are more affected, the impact is lower in banks with higher levels of risk. On the other hand, we find that highly capitalized banks can offset the negative effects of green credit, while large banks and those highly involved in green credit, benefit from this activity
Refractive management of patients undergoing cataract surgery. The development of pre and post-operative refractive management guidelines for patients undergoing cataract surgery in the UK
No full textCataract surgery is the most commonly performed surgery within the UK with 400,000 surgeries performed each year. Currently no guidelines exist for clinicians regarding target refraction discussions, spectacle provision post-operatively and driving advice following surgery. The PhD aimed to start the process of developing pre- and post-operative management guidelines for patients developed by both optometrists and ophthalmologists which could then be disseminated to both professions in the hope of improving the overall outcome of surgery.
The current literature highlighted target refraction discussions were lacking or non-existent which left some myopes dissatisfied after surgery due to an emmetropic target refraction leaving them unable to read without glasses as they did prior to surgery. Target refraction discussions were found to be linked with years of experience and this needs further exposure in continuing professional development.
Post-operative driving advice was found to be inconsistent and vary between practitioners and between optometry and ophthalmology. Advice was found to vary from driving “immediately” following surgery up to 6 weeks post-operatively.
Re-analysis of (de Juan et al. 2013) data during our systematic review and meta-analysis found refraction to be stable 1-2 weeks following surgery for 93% of patients. It was found a large change between pre- and post-surgery cylindrical power/axis may be an indicator that refractive stability has not occurred. Although this study had limitations it confirmed refraction is stable sooner than the current guidelines of 4-6 weeks.
Finally, we used a Delphi process to develop refractive management guidelines with a total of fifteen recommendations finalised
Analysis of experience using human rights to accelerate WASH access in four countries
Get PDFYesHuman rights to water and sanitation have been widely recognised in legal instruments at the international, regional, and national levels of governance. More awareness of states’ obligations has provided additional impetus to promote human rights in policy advocacy. The international non-governmental organisation WaterAid, as a non-state actor specialising in the water, sanitation, and hygiene services (WASH) sector, adopts a human rights-based approach (HRBA) to WASH programming. This paper draws on the experiences from WaterAid WASH projects in four countries – Nepal, Ghana, Mali, and Burkina Faso, to evaluate the practical impacts of the HRBA to ensure that governments fulfil their responsibility to realise universal access to water and sanitation services in different contexts. The outcomes highlight that three important contributions of the HRBA: (1) generates greater awareness among rightsholders and duty bearers about responsibilities and entitlements over safe drinking water and sanitation; (2) promotes constructive engagement between the government and rightsholders; and (3) equips people with the motivation, skills, and agency which are critical dimensions to work on sustainable WASH. The WASH sector should, therefore, embrace the power of human rights and invest in the specific activities and frameworks to integrate human rights into systems strengthening the WASH sector, while continuing to analyse and learn how to adapt and improve the approach in different contexts
Curbing Bribe-Giving in Malaysia: The Role of Attitudes and Parents
Get PDFYesOne of the main challenges developing nations face is curbing bribery. While there are many efforts to curb bribery, most focused at macro level, such as law, while little has been examined at the micro level, e.g., individual behavior and intention. Those who did investigate at the micro level tend to focus on the recipients rather than the ones giving the bribe. We explored eight factors that influence Malaysian young adults’ bribe giving intention based on the Reasoned Action Approach (RAA). A total of 345 respondents (M age = 20.68, SD = 2.01, 189 are females) completed questionnaires about all RAA variables. Partial Least Squares Structural Equation Modelling (PLS-SEM) was carried out using smartPLS3.0 to analyze the result. The result revealed that out of the eight variables, four variables—Instrumental attitudes, Experiential Attitudes, Parents’ descriptive norms and Capacity—explain 74% of the variance in bribe giving intention. An important take-away is that young adult’s perception of whether their parents gave or did not give bribes in a given situation is important in influencing their bribe giving intention. Bribe giving prevention messages must be targeted explicitly toward parents, where they play a crucial role in curbing this dishonesty
SMN-deficient cells exhibit increased ribosomal DNA damage.
Get PDFYesSpinal muscular atrophy, the leading genetic cause of infant mortality, is a motor neuron disease caused by low levels of survival motor neuron (SMN) protein. SMN is a multifunctional protein that is implicated in numerous cytoplasmic and nuclear processes. Recently, increasing attention is being paid to the role of SMN in the maintenance of DNA integrity. DNA damage and genome instability have been linked to a range of neurodegenerative diseases. The ribosomal DNA (rDNA) represents a particularly unstable locus undergoing frequent breakage. Instability in rDNA has been associated with cancer, premature ageing syndromes, and a number of neurodegenerative disorders. Here, we report that SMN-deficient cells exhibit increased rDNA damage leading to impaired ribosomal RNA synthesis and translation. We also unravel an interaction between SMN and RNA polymerase I. Moreover, we uncover an spinal muscular atrophy motor neuron-specific deficiency of DDX21 protein, which is required for resolving R-loops in the nucleolus. Taken together, our findings suggest a new role of SMN in rDNA integrity
Numerical and theoretical research on flexural behaviour of steel-precast UHPC composite beams
Get PDFYesIn order to promote the utilization of high strength materials and application of prefabricated structures, flexural behaviour of section steel-precast UHPC (Ultra-High performance concrete) slab composite beams prefabricated with bolt shear connectors are numerically simulated by the finite element (FE) software ABAQUS. The model is verified by three prefabricated steel-concrete composite beams tested. Numerical analysis results are in good accordance with experimental results. Furthermore, parametric studies are conducted to investigate the effects of strength of section steel and concrete of precast slab, thickness of section steel, width and height of precast concrete slab, diameters of steel bars and bolt shear connectors. The flexural behaviour of composite beams, in terms of bearing capacity, deflection, ductility and energy dissipation, are compared. The numerical results indicate that the improvement of strength of section steel results in a decrease of ductility, but a significant increase of the ultimate load and energy dissipation. Compared with composite beam made of section steel with thickness of 10 mm, the ultimate load of beams made of section steel with thickness of 14 and 18 mm improve by 29.0% and 58.8%, respectively, the ductility enhance by 2.8% and 8.3%, respectively, and the energy dissipation improve by 8.0% and 12.3%, respectively. With the increase of concrete strength, the ultimate load, deflection and energy dissipation gradually increase. The ductility of steel-UHPC composite beam is the highest, that of steel-HSC composite beam is the lowest. The effect of reinforcement ratio of concrete slab and diameter of shear bolts on the ultimate load of composite beam is limited. Simplified formulae for two different sectional types of proper-reinforced section steel-precast UHPC slab composite beams occurred bending failure are proposed, and the predicted results fit well with the simulated results. The results can be taken as a reference for the design and construction of section steel-precast UHPC slab composite beams